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Synthesis, Crystal Structure and Antibacterial Activities of 3-[3-Methyl-(2-thienyl)methyl- enehydrazinocarbonyl]-(1H)-1,2,4-triazole

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Chinese Journal of Structural Chemistry 2005年第11期 68-71+9页

作者： YANG Jian-Guoa PAN Fu-Youb② SHAO Hongb a (Office of Assets administration, Taizhou University, Zhejiang 317000, china) b (Department of Chemistry, Taizhou University, Zhejiang 317000, china) Office of Assets administration， Taizhou University， Zhejiang 317000， china Department of Chemistry， Taizhou University， Zhejiang 317000， china

The title compound, C9H9N5OS, was synthesized by the reaction of 3-(1H)-1,2,4 -triazole hydrazine with 3-methyl-2-thiophenecarboxaldehyde in ethanol. The single crystal struc- ture has been determined by X-ray diffraction analysis. The crystal belongs to monoclinic system, space group P21/n with a = 9.5550(10), b = 11.9847(12), c = 10.1074(11) ?, β = 112.995(2)°, V = 1065.47(19) ?3, Z = 4, μ = 0.290 mm-1, Mr = 235.27, Dc = 1.467 g/cm3 and F(000) = 488. The structure was solved by direct methods and refined to R = 0.0449. The crystal structure involves intermolecular hydrogen bonds of N–H…O and N–H…N as well as intramolecular hydrogen bond of N–H…N. Its biological activity has also been determined showing this type of compounds has certain antibacterial activity.

关键词： synthesis crystal structure antibacterial activities (1H)-1 2 4-triazole

关于“层状介质时移时差研究”一文的几点注记

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石油地球物理勘探 2004年第5期39卷 624-627页

作者：云美厚中石化胜利石油管理局物探公司

20 0 4年第 1期《石油地球物理勘探》上发表的“层状介质时移时差研究”(以下简称“时差”)一文有关近似速度反演方法值得讨论 ,本文给出了直接速度反演的精确公式。通过理论分析 ,笔者认为对于均匀水平层状介质 ,相应于同一激发点和检... 详细信息

20 0 4年第 1期《石油地球物理勘探》上发表的“层状介质时移时差研究”(以下简称“时差”)一文有关近似速度反演方法值得讨论 ,本文给出了直接速度反演的精确公式。通过理论分析 ,笔者认为对于均匀水平层状介质 ,相应于同一激发点和检波点的射线路径是惟一的。模型计算表明 ,在不同水驱条件下 ,“时差”一文基于同激发点和接收点的时差计算结果普遍偏大 ,但其所反映出的时差变化规律性与本文所给出的定性分析结论是一致的。

关键词：时移时差速度反演水平层状介质检波点注记模型计算路径《石油地球物理勘探》激发结论

Synthesis of an enzyme-dependent prodrug and evaluation of its potential for colon targeting

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World Journal of Gastroenterology 2002年第5期8卷 913-917页

作者： Yi-Nuo Pang Yan Zhang West china School of Pharmacy,Sichuan University,Chengdu,610041,Sichuan province,china West china School of Pharmacy Sichuan University Chengdu 610041 Sichuan Province China.

AIM: To synthesize dexamethasone-succinate-dextran(DSD) conjugate and to evaluate the potentiality of DSD forthe treatment of inflammatory bowel ***: Dexamethasone was attached to dextran(average molecular weight＝70 400 Dalton) using succinateanhydride in an anhydrous environment catalyzed by 4-dimethylaminopyridine and 1, 1′-carbonyldiimidazole. Thechemical structure of DSD was identified by UV, IR and NMR,and the in vivo drug release behavior of this prodrug wasinvestigated after oral administration of DSD ***: The DSD conjugate was obtained in two stepsand the content of dexamethasone in DSD was 11.28 %.The dextran prodrug was stable in rat stomach and smallintestine and negligibly absorbed from these tracts. Four tonine hours after the oral administration, most of the prodrug(＞95 %) had moved to the cecum and colon, and was easilyhydrolyzed by an endodextranase. Recover ofdexamethasone from colon and cecum after administrationof DSD conjugate was 6-12 folds higher than the recoveryafter administration of unmodified dexamethasone(t＝2.74,P＜0.05). The preferential release of free dexamethasone incecum and colon over that in the small intestine wasstatistically significant (t＝2.27, P＜0.05).CONCLUSION: The results of this study indicate thatdextran conjugates may be useful in selectively deliveringglucocorticoids to the colon.

