检索结果-南通市图书馆

chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)

Frontiers of Medicine 2022年第5期16卷 815-826页

作者： Suning Chen Weili Zhao Jianyong Li Depei Wu on behalf of Lymphoid disease Group,chinese Society of Hematology,chinese Medical Association national Clinical Research center for Hematologic diseases Suzhou 215006China Jiangsu Institute of Hematology the First Affiliated Hospital of Soochow UniversitySuzhou 215006China shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalCollaborative Innovation Center for Cancer Personalized MedicineNanjing 210029China

Oral drugs such as ibrutinib play an important role in the treatment of mature B-cell lymphoma(BCL)due to their reliable efficacy,manageable safety,high accessibility,and convenience for ***,no guidelines or consensus focusing on oral drug therapies for BCL is *** provide a reference of oral agent-based treatment for mature BCL,a panel of experts from the Lymphocyte disease Group,chinese Society of Hematology,chinese Medical Association conducted an extensive discussion and reached a consensus on oral drugs for chinese BCL patients on the basis of the current application status of oral drugs in china,combined with the latest authoritative guidelines in the world and current research *** consensus reviewed the application of oral drugs in the treatment of BCL and the latest research and provided appropriate recommendations on the use of oral drugs for indolent or aggressive BCL *** the deepening of research and the development of standardized clinical applications,oral medications will bring better treatment to BCL patients,enabling more patients to benefit from them.

关键词： B-cell lymphoma oral drug targeted therapy immunotherapy COVID-19 pandemic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

脑出血医疗质量控制指标

引用

中国卒中杂志 2024年第1期19卷 44-49页

作者：国家神经系统疾病医疗质量控制中心脑血管病质控专病组中国卒中学会医疗质量管理与促进分会董强赵性泉王晶李子孝不详复旦大学附属华山医院神经内科上海200040 首都医科大学附属北京天坛医院神经病学中心首都医科大学附属北京天坛医院

国家神经系统疾病医疗质量控制中心脑血管病质控专病组联合中国卒中学会医疗质量管理与促进分会,通过系统回顾循证医学证据和国内外指南,广泛征询脑血管病相关临床、康复和科研领域的专家意见,制定了脑出血医疗质量控制指标体系。该指... 详细信息

国家神经系统疾病医疗质量控制中心脑血管病质控专病组联合中国卒中学会医疗质量管理与促进分会,通过系统回顾循证医学证据和国内外指南,广泛征询脑血管病相关临床、康复和科研领域的专家意见,制定了脑出血医疗质量控制指标体系。该指标体系涵盖脑出血的急性期救治、病因和并发症的筛查、康复及长期管理等不同方面,以率的形式对脑出血诊疗全周期的质量控制进行量化评估,有利于我国脑出血诊疗工作的规范性和同质性建设。

关键词：脑出血医疗质量质量控制指标

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An efficient PCR-based pool screening method for construction of BAC contigs

An efficient PCR-based pool screening method for constructio...

引用

第十一届全国植物基因组学大会

作者： Danfeng Lv,Yan Zhou,Bin Han~* national center for Gene Research,chinese Academy of Sciences,shanghai,200233

As the completion of rice genome sequencing and the accumulation of the rice genomic information, we have developed an efficient rice bacterial artificial chromosome(BAC) library screening strategy for construction of...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Cloning,Sequence Analysis and Putative Promoter Region of a Glyceraldehyde-3-Phosphate Dehydrogenase Gene from Volvariella volvacea,and Expression Pattern Under Cold Stress

引用

食用菌学报 2008年第1期 25-31页

作者： SUN Xiaohong1,2,3,CHEN Mingjie1,PAN Yingjie11 shanghai Edible Fungi Biotechnology and Engineering Research center,Key laboratory of AgriculturalGenetics and Breeding of shanghai,Institute of Edible Fungi,shanghai Academy of Agricultural Sciences,shanghai 201106,china 2 College of Life Sciences,Nanjing Agricultural University,Nanjing,Jiangsu 210095,china 3shanghai Fisheries University,shanghai 200090,china

