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Taurine antagonized oxidative stress injury induced by homocysteine in rat vascular smooth muscle cells

Acta Pharmacologica Sinica 2004年第3期25卷 87-92页

作者： Lin CHANG2,3,Jian-xin XU4,Jing ZHAO5,Yong-zheng PANG2,3,Chao-shu TANG2,3,Yong-fen QI5,6 2Institute of Cardiovascular Diseases,the FirstHospital,Peking University,beijing 100034 3Institute of Cardiovascular Diseases,Peking University,beijing 100083 4instituteof biophysics,chinese academy of sciences,beijing 100101 5Department of Physiology,Health Science Center,Peking University,beijing 100083,China Institute of Cardiovascular Diseases the First Hospital Peking University 北京 100034 Institute of biophysics Chinese Academy of Sciences 北京 100101 Department of Physiology Health Science Center Peking University 北京 100083

AIM: To observe protective effects of taurine on reactive oxygen species generation induced by homocysteine in rat vascular smooth muscle cells (VSMC). METHODS: Rat VSMC was incubated with various concentrations of homocysteine and taurine. The lactate dehydrogenase (LDH) activity which released into culture medium was elevated as an indicator for VSMC injury. The reactive oxygen species (ROS) — hydrogen peroxide (H2O2) and superoxide anion (O2ˉ· )were measured with luminol or lucigenin chemiluminescences method, and the mitochondria Mn-superoxide dismutase (Mn-SOD) and catalase (CAT) were also measured in treated VSMC. RESULTS: LDH leakage from cultured VSMC treated with homocystenie, was increased (P0.05 vs control). In this study, the superoxide anion in VSMC was not detectable by chemiluminent method. In addition, treatment of VSMC with taurine increased mitochondria Mn-SOD and CAT activity in a concentration dependent manner (P<0.05), but homocysteine decreased mitochondria Mn-SOD and CAT activity (P<0.01 vs control). In addition, co-administration of taurine markedly ameliorated homocysteine-induced inhibition of Mn-SOD and CAT activity in VSMC (P<0.01 vs homocysteine alone group). CONCLUSION: Taurine antagonized the effects of homocysteine on ROS generation and anti-oxidant enzyme activities in rat VSMC in vitro.

关键词： homocysteine taurine vascular smooth muscle mitochondria reactive oxygen species

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Two special topics on the avian influenza virus and on epigenetics,have drawn much attention

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Science China(Life sciences) 2010年第12期53卷 1483-1484页

作者： HU YongLin Institute of biophysics,chinese academy of sciences,beijing 100101,China Institute of biophysics Chinese Academy of Sciences Beijing China

Several excellent well-organized reviews and research papers on two special topics, "The challenges of avian influenza virus: mechanism, epidemiology, and control" and "Molecular

关键词： APOBEC gene Two special topics on the avian influenza virus and on epigenetics,have drawn much attention

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Selection,distribution and way of development of leading industries in the beijing-Kowloon economic belt

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Journal of Geographical sciences 1998年第3期8卷 36-48页

作者： JIN Fengjun Institute of Geography, chinese academy of sciences, beijing 100101 CHINA

In this paper, the development issue of leading industries of beijing Kowloon Economic Belt is discussed. According to the regional base and the development conditions, the development strategy of beijing Kowloon Economic Belt should concentrate on developing the following leading industries: Machine building and electronics, textile and its deep processing industry, food processing, chemical industry, and power industry. Meantime, the industrial centers such as Nanchang, Jiujiang, Shenzhen, Huizhou, Ji'an, Fuyang, Shangqiu, and so on should be constructed particularly.

关键词： Leading industry industrial center economic belt beijing Kowloon railway.

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Recent beijing Spectroscopy (BES) results

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Science China(Physics,Mechanics & Astronomy) 2008年第6期51卷 567-576页

作者： LI WeiGuo Institute of High Energy Physics, chinese academy of sciences, beijing 100049, China Institute of High Energy Physics Chinese Academy of Sciences Beijing China

Recent experimental results from beijing Spectroscopy (BES) are reviewed, including the hadron spectroscopy from J/ψ decays, and a number of new states are found or confirmed, including σ, κ, X(1835), ωφ threshold enhancement in J/ψ→γωφ, a broad resonance in J/ψ→K + K ? π 0, decay studies of ψ(2S) and χ CJ , as well as the results of ψ(3770) non-D $ \bar D $ decays. The current status of BEPCII/BESIII, the major upgrade of BEPC/BESII, is also reported.

关键词： beijing Spectroscopy hadron spectroscopy charm physics BEPCII

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PLS path model building:A multivariate approach to land price studies-A case study in beijing

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Progress in Natural Science:Materials International 2009年第11期19卷 1643-1649页

作者： Wenjie Wu~(a,b),Wenzhong Zhang~(a,*) a Institute of Geographic sciences and Natural Resources Research,CAS,beijing 100101,China b Graduate University of chinese academy of sciences,beijing 100049,China Institute of Geographic sciences and Natural Resources Research CAS Beijing 100101 China Graduate University of chinese academy of sciences Beijing 100049 China

Previous studies have revealed that statistical methods can be used to analyze land-leasing parcel ***,the conventional statistical methods used in land analysis have some limitations,especially in cases of limited observational *** this paper,with the help of geographic information system(GIS) techniques,a partial least squares(PLS) path model is applied to study the relationship between residential land prices and various determinants through a case study of beijing in *** a preliminary analysis,four latent variables are selected:accessibility of the workplace center,livability,traffic,and environment *** results show that the observation variables have a strong explanatory power for their corresponding latent variables,and the four latent variables have varying impacts on residential land *** the latent variables,accessibility to the workplace center has the strongest impact on the residential land price.

