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Tungsten 2024年第1期6卷 134-140页

作者： Lin-Chao Zhang Ke Jing Rui Liu Zhuo-Ming Xie Jun-Feng Yang Gang Li xian-Ping Wang Xue-Bang Wu Qian-Feng Fang Chang-Song Liu Key Laboratory of Materials Physics Institute of Solid State PhysicsHFIPSChinese Academy of SciencesHefei 230031China University of Science and Technology of china Hefei 230026China Science and Technology on Reactor Fuel and Materials Laboratory Nuclear Power Institute of ChinaChengdu 610041China

The cermet fuels have been considered as a potential key component for the nuclear thermal propulsion,and the homogeneity of the fuel particles in the metal matrix plays a crucial role in stabilizing the structure at extremely high *** this work,liquid paraffin was used as additive to improve the distribution of yttria-stabilized zirconia(YSZ,an appropriate surrogate for UO_(2) fuel)microspheres in the tungsten(W)matrix,and the W-YSZ cermet wafers(volume ratio 1:1)with a relative density of 97.6%were fabricated by spark plasma sintering with a specifically designed *** effects of the paraffin dosage(0-5.wt.%)on the homogeneity,microstructure,mechanical properties,and the thermal conductivity of W-YSZ cermet were *** W-YSZ sample with 2 wt.%paraffin shows the highest homogeneity and exhibits the best comprehensive properties,including the ultimate tensile strength of 132.2 MPa at 600℃,the bending strength of45. MPa and thermal conductivity of 5. W·m^(-1)·K^(-1)at room ***,the cermet could keep structurally sound after thermal shocked at a heat load of 20 MW·m^(-2).These results would be helpful for the design and optimization of the cermet fuels in the nuclear thermal propulsion.

关键词： Nuclear thermal propulsion Tungsten Cermet Liquid paraffin Thermal shock

Efficacy and Safety of Bufei Jiedu Granules in Treating Multidrug-Resistant Pulmonary Tuberculosis:A Multi-center,Double-Blinded and Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第7期30卷 579-587页

作者： ZHANG Shao-yan QIU Lei ZHANG Shun-xian XIAO He-ping CHU Nai-hui ZHANG Xia ZHANG Hui-qiang ZHENG Pei-yong ZHANG Hui-yong LU Zhen-hui institute of Respiratory Diseases Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai200032China Clinical research Center Shanghai University of Traditional Chinese MedicineShanghai200032China Department of Tuberculosis Shanghai Pulmonary HospitalTongji UniversityShanghai200433China Department of Tuberculosis Beijing Chest HospitalCapital Medical UniversityBeijing101100China Department of Tuberculosis the Second Hospital of NanjingNanjing210003China Department of Tuberculosis the First Hospital Affiliated to Xinxiang Medical CollegeXinxiangHenan Province453100China

Objective: To assess the efficacy and safety of Bufei Jiedu(BFJD) Granules as adjuvant therapy for patients with multidrug-resistant pulmonary tuberculosis(MDR-PTB). Methods: A large-scale, multi-center, double-blinded, and randomized controlled trial was conducted in 18 sentinel hospitals in china from December 2012 to December 2016. A total of 312 MDR-PTB patients were randomly assigned to BFJD Granules or placebo groups(1:1) using a stratified randomization method, which both received the long-course chemotherapy regimen for 18 months(6 Am-Lfx-P-Z-Pto, 12 Lfx-P-Z-Pto). Meanwhile, patients in both groups also received BFJD Granules or placebo twice a day for a total of 18 months, respectively. The primary outcome was cure rate. The secondary outcomes included time to sputum-culture conversion, changes in lung cavities and quality of life(QoL) of patients. Adverse reactions were monitored during and after the trial. Results: A total of 216 cases completed the trial, 111 in the BFJD Granules group and 105.in the placebo group. BFJD Granules, as adjuvant treatment, increased the cure rate by 13.6% at the end of treatment, compared with the placebo(5..4% vs. 44.8%, P=0.02), and accelerated the median time to sputum-culture conversion(5.months vs. 11 months). The cavity closure rate of the BFJD Granules group(5..6%, 43/85. was higher than that of the placebo group(32.1%, 26/81;P=0.02) in patients who completed the treatment. At the end of the intensive treatment, according to the 36-item Short Form, the BFJD Granules significantly improved physical functioning, general health, and vitality of patients relative to the placebo group(all P5.1%(8/15.) in the BFJD Granules group and 2.6%(4/15.) in the placebo group. Conclusions: Supplementing BFJD Granules with the long-course chemotherapy regimen significantly increased the cure rate and cavity closure rate, and rapidly improved QoL of pati