The complete sequence(from ATG to TAA) of a glyceraldehyde-3-phosphate dehydrogenase(gpd) gene isolated from Volvariella volvacea consisted of 1489 bp and contained nine introns of similar *** full-length cDNA of gpd contained 1157 nucleotides with a predicted ORF of 1011 bp encoding for 337 amino acids and a 3'-untranslated region of 95 *** promoter elements have been identified in a 1220 bp 5'-flanking region,analysis of which revealed two TATA boxes located 80 and 559 bp upstream of the start codon,and three CAAT boxes 333,340 and 406 bp upstream of the initiating *** blot analysis suggested that the *** genome contained only one copy of the gpd *** blot analysis revealed that gpd gene expression was not induced by cold stress,which may explain in part why this mushroom is more perishable than other mushrooms in which gpd expression increases during exposure to low temperatures.

关键词： cold stress gene expression glyceraldehyde-3-phosphate dehydrogenase gene regulatory elements Volvariella volvacea

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Inhibition of G9a by a small molecule inhibitor, UNC0642,induces apoptosis of human bladder cancer cells

引用

Acta Pharmacologica Sinica 2019年第8期40卷 1076-1084页

作者： Yue-peng Cao Jing-ya Sun Mei-qian Li Yu Dong Yuan-heng Zhang Jun Yan Rui-min Huang Xiang Yan Department of Urology Nanjing Drum Tower HospitalNanjing University Medical School shanghai Institute of Materia Medica Chinese Academy of Sciences University of chinese Academy of Sciences MOE Key laboratory of Model Animals for disease Study Model Animal Research Center of Nanjing University shanghai University

Urinary bladder cancer（UBC）is characterized by frequent recurrence and metastasis despite the standard chemotherapy with gemcitabine and cisplatin *** modifiers are often dysregulated in cancer development,thus they can serve as an excellent drug targets for cancer ***,we investigated whether G9a,one of the histone H3 methyltransferases,was associated with UBC *** first analyzed clinical data from public databases and found that G9a was significantly overexpressed in UBC *** TCGA Provisional dataset showed that the average expression level of G9a in primary UBC samples（n = 408）was 1.6-fold as much as that in normal bladder samples（n = 19;Phuman UBC T24 and J82 cell lines in vitro,and observed that the cell viability was significantly decreased and cell apoptosis ***,we choosed UNC0642,a small molecule inhibitor targeting G9a,with low cytotoxicity,and excellent in vivo pharmacokinetic properties,to test its anticancer effects against UBC cells in vitro and in *** with UNC0642 dose-dependently decreased the viability of T24,J82,and 5637 cells with the IC50 values of 9.85±0.41,13.15±1.72,and 9.57±0.37 μM,***,treatment with UNC0642（1-20 μM）dose-dependently decreased the levels of histone H3 K9 me2,the downstream target of G9a,and increased apoptosis in T24 and J82 *** nude mice bearing J82 engrafts,administration of UNC0642（5 mg/kg,every other day,i.p.,for 6 times）exerted significant suppressive effect on tumor growth without loss of mouse body ***,administration of UNC0642 significantly reduced Ki67 expression and increased the level of cleaved Caspase 3 and BIM protein in J82 xenografts evidenced by immunohistochemistry and western blot analysis,*** together,our data demonstrated that G9a may be a promising therapeutic target for UBC,and an epigeneticsbased therapy by UNC0642 is suggested.

