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Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients

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Acta Pharmacologica Sinica 2006年第8期27卷 966-970页

作者： Sheng-nan WU~(2,3,5,6) Rui GAO~(2,3,6) Qing-he XING~(2,3,6) Hua-fang LI~4 Yi-feng SHEN~4 Niu-fan GU~4 Guo-yin FENG~4 Lin HE~(2,3,7)2 Bio-X Life Science Research Center,shanghai jiaotong university,shanghai 200030,china 3 institute of Nutritional Sciences,SIBS,Chinese Academy of Sciences,shanghai 200031,china 4 shanghai institute of Mental Health,shanghai 200030,china 5 shanghai institute of hypertension,ruijin hospital,medical school of shanghai jiaotong university,shanghai 200025,china Bio-X Life Science Research Center Shanghai Jiaotong University Shanghai China institute of Nutritional Sciences SIBS Chinese Academy of Sciences Shanghai China shanghai institute of hypertension Ruijin Hospital Medical School of Shanghai Jiaotong University Shanghai China shanghai institute of Mental Health Shanghai China

Aim:Extrapyramidal syndrome (EPS) is most commonly affected by typical antip-sychotic drugs that have a high affinity with the D2 ***,manyresearch groups have reported on the positive relationship between the geneticvariations in the DRD2 gene and the therapeutic response in schizophrenia pa-tients as a result of the role of variations in the receptor in modulating *** this study,we evaluate the role DRD2 plays in chlorpromazine-induced EPS in schizophrenic ***:We identified seven SNP(singlenucleotide polymorphism) (-141Cins>del,TaqIB,TaqID,Ser311Cys,rs6275,rs6277and TaqIA) in the DRD2 gene in 146 schizophrenic inpatients (59 with EPS and 87without EPS according to the Simpson-Angus Scale) treated with chlorpromazineafter 8 *** alleles of all loci were determined by PCR (polymerase chainreaction).Results:Polymorphisms TaqlD,Ser311Cys and rs6277 were not poly-morphic in the population recruited in the present *** statistical signifi-cance was found in the allele distribution of-141Cins>del,TaqIB,rs6275 andTaqIA or in the estimated haplotypes (constituted by TaqIB,rs6275 and TaqIA) inlinkage disequilibrium between the two ***:Our results did notlend strong support to the view that the genetic variation of the DRD2 gene playsa major role in the individually variable adverse effect induced by chlorpromazine,at least in Chinese patients with *** results confirmed a previousstudy on the relationship between DRD2 and EPS in Caucasians.

关键词： dopamine receptors basal ganglia disease polymorphism chlorpromazine schizophrenia

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Current Perspectives on Histone Demethylases

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Acta Biochimica et Biophysica Sinica 2007年第2期39卷 81-88页

作者： Xiaoqing TIAN and Jingyuan FANG shanghai jiaotong university school of Medicine,Renji hospital,shanghai instituteof Digestive Disease,shanghai 200001,china shanghai jiaotong university school of Medicine Renji Hospital Shanghai Institute of Digestive DiseaseShanghai 200001 China

The posttranslational modification of histones plays an important role in chromatin *** methylation influences constitutive heterochromatin,genomic imprinting,X-chromosome inactivationand gene *** demethylase catalyzes the removal of methyl groups on lysine or arginineresidues of *** kinds of histone lysine demethylases have been identified, including lysine specificdemethylase 1 and Jumonji C (JmjC) domain family *** histone demethylases are involved in theregulation of gene *** modification is a dynamic process,and the imbalance of histonemethylation has been linked to ***,histone demethylases may represent a new target foranti-cancer therapy.

关键词： epigenetic modification histone methylation demethylase lysine specific demethylase 1 Jumonji C(JmjC)protein

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Identification and Characterization of hmr19 Gene Encoding a Multidrug Resistance Efflux Protein from Streptomyces hygroscopicus *** Strain 10-22

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Acta Biochimica et Biophysica Sinica 2004年第8期36卷 519-528页