关键词：结肠疾病酶前体药物药物合成靶向治疗

GIS-based analysis of forest degradations in Baihe Forestry Bureau,northeast china

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Science china(Technological Sciences) 2006年第z1期49卷 167-176页

作者： ZHOU Li, DAI Limin , Guofan Shao, XU Dong, WANG Hui & BAI Jianwei Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, china Graduate University of Chinese Academy of Sciences, Beijing 100101, china Department of Forestry and Natural Resources, Purdue University, West Lafayette, IN 47907, USA Department of City Development, Jinan University, Jinan 250002, china Academy of Forest Inventory and Planning, State Forestry administration, Beijing 100714, china 1. Institute of Applied Ecology Chinese Academy of Sciences Shenyang 110016 China 2. Graduate University of Chinese Academy of Sciences Beijing 100101 China 3. Department of Forestry and Natural Resources Purdue University West Lafayette IN 47907 USA 4. Department of City Development Jinan University Jinan 250002 China 5. Academy of Forest Inventory and Planning State Forestry Administration Beijing 100714 China

Forests in the Changbai Mountains are important timber sources for economic development of the society and provide ecological services in northeast china. In order to strengthen forest resource management, this paper analyzed management-induced changes in forest structure, tree species composition and forest landscape pattern from 1987 to 2000 for Baihe Forestry Bureau in Jilin province based on digitized forest parcel maps and forest survey data. The results suggested that the area of Mature, High-Stocking, and Close-Canopy Forests decreased by 31.4%, 55.9% and 10.7% respectively; volume of Mixed Forest, the native forest vegetation type, decreased by 17.8%;the number of patches increased tremendously but the mean patch density decreased sharply for Mature, High-Stocking, Close-Canopy, and Mixed Forests. All the changes in forest structure, species composition, and landscape pattern indicated severe degradations going on with the forests in Baihe Forestry Bureau. Because of the effect of degradation to forest services, restoring forest resources and protecting biodiversity has become urgently important. The strategies of sustainable forest management need to be worked out and implemented.

关键词： geographic information system, forest management, Changbai Mountains, forest change, forest decline.

A numerical study of summertime expansion pattern of Changjiang (Yangtze) River diluted water

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Acta Oceanologica Sinica 2009年第3期28卷 11-16页

作者： SHAN Feng QIAO Fangli XIA Changshui College of Physical and Environmental Oceanography Ocean University of China Qingdao Qingdao 266003 China First Institute of Oceanography State Oceanic Administration Qingdao 266061 China

Observations show that during summer especially in August, the northward expansion of the Changjiang（Yangtze） River diluted water （CRDW） is blocked in the vicinity of the Changjiang Estuary. To explain this phenomenon, Princeton ocean model （POM） is applied to simulate the summertime expansion pattern of CRDW. Numerical experiments show that to the north of the Changjiang Estuary, a tide-induced temperature front of a cold water centered at （34°N, I22.5°E） plays the key role in determining the expansion pattern of CRDW. This front splits the CRDW into two parts： the main part expands northeastward, and the other small part expands northwestward off the coast of Jiangsu province, china.

关键词： Changjiang River diluted water Princeton ocean model expansion dynamics

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重庆地区地震统计单元b值和ν4值的讨论

四川地震 2010年第1期 42-44页

作者：秦娟李光王宏超重庆市地震局安徽省地震局

b值和ν4是地震安全性评价工作中进行地震危险性概率计算的两个重要参数,其取值是否合理将影响地震危险性计算结果的合理性。本文采取两种不同的计算方法对重庆地区的b值和ν4进行计算,并对于这两个参数进行了讨论.我们认为取b=1.19和ν... 详细信息

b值和ν4是地震安全性评价工作中进行地震危险性概率计算的两个重要参数,其取值是否合理将影响地震危险性计算结果的合理性。本文采取两种不同的计算方法对重庆地区的b值和ν4进行计算,并对于这两个参数进行了讨论.我们认为取b=1.19和ν4=2.48基本上是合理的,该结果对重庆地区开展地震安全性评价工作和地震中长期预报工作具有一定的参考价值。

关键词：地震安全性评价地震危险性概率地震中长期预报重庆地区

Study of statistically correcting model CMAQ-MOS for forecasting regional air quality

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Science china Earth Sciences 2005年第S2期48卷 155-172页