关键词： human urinary bladder cancer G9a UNC0642 apoptosis

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Isolation and annotation of 10828 putative full length cDNAs from indica rice

引用

Science china(Life Sciences) 2005年第5期48卷 445-451页

作者： XIE Kabin1, ZHANG Jianwei1, XIANG Yong1, FENG Qi2, HAN Bin2, CHU Zhaohui1, WANG Shiping1, ZHANG Qifa1 & XIONG Lizhong1 1. national Key laboratory of Crop Genetic Improvement and national center of Plant Gene Research (Wuhan), Huazhong Agricultural University, Wuhan 430070, china 2. national center for Gene Research, chinese Academy of Sciences, shanghai 200233, china 1. national Key laboratory of Crop Genetic Improvement and national center of Plant Gene Research (Wuhan) Huazhong Agricultural University 430070 Wuhan China 2. national center for Gene Research Chinese Academy of Sciences 200233 Shanghai China

We reported the isolation and identification of 10828 putative full-length cDNAs (FL-cDNA) from an indica rice cultivar, Minghui 63, with the long-term goal to isolate all full-length cDNAs from indica genome. Comparison with the databases showed that 780 of them are new rice cDNAs with no match in japonica cDNA database. Totally, 9078 of the FL-cDNAs contained predicted ORFs matching with japonica FL-cDNAs and 6543 could find homologous proteins with complete ORFs. 53% of the matched FL-cDNAs isolated in this study had longer 5′UTR than japonica FL-cDNAs. In silico mapping showed that 9776 (90.28%) of the FL-cDNAs had matched genomic sequences in the japonica genome and 10046 (92.78%) had matched genomic se-quences in the indica genome. The average nucleotide sequence identity between the two sub-species is 99.2%. A majority of FL-cDNAs (90%) could be classified with GO (gene ontology) terms based on homology proteins. More than 60% of the new cDNAs isolated in this study had no homology to the known proteins. This set of FL-cDNAs should be useful for functional ge-nomics and proteomics studies.

关键词： Oryza sativa L., indica, functional genomics.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

中国急性胰腺炎影像学诊断报告规范循证学指南

引用

中华胰腺病杂志 2024年第3期24卷 173-185页

作者：中国医师协会胰腺病学专业委员会中华医学会放射学分会国家消化系统疾病临床医学研究中心(上海) 上海市医学会放射诊断质控中心边云王铁功李兆申陆建平邵成伟刘士远陈敏李汛陈克敏不详海军军医大学第一附属医院海军军医大学第一附属医院消化内科上海200433 海军军医大学第一附属医院放射诊断科上海200433 海军军医大学第二附属医院放射诊断科上海200003 北京医院放射科北京100005 兰州大学第一医院普外科兰州730000 上海交通大学医学院附属瑞金医院放射科上海200025

急性胰腺炎是一种常见的急腹症。客观、准确、全面的影像学检查及诊断报告对急性胰腺炎的分级、进一步的临床治疗决策和患者预后评估具有重要的指导意义。目前国内缺乏相应指南,导致影像学诊断报告主观性强、描述内容不全面、术语使用... 详细信息

急性胰腺炎是一种常见的急腹症。客观、准确、全面的影像学检查及诊断报告对急性胰腺炎的分级、进一步的临床治疗决策和患者预后评估具有重要的指导意义。目前国内缺乏相应指南,导致影像学诊断报告主观性强、描述内容不全面、术语使用不规范的问题较为突出。本指南结合国内外研究进展,基于循证医学,共提出了17条推荐意见,旨在规范我国急性胰腺炎影像诊断报告的准确性及一致性,进一步提升该病的规范化影像诊断并辅助临床治疗策略的选择。

关键词：急性胰腺炎影像报告诊断结构化

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cell-based screening identifies CHMP4A associated with hypoxia-inducible transcription Factor 1α

Cell-based screening identifies CHMP4A associated with hypox...

引用

第六届全国免疫学学术大会

作者： Taiping Shi~(1,2,3) Yunqiao Dong~1 Weiwei Deng~1 Peng Gao~1 Dalong Ma~(1,2,3) 1 chinese national human genome center,#3-707 North YongChang Road BDA,Beijing 100176,P.R.china 2 laboratory of Medical Immunology,School of Basic Medical Science,Peking University health Science center,38# Xueyuan Road,Beijing,100191,P.R.china. 3 Peking University center for human disease genomics,38# Xueyuan Road,Beijing,100191,P.R.china.

