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Focal plane wave-front sensing algorithm for high-contrast imaging

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Science China(Physics,Mechanics & Astronomy) 2009年第8期52卷 1284-1288页

作者： DOU JiangPei1,2,3,REN DeQing1,2,4,ZHU YongTian1,2 & ZHANG Xi1,2,3 1 National Astronomical Observatories/Nanjing institute of Astronomical Optics & Technology,Chinese Academy of Sciences,Nanjing 210042,China 2 Key Laboratory of Astronomical Optics & Technology,Nanjing institute of Astronomical Optics & Technology,Chinese Academy of Sciences,Nanjing 210042,China 3 Graduate university of Chinese Academy of Sciences,Beijing 100049,China 4 Physics & Astronomy Department,California State university Northridge,18111 Nordhoff Street,Northridge,California 91330-8268,usa National Astronomical Observatories/Nanjing institute of Astronomical Optics & Technology Chinese Academy of Sciences Nanjing China Key Laboratory of Astronomical Optics & Technology Nanjing Institute of Astronomical Optics & Technology Chinese Academy of Sciences Nanjing China Graduate university of Chinese Academy of Sciences Beijing China Physics & Astronomy Department California State University Northridge Northridge USA

High-contrast imaging provided by a coronagraph is critical for the direction imaging of the Earth-like planet orbiting its bright parent star.A major limitation for such direct imaging is the speckle noise that is induced from the wave-front error of an optical *** derive an algorithm for the wave-front measurement directly from 3 focal plane *** 3 images are achieved through a deformable mirror to provide specific phases for the optics *** introduce an extra amplitude modulation on one deformable mirror configuration to create an uncorrelated wave-front,which is a critical procedure for wave-front *** simulation shows that the reconstructed wave-front is consistent with the original wave-front theoretically,which indicates that such an algorithm is a promising technique for the wave-front measurement for the high-contrast imaging.

关键词： high-contrast imaging multi-image algorithm speckle nulling technique wave-front sensing

Geochemical characteristics of pyrolysis gas from epimetamorphic rocks in the northern basement of Songliao Basin,Northeast China

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Science China Earth Sciences 2008年第S1期51卷 140-147页

作者： YANG Chun 1 ,LUO Xia 2 ,LI Jian 2 ,LI ZhiSheng 2 ,LIU QuanYou 3 &Wang YuLin 4 1 Department of Earth Sciences,Zhejiang university,Hangzhou 310027,China 2 Research institute of Petroleum Exploration and Development(Langfang Branch),Langfang 065007,China 3 Research institute of Petroleum Exploration and Development,Beijing 100083,China 4 Department of Source and Environment,Liaoning Technical university,Fuxin 123000,China Department of Earth Sciences Zhejiang University Hangzhou China Research institute of Petroleum Exploration and Development (Langfang Branch) Langfang China Research institute of Petroleum Exploration and Development Beijing China Department of Source and Environment Liaoning Technical University Fuxin China

The Xushen gas field,located in the north of Songliao Basin,is a potential giant gas area for China in the *** proved reserves have exceeded 1000×10 8 m 3 by the end of ***,the origin of natural gases from the deep strata is still in *** rocks as a potential gas source are widely spreading in the northern basement of Songliao *** to pyrolysis experiments for these rocks in the semi-confined system,gas production and geochemistry of alkane gases are discussed in this *** Carboniferous-Permian epimetamorphic rocks were heated from 300℃to 550℃,with temperature interval of 50℃.The gas production was quantified and measured for chemical and carbon isotopic *** show thatδ13C 1 is less than?20‰,carbon isotope trend of alkane gas isδ13C 1 δ13C 3 ,these features suggest that the gas would be coal-type gas at high-over maturity,not be inorganic gas with reversal trend of gaseous alkanes (δ13C 1 >δ13C 2 >δ13C 3 ).These characteristics of carbon isotopes are similar with the natural gas from the basin basement,but disagree with gas from the Xingcheng ***,the mixing gases from the pyrolysis gas with coal-typed gases at high-over maturity or oil-typed gases do not cause the reversal trend of carbon *** gas generation intensity for epimetamorphic rocks is 3.0×10 8 ―23.8×10 8 m 3 /km 2 ,corresponding to Ro from 2.0%to 3.5%for organic matter.

