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Sex differentiation of effect of microinjection of somatostatin into ventrolateral orbital cortex on formalin-induced nociceptive behavior in rats

Sex differentiation of effect of microinjection of somatosta...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Chao-Ling QU~(1,*),Bo XING~2,Yong-Hui DANG~2,Yan ZHAO~2,Feng-Yi XU~1,Fu-Quan HUO~1,Jing-Shi TANG~1 1 Department of Physiology and Pathophysiology,Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education,Xi’an Jiaotong University school of Medicine,Xi’an 710061,china 2 Department of Forensic Medicine,Key Laboratory of Environment and Gene Related to Diseases,Ministry of Education, Xi’an Jiaotong University school of Medicine,Xi’an 710061,china

Objective As a neuromodulator,somatostatin(SOM) and its receptors are involved in the antinociception in the spinal cord and the supraspinal ***,sex differences are observed in some pain-related *** studies have indicated that the ventrolateral orbital cortex(VLO) is involved in modulation of nociception as part of an endogenous analgesic system consisting of the spinal cord-nucleus submedius-VLO-periaqueductal gray-spinal cord *** aim of the current study was to examine whether the SOM and its receptors are involved in the VLO-induced antinociception in the rat formalin test,and determine whether there was a sex differentiation in the formalin *** After 5.formalin (5.μl) was injected subcutaneously into the plantar surface of the hindpaw,the number of times of flinching the hindpaw per 5.min was measured as an index of nociceptive response to observe the effect of microinjection of SOM into the VLO on the nociceptive behavior in different sex *** SOM(10μg/0.5.l)microinjected into the VLO significantly decreased the number of the flinches in either early or later phases in the female rat,and this inhibitory effect was blocked by pre-treatment with its antagonist cyclo-somatostatin(c-SOM,25.g/0.5.l),whereas the SOM had no effect on the formalin-induced flinching behavior in the male ***,c-SOM microinjected alone into the VLO did not influence the flinching behavior in both male and female *** These results suggest that SOM and its receptors are involved in the antinociception in the VLO of the female,but not the male rats in the formalin test.

关键词： Ventrolateral orbital cortex sex difference octreotide cyclo-somatostatin formalin test Flinching rat

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地方政府怎样规制民间借贷？--来自鄂尔多斯市的调研报告

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中国社会科学院研究生院学报 2012年第6期 23-31页

作者：中央党校第12.中青二班二支部调研组李国俭文学国中央党校第12.中青二班二支部调研组

民间借贷在全国范围内存在,在一些经济发达地区尤其活跃,但民间借贷的不规范行为极易引发地方性的金融危机与群体性事件。作者通过对鄂尔多斯市政府规制民间借贷行为的实践进行调研,总结了鄂尔多斯市政府在规制民间借贷行为方面的经验,... 详细信息

民间借贷在全国范围内存在,在一些经济发达地区尤其活跃,但民间借贷的不规范行为极易引发地方性的金融危机与群体性事件。作者通过对鄂尔多斯市政府规制民间借贷行为的实践进行调研,总结了鄂尔多斯市政府在规制民间借贷行为方面的经验,调研报告对民间借贷行为规制中遇到的难点问题提出了相关政策建议。

关键词：民间借贷金融危机政府规制

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大鼠不同脑区中环磷酸腺苷(cAMP)环磷酸鸟苷(cGMP)和甲硫氨酸脑啡肽(Met-Enk)的微量测定

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针刺研究 1981年第4期 251-258页

作者：何仁杰周舒娄艾琳叶智文白呼群姚冠贞陈玉珍许荣焜薛祚紘程兰英朱广瑾郑肖剑美国迈阿密大学医学院生物化学系中国医学科学院基础医学研究所针麻原理研究室

在我们已往的工作中,曾观察到针麻胃大部切除手术病人及狗实验模型上,血中反映交感神经机能状态的多巴胺β-羟化酶活性降低,手术器官组织肾上腺素能神经纤维去甲肾上腺素释放减少。血中游离5.羟色胺含量减少。在中枢神经系统、中脑、桥... 详细信息

