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Self-centering seismic retrofit scheme for reinforced concrete frame structures:SDOF system study

Earthquake Engineering and Engineering Vibration 2010年第2期9卷 271-283页

作者： Yunfeng Zhang and Xiaobin Hu department of Civil and Environmental Engineering,university of maryland,college park,md 2074.,usa department of Civil and Environmental Engineering University of Maryland College Park 20742 USA

This paper presents the results of a parametric study of self-centering seismic retrofit schemes for reinforced concrete (RC) frame buildings. The self-centering retrofit system features flag-shaped hysteresis and minimal residual deformation. For comparison purpose,an alternate seismic retrofit scheme that uses a bilinear-hysteresis retrofit system such as buckling-restrained braces (BRB) is also considered in this paper. The parametric study was carried out in a single-degree-of-freedom (SDOF) system framework since a multi-story building structure may be idealized as an equivalent SDOF system and investigation of the performance of this equivalent SDOF system can provide insight into the seismic response of the multi-story building. A peak-oriented hysteresis model which can consider the strength and stiffness degradation is used to describe the hysteretic behavior of RC structures. The parametric study involves two key parameters -the strength ratio and elastic stiffness ratio between the seismic retrofit system and the original RC frame. An ensemble of 172 earthquake ground motion records scaled to the design basis earthquake in California with a probability of exceedance of 10% in 50 years was constructed for the simulation-based parametric study. The effectiveness of the two seismic retrofit schemes considered in this study is evaluated in terms of peak displacement ratio,peak acceleration ratio,energy dissipation demand ratio and residual displacement ratio between the SDOF systems with and without retrofit. It is found from this parametric study that RC structures retrofitted with the self-centering retrofit scheme (SCRS) can achieve a seismic performance level comparable to the bilinear-hysteresis retrofit scheme (BHRS) in terms of peak displacement and energy dissipation demand ratio while having negligible residual displacement after earthquake.

关键词： earthquake reinforced concrete frame structure nonlinear analysis SDOF system seismic retrofit self-centering

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Genetic regulation of programmed cell death in Drosophila

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Cell Research 2000年第3期10卷 193-204页

作者： LEE CHENG-YU, ERIC H BAEHRECKE (l Center for Agricultural Biotechnology, university of maryland Biotechnology institute, college park, maryland 2074.,usa department of Biology, university of maryland, college park, maryland 2074., usa) CenterforAgriculturalBiotechnology UniversityofMarylandBiotechnologyInstituteDepartmentofBiologyUniversityofMarylandCollegePark20742USA.

Programmed cell death plays an important role in maintaining homeostasis during animal development, and has been conserved in animals as different as nematodes and humans. Recent studies of Drosophila have provided valuable information toward our understanding of genetic regulation of death. Different signals trigger the novel death regulators rpr, hid, and grim, that utilize the evolutionarily conserved iap and ark genes to modulate caspase function. Subsequent removal of dying cells also appears to be accomplished by conserved mechanisms. The similarity between Drosophila and human in cell death signaling pathways illustrate the promise of fruit mes as a model system to elucidate the mechanisms underlying regulation of programmed cell death.

关键词： Apoptosis autophagy phagocytosis development.

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Dependence of Hurricane Intensity and Structures on Vertical Resolution and Time-Step Size

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Advances in Atmospheric Sciences 2003年第5期20卷 711-725页

作者： Da-Lin ZHANG and Xiaoxue WANGdepartment of Meteorology, university of maryland, college park, maryland, 2074. usa department of Meteorology University of Maryland 20742 College Park Maryland USA

In view of the growing interests in the explicit modeling of clouds and precipitation, the effects of varying vertical resolution and time-step sizes on the 72-h explicit simulation of Hurricane Andrew (1992) are studied using the Pennsylvania State university/National Center for Atmospheric Research (PSU/NCAR) mesoscale model (i.e., MM5) with the finest grid size of 6 km. It is shown that changing vertical resolution and time-step size has significant effects on hurricane intensity and inner-core cloud/precipitation, but little impact on the hurricane track. In general, increasing vertical resolution tends to produce a deeper storm with lower central pressure and stronger three-dimensional winds, and more precipitation. Similar effects, but to a less extent, occur when the time-step size is reduced. It is found that increasing the low-level vertical resolution is more efficient in intensifying a hurricane, whereas changing the upper-level vertical resolution has little impact on the hurricane intensity. Moreover, the use of a thicker surface layer tends to produce higher maximum surface winds. It is concluded that the use of higher vertical resolution, a thin surface layer, and smaller time-step sizes, along with higher horizontal resolution, is desirable to model more realistically the intensity and inner-core structures and evolution of tropical storms as well as the other convectively driven weather systems.