关键词： alternative medicine Chinese herbal formula Bufei Jiedu Granules multidrug-resistant tuberculosis long-course chemotherapy regimen randomized controlled trial

Ultrafast laser state active controlling based on anisotropic quasi-1D material

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Light(Science & Applications) 2024年第4期13卷 717-726页

作者： Zixin Yang Qiang Yu Jian Wu Haiqin Deng Yan Zhang Wenchao Wang Tianhao xian Luyi Huang Junrong Zhang Shuai Yuan Jinyong Leng Li Zhan Zongfu Jiang Junyong Wang Kai Zhang Pu Zhou College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangsha 410073China. Nanhu Laser Laboratory National University of Defense TechnologyChangsha 410073China. i-Lab&Key Laboratory of Nanodevices and Applications&Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China. School of Applied and Engineering Physics Cornell UniversityIthacaNY 14853USA. State Key Laboratory of Advanced Optical Communication Systems and Networks School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China. Shanghai Key Lab of Modern Optical System University of Shanghai for Science and TechnologyShanghai 200093China

Laser state active controlling is challenging under the influence of inherent loss and other nonlinear effects in ultrafast *** an extension of degree of freedom in optical devices based on low-dimensional materials may be a way ***,the anisotropic quasi-one-dimensional layered material Ta2PdS6 was utilized as a saturable absorber to modulate the nonlinear parameters effectively in an ultrafast system by polarization-dependent *** polarization-sensitive nonlinear optical response facilitates the Ta2PdS6-based mode-lock laser to sustain two types of laser states,i.e.,conventional soliton and noise-like *** laser state was switchable in the single fiber laser with a mechanism revealed by numerical *** coding was further demonstrated in this platform by employing the laser as a codable light *** work proposed an approach for ultrafast laser state active controlling with low-dimensional material,which offers a new avenue for constructing tunable on-fiber devices.

关键词： polarization fiber controlling

Novel PIKfyve/Tubulin Dual-target Inhibitor as a Promising Therapeutic Strategy for B-cell Acute Lymphoblastic Leukemia

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Current Medical Science 2024年第2期44卷 298-308页

作者： Zhen LU Qian LAI Zhi-feng LI Meng-ya ZHONG Yue-long JIANG Li-ying FENG Jie ZHA Jing-wei YAO Yin LI xian-ming DENG Bing XU Department of Hematology The First Affiliated Hospital of Xiamen University and Institute of HematologySchool of MedicineXiamen UniversityXiamen361005China Key Laboratory of Xiamen for Diagnosis and Treatment of Hematological Malignancy Xiamen361005China Department of Oncology The First Affiliated Hospital of Jinan UniversityJinan UniversityGuangzhou510630China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling NetworkSchool of Life SciencesXiamen UniversityXiamen361003China

Objective:In B-cell acute lymphoblastic leukemia(B-ALL),current intensive chemotherapies for adult patients fail to achieve durable responses in more than 5.%of cases,underscoring the urgent need for new therapeutic regimens for this patient *** present study aimed to determine whether HZX-02-05.,a novel dual-target inhibitor targeting both phosphatidylinositol-3-phosphate 5.kinase(PIKfyve)and tubulin,is lethal to B-ALL cells and is a potential therapeutic for B-ALL ***:Cell proliferation,vacuolization,apoptosis,cell cycle,and in-vivo tumor growth were *** addition,Genome-wide RNA-sequencing studies were conducted to elucidate the mechanisms of action underlying the anti-leukemia activity of HZX-02-05. in ***:HZX-02-05. was found to inhibit cell proliferation,induce vacuolization,promote apoptosis,block the cell cycle,and reduce in-vivo tumor *** of the p5. pathway and suppression of the phosphoinositide 3-kinase(PI3K)/AKT pathway and the downstream transcription factors c-Myc and NF-κB were responsible for these ***:Overall,these findings suggest that HZX-02-05. is a promising agent for the treatment of B-ALL patients resistant to conventional therapies.

关键词： B-cell acute lymphoblastic leukemia dual-target inhibitor NF-kB c-Myc PI3K/AKT p5.