关键词： Northern Songliao Basin epimetamorphic rock pyrolysis experiment gas generation potential carbon isotope

Efficient inhibition of human telomerase activity by antisense oligonucle-otides sensitizes cancer cells to radiotherapy

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Acta Pharmacologica Sinica 2006年第9期27卷 1185-1191页

作者： Xue-mei JI~2 Cong-hua XIE~2 Ming-hao FANG~3 Fu-xiang ZHOU~2 Wen-jie ZHANG~4 Ming-sheng ZHANG~2 Yun-feng ZHOU~(2,5)2 Department of Chemotherapy and Radiation Oncology,Zhongnan Hospital,Wuhan university,Wuhan 430071,China 3 Department of Emergency,Tongji Hospital,Tongji Medical College,Huazhong university of Science and Technology,Wuhan 430030,China 4 Cancer Research institute,Wuhan university,Wuhan 430071,China Department of Chemotherapy and Radiation Oncology Zhongnan Hospital Wuhan University Wuhan China Department of Emergency Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Cancer Research institute Wuhan University Wuhan China

Aim:To investigate the effect of the antisense otigonucleotides（ASODN）spe-cific for human telomerase RNA（hTR）on radio sensitization and proliferationinhibition in human neurogliocytoma cells（U251）.Methods:U251 cells weretransfected with hTR ASODN or nonspecific oligonucleotides（NSODN）.Beforeand after irradiation of60Co-γray,telomerase activity was assayed by telomericrepeat amplification protocol（TRAP-PCR-ELISA）,and DNA damage and repairwere examined by the comet *** classical colony assay was used to plotthe cell-survival curve,to detect the ***:hTR antisense oligo-nucleotides could downregulate the telomerase activity,increase radiation in-duced DNA damage and reduce the subsequent ***,it could in-hibit the proliferation and decrease the D0value which demonstrates ***,telomere length was unchanged over a short period ***:These findings suggest that an ASODN-based strategy may beused to develop telomerase inhibitors,which can efficiently sensitize radiotherapy.

关键词： oligonucleotides,antisense telomerase radiotherapy glioma,astrocytic gene therapy

Principle of small target detection for hyperspectral imagery

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Science China Earth Sciences 2007年第8期50卷 1225-1231页

作者： GENG XiuRui1,2,3 & ZHAO YongChao2,3,4 1 Research Center for Remote Sensing and GIS, Department of Geography, Beijing Normal university, Beijing 100875, China 2 State Key Laboratory of Remote Sensing Science, Chinese Academy of Sciences, Beijing 100101, China 3 institute of Erectronics, Chinese Academy of Sciences, Beijing 100080, China 4 Center for for Assessment and Monitoring of Forest and Environmental Resources and Division of Ecosystem Sciences university of California Berkeley, CA 94720-3114, usa Research Center for Remote Sensing and GIS Department of Geography Beijing Normal University Beijing China State Key Laboratory of Remote Sensing Science Chinese Academy of Sciences Beijing China institute of Erectronics Chinese Academy of Sciences Beijing China Center for for Assessment and Monitoring of Forest and Environmental Resources and Division of Ecosystem Sciences University of California Berkeley USA

This paper generalizes the progress of algorithms in small target detection for hyperspectral imaging, and finds that whitening the image is the key point of many methods in small target detection. An al-gorithm is presented to detect desired targets by converting large targets into small ones based on the weighted sample autocorrelation matrix.

关键词： hyperspectral whiten target detection

A meta-analysis of oxidative stress markers in schizophrenia

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中国科学：生命科学英文版 2010年第1期53卷 112-124页

作者： ZHANG Ming1,2,ZHAO ZhongMing3,HE Lin1,2,4 & WAN ChunLing1,2 1 Bio-X Center,Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education),Shanghai Jiao Tong university,Shanghai 200030,China 2 institutes for Nutritional Sciences,Shanghai institute of Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China 3 Departments of Biomedical Informatics,Psychiatry,and Cancer Biology,Vanderbilt university Medical Center,Nashville,TN 37232,usa 4 institutes of Biomedical Sciences,Fudan university,Shanghai 200032,China Bio-X Center Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) Shanghai Jiao Tong University Shanghai China institutes for Nutritional Sciences Shanghai Institute of Biological Sciences Chinese Academy of Sciences Shanghai China Departments of Biomedical Informatics Psychiatry and Cancer Biology Vanderbilt University Medical Center Nashville USA institutes of Biomedical Sciences Fudan University Shanghai China

Oxidative stress has been identified as a possible element in the neuropathological processes of schizophrenia(SCZ).Alteration of oxidative stress markers has been reported in SCZ studies,but with inconsistent *** evaluate the risk of oxidative stress to schizophrenia,a meta-analysis was conducted,including five markers of oxidative stress [thiobarbituric reactive substances(TBARS),nitric oxide(NO),catalase(CAT),glutathione peroxidase(GP) and superoxide dismutase(SOD)] in SCZ patients versus healthy *** study showed that TBARS and NO significantly increased in SCZ,while SOD activity significantly decreased in the disorganized type of SCZ *** significant effect size was found for the activities of GP and CAT in SCZ patients(P>0.05).Egger’s regression test observed no significant publication bias across the oxidative stress markers,but found high heterogeneities in all the 5 *** subgroup analysis suggested that the ethnicity,sample size of patients and sample sources may contribute to the heterogeneity of the results for TBARS,NO and *** result further demonstrated the involvement of oxidative stress in the pathophysiology of schizophrenia.