关键词： hurricane intensity vertical resolution numerical weather prediction

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Vegetation and soil carbon storage in China

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Science China Earth Sciences 2004年第1期47卷 49-57页

作者： LI Kerang, WANG Shaoqiang & CAO MingkuiInstitute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China department of geography, maryland university, college park,md 2074., usa Correspondence should be addressed to Li Kerang Inst. of Geogr. Sci./Nat. Rsrc. Res. Chinese Academy of Sciences Beijing 100101 China department of geography Maryland University College Park MD 20742 United States

This study estimated the current vegetation and soil carbon storage in China using a biogeochemical model driven with climate, soil and vegetation data at 0.5°latitude-longitude grid spatial resolution. The results indicate that the total carbon storage in China's vegetation and soils was 13.33 Gt C and 82.65 Gt C respectively, about 3% and 4% of the global total. The nationally mean vegetation and soil carbon densities were 1.47 kg C/m2 and 9.17 kg C/m2, respectively, differing greatly in various regions affected by climate, vegetation, and soil types. They were generally higher in the warm and wet Southeast China and Southwest China than in the arid Northwest China; whereas vegetation carbon density was the highest in the warm Southeast China and Southwest China, soil carbon density was the highest in the cold Northeast China and southeastern fringe of the Qinghai-Tibetan Plateau. These spatial patterns are clearly correlated with variations in the climate that regulates plant growth and soil organic matter decomposition, and show that vegetation and soil carbon densities are controlled by different climatic factors.

关键词： carbon storage, vegetation, soil, China.

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Fine-tuning electronic structure of N-doped graphitic carbon-supported Co-and Fe-incorporated Mo_(2)C to achieve ultrahigh electrochemical water oxidation activity

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Carbon Energy 2024年第7期6卷 134-149页

作者： md.Selim Arif Sher Shah Hyeonjung Jung Vinod K.Paidi Kug-Seung Lee Jeong Woo Han Jong Hyeok park department of Chemical and Biomolecular Engineering Yonsei UniversitySeoulRepublic of Korea department of Chemistry University of North BengalRaja RammohunpurDarjeelingWest BengalIndia department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoulRepublic of Korea Pohang Accelerator Laboratory Beamline DivisionPohangRepublic of Korea European Synchrotron Radiation Facility France

Mo_(2)C is an excellent electrocatalyst for hydrogen evolution reaction(HER).However,Mo_(2)C is a poor electrocatalyst for oxygen evolution reaction(OER).Herein,two different elements,namely Co and Fe,are incorporated in Mo_(2)C that,therefore,has a finely tuned electronic structure,which is not achievable by incorporation of any one of the ***,the resulting electrocatalyst Co_(0.8)Fe_(0.2)-Mo_(2)C-80 displayed excellent OER catalytic performance,which is evidenced by a low overpotential of 214.0(and 246.5)mV to attain a current density of 10(and 50)mA cm^(-2),an ultralow Tafel slope of 38.4 mV dec^(-1),and longterm stability in alkaline *** data demonstrates that Co_(0.8)Fe_(0.2)-Mo_(2)C-80 requires the lowest overpotential(1.00 V)for OER and Co centers to be the active *** ultrahigh catalytic performance of the electrocatalyst is attributed to the excellent intrinsic catalytic activity due to high Brunauer-Emmett-Teller specific surface area,large electrochemically active surface area,small Tafel slope,and low chargetransfer resistance.