Combined adjustment project of national astronomical geodetic networks and 2000' national GPS control network

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Progress in Natural Science:Materials International 2005年第5期15卷 435-441页

作者： YANG Yuanxi1*, ZHA Ming2, SONG Lijie3, WEI Ziqing1, WANG Zhouping2, OUYANG Guichong2, XU Bilin2, WU Xiaoping3 and WANG Junqin4(1. Xi'an research {5. of surveying and map.ing, Xi'an 710054. china 2. Xi'an Informational and Technical Center of surveying and map.ing, Xi'an 710054. china 3. Zhengzhou {5. of surveying and map.ing, Zhengzhou 45.05., china 4. The First surveying Team of Tianjin, Tianjin 300140, china) xian research institute of surveying and map.ing Xi''an 710054 China Xi''an Informational and Technical Center of surveying and map.ing Xi''an 710054 China Zhengzhou institute of surveying and map.ing Zhengzhou 450052 China

The combined adjustment project of the nationwide astronomical geodetic networks and 2000' national GPS control network involve 485.9 terrestrial observational stations and 2666 GPS observational stations. In the terrestrial network, 25.07 stations are height fixed and 23412 stations are in three dimensions. 440793 terrestrial observations and 183668 unknowns are involved in the adjustment. The three-dimensional observational models for the adjustment have been established. The crustal deformation influences and corrections are researched. Fast methods of solving partitioned adjustment for super large-scale geodetic network have been studied. The standard deviations of three-dimensional coordinates for all stations are evaluated. As a result of the combined adjustment, a unified national geodetic network with nearly 5.000 stations is established, the high accurate three-dimensional geocentric coordinates are obtained. The standard deviation for geoid is averagely 0.2 m, for vertical deflection is about 1.5., for the horizontal position is about 0.12 m, for the geodetic height is about 0.14 m, and for the three-dimensional position is averagely 0.3 m.

关键词： astronomical geodetic network GPS network combined adjustment datum geocentric coordinates.

智能电子产品典型材料中7种二甲基环硅氧烷含量的测定

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分析测试学报 2024年第4期43卷 643-648页

作者：幸苑娜彭先芝中国科学院广州地球化学研究所广东广州510640 中国科学院大学北京100049

智能电子产品中残留的二甲基环硅氧烷(DMCs)可能随设备报废而进入环境。该研究针对智能电子产品材料基质复杂且溶解性和分散性差的特点,选取硅橡胶、胶黏剂和塑料3种典型材料为代表,采用丙酮对颗粒度为0.5.cm×0.5.cm的样品进行超声萃取... 详细信息

智能电子产品中残留的二甲基环硅氧烷(DMCs)可能随设备报废而进入环境。该研究针对智能电子产品材料基质复杂且溶解性和分散性差的特点,选取硅橡胶、胶黏剂和塑料3种典型材料为代表,采用丙酮对颗粒度为0.5.cm×0.5.cm的样品进行超声萃取,选择SH-Rxi-5.il MS毛细管柱(30 m×0.25.mm×0.25.m)进行气相色谱-质谱(GC-MS)分离,通过特征碎片离子实现了7种DMCs(D3、D4、D5.D6、D7、D8、D9)的定性定量分析。7种DMCs在0.1~10.0 mg/L质量浓度范围内呈良好的线性关系(r^(2)≥0.9993),方法定量下限为0.5.g/g;7种DMCs在智能电子产品3种典型材料中的平均加标回收率为83.8%~105.,相对标准偏差(RSD,n=6)为1.5.~4.6%。将该方法用于7种不同智能电子产品材料中DMCs的分布分析,结果在6个样品中检出DMCs,总含量为30.0~1.6×10^(3)µg/g。

关键词：二甲基环硅氧烷气相色谱-质谱智能电子产品硅橡胶胶黏剂塑料

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ANN-FLUS模型在历史耕地分布变化重建上的应用——以1885.2000年的越南为例

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自然资源学报 2024年第6期39卷 1473-1492页

作者：刘娴刘浩龙中国科学院地理科学与资源研究所陆地表层格局与模拟重点实验室北京100101 中国科学院大学北京100049

历史土地利用及其覆被的变化对于理解不同时期的人地关系具有重要指导意义。传统的耕地开垦优先度模型未考虑土地利用转换规则及邻域效应,重建精度不高。基于多源史料提取越南1885.2000年5.关键年份耕地总量及其9个驱动因素,并应用有... 详细信息