关键词： schizophrenia oxidative stress meta-analysis lipid peroxidation nitric oxide antioxidant enzymes

Orthogonal design for optimization of pigment extraction from surface sediments of the Changjiang River Estuary

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Acta Oceanologica Sinica 2011年第4期30卷 33-42页

作者： ZHAO Jun YAO Peng YU Zhigang Thomas S Bianchi Key Laboratory of Marine Environment and Ecology Ministry of Education Ocean University of China Qingdao 266100 China Department of Oceanography Texas A ＆ M University College Station TX 77843 USA Key Laboratory of Marine Chemistry Theory and Technology Ministry of Education Ocean University of China Qingdao 266100 China institute of Marine Organic Geochemistry College of Chemistry and Chemical Engineering Ocean University of China Qingdao 266100 China

Using a suitable solvent for extracting pigments from sediment for high performance liquid chromatography（HPLC） analysis is critical for obtaining qualitative and quantitative estimates of phytoplanktonic and benthic algal biomass,as well as community composition. Five methodological factors（sample dehydration,extraction solvent,extraction duration,number of extractions,and ratio of solvent volume：sample weight） were studied using an L 9（3 4 ） orthogonal design in a sedimentary pigment extraction experiment on samples collected from the Changjiang large-river delta-front estuary（LDE）,using HPLC analysis. The results show that the optimal extraction method for sedimentary pigments should include freeze-drying samples prior to extraction. The effects of different factors on sedimentary pigment extraction were separated by the L 9（3 4 ） orthogonal design experiments and showed that the extraction solvent was the most important,with extraction duration the second most important,and numbers of extraction and ratio of solvent volume：sample weight was the least important. The mixed solvent treatment comprised of acetone,methanol and water（80：15：5,by volume） was best for polar pigment extraction,with 100% acetone better for apolar pigments. For most pigments employed in this study（i.e.,peridinin,fucoxanthin,alloxanthin,diatoxanthin,zeaxanthin,pheophytin-a and β-carotene） ,3 h was found to be enough time for extraction from these deltaic sediments. However,for chlorophyll-a,the most important pigment used for estimating algal biomass,12 h was needed. A small amount of solvent（3 ml） with duplicate extractions obtained the greatest amount and diversity of pigments. Unfortunately,no extraction method was found to be suitable for all pigments in sediments. The choice of extraction procedure should be made in accordance with the objective of each study,taking into consideration the properties of sediments and pigments in question.

关键词： sedimentary pigments extraction orthogonal design HPLC Changjiang River Estuary

Antioxidant properties of berberine on cultured rabbit corpus cavernosum smooth muscle cells injured by hydrogen peroxide

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Acta Pharmacologica Sinica 2007年第12期28卷 1914-1918页

作者： Yan TAN~(2,3,5),Qiang TANG~4,Ben-rong HU~4,Ji-zhou XIANG~4~2 institute of Urology,Renmin Hospital,Yunyang Medical College,Shiyan 442000 China,~3 Department of Pharmacology,Yunyang MedicalCollege,Shiyan 442000,China,~4 Department of Pharmacology,Tongji Medical College,Huazhong university of Science and Teehnology,Wuhan 430030,China institute of Urology Renmin Hospital Yunyang Medical College Shiyan China Department of Pharmacology Yunyang Medical College Shiyan China Department of Pharmacology Tongji Medical College Huazhong University of Science and Technology Wuhan China

Aim:To investigate the antioxidant properties of berberine (Ber) on corpuscavenosum smooth muscle cells (CCSMC) in penile erectile ***:We examined the effects of Ber on cultured rabbit CCSMC damaged by hydrogenperoxide (H2O2) through examining cell viability by methyl thiazolyl tetrazoliumassay and assessing the level of malondialdehyde (MDA),superoxide dismutase,(SOD) activity,nitric oxide (NO) products,and lactate dehydrogenase (LDH) re-lease in cells after stimulation with ***:Treatment with 1 mmol/L H2O2significantly decreased the cell viability,NO products,and SOD activity of CCSMCfrom 100% to 48.57%±4.1% (P49.5±1.8 to 30.1±2.6 U/mL (P497.6±69.5 to 1100.5±56.3 U/L (P4±2.9nmol/mg protein (P<0.01),***,treatment with different con-centrations of Ber (10-1000 μmol/L) inhibited the damaging effects of H2O2,withincreased cell viability (P<0.05 or P<0.01),NO production (P<0.01),and SODactivity (P<0.01) and decreased LDH release and MDA content (both P<0.01).Conclusion:Bet could produce its antioxidant action on oxidative stress-inducedcultured *** effects may be of benefit in the prevention of penileerectile dysfunction.