关键词： fine-tuning electronic structures heteronanostructures Mo_(2)C multimetal(Co/Fe) oxygen evolution reaction

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Signaling, Actin Dynamics and Endocytosis

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生物物理学报 2001年第1期17卷 10-18页

作者： SONG Wen-xia(department of Cell Biology and Molecular Genetics, university of maryland, college park, md 2074., usa) university of maryland 美国 20742

Endocytosis is an essential process for normal function of all living cells. Cells get nutrients, and control the surface-expressional level of proteins as well as membrane hemostats through the endocytosis. Endocytosis process is regulated in response to functional status of a particular cell. Signaling events and the endocytosis process go hand in hand to fulfill cellular functions. Although our understanding of the endocytosis process has grown rapidly during the last decade, little is known about how it is interconnected functionally with the signaling status of cells. During endocytosis, vesicles are formed from the plasma membrane through complex molecular machinery. The location where the vesicles are formed is rich in cortical actin cytoskeleton that supports the plasma membrane. To enter cells, vesicles have to diffuse through the cortical actin cytoskeleton. The actin cytoskeleton has a very dynamic structure and actively participates a wide variety of cellular functions. In addition to its central role in cytokinesis, cell shape, cell motility, and cell polarity, a connection between the endocytosis process and the actin cytoskeleton has been implicated in both yeast and mammalian system. In recent years the knowledge on how the actin cytoskeleton participates in the generation of coordinated cellular responses to external stimuli is grown rapidly. In this review, we focus on the potential roles of the actin cytoskeleton in regulating the endocytosis process in response to signaling events.

关键词：信号肌动蛋白胞吞

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The link between intracellular calcium signaling and exosomal PD-L1 in cancer progression and immunotherapy

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Genes & Diseases 2024年第1期11卷 321-334页

作者： md Rakibul Alam md Mizanur Rahman Zhiguo Li department of Toxicology and Cancer Biology College of MedicineUniversity of KentuckyLexingtonKY 40506USA department of Medicine(Nephrology) Faculty of Medicine and DentistryUniversity of AlbertaEdmontonAlberta T6E2H7Canada

Exosomes are small membrane vesicles containing microRNA,RNA,DNA fragments,and proteins that are transferred from donor cells to recipient *** cells release exo-somes to reprogram the factors associated with the tumor microenvironment(TME)causing tu-mor metastasis and immune *** evidence revealed that cancer cell-derived exosomes carry immune inhibitory molecule program death ligand 1(PD-L1)that binds with re-ceptor program death protein 1(PD-1)and promote tumor progression by escaping immune ***,some FDA-approved monoclonal antibodies are clinicallyused for cancer treatment by blocking PD-1/PD-L1 *** notable treatment outcomes,some pa-tients show poor drug *** PD-L1 plays a vital role in lowering the treatment response,showing resistance to PD-1/PD-L1 blockage therapy through recapitulating the ef-fect of cell surface *** enhance therapeutic response,inhibition of exosomal PD-L1 is *** signaling is the central regulator of tumorigenesis and can regulate exosome biogenesis and secretion by modulating Rab GTPase family and membrane fusion ***-mune checkpoints are also connected with calcium signaling and calcium channel blockers like amlodipine,nifedipine,lercanidipine,diltiazem,and verapamil were also reported to suppress cellular PD-L1 ***,to enhance the PD-1/PD-L1 blockage therapy response,the reduction of exosomal PD-L1 secretion from cancer cells is in our therapeutic *** this review,we proposed a therapeutic strategy by targeting calcium signaling to inhibit the expression of PD-L1-containing exosome levels that could reduce the anti-PD-1/PD-L1 therapy resistance and increase the patient's drug response rate.

关键词： Calcium signaling CD8^(+)T cells Exosomal PD-L1 Exosomes biogenesis Immunosuppression Immunotherapy

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Improvement of a 3D radar backscattering model using matrix-doubling method

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Science China Earth Sciences 2010年第7期53卷 1029-1035页

作者： NI WenJian1,2, GUO ZhiFeng1 & SUN GuoQing3 1 State Key Laboratory of Remote Sensing Science, jointly sponsored by the Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal university, Beijing 100101, China 2 Graduate university of Chinese Academy of Sciences, Beijing 100049, China 3 department of geography, university of maryland, college park, md 27042, usa 1. State Key Laboratory of Remote Sensing Science jointly sponsored by the Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University Beijing 100101 China2. Graduate University of Chinese Academy of Sciences Beijing 100049 China3. Department of Geography University of Maryland College Park MD 27042 USA

Radiative transfer models have been widely used to simulate the radar backscattering from forested areas. A three-dimensional radar backscatter model of forest canopy developed in previous studies takes full account of spatial position of trees in a forest stand, and the interactions among crown, trunk and ground surface. The model predicted well for the co-polarized backscatter measurements, but underestimated the backscattering for cross-polarization, primarily because only the first-order scattering within tree crowns was considered in the model. The backscattering at cross-polarization depends strongly on multiple scatter- ing within tree crowns. To produce good estimations for cross-polarized component, the matrix-doubling method is employed here to compute multiple-scattering within the crown. The modified model is compared with the original model, and the field forest measurements and AIRSAR data are used for validation of the modified model. The cross-polarization backscattering is improved in different degrees for different crown structures and at different bands.

