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Acta Metallurgica Sinica(English Letters) 2024年第6期37卷 1007-1018页

作者： Huanzhi Zhang Tianxin Li Qianqian Wang Zhenbo Zhu hefei Huang Yiping Lu Engineering Research Center of High Entropy Alloy Materials(Liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian116024China Shanghai institute of Applied Physics Chinese Academy of Sciences(CAS)Shanghai201800China

Interstitial strengthening with nitrogen(N)is one of the effective ways to improve the mechanical properties of HEAs,but the effects of N on the microstructures and mechanical properties of the irradiated HEAs have not been studied ***,the microstructures and mechanical properties of N-free and N-doped Ti_(2)ZrNbV_(0.5)Mo_(0.2)HEAs before and after He irradiation were *** results showed that the solid solution strengthening caused by interstitial N improved the yield strength at room temperature and 1023 K without significantly reducing plasticity.N doping significantly promoted the growth,aggregation and wider spatial distribution of He bubbles by enhancing the mobility of He atoms/He-vacancy complexes,with the average size of He bubbles increasing from 10.4 nm in N-free HEA to 31.0 nm in N-doped *** addition,N-doped HEA showed a much higher irradiation hardness increment and hardening fraction than N-free *** to conventional materials doped with N,the introduction of N into Ti_(2)ZrNbV_(0.5)Mo_(0.2)HEA had adverse effects on its resistance to He bubble growth and irradiation *** results of this study indicated that N doping may not improve the irradiation resistance of HEAs.

关键词： High-entropy alloys Nitrogen doping Mechanical properties Helium bubbles Irradiation resistance

Synergistic effect of combining paeonol and cisplatin on apoptotic induction of human hepatoma cell lines

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Acta Pharmacologica Sinica 2007年第6期28卷 869-878页

作者： Shu-ping XU~2,guo-ping SUN~(4,5),Yu-xian SHEN~2,Wan-ren PENg~4,Hua WANg~3,Wei WEI~2~2 institute of Clinical Pharmacology,anhui Medical University,Key Laboratory of Anti-inflammatory and Immunological Pharmacology,Key Laboratory of Research and Development of Chinese Medicine,hefei 230032,china ~3 Department of Oncology,Provincial Hospital ofanhui,hefei 230001,china ~4 Department of Oncology,The First Affiliated Hospital of anhui Medical University,hefei 230022,china institute of Clinical Pharmacology Anhui Medical University Key Laboratory of Anti-inflammatory and Immunological Pharmacology Key Laboratory of Research and Development of Chinese Medicine Hefei China Department of Oncology The First Affiliated Hospital of Anhui Medical University Hefei China Department of Oncology Provincial Hospital of Anhui Hefei China

Aim:To investigate whether paeonol （Pae） has synergistic effects with cisplatin（CDDP） on the growth-inhibition and apoptosis-induction of human hepatomacell lines Hepg2and ***:The cytotoxic effect of drugswas measured by 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyl-tetrazolium *** coefficient of drug interaction was used to analyze the nature of *** changes were observed by acridine orange fluo-rescence *** cycle and the apoptosis rate were detected by ***-2 and Bax expression were assayed by ***:Pae or CDDP had antiproliferative effect on the 2 cell linesin a dose-dependent manner,with different sensitivities to ***,a synergistic inhibitory effect on the viability of the 2 cell lineswas observed after treatment with a combination of Pae （15.63,31.25,and 62.5mg/L） with various concentrations of *** study showed typical mor-phological changes of apoptosis if the cells were exposed to the two agents for24 *** apoptotic rate of the cells with combination treatment was signifi-cantly higher than that of cells treated with Pae or CDDP *** expressionof Bcl-2 decreased and that of Bax increased in the treated groups,especially inthe combination group,with the ratio of Bcl-2/Bax decreasing ***,a combination of Pae with CDDP resulted in a stronger S phasearrest,compared with Pae or CDDP ***:Pae,in combinationwith CDDP,had a significantly synergistic growth-inhibitory and apoptosis-in-ducing effect on the 2 human hepatoma cell lines,which may be useful inhepatoma treatment.