作者： Lei QIN , Heng-An WANG1 , Zhong-Qin WU, Xiao-Feng ZHANG, Mei-Lei JIN,Zi-Xin DENG2, and Guo-Ping ZHAOshanghaiResearch Center of Biotechnology, shanghai institute for Biological Sciences, Chinese Academy of Sciences,Graduate school of the Chinese Academy of Sciences, shanghai 200233, china 1school of Agriculture and Biology, shanghai jiaotong university, shanghai 201101, china 2school of Life Science and Biotechnology, shanghai jiaotong university, shanghai 200030, china shanghai Research Center of Biotechnology Shanghai Institute for Biological Sciences Chinese Academy of Sciences Graduate School of the Chinese Academy of SciencesShanghai 200233 China school of Agriculture and Biology Shanghai Jiaotong UniversityShanghai 201101 China school of Life Science and Biotechnology Shanghai Jiaotong UniversityShanghai 200030 China

The hmr19 gene was cloned from Streptomyces hygroscopicus subsp. yingchengensis strain 10- 22, a bacterium strain producing agricultural antibiotics. Sequence similarity comparison indicates that hmr19 gene may encode a predicted protein with 14 putative transmembrane α-helical spanners, belonging to the drug:H+ antiporter-2 family of the major facilitator superfamily. The expression of hmr19 in the mycelium of strain 10-22 was detected by Western blotting analysis. Gene replacement technology was employed to construct an hmr19 disruption mutant. The growth inhibition test against different antibiotics indicated that the mutant strain was 5–20 fold more susceptible to tetracycline, vancomycin and mitomycin C than the parental wild type strain. The mutant took up tetracycline much faster and accumulated more antibiotics than the wild type strain 10-22. While with the addition of an energy uncoupler, carbonyl cyanide m- chlorophenylhydrazone, the characteristics of the accumulation of [3H]tetracycline in these two strains were almost the same. It was thus concluded that hmr19 encoded a multidrug resistance efflux protein.

关键词： multidrug resistance (MDR) gene replacement (knockout) Streptomyces Streptomyces hygroscopicus subsp. yingchengensis strain 10-22

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SEEPAGE ANALYSIS OF LANDFILL FOUNDATIONS IN shanghai LAOGANG LANDFILL PHASE IV

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Journal of Hydrodynamics 2006年第5期18卷 613-619页

作者： ZHANG Qian-fei WANG Yan-ming XU Yong-fu school of Naval Architecture Ocean and Civil Engineering Shanghai Jiaotong University Shanghai 200030 China shanghai Municipal Engineering Design institute Shanghai 200092 China

A complex seepage flow field with unknown free surface was formed in the shanghai Laogang Municipal Solid Waste （MSW） Landfill by the perimeter cut-off wall around the landfill site and the Prefabricated Vertical Drains （PVD） in the foundation of landfill. First, the equivalent vertical permeability was presented based on the drainage mechanism of PVD and the related calculation method was studied to macroscopically reflect the impact of PVD on the seepage flow status of the landfill foundation. With the influence of the cut-off wall and the PVD on the infiltration of groundwater, the total inflow was classified into two parts： the lateral inflow through the cut-off wall outside the landfill, and the upward infiltration through the PVD from the foundation of the landfill. Seepage analysis was conducted using the finite element method according to the actual scenario of Laogang Landfill, and the lateral infiltration and the upward infiltration were calculated, respectively. The results show that the total inflow into the landfill area was mostly supplied by the upward infiltration through the PVD and the perimeter cut-off wall was significantly effective to depressurize the seepage pressure and to reduce the flow rate.

关键词： Municipal Solid Waste (MSW) landfill foundations of landfill cut-off wall Prefabricated Vertical Drain (PVD) lateral infiltration upward infiltration finite element analysis

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cvhA Gene of Streptomyces hygroscopicus 10-22 Encodes a Negative Regulator for Mycelia Development

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Acta Biochimica et Biophysica Sinica 2006年第4期38卷 271-280页

作者： Heng-An WANG~(1,2#) Lei QIN~(2#) Ping LU~(1*) Zhi-Xuan PANG~2 Zi-Xin DENG~(3*) Guo-Ping ZHAO~(2*) 1 Biotechnology institute,school of Agriculture and Biology,shanghai jiaotong university,shanghai 201101,china 2 Laboratory of Molecular Microbiology,institute of Plant Physiology and Ecology,shanghai institute for Biological Sciences,Chinese Academy of Sciences,shanghai 200032,china 3 Bio-X Life Science Research Center,shanghai jiaotong university,shanghai 200030,china. Biotechnology institute School of Agriculture and Biology Shanghai Jiaotong UniversityShanghai 201101 China Laboratory of Molecular Microbiology Institute of Plant Physiology and Ecology Shanghai Institute for Biological Sciences Chinese Academy of SciencesShanghai 200032 China Bio-X Life Science Research Center Shanghai Jiaotong UniversityShanghai 200030 China.