在我们已往的工作中,曾观察到针麻胃大部切除手术病人及狗实验模型上,血中反映交感神经机能状态的多巴胺β-羟化酶活性降低,手术器官组织肾上腺素能神经纤维去甲肾上腺素释放减少。血中游离5.羟色胺含量减少。在中枢神经系统、中脑、桥脑、延脑等脑区内,5.羟色胺的含量有所升高,去甲肾上腺素有所降低。近几年来,随着国外关于内源性吗啡样物质的发现,在针刺镇痛原理的研究中,也报导脑脊液中内源性吗啡样物质的含量有所增加。由于这些物质都是通过细胞表面的特殊受体而影响细胞内 cAMP 的含量,也

关键词： cGMP 标准曲线 Met-Enk cAMP 大鼠不同脑区

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5.HT2 receptor mediated antinociception in the ventrolateral orbital cortex:A possible pre-synaptic facilitatory effect

5-HT2 receptor mediated antinociception in the ventrolateral...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Hai-Yan SHENG,Fu-Quan HUO~*,Chao-Ling QU,Jing-Shi TANG Department of Physiology and Pathophysiology,Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education,Xi''an Jiaotong University school of Medicine,Xi''an 710061,china

＜正＞Objective Behavioral study has shown that 5.HT2 receptor was involved in the VLO-mediated descending *** 5.HT2 receptor is an excitatory G-protein-coupled receptor and is distributed not only in the postsynaptic neurons,but also in pre-synaptic neurons or ***,we suppose that activation of 5.HT2 receptor induced antinociception in VLO may be produced,except for by post-synaptic activation of the VLO neurons projecting to PAG,also probably through a pre-synaptic facilitatory effect on the excitatory synapse *** provide support for this hypothesis,the current study was designed to examine whether 5.HT2 receptor activation-induced antinociception could be blocked by glutamate receptor antagonist and enhanced by its *** radiant heatevoked tail flick（TF） reflex was used as an index of nociceptive *** effect of microinjection of drugs into the VLO on the TF reflex was *** Microinjection of DOI（4,8,16 nmol）,a 5.HT2 receptor agonist,into VLO depressed the TF reflex in a dose-dependent manner（r=0.999,P=0.008,y=5.35.+3.5.4x）,and this inhibitory effect was significantly attenuated,but not completely blocked,by pre-microinjection of a non-selective glutamate receptor antagonist KA into VLO.A small dose（100 nmol） of glutamate administered into the VLO significantly enhanced the DOI-induced *** of KA alone into VLO did not change the baseline of TF *** These results provide support for above-mentioned hypothesis that 5.HT2 receptor activation-induced antinociception in VLO is produced at least partially through a pre-synaptic facilitatory effect on excitatory synapse transmission leading to activation of the VLO-PAG brainstem descending inhibitory system and depression of the nociceptive inputs at the spinal level.

关键词： antinocieption 5.HT2 receptor glutamate ventrolateral orbital cortex

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化学镀Ni-Co-P合金对Mm(NiCoAlMn)_5.氢合金电极动力学性能的影响

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中国稀土学报 2001年第2期19卷 115-120页

作者：孙春文唐致远郭鹤桐胡万起李道昭中国科学院化工冶金研究所北京100080 天津大学化工学院天津300072

通过电化学方法 ,研究了化学镀Ni Co P合金对Mm(NiCoAlMn) 5.五元稀土贮氢合金电极动力学性能的影响。研究表明 ,引入很少量(1%～ 2 % )Co的Ni Co P合金镀层可有效地提高MH电极的交换电流密度i0 、极限电流密度iL 及α相中氢的扩散系数D... 详细信息

