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Tetramethylpyrazine protected photoreceptor cells of rats by modulating nuclear translocation of NF-κB

Acta Pharmacologica Sinica 2005年第7期26卷 887-892页

作者： Jin-nan YANG~(2,3) Jin-mao CHEN~4 Lin LUO~4 Shao-chun LIN~4 Dai LI~4 Shi-xing HU~(4,5,6) 2 School of Pharmacy,Xinxiang Medical College,Xinxiang 453003,china 4 Zhongshan Ophthalmic Centre,Sun Yat-sen University,Guangzhou 510060,china 5 eye hospital of china,academy of traditional chinese medicine,beijing 100040,china School of Pharmacy Xinxiang Medical College Xinxiang China Zhongshan Ophthalmic Centre Sun Yat-sen University Guangzhou China eye hospital of china Academy of Traditional Chinese Medicine Beijing China

Aim:To evaluate the effect of tetramethylpyrazine(TMP)injection on retinaldamage induced by N-methyl-N-nitrosourea(MNU)in rats and on nuclear factor-kappa B(NF-κB)family ***:Female Sprague-Dawley(SD)ratswere randomly divided into groups:(i),control group;(ii),model group;and(iii),TMP-injection groups,in which the rats were subdivided into 40 mg/kg,80 mg/kgand 160 mg/kg *** were injected ip into 47-day-old SD rats once a *** 50 days of age,all rats in the model group and drug groups also received asingle ip injection of 60 mg/kg *** in group 1 received ip injection ofphysiological *** rats were killed at different times after MNU or physi-ological saline *** apoptotic index of photoreceptor cells was calcu-lated by TUNEL labeling;retinal damage was evaluated based on retinal thicknessand the expression of NF-κB family members was detected by Western ***:TMP injections,in a dose-dependent manner,suppressed photorecep-tor cell apoptosis and decreased its loss in the peripheral *** comparedwith the MNU-treated group,TMP injection at a dose of 160 mg/kg also time-dependently upregulated the NF-κB/p65 protein level in the nucleus anddownregulated the IκBα protein level in the ***,no protectiveeffect of TMP injection on MNU-induced central retinal damage was ***:TMP injection partially protects against MNU-induced retinal dam-age by upregulating the nuclear translocation of p65 to inhibit photoreceptor cellsapoptosis.

关键词： tetramethylpyrazine photoreceptors methylnitrosourea apoptosis NF-kappa B retinitis pigmentosa

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Gene expression profile induced by oral administration of baicalin and gardenin after focal brain ischemia in rats

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Acta Pharmacologica Sinica 2005年第3期26卷 307-314页

作者： Zhan-jun ZHANG~2 Zhong WANG~3 Xiao-yan ZHANG~4 Kang YING~5 Jian-xun LIU~3 Yong-yan WANG~62 The Clinical School of beijing University of traditional chinese medicine,beijing 100029,china 3 Xi-yuan hospital of the academy o] traditional chinese medicine,beijing 100089,china 4 beijing Normal University,beijing 100036,china 5 BioStar Genechip Incorporated,Shanghai 200012,china 6 The academy of traditional chinese medicine,beijing 100059,china The Clinical School of beijing University of traditional chinese medicine Beijing China Xi-yuan hospital of the academy of traditional chinese medicine Beijing China beijing Normal University Beijing China BioStar Genechip Incorporated Shanghai China The academy of traditional chinese medicine Beijing China

Aim:To investigate differential gene expression and the pharmacological mecha-nism of baicalin and gardenin in focal cerebral ischemia in rats with high-densitycDNA ***:Rat left middle cerebral arteries were occluded andtreated with either baicalin or *** pharmacological effects were inves-tigated using the difference in infarction areas before and after treatment,whichwere determined by 2,3,5-triphenyltetrazolium chloride (TTC) *** ex-pression was demonstrated using a"Biostar40S"gene *** transcription-polymerase chain reaction (RT-PCR) was used to verify theresult of the selected ***:Both baicalin and gardenin reduced theinfarction areas in focal cerebral ischemia rats (P5).The differential geneswere 211,177,and 70 (upregulated or downregulated) in the model group,baicalin,and gardenin treatment groups compared with the sham-operated group,*** expression of RpL19 and Csnk2 underwent an approximately1.9 and 2.1-fold increase,respectively,verified by semiquantitative RT-PCR,whichwas the same trend as the cDNA ***:Differential gene ex-pression with respect to the pharmacological effects of baicalin and gardenin onfocal cerebral ischemia by cDNA microarray revealed a number of clues with re-spect to the therapeutic mechanisms of chinese traditional *** additionthe present study provided theoretical and experimental evidence that will aidfuture studies examining cerebral ischemia.