历史土地利用及其覆被的变化对于理解不同时期的人地关系具有重要指导意义。传统的耕地开垦优先度模型未考虑土地利用转换规则及邻域效应,重建精度不高。基于多源史料提取越南1885.2000年5.关键年份耕地总量及其9个驱动因素,并应用有大数据处理和土地转换规律挖掘优势的ANN-FLUS模型探讨耕地分布变化。结果表明:(1)耕地总量由15.2千hm^(2)增至6200千hm^(2),其变化以1940年代为转折阶段而表现出前快、后慢的差异;(2)耕地历来集中在红河、湄公河三角洲以及中部沿海平原,其在全国尺度上开发模式由“聚点式”缓慢延伸逐渐转变为“散点”式迅速扩张;(3)ANN-FLUS模型在越南195.年耕地分布格局上的重建精度为Kappa系数0.65.显著优于开垦优先度模型(0.5.)及HYDE 3.2数据集模型(0.5.)。

关键词：历史耕地分布变化机器学习 ANN-FLUS模型重建越南

Rare earth element enrichment in sedimentary phosphorites formed during the Precambrian-Cambrian transition,Southwest china

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Geoscience Frontiers 2024年第2期15卷 334-348页

作者： Jieqi Xing Yuhang Jiang Haiyang xian Wubin Yang Yiping Yang Hecai Niu Hongping He Jianxi Zhu CAS Key Laboratory of Mineralogy and Metallogeny Guangdong Provincial Key Laboratory of Mineral Physics and MaterialsGuangzhou Institute of GeochemistryChinese Academy of Sciences(CAS)Guangzhou 510640China CAS Center for Excellence in Deep Earth Science Guangzhou 510640China University of Chinese Academy of Sciences Beijing 100049China

Numerous sedimentary phosphorites in Southwest china were formed around the Precambrian–Cambrian transition(PC–C),including the upper Ediacaran Doushantuo Formation and lower Cambrian Gezhongwu *** Gezhongwu phosphorites in Zhijin exhibit marked rare earth element(REE)enrichment(>1000 ppm),and may represent new REE *** the main characteristics of the Gezhongwu phosphorites have been well constrained,the REE enrichment mechanisms remain *** undertook a comparative study of three typical sedimentary phosphorites with variable REE contents formed at the PC–C transition in central Guizhou Province,Southwest *** include sections A and B of the Doushantuo phosphorites(5.0±8 Ma)from the Weng’an area(i.e.,WA-A and WA-B),and the Gezhongwu phosphorites(5.7±24 Ma)from the Zhijin area(ZJ).The phosphorites were investigated with state-of-the-art macroscale to nanoscale analytical *** contrast to the extraordinary REE enrichment in the ZJ phosphorites(average RREE=115. ppm),the phosphorites in WA-A(average RREE=234 ppm)and WA-B(average RREE=114 ppm)are *** map.ing by laser ablation–inductively coupled plasma–mass spectrometry,along with transmission electron microscopy analyses,showed the REEs in the studied phosphorites are hosted in nanoscale *** 87Sr/86Sr and Y/Ho ratios of the francolite grains indicate that greater terrigenous input may have led to more REE enrichment in the WA-A than WA-B phosphorites,but this cannot explain the extraordinary REE enrichment in the ZJ *** F/P_(2)O_(5.values of the francolite grains in the ZJ phosphorites(~0.097)are higher than those in the WA-A(~0.084)and WA-B(~0.084)phosphorites,and the grain size of the francolite in the ZJ phosphorites(~89.9 nm)is larger than those in the WA-A(~5..6 nm)and WA-B(~5..4 nm)phosphorites,indicative of more intense reworking of the ZJ than WA phosphorites during early diagenesis.A plot of Nd concentration versus Ce/Ce^(*)r

关键词： REE enrichment Francolite,phosphorites Sedimentary reworking Rate of sedimentary

National 2000' GPS control network of china

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Progress in Natural Science:Materials International 2007年第8期17卷 983-987页