通过电化学方法 ,研究了化学镀Ni Co P合金对Mm(NiCoAlMn) 5.五元稀土贮氢合金电极动力学性能的影响。研究表明 ,引入很少量(1%～ 2 % )Co的Ni Co P合金镀层可有效地提高MH电极的交换电流密度i0 、极限电流密度iL 及α相中氢的扩散系数Dα(H ) ;还研究了化学镀Ni Co P合金对稀土贮氢合金电极循环伏安 (CV)曲线和阴、阳极极化曲线及对称因子 β的影响。

关键词：稀土基贮氢合金化学镀电极动力学性能 MH-Ni电池碱性蓄电池镍钴磷合金

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五味子中木脂素类成分的高效液相色谱-电喷雾质谱研究

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化学学报 2008年第9期66卷 1059-1066页

作者：黄鑫宋凤瑞刘志强刘淑莹中国科学院长春应用化学研究所长春质谱中心

采用液相色谱-电喷雾质谱联用(HPLC-ESI-MSn)技术,对北五味子与南五味子中木脂素类成分进行了系统研究.通过HPLC-ESI-MS技术,获得了相应化合物的保留时间、紫外光谱和分子量等信息,利用电喷雾多级串联质谱技术(ESI-MSn),获得了相应化合... 详细信息

采用液相色谱-电喷雾质谱联用(HPLC-ESI-MSn)技术,对北五味子与南五味子中木脂素类成分进行了系统研究.通过HPLC-ESI-MS技术,获得了相应化合物的保留时间、紫外光谱和分子量等信息,利用电喷雾多级串联质谱技术(ESI-MSn),获得了相应化合物的结构信息.研究结果表明,北五味子与南五味子的主要木脂素成分除5.共有成分外其它成分差异较大,并且其共有成分含量差别较大.在此基础上,建立了简便、快速的北五味子与南五味子药材分析鉴定的新方法.

关键词：北五味子南五味子木脂素高效液相色谱-电喷雾质谱

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NONLINEAR COMPUTATIONAL INSTABILITY IN CALCULATION OF DISCONTINUOUS SOLUTION

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中国科学院研究生院学报 1991年第1期8卷 23-31页

作者： Ji Zhongzhen, Guo Dongjian(LASG, Institute of Atmospheric Physics, Academia Siniea)Ji Suzhen(Computer Center, Shanxi Institute of Meehancal Engineering, Xian, china)

Starting from one-dimensional nonlinear advecting equations, this paper has probed the energy properlies of discontinuous solutions, investigated that it is suitable to adopt energy decaying scheme to compute discontinuous solutions, compared and testified several difference schemes with dissipation effects, pointed out that it is easy to bring about nonlinear stabilities in doing discontinuous computation, and listed several better-effect schemes.

关键词： nonlinearinstability energy decaying scheme discontinuous solution

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Time-dependent loss of orexin neurons in hypothalamus in the rat model of Parkinson’s disease

Time-dependent loss of orexin neurons in hypothalamus in the...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Juan SHI~(1,*),Long-Biao CUI~(1,2),Bo-Wei LI~(1,2),Xiao-Hang JIN~1 1 Department of Anatomy,Histology and Embryology,K.K.Leung Brain Research Centre,Fourth Military Medical University,Xi''an 710032,china 2 school of Aerospace Medicine,the Fourth Military Medical University,Xi''an 710032,china

＜正＞Objective Orexins,including orexin A and B,are neuropeptides expressed by the neurons of lateral hypothalamus and play multiple roles in feeding,sleeping,rewarding,*** is recently reported that the number of orexin neurons can be negatively affected with the progression of Parkinson’s disease（PD）,but the detailed time dependency is not clear so *** we investigated the schedule of orexin neurons’ loss in PD rats by immunohistochemical and ELISA methods. Methods PD rats were made by injection of 6-OHDA into the medial prefrontal *** post operation of 4 d,7 d,10 d, 2 w,3 w,5.w,7 w and 9 w,cerebrospinal fluid（CSF） of each rats was obtained through cisterna magna for ELISA assay and the rats were then sacrificed for immunohistochemical staining of tyrosine hydroxylase（TH） in midbrain and orexin A in *** TH neurons in substantia nigra pars compacta decreased significantly at 4 d after operation and nearly totally disappeared at 1 w after *** contrast to this,the number of orexin A neurons decreased at 7 w after operation and reached only half of the control at 9 *** to this tendency,the concentration of orexin A in the CSF of 9 w group was significantly reduced by 25.as compared with that of *** Collectively,these results suggest that the degeneration of orexin neurons in hypothalamus is far preceded by that of TH neuron and may thus underlie the sleep disorders in PD patients in the later phase of the disease.