作者： XU Jianming, XU Xiangde, LIU Yu, DING Guoan, CHEN Huailiang, HU Jiangkai, ZHANG Jianchun, WU Hao, LI Weiliang, HE Jinhai, YANG Yuanqin & WANG Jiahe Nanjing University of Information Science & Technology, Nanjing 210044, china State Key Laboratory of Severe Weather, Chinese Academy of Meteorological Sciences, Beijing 100081, china Meteorological Bureau of Henan province, Institute of Meteorological Sciences, Zhengzhou 450000, china National Meteorological Centre of china Meteorological administration, Beijing 100081, china National Meteorological Information Centre of china Meteorological administration, Beijing 100081, china Nanjing University of Information Science & Technology Nanjing 210044 China State Key Laboratory of Severe Weather Chinese Academy of Meteorological Sciences Beijing 100081 China Meteorological Bureau of Henan province Institute of Meteorological Sciences Zhengzhou 450000 China National Meteorological Centre of china Meteorological administration Beijing 100081 China National Meteorological Information Centre of china Meteorological administration Beijing 100081 China

Based on analysis of the air pollution observational data at 8 observation sites in Beijing including outer suburbs during the period from September 2004 to March 2005, this paper reveals synchronal and in-phase characteristics in the spatial and temporal variation of air pollutants on a city-proper scale at deferent sites; describes seasonal differences of the pollutant emission influence between the heating and non-heating periods, also significantly local differences of the pollutant emission influence between the urban district and outer suburbs, i.e. the spatial and temporal distribution of air pollutant is closely related with that of the pollutant emission intensity. This study shows that due to complexity of the spatial and temporal distribution of pollution emission sources, the new generation Community Multi-scale Air Quality (CMAQ) model developed by the EPA of USA produced forecasts, as other models did, with a systematic error of significantly lower than observations, albeit the model has better capability than previous models had in predicting the spatial distribution and variation tendency of multi-sort pollutants. The reason might be that the CMAQ adopts average amount of pollutant emission inventory, so that the model is difficult to objectively and finely describe the distribution and variation of pollution emission sources intensity on different spatial and temporal scales in the areas, in which the pollution is to be forecast. In order to correct the systematic prediction error resulting from the average pollutant emission inventory in CMAQ, this study proposes a new way of combining dynamics and statistics and establishes a statistically correcting model CMAQ-MOS for forecasts of regional air quality by utilizing the relationship of CMAQ outputs with corresponding observations, and tests the forecast capability. The investigation of experiments presents that CMAQ-MOS reduces the systematic errors of CMAQ because of the uncertainty of pollution e

关键词： CMAQ-MOS point-area combination emission source influence emission inventory air quality.

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英汉言语行为动词分类及其语义认知解释

上饶师范学院学报 2004年第5期24卷 88-91页

作者：钟守满张伟华许婴南京师范大学江西税务学校江苏南京210097 不详

动词在许多语法理论里被看成句子结构最重要的成分。文章从语义认知角度对英汉言语行为动词进行了讨论。先讨论了英汉言语行为动词的可比性;然后讨论了英汉言语行为动词的认知结构分类问题并进行解释。最后还就英汉言语行为动词句法结... 详细信息

动词在许多语法理论里被看成句子结构最重要的成分。文章从语义认知角度对英汉言语行为动词进行了讨论。先讨论了英汉言语行为动词的可比性;然后讨论了英汉言语行为动词的认知结构分类问题并进行解释。最后还就英汉言语行为动词句法结构进行了讨论。

关键词：英汉言语行为动词句语义认知解释语法理论句法结构认知结构分类问题文章

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我国深水石油钻采装备现状及发展建议

石油机械 2009年第8期37卷 87-91页

作者：李国荣江汉石油管理局第四机械厂

从我国自行设计建造的勘探3号半潜式石油钻井平台、渤海友谊号浮式生产储油船(FPSO)、伊朗戴维尔号30万t超大型油船(VLCC)、海洋石油941自升悬臂式钻井船、中海油3000m深水半潜式钻井平台及深水导管架等方面阐述了我国深水石油钻采装备... 详细信息

从我国自行设计建造的勘探3号半潜式石油钻井平台、渤海友谊号浮式生产储油船(FPSO)、伊朗戴维尔号30万t超大型油船(VLCC)、海洋石油941自升悬臂式钻井船、中海油3000m深水半潜式钻井平台及深水导管架等方面阐述了我国深水石油钻采装备的现状。对深水石油钻采装备国产化进行了初步探索,提出制订深海发展计划,建立多元化、多渠道的资金投入体系,开展深水钻采系列技术交流与技术储备,开发拥有自主知识产权的深水钻采装备以及优先实现大型装备配套件国产化等多项建议。

关键词：深水钻采装备钻井平台 FPSO 钻井船国产化