关键词： microarray gene expression baicalin gardenin brain ischemia

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多剂量包装中药配方颗粒调剂管理上海共识（2023）

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上海中医药大学学报 2024年第5期 1-9页

作者： Clinical chinese Materia Medica Group of hospital Pharmacy Professional Committee of Shanghai Pharmaceutical Association hospital Pharmacy Branch of Shanghai Association of traditional chinese medicine Writing Group of"Shanghai Consensus on Dispensing Management of Multi-dose Packaged traditional chinese medicine Formula Granules (2023)" 上海市药学会医院药学专业委员会临床中药学组上海市中医药学会医院药学分会《多剂量包装中药配方颗粒调剂管理上海共识（2023）》编写组

多剂量包装中药配方颗粒利用设备进行调剂，在上海各医疗机构使用广泛，但药品的调剂质量受多方面因素影响较大，管理要求亟待完善提高。为此，上海市药学会医院药学专业委员会临床中药学组等单位组织专家，根据有关政策法规要求，参考... 详细信息

多剂量包装中药配方颗粒利用设备进行调剂，在上海各医疗机构使用广泛，但药品的调剂质量受多方面因素影响较大，管理要求亟待完善提高。为此，上海市药学会医院药学专业委员会临床中药学组等单位组织专家，根据有关政策法规要求，参考相关标准规范和近5年的文献报道，结合上海市实际情况，围绕与多剂量包装中药配方颗粒调剂相关的人员要求、温湿度控制、设备要求、清洁污染、效期管理、发药交待等管理问题，以“陈述”形式形成上海地区多剂量包装中药配方颗粒调剂管理专家共识，以期进一步规范中药配方颗粒的临床调剂工作，加强应用的安全性、合理性和可控性。

关键词：中药配方颗粒多剂量包装调剂专家共识上海

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Effect of combination of extracts of ginseng and ginkgo biloba on acetylcholine in amyloid beta-protein-treated rats determined by an improved HPLC

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Acta Pharmacologica Sinica 2004年第9期 16-21页

作者： Jian-xun LIU, Wei-hong CONG, Li XU, Jian-nong WANG Research Center, Xiyuan hospital, china academy of traditional chinese medicine, beijing 100091, china

AIM: To determine the concentration of acetylcholine (ACh) in amyloid beta-protein (Aβ) treated rats and offer a method determining ACh as well. METHODS: A 1-month combination of extrats of ginseng and ginkgo biloba (Naoweikang) ig administration to rats was performed daily after bilateral injection of Aβ1-40 (4 g/L, 1μL for each side) into hippocampus. After

关键词： ginseng ginkgo biloba acetylcholine high pressure liquid chromatography amyloid beta-protein

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Investigation of the effect of berberines alkaloids in Coptis chinensis Franch on Bacillus shigae growthby microcalorimetry

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Science china Chemistry 2007年第5期50卷 638-642页

作者： YAN Dan1,2,3, JIN Cheng1, XIAO XiaoHe1 & DONG XiaoPing2 1 Institute of chinese medicine, 302 hospital of People’s Liberation Army, beijing 100039, china 2 Chengdu University of traditional chinese medicine, Chengdu 610075, china 3 Chongqing Institute of Technology, Chongqing 400050, china Institute of chinese medicine 302 Hospital of People’s Liberation Army Beijing China Chengdu University of traditional chinese medicine Chengdu China Chongqing Institute of Technology Chongqing China

The inhibitory effects of five berberines alkaloids (BAs) from rhizoma ofCoptis chinensis Franch,a traditional chinese medicinal (TCM) herb,on Bacillus shigae(***)growth were investigated by *** power-time curves of *** with and without BAswere acquired;meanwhile,the extent and duration of inhibitory effects on the metabolism wereevaluated by growth rate constants (k1,k2),half inhibitory ratio (IC50),maximum heat output(P_(max)),and peak time (t_p).The values of k1 and k2 of a shigae in the presence of the five BAsdecreased with the increasing concentrations of ***,P_(max) was reduced,and the value oft_p increased with increasing concentrations of the five *** inhibitory activity varied withdifferent ***50 of the five BAs was respectively 75 mu g/mL for berberine,90 ng/mL forcoptisine,115 mu g/mL for palmatine,220 mu g/mL for epiberberine,and 400 mu g/mL *** sequence of antimicrobial activity of the five BAs:berberine > coptisine >palmatine > epiberberine > *** functional groups methylenedioxy at C2 and C3 on phenylring improve antimicrobial activity more strongly than methoxyl at C2 and C3 on ***,the effect of bacteriostasis is not significant with methylenedioxy or methoxyl at C9and C10 on phenyl ring.