Background:Hypoxia-Inducible Transcription Factor(HIF-1α)is the most intimate transcription factor associated with hypoxia and overexpressed in most solid *** plays a vital role in hypoxic acclimatization,energy meta...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Tripchlorolide protects against 1-methy1-4-phenyl-1,2,3,6-tetrahydropyridine（MPTP）-induced neurotoxicity in C57BL/6 mice

Tripchlorolide protects against 1-methy1-4-phenyl-1,2,3,6-te...

引用

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Zhen HONG,~1 Gang WANG,~1 Jing GU,~3 Jing PAN~1,Li BAT~1,Shi ZHANG~1,Sheng-Di CHEN~(1,2*) 1 Department of Neurology and Institute of Neurology,Ruijin Hospital affiliated to shanghai Jiaotong University School of Medicine,shanghai,200025 china 2 Institute of health Science,shanghai Institutes of Biological Sciences(SIBS),chinese Academy of Sciences(CAS) & shanghai Jiaotong University School of Medicine,shanghai,200025 china 3 national Key laboratory of Medical Neurobiology,Medical center of Fudan University,shanghai,200032 china.

＜正＞Many current theories of Parkinson’s disease（PD） suggest that inflammation is involved in the neurodegenerative ***（TW397）,a traditional chinese herbal compound with anti-inflammatory and immunosuppressive properties,has been shown to protect and restore dopaminergic neurons against the neurotoxicity induced by 1-methyl- 4-phenylpyridinium ion in *** study was designed to investigate TW397’s effect in vivo in the PD model of 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine（MPTP） lesioned C57BL/6 *** the present study,the neurotoxin MPTP reduced the survival ratio of tyrosine hydroxylase-immunoreactive（TH-IR） neurons in the substantia nigra pars compacta and TH-IR fibers in striatum to 65%and 12%of the normal control,***,treatment with TW397 of 1μg/kg for 16 days once per day dramatically improved the survival rate of TH-IR neurons in the substantia nigra pars compacta and TH-IR fibers in striatum to 82%and 38%of the control,meanwhile,significantly improved the level of dopamine in the substantia nigra and striatum to 157%and 191%of the vehicle-treated group,*** addition,the Rota-Rod performance of the animals treated with 0.5μg/kg or 1μg/kg TW397 were significantly improved for about 2 or 3 fold relative to vehicle-treated animals,*** data demonstrate a neuroprotective action of TW397 in vivo against MPTP toxicity,which has important implications for the treatment of PD.

关键词： Tripchlorolide neurotrophic Parkinson’s disease immunosuppressant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP) Tripterygium wilfordii Hook F.

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Overexpression of CHMP6 induces cellular' oncosis and apoptosis in HeLa cell

Overexpression of CHMP6 induces cellular' oncosis and apopto...

引用

第六届全国免疫学学术大会

作者： Dongxu FU~(1,2) Linjie TIAN~(3,4) Zhi PENG~2 Weiwei DENG~2 Jinsong YUAN~2 Dalong MA~(2,3,4) Taiping SHI~(2,3,4,+) Dianjun LI~(1,+) Ying WANG~(3,4,+) 1 laboratory of Medical Immunology,School of Basic Medical Science,Harbin Medical University,#157 Baojian Road,Harbin 150081,P R.china. 2 chinese national human genome center,#3-707 North YongChang Road BDA,Beijing 100176,P R.china. 3 laboratory of Medical Immunology,School of Basic Medical Science,Peking University health Science center,#38 Xueyuan Road,Beijing,100083,P R.china. 4 Peking University center for human disease genomics,38#Xueyuan Road,Beijing,100083,P R.china.

Cell death can proceed through at least two distinct pathways,apoptosis and *** is an energy-dependent process characterized morphologically by cell shrinkage,whereas oncosis is a defined as a prelethal pathway leadin...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：