A five-gene cluster cvhABCDE was identified from Streptomyces hygroscopicus *** thefirst gene of this cluster,cvhA encoded a putative sensor histidine kinase with a predicted sensor domainconsisting of two trans-membrane segments at the N-terminus and a conserved HATPasecdomain at the *** C-terminus polypeptide of CvhA expressed in Escherichia coli was purified and shown to beautophosphorylated with [γ-32P]ATP in *** phosphoryl group was acid-labile and basic-stable,whichsupported histidine as the phosphorylation *** obvious difference of mycelia development was ob-served between the null mutant of cvhA generated by targeted gene replacement and the wild-type parentalstrain 10-22 grown on solid soya flour medium with 2%-8% glucose or sucrose,but the cvhA mutant couldform much more abundant aerial mycelia and spores than the wild-type strain on solid soya flour mediumsupplemented with 6%-8% mannitol,6%-8% sorbitol,4%-6% mannose,or 4%-6% *** pheno-type was complemented by the cloned wild-type cvhA gene,and no difference was observed for growthcurves of the cvhA mutant and the wild strain in liquid minimal medium with the tested sugars at a concen-tration of 4%,6% and 8%.We thus propose that CvhA is likely a sensor histidine kinase and negativelyregulates the morphological differentiation in a sugar-dependent manner in *** 10-22.

关键词： sensor histidine kinase aerial mycelia sugar metabolism

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A LINEAR HYBRID MODEL OF MSE AND BEM FOR FLOATING STRUCTURES IN COASTAL ZONES

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Journal of Hydrodynamics 2006年第6期18卷 649-658页

作者： ZHANG Jun MIAO Guo-ping school of Naval Architecture Ocean and Civil Engineering Shanghai Jiaotong University Shanghai 200030China The First Engineers Scientific Research institute of the General Armaments Wuxi 214035 China

A linear hybrid model of Mild Slope Equation （MSE） and Boundary Element Method （BEM） is developed to study the wave propagation around floating structures in coastal zones. Both the wave refraction under the influence of topography and the wave diffraction by floating structures are considered. Hence, the model provides wave properties around the coastal floating structures of arbitrary shape but also the wave forces on and the hydrodynamic characteristics of the structures. Different approaches are compared to demonstrate the validity of the present hybrid model. Several numerical tests are carried out for the cases of pontoons under different circumstances. The results show that the influence of topography on the hydrodynamic characteristics of floating structures in coastal regions is important and must not be ignored in the most wave period range with practical interests.

关键词： hybrid model Mild Slope Equation (MSE),Boundary Element Method (BEM) marine floating structures,coastal regions wave propagation wave force

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NUMERICAL SIMULATION OF TWO-DIMENSIONAL OVERTOPPING AGAINST SEAWALLS ARMORED WITH ARTIFICIAL UNITS IN REGULAR WAVES

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Journal of Hydrodynamics 2007年第3期19卷 322-329页

作者： LU Yong-jin LIU Hua WU Wei ZHANG Jiu-shan school of Naval Architecture Ocean and Civil Engineering Shanghai Jiaotong University Shanghai 200030 China shanghai Hydraulic Engineering Design and Research institute Shanghai 200063 China school of Naval Architecture Ocean and Civil Engineering Shanghai Jiaotong University Shanghai 200030China

A new mathematical model for the overtopping against seawalls armored with artificial units in regular waves was established. The 2-D numerical wave flume, based on the Reynolds Averaged Navier-Stokes （RANS） equations and the standard κ-ε turbulence model, was developed to simulate the turbulent flows with the free surface, in which the Volume Of Fluid （VOF） method was used to handle the large deformation of the free surface and the relaxation approach of combined wave generation and absorbing was implemented. In order to consider the effects of energy dissipation due to the armors on a slope seawall, a porous media model was proposed and implemented in the numerical wave flume. A series of physical model experiments were carried out in the same condition of the numerical simulation to determine the drag coefficient in the porous media model in terms of the overtopping discharge. Compared the computational value of overtopping over the seawall with the experimental data, the values of the effective drag coefficient was calibrated for the layers of blocks at different locations along the seawalls.