关键词： berberines alkaloids, microcalorimetry, Bacillus shigae, inhibitory effect

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Association of apolipoprotein E 4 polymorphism with cerebral infarction in chinese Han population

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Acta Pharmacologica Sinica 2004年第3期25卷 98-102页

作者： Zhu-qing JIN2,Yong-sheng FAN3,Jing DING4,Mei CHEN5,Wei FAN4,Guang-ji ZHANG2,Bin-hui ZHANG5,Suo-jing YU2,Yong-sheng ZHANG2,Wei-feng JI5,Jian-gang ZHANG6 2Genomic Research Centre,Zhejiang College of traditional chinese medicine,Hangzhou 310053 3Schoolof Basic Medical Sciences,Zhejiang College of traditional chinese medicine,Hangzhou 310053 4Department of Neurology,Zhongshan hospital,Fudan University,Shanghai200032 5Department of Neurology,Zhejiang hospital of traditional chinese medicine,Zhejiang Collegeof traditional chinese medicine,Hangzhou 310006,china Genomic Research Centre Zhejiang College of Traditional Chinese Medicine Hangzhou 310053 School of Basic Medical Sciences Zhejiang College of Traditional Chinese Medicine Hangzhou 310053 Department of Neurology Zhongshan Hospital Fudan University 上海 200032 Department of Neurology Zhejiang Hospital of Traditional Chinese Medicine Zhejiang College of Traditional Chinese Medicine Hangzhou 310006

AIM: To study the association between APOE polymorphisms and cerebral infarction through a case-control study among the chinese Han population. METHODS: First-ever cerebral infarction patients (n=226) whose ages ranged from 40 to 60 years old were recruited from Department of Neurology, Zhongshan hospital, Shanghai, and Zhejiang chinese traditional medicine hospital, Zhejiang, china. Unrelated healthy controls (n=201) were selected from the general population in the same area with similar age and sex distribution. APOE was amplified by one-stage PCR using the forward primer: 5'-GGC ACG GCT GTC CAA GGA GCT-3' and reverse primer: 5'-GAT GGC GCTGAG GCC GCG CT-3'. The PCR product was digested directly with 5 U of CfoI and separated by a 20 % polyacryla- mide (acrylamide: bis-acrylamide=29:1) nondenaturing gel. RESULTS: Both cerebral infarction patient and control groups were in Hardy-Weinberg equilibrium. The allele frequency of APOE*2, APOE*3, and APOE*4 was 4.6 %, 81.9 %, and 13.5 % respectively in the patients with cerebral infarction; 5.7 %, 87.3 %, and 7.0 % respectively in the healthy control group. Compared with APOE3/3 subjects, APOE4/4 carriers had a 2.1-fold risk of cerebral infarction (odds ratio 2.1, 95 % confidence limits 1.3 to 3.4). The allele frequency of APOE*4 in the cerebral infarction patient group was significantly higher than that in the control group (13.5 % vs 7.0 %; P=0.002). CONCLUSION: APOE 4 is a risk factor for cerebral infarction among the chinese Han population.

关键词： apolipoproteins E human alleles polymorphism brain infarction

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CLINICAL OBSERVATION ON THE APHAGIA OF PSEUDOBULBAR PALSY TREATED WITH ACUPUNCTURE

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World Journal of Acupuncture-Moxibustion 1993年第1期3卷 17-18,9页

作者： Liu Zhishun, Guanganmen hospital, china academy of traditional chinese medicine, beijing 100053, china

This paper presents clinical observation on 30 cases with aphagia of pseudobul-bar palsy treated by acupuncture. As a result, 16 cases (53.33%) were cured, 12 (40%) markedlyimproved and 2 (6.67%) ineffective, after on... 详细信息

关键词： Aphagia Pseudobular palsy Acupuncture Therapy

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Application　of　＂Qi　Ci＂　and　＂Yang　Ci＂　Methods　to　the　Treatment　of　＂Frozen　Shoulder＂：　97　Cases　Report．

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中国针灸 1995年第S2期15卷 346-347页

作者： Wang Linpeng(beijing hospital of traditional chinese medicine 100010)