作者： Yang Yuanxi~(1**) Tang Yingzhe~1 Chen Chuanlu~2 Wang Min~3 Zhang Peng~4 Wang Xiaorui~2 Song Lijie~5.Zhang Zusheng~6 (1.Xi'an research institute of surveying and map.ing,Xi'an {5.china 2.Geodetic Data Processing Center,Xi'an {5.china 3.Center of Earthquake Analysis and Prediction,china Seismological Bureau,Beijing 100036,china 4.National Geomatics Center of china,Beijing 100044,china 5.institute of surveying and map.ing,Zhengzhou University of Information Engineering,Zhengzhou 45.05.,china 6.First Crustal Deformation Monitoring Center,china Seismological Bureau,Tianjin 300180,china) [a]Xi' an research institute of surveying and map.ing Xi' an China [b]Geodetic Data Processing Center Xi'an China [c]Center of Earthquake Analysis and Prediction China Seismological Bureau Beijing China [d]National Geomatics Center of Chinna Beijing China [e]institute of surveying and map.ing Zhengzhou University of Information Engineering Zhengzhou China [f]First Crustal Deformation Monitoring Center China Seimological Bureau Tianjin China

An accurately unified national GPS network with more than 25.0 stations,named"National 2000' GPS Control Net- work",signed the epoch 2000.0,has been established by integrating the existing six nationwide GPS networks of china set up by differ- ent departments with different *** paper presents the characteristics of the existing GPS networks,summarizes the strategies in the integrated adjustment of the GPS network,including functional model,stochastic model as well as the adjustment principle modifi- *** modifying the adjustment strategies according to the characteristics of the existing GPS networks and under the support of the IGS stations,the accuracy of the integrated national GPS network is greatly *** datum differences among the sub networks disappear,the systematic error influences are weakened,and the effects of the outliers on the estimated coordinates and their variances are *** is shown that the average standard deviation for the horizontal component is smaller than 1.0 cm,the vertical component is smaller than 2.0 cm,and the three-dimensional (3-D) position of geocenter coordinates is smaller than 3.0 *** exterior checking ac- curacy for the 3-D position is averagely better than 1.0 cm.

关键词： GPS control network adjustment systematic errors robust estimation variance component estimation coordinate system

Telomere-to-telomere genome of the allotetraploid legume Sesbania cannabina reveals transposon-driven subgenome divergence and mechanisms of alkaline stress tolerance

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Science china(Life Sciences) 2024年第1期67卷 149-160页

作者： Haofei Luo Xiaofei Wang Changqing You Xuedan Wu Duofeng Pan Zhiyao Lv Tong Li Dongmei Zhang Zhongbao Shen Xiaodong Zhang Guodao Liu Kaixuan He Qingtong Ye Yajun Jia Qinghua Zhao xian Deng Xiaofeng Cao xianwei Song Gai Huang State Key Laboratory of Plant Genomics and National Center for Plant Gene research Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Hainan Yazhou Bay Seed Lab Sanya 572025China University of Chinese Academy of Sciences Beijing 100049China institute of Forage and Grassland Sciences Heilongjiang Academy of Agricultural SciencesHarbin 150086China Shandong Academy of Agricultural Sciences Jinan 250100China National Center of Technology Innovation for Comprehensive Utilization of Saline-Alkali Land Dongying 257345China Shandong Green Manure Ecological Technology Co. LtdDongying 257345China State Key Laboratory of Tropical Crop Breeding Chinese Academy of Tropical Agricultural SciencesHaikou 571101China

Alkaline soils pose an increasing problem for agriculture worldwide,but using stress-tolerant plants as green manure can improve marginal ***,we show that the legume Sesbania cannabina is very tolerant to alkaline conditions and,when used as a green manure,substantially improves alkaline *** understand genome evolution and the mechanisms of stress tolerance in this allotetraploid legume,we generated the first telomere-to-telomere genome assembly of *** spanning~2,087 *** assembly included all centromeric regions,which contain centromeric satellite repeats,and complete chromosome ends with telomeric *** genome analysis distinguished A and B subgenomes,which diverged approximately 7.9 million years *** genomic analysis revealed that the chromosome homoeologs underwent large-scale inversion events(>10 Mb)and a significant,transposon-driven size expansion of the chromosome 5. *** further identified four specific alkali-induced phosphate transporter genes in ***;these may function in alkali tolerance by relieving the deficiency in available phosphorus in alkaline *** work highlights the significance of *** as a green tool to improve marginal lands and sheds light on subgenome evolution and adaptation to alkaline soils.

关键词： Sesbania cannabina alkaline stress telomere-to-telomere genome legume green manure phosphate transporter allotetraploid