关键词： remote sensing forestry electromagnetic propagation radar backscattering model matrix-doubling

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Retrieving crop leaf area index by assimilation of MODIS data into a crop growth model

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Science China Earth Sciences 2010年第5期53卷 721-730页

作者： WANG DongWei1,2,3, WANG JinDi1,2 & LIANG ShunLin4 1 State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Beijing Normal university and Institute of Remote Sensing Applications, CAS, Beijing 100875, China 2 School of geography, Beijing Key Laboratory of Environmental Remote Sensing and Digital City, Beijing Normal university, Beijing 100875, China 3 Haihe River Water Conservancy Commission, Tianjin 300170, China 4.department of geography, university of maryland, college park, md 2074., usa 1. State Key Laboratory of Remote Sensing Science Jointly Sponsored by Beijing Normal University and Institute of Remote Sensing Applications CAS Beijing 100875 China2. School of Geography Beijing Key Laboratory of Environmental Remote Sensing and Digital City Beijing Normal University Beijing 100875 China3. Haihe River Water Conservancy Commission Tianjin 300170 China4. Department of Geography University of Maryland College Park MD 20742 USA

Leaf area index (LAI) is an important parameter in monitoring crop growth. One of the methods for retrieving LAI from remotely sensed observations is through inversion of canopy reflectance models. Many model inversion methods fail to account for variable LAI values at different crop growth stages. In this research, we use the crop growth model to describe the LAI changes with crop growth, and consider a priori LAI values at different crop growth stages as constraint information. The key approach of this research is to assimilate multiple canopy reflectance values observed at different growth stages and a priori LAI values into a coupled crop growth and radiative transfer model sequentially using a variational data assimilation algorithm. Adjoint method is used to minimize the cost function. Any other information source can be easily incorporated into the inversion cost function. The validation results show that the time series of MODIS canopy reflectance can greatly reduce the uncertainty of the inverted LAI values. Compared with MODIS LAI product at Changping and Shunyi Counties of Beijing, this method has significantly improved the estimated LAI temporal profile.

关键词： inversion leaf area index crop growth model time series MODIS

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Application of ensemble kalman filter to geophysical parameters retrieval in remote sensing:A case study of kernel-driven BRDF model inversion

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Science China Earth Sciences 2006年第6期49卷 632-640页

作者： QIN Jun1, YAN Guangjian1, LIU Shaomin1, LIANG Shunlin2, ZHANG Hao1, WANG Jindi1 & LI Xiaowen1 1. State Key Laboratory of Remote Sensing Science, School of geography and Remote Sensing, Research Center for RS&GIS, Beijing Normal university, Beijing 100875, China 2. department of geography, 2181 Lefrak Hall, university of maryland, college park, md2074., usa 1. State Key Laboratory of Remote Sensing Science School of Geography and Remote Sensing Research Center for RS&GIS Beijing Normal University Beijing 100875 China 2. department of geography 2181 Lefrak Hall University of Maryland College Park MD20742 USA

The use of a priori knowledge in remote sensing inversion has great implications for ensuring the stability of inversion process and reducing uncertainties in retrieved results, especially under the condition of insufficient observations. Common optimization algorithms have difficulties in providing posterior distribution and thus cannot directly acquire uncertainties in inversion results, which is of no benefit to remote sensing application. In this article, ensemble Kalman filter (EnKF) has been introduced to retrieve surface geophysical parameters from remote sensing observations, which has the capability of not merely obtaining inversion results but also giving its posterior distribution. To show the advantage of EnKF, it is compared to standard MODIS AMBRALS algorithm and highly effi-cient global optimization method SCE-UA. The inversion abilities of kernel-driven BRDF models with different kernel combinations at several main cover types are emphatically discussed when observa-tions are deficient and a priori knowledge is introduced into inversion.

关键词： remote sensing inversion, a priori knowledge, posterior distribution, ensemble kalman filter, BRDF, kernel-driven model, albedo.

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