关键词： porous media overtopping seawall armored units 2-D numerical wave flume regular waves

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A NEW NUMERICAL METHOD FOR GROUNDWATER FIOW AND SOLUTE TRANSPORT USING VELOCITY FIELD

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Journal of Hydrodynamics 2008年第3期20卷 356-364页

作者： ZHANG Qian-fei LAN Shou-qi WANG Yan-ming XU Yong-fu school of Naval Architecture Ocean and Civil Engineering Shanghai Jiaotong University Shanghai 200030China shanghai Municipal Engineering Design institute Shanghai 200092 China Department of Geotechnical Engineering Tongji University Shanghai 200092 China

A new numerical method for groundwater flow analysis was introduced to estimate simultaneously velocity vectors and water pressure head. The method could be employed to handle the vertical flow under variably saturated conditions and for horizontal flow as well. The method allows for better estimation of velocities at the element nodes which can be used as direct input to transport models. The advection-dispersion process was treated by the Eulerian-Lagrangian approach with particle tracking technique using the velocities at FEM nodes. The method was verified with the classical one dimensional model and applied to simulate contaminant transport process through a slurry wall as a barrier to prevent leachate pollution from a sanitary landfill.

关键词： groundwater flow solute transport velocity vectors finite element method Eulerian-Lagrangian approach particletracking technique

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Inhibitory Effect of CT120B,an Alternative Splice Variant of CT120A,on Lung Cancer Cell Growth

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Acta Biochimica et Biophysica Sinica 2005年第9期37卷 588-592页

作者： Dong-Ning PAN~(1,2) Jin-Jun LI~(2,3) Lin WEI~2 Ming YAO~(2,3) Da-Fang WAN~(2,3*) Jian-Ren GU~(1,2,3*) 1 shanghai medical College,Fudan university,shanghai 200032,china 2 National Laboratory for Oncogenes and Related Genes,shanghai Cancer institute,shanghai 200032,china 3 medical school of shanghai jiaotong university,shanghai 200032,china shanghai medical College Fudan UniversityShanghai 200032 China National Laboratory for Oncogenes and Related Genes Shanghai Cancer InstituteShanghai 200032 China medical school of shanghai jiaotong universityshanghai 200032 China

The expression product of ct120a,a novel gene isolated from human chromosome 17p13.3in our laboratory,was predicted to have seven transmembrane domains and could cause malignanttransformation of mouse NIH3T3 *** existed an mRNA splicing variant of ct120a,namely ct120b,which had a 96-nucleotide deletion and produced an in-frame loss of 32 amino acids from codon 136 tocodon 167 of *** CT120B protein was predicted to have six transmembrane *** thisstudy,we observed that the green fluorescent protein-tagged CT120B was localized on plasma membraneand in cytoplasm in SPC-A-1 *** expression of CT120B/A in normal lung tissue and in lung cancercells was also *** showed that the stable CT120B overexpression in SPC-A-1 cells resultedin a reduction of cell growth rate,and inhibited tumorigenecity and anchorage-independent growth in *** functions of CT120A and CT120B for cell growth appeared *** suggested that thedelayed G1/S phase transition might contribute to the inhibitory activities of CT120B on cell growth and thatthe deleted 32 amino acids missing in CT120B might be essential for the oncogenetic activities of CT120A.

关键词： CT120B alternative splicing cell growth lung cancer

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Current research status of immunology in the genomic era

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Science china(Life Sciences) 2009年第1期52卷 43-49页

作者： LI HaoWen1,LI JinZhi1,ZHAO GuoPing2 & WANG Ying1,2 1 shanghai institute of Immunology,institute of medical Science,shanghai jiaotong university school of Medicine,shanghai 200025,china 2 shanghai-MOST Key Laboratory of Health and Disease Genomics,Chinese National Human Genome Center,shanghai 201203,china shanghai institute of Immunology Institute of Medical Science Shanghai Jiaotong University School of Medicine Shanghai 200025 China.

This review updates the current status of immunology research under the influence of genomics,both conceptually and *** particularly highlights the advantages of employing the high-throughput and large-scale technology,the large genomic database,and bioinformatic power in the immunology *** fast development in the fields of basic immunology,clinical immunology(tumor and infectious immunology) and vaccine designing is illustrated with respect to the successful usage of genomic *** also speculate the future research directions of immunology in the era of genomics and post-genomics.

关键词： genomics immunology clinical immunology vaccine design

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