关键词： Land PLS path model GIS beijing

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RECENT DOMESTIC PROGRESS IN SPACE CRYSTALLIZATION OF PROTEINS

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空间科学学报 1998年第S1期18卷 98-103页

作者： BI Ru-chang (Institute of biophysics, The chinese academy of sciences, beijing 100101)

The advances of protein crystal growth in microgravity are limited by its low success rate of space crystallization experiments. Our recent efforts have concentrated on exploration of the ways to increase the success rate of the *** corresponding studies include structural comparisons of space- and Earthgrown protein crystals, numerical simulations of solute transport in protein crystallizer, optimization of protein crystailization conditions and improvement of crystallization techniques used. These studies show that the success rate of space protein crystallization could be improved by different ways.

关键词： Protein Crystal growth Microgravity Success rate of experiments

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NF-κB,a hot topic in biochemical and medical studies in China

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Science China(Life sciences) 2010年第12期53卷 1485-1487页

作者： WEI Yan State Key Laboratory of Brain and Cognitive sciences,Institute of biophysics,chinese academy of sciences,beijing 100101,China State Key Laboratory of Brain and Cognitive sciences Institute of Biophysics Chinese Academy of Sciences Beijing China

In 1986, nuclear factor (NF)-κB was first discovered in the laboratory of Nobel Prize laureate David Baltimore via its interaction with a sequence (5′-GGGACTTTCC-3′) in the immunoglobulin light-chain enhancer in B

关键词： NF-κB transcription factor signaling pathway upregulation downregulation

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Function of Agricultural Land Use and Its Evolvement in Peri-urban Area: A Case Study of beijing

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chinese Journal of Population,Resources and Environment 2007年第2期5卷 67-71页

作者： Yuan Hong, Cai Jianming, Jiang Fang, Liu Shenghe Institute of Geographical sciences and Natural Resources Research, chinese academy of sciences, beijing 100101, China Institute of Geographical sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China

Rapid urbanization in beijing stimulates the urban land expansion and diminishes available agricultural land. Monofunctional agricultural land use can not meet the demand of the devel- opment of the multifunctional agriculture and urbanization any more, so multifunctional agricultural land use is going to be promoted in the city. This article proposes the evolvement of the land use change from 1992 to 2004 and discusses some evolvement views.

关键词： function agricultural land use peri-urban area

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Interannual variation of annual precipitation and urban effect on precipitation in the beijing region

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Progress in Natural Science:Materials International 2007年第9期17卷 1042-1050页

作者： Yu Shuqiu(State Key Laboratory on Severe Weather,chinese academy of Meteorological sciences,beijing 100081,China) State Key Laboratory on Severe Weather Chinese Academy of Meteorological Sciences Beijing 100081 China

The large scale character of the interannual variation of precipitation and the urban effect on local annual precipitation anomaly are investigated in this paper based on the 1960-2000 annual precipitation observations at 20 stations in the beijing *** results show that:the annual precipitation in the beijing region possesses the large scale variation character with the linear trend of-1.197/10 yr,which corresponds to a total reduction of 27.82 mm in annual precipitation in the 41 years;the local annual precipitation anomalies(percent of the normal 1960-2000)show a positive center near the urban area,*** precipitation island(UPI),whose intensity increases with the linear trend of 0.6621%/10 yr,opposite to the interannual trend of large scale precipitation over the beijing region;changes in the UPI are also associated with the intensity of synoptic processes of precipitation,and when the synoptic processes are strong(wet years),the intensity of UPI strengthens,while the synoptic processes are weak(dry years),and the UPI disappears in the beijing region.

关键词： urban precipitation island effect interannual climate variation precipitation beijing atmospheric science

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Relationship between Environmental Pollution of Coal Mine and Spectral Characteristics of Nearby Plants

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Journal of University of Science and Technology beijing 2001年第1期8卷 10-14页

作者： Liqing Lei Institute of Geographic sciences and Natural Resources Research, chinese academy of sciences, beijing 100101, China Inst. of Geogr. Sci./Nat. Rsrc. Res. Chinese Academy of Sciences Beijing 100101 China

Remote sensing technology, as the most advanced method for collecting data, along with the common ways often used in the past on research of environmental science, was integrated to study the relationship between environmental pollution of coal mine and spectral characteristics of nearby plants. With compositive index and mean reflectivity at near infrared, a regression equation was established, and a conclusion was made that spectral reflectivity can be used to distinguish regions with different pollution degree. Through testing with real status of the research region, it is verified that this kind of integration and conclusion not only are helpful for human being in controlling the movement law of pollutants and the corresponding change of coal mine environmental quality but also bring a new way for the research of environment problems of coal mine.

关键词： remote sensing spectral characteristics reflectivity pollution index compositive index atmospheric pollution

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