Ａｐｐｌｉｃａｔｉｏｎｏｆ＂ＱｉＣｉ＂ａｎｄ＂ＹａｎｇＣｉ＂ＭｅｔｈｏｄｓｔｏｔｈｅＴｒｅａｔｍｅｎｔｏｆ＂ＦｒｏｚｅｎＳｈｏｕｌｄｅｒ＂：９７ＣａｓｅｓＲｅｐｏｒｔ．￥ＷａｎｇＬｉｎｐｅｎｇ（ＢｅｉｊｉｎｇＨｏｓｐ... 详细信息

Ａｐｐｌｉｃａｔｉｏｎｏｆ＂ＱｉＣｉ＂ａｎｄ＂ＹａｎｇＣｉ＂ＭｅｔｈｏｄｓｔｏｔｈｅＴｒｅａｔｍｅｎｔｏｆ＂ＦｒｏｚｅｎＳｈｏｕｌｄｅｒ＂：９７ＣａｓｅｓＲｅｐｏｒｔ．￥ＷａｎｇＬｉｎｐｅｎｇ（ＢｅｉｊｉｎｇＨｏｓｐｉｔａｌｏｆＴｒａｄｉｔｉｏｎａｌ...

关键词： Application Should Report

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卫气虚证诊断规范

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北京中医药大学学报 2024年第8期47卷 1177-1179页

作者：北京中医药大学福建中医药大学河南中医药大学天津中医药大学第二附属医院广州中医药大学第二附属医院云南中医药大学第三附属医院王天芳不详

1范围本文件规定了卫气虚证诊断标准与卫气虚证严重程度评定。本文件适用于中、西医医疗机构,健康管理机构及中医治未病机构的医务工作者,对18周岁及以上具有卫气虚证表现的亚健康及疾病人群的卫气虚证诊断与程度评定。

关键词：卫气虚证诊断规范

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Antisense oligonucleotides-induced local blockade of T-bet expression leads to airway inflammation in rats

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Acta Pharmacologica Sinica 2006年第5期27卷 561-567页

作者： Gang WANG~2 Chun-tao LIU~(3,4) Zeng-li WANG~3 Li-li JIANG~5 Cun-liang YAN~6 Feng-min LUO~3 ~2Department of Integrated traditional chinese and Western medicine.West china hospital.Sichuan University,Chengdu 610041,china.~3Department of Respiratory medicine,West china hospital,Sichuan University.Chengdu 610041.china ~5Department of Pathology,West china hospital.Sichuan University,Chengdu 610041,china:~6Department of Laboratory medicine.Shenzhen hospital,Peking University.Shenzhen 518036,china Department of Integrated traditional chinese and Western medicine West China Hospital Sichuan University Chengdu China Department of Respiratory medicine West China Hospital Sichuan University Chengdu China Department of Pathology West China Hospital Sichuan University Chengdu China Department of Laboratory medicine Shenzhen Hospital Peking University Shenzhen China

Aim:To explore whether local blockade of T-box expressed in T cells (T-bet)expression in the lungs could lead to airway ***:Twenty-fourrats were randomly divided into 4 groups:saline group,ovalbumin (OVA)-sensi-tized group,nonsense group,and the antisense *** OVA-sensitized ratswere sensitized and challenged with OVA,and the rats in the nonsense andantisense groups were subjected to an aerosol delivery of the nonsense andantisense oligonucleotides (AS-ODN) of T-bet (0.1%,w/v).The levels of inter-feron-γ(IFN-γ),interleukin-4(IL-4),and IL-5 in the bronchoalveolar lavage fluid(BALF) were detected by ELISA,and the mRNA and the protein expression ofT-bet and GATA-3 genes were examined by in situ hybridization and Western blotanalysis,***:The expression of T-bet mRNA and protein in thelungs of the rats in the antisense group were inhibited *** lungs ofthe rats in the antisense and OVA-sensitized groups showed eosinophil and lym-phocyte inflammatory infiltration,and eosinophilia located predominantly aroundthe *** number of GATA-3 mRNA-positive cells and the level of GATA-3protein in the lungs of the rats in the antisense and the OVA-sensitized groupssignificantly *** level of IL-4 and IL-5 in the BALF in the antisenseand OVA-sensitized groups were elevated,but the level of IFN-γ ***:Antisense ODN-induced local blockade of T-bet expres-sion leads to airway inflammation with a selective alteration in patterns of cytokineexpression and recruitment of eosinophil cells similar to that in the OVA-sensitizedanimals.

关键词： airway inflammation antisense oligonucleotides GATA3 transcription factor interferon type Ⅱ interleukin-4 interleukin-5 Tbox expressed in T cells

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