关键词： orexin Parkinson’s disease degeneration immunohistochemical staining ELISA

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Role of CDK5.on ATM phosphorylation in neuronal death induced by DNA damage

Role of CDK5 on ATM phosphorylation in neuronal death induce...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Bo TIAN~(1,2),Zi-Xu MAO~(1,*) 1 Department of Pharmacology and Neurology,Emory University school of Medicine,Atlanta,GA 30322 2 Department of Neurology,Tongji Medical college of Huazhong University of Science and Technology,Wuhan,400030, china

＜正＞Objective The phosphatidylinositol-3-kinase-like kinase ATM（Ataxia - telangiectasia mutated） plays a central role in coordinating the DNA damage responses including cell cycle checkpoint control,DNA repair,and apoptosis. Mutations of ATM cause a spectrum of defects ranging from neurodegeneration to cancer ***,the mechanism by which DNA damage activates ATM is poorly *** Different analysis by protein determination,kinase assays,real-time PCR,infection with adenoviruses or Antiviruses and survival assays among others,were used to demonstrate that Cdk5.mediates DNA damage signaling through ATM *** We show that Cdk5.cyclin-dependent kinase 5.,activated by DNA damage,directly phosphorylates ATM at serine 794 in postmitotic *** at serine 794 precedes and is required for ATM autophosphorylation at serine 1981, and activates ATM kinase ***5.ATM signal regulates phosphorylation and function of ATM targets p5. and *** of Cdk5.ATM pathway attenuates DNA damage-induced neuronal cell cycle reentry and expression of p5. targets PUMA and Bax,protecting neurons from DNA damage-induced *** This study reveals the role of Cdk5.on ATM phosphorylation after DNA *** of Cdk5.by DNA damage serves as a critical signal to initiate ATM response and regulate ATM-dependent cellular processes.

关键词： CDK5 ATM DNA damage neuronal death phosphorylation

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Tetris:A Heuristic Static Memory Management Framework for Uniform Memory Multicore Neural Network Accelerators

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Journal of Computer Science & Technology 2022年第6期37卷 1255-1270页

作者： Xiao-Bing Chen Hao Qi Shao-Hui Peng Yi-Min Zhuang Tian Zhi Yun-Ji Chen Distinguished Member,CCF State Key Laboratory of Computer Architecture Institute of Computing TechnologyChinese Academy of SciencesBeijing 100190China University of chinese academy of sciences Beijing 100049China school of Computer Science and Technology University of Science and Technology of ChinaHeFei230026China chinese academy of sciences Center for Excellence in Brain Science and Intelligence Technology Shanghai200031China 不详

Uniform memory multicore neural network accelerators(UNNAs)furnish huge computing power to emerging neural network ***,with neural network architectures going deeper and wider,the limited memory capacity has become a constraint to deploy models on UNNA *** how to efficiently manage memory space and how to reduce workload footprints are urgently *** this paper,we propose Tetris:a heuristic static memory management framework for UNNA *** reconstructs execution flows and synchronization relationships among cores to analyze each tensor’s liveness *** the memory management problem is converted to a sequence permutation *** uses a genetic algorithm to explore the permutation space to optimize the memory management strategy and reduce memory *** evaluate several typical neural networks and the experimental results demonstrate that Tetris outperforms the state-of-the-art memory allocation methods,and achieves an average memory reduction ratio of 91.9%and 87.9%for a quad-core and a 16-core Cambricon-X platform,respectively.

关键词： multicore neural network accelerators liveness analysis static memory management memory reuse genetic algorithm

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