关键词： berberine antioxidant action corpus cavernosum erectile dysfunction

Taurine antagonized oxidative stress injury induced by homocysteine in rat vascular smooth muscle cells

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Acta Pharmacologica Sinica 2004年第3期25卷 87-92页

作者： Lin CHANG2,3,Jian-xin XU4,Jing ZHAO5,Yong-zheng PANG2,3,Chao-shu TANG2,3,Yong-fen QI5,6 2institute of Cardiovascular Diseases,the FirstHospital,Peking university,Beijing 100034 3institute of Cardiovascular Diseases,Peking university,Beijing 100083 4instituteof Biophysics,Chinese Academy of Sciences,Beijing 100101 5Department of Physiology,Health Science Center,Peking university,Beijing 100083,China institute of Cardiovascular Diseases the First Hospital Peking University 北京 100034 institute of Biophysics Chinese Academy of Sciences 北京 100101 Department of Physiology Health Science Center Peking University 北京 100083

AIM: To observe protective effects of taurine on reactive oxygen species generation induced by homocysteine in rat vascular smooth muscle cells (VSMC). METHODS: Rat VSMC was incubated with various concentrations of homocysteine and taurine. The lactate dehydrogenase (LDH) activity which released into culture medium was elevated as an indicator for VSMC injury. The reactive oxygen species (ROS) — hydrogen peroxide (H2O2) and superoxide anion (O2ˉ· )were measured with luminol or lucigenin chemiluminescences method, and the mitochondria Mn-superoxide dismutase (Mn-SOD) and catalase (CAT) were also measured in treated VSMC. RESULTS: LDH leakage from cultured VSMC treated with homocystenie, was increased (P0.05 vs control). In this study, the superoxide anion in VSMC was not detectable by chemiluminent method. In addition, treatment of VSMC with taurine increased mitochondria Mn-SOD and CAT activity in a concentration dependent manner (P<0.05), but homocysteine decreased mitochondria Mn-SOD and CAT activity (P<0.01 vs control). In addition, co-administration of taurine markedly ameliorated homocysteine-induced inhibition of Mn-SOD and CAT activity in VSMC (P<0.01 vs homocysteine alone group). CONCLUSION: Taurine antagonized the effects of homocysteine on ROS generation and anti-oxidant enzyme activities in rat VSMC in vitro.

关键词： homocysteine taurine vascular smooth muscle mitochondria reactive oxygen species

The influence of the Three-Gorges Dam on hydrographic and hydrodynamic conditions of the East China Sea

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Acta Oceanologica Sinica 2011年第5期30卷 45-55页

作者： FAN Xiaopeng ZHOU Feng CHEN Xueen HUANG Daji POHLMANN Thomas State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of Oceanography State Oceanic Administration Hangzhou 310012 China institute of Physical Oceanography Ocean University of China Qingdao 266002 China institute of Oceanography University of Hamburg Hamburg 20146 Germany Department of Ocean Science and Engineering Zhejiang University Hangzhou 310058 China

A fine resolution model has been applied to get more insight into the effects of a modified runoff due to the Three-Gorges-Dam （TGD） on the East China Sea （ECS）.The region of interest was confined to the offshore area in the vicinity of the Changjiang *** the east,it extended up to the area southwest of Cheju *** model was used to evaluate the effect of a modified runoff on the water properties of the adjacent regions like the Changjiang diluted water （CDW） and the Zhoushan Fishing *** sensitivity of the ECS to a modified Changjiang runoff was explored firstly by sensitivity studies and secondly by experiments based on historical runoff records and water management plans of the *** experiments led to the general conclusion that the most affected area by runoff is located close to the Changjiang River *** area of influence has an extension of about 150 km×150 *** the realistic experiment,the related anomalies reached their maximum value in early summer （May）.In normal years the related salinity anomalies can get to as large as 2.

关键词： Three-Gorges-Dam surface salinity anomalies stratification East China Sea