关键词： paeonol cisplatin drug interaction human hepatoma cell line apoptosis cell cycle

Tectonodynamic Adjustment of Crustal Materials in the Middle-Lower Reaches of the Yangtze River

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Acta g.olog.ca Sinica(English Edition) 1989年第4期63卷 325-342,447页

作者： Dong Shuwen anhui institute of g.olog., hefei, anhui Liu Linqun anhui institute of g.olog. Hefei Anhui

Under the tectonodynamic process, crustal materials tend to experience two modes of adjustment: (1) structural (physical) adjustment, manifested by folding, faulting, uplifting, downwarping, etc.: (2) compositional adjustment, represented by element migration, concentration and dispersion, crystalline and dynamic differentiation of crystals, metamorphism, etc. (Yang Kaiqing. 1986; Yang Kaiqing et al., 1986). The dynamic adjustment of crustal materials in the middle-lower reaches of the Yangtze mainly occurred in the Mesozoic under the conditions of intense collision between the North china (Dabie) massif and the Yangtze massif. The structural adjustment refers to various types of deformation within the two massifs and the intensive shortening of the stratigraphic coyer of the Yangtze massif, whereas the compositional adjustment implies the structural remelting of the basement and the ore. and rock- forming processes in the two massifs.

关键词： Tectonodynamic Adjustment of Crustal Materials in the Middle-Lower Reaches of the Yangtze River

A Preliminary Research on Skarns of Magmatic Origin

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Journal of Earth Science 1999年第1期18卷 58-61页

作者： Wu Yanchang anhui institute of g.olog.cal Sciences, hefei 230001

Skarns of magmatic origin, or magmatic skarns as called, are formed by crystallization of skarnic magma injecting into structural fissures. They occur in various rocks (rock formations), mainly in form of veins. Usually, they possess massive structure and cumulative texture. They mainly consist of calc silicate, without or with minor water bearing silicates. The typical minerals in it include alkali feldspar, calcite and anhydrite. Some silicate melt inclusions and high temperature, high salinity poly phase inclusions can be seen in the crystals of their host minerals. The particular members of the magmatic skarns are transitional skarn and skarnic pegmatite. The magmatic skarn and the congenetic alkali rich diorite usually collaborate in a conjugating and complementary manner. They probably are the products of calcic contamination, degassing, desilicification and separation in melt state of deep seated (high level magma chamber) alkali rich intermediate acid magma.

关键词： magmatic skarn magmatic skarn alkali intrusive pair the middle and lower reaches of Changjiang River.

Using Fractal Function Auto-correlative Method to Confirm Fractal Dimension of Function graph

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Chinese Journal of Lasers 1999年第2期8卷 54-57页

作者： FAN Chengyu (anhui institute of Optics and Fine Mechanics, The Chinese Academy of Sciences, hefei 230031, china) 中科院安徽光学精密机械所安徽合肥 230031

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关键词： function graph fractal dimension power spectrum

Upregulation of TNF-αand IL-6 mRNA in mouse liver induced by bacille Calmette-guerin plus lipopolysaccharide

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Acta Pharmacologica Sinica 2006年第4期27卷 460-468页

作者： Dao-fang LIU~(1,2,3) Wei WEI~(1,4) Li-hua SONg~(1,2,3,4) ~1institute of Clinical Pharmacology,Key Laboratory of Anti-inflammatory and Immunopharmacology in anhui Province.Key Laboratory of Research and Development of Chinese Medicine in anhui Province.anhui Medical University,hefei 230032,china:~2Molecular Biology Laboratory,anhui Biology institute,hefei 230088,china ~3Center of Research and Development,anhui Anke Biotechnology group,hefei 230088.china institute of Clinical Pharmacology Key Laboratory of Anti-inflammatory and Immunopharmacology in Anhui Province Key Laboratory of Research and Development of Chinese Medicine in Anhui Province Anhui Medical University Hefei China Molecular Biology Laboratory Anhui Biology Institute Hefei China Center of Research and Development Anhui Anke Biotechnology Group Hefei China

Aim:To investigate the mechanism of immunological liver injury induced by bacilleCalmette-guerin(BCg)plus lipopolysaccharide(LPS).Methods:Mice were in-jected via the tail vein with 125 mg/kg BCg,and 12 d later,the mice were injectedintravenously with different doses of LPS(125,250,or 375 μg/kg).Serum alanineaminotransferase(ALT)activity and liver pathological changes were *** expression of tumor necrosis factor(TNF)-α interleukin(IL)-6,lipopolysac-charide binding protein(LBP)and CD14 mRNA,and NF-κB and IκB-α protein inmouse liver at different time points after BCg and LPS injection were measuredusing RT-PCR,immunohistochemistry and Western blotting analysis,***:The activity of serum ALT in mice treated with BCg and LPS was signifi-cantly *** degrees of liver injury,such as inflammatory cellinfiltration,spotty necrosis,piecemeal necrosis,even bridging necrosis,could beseen in liver sections from mice after BCg and LPS ***,thelevels of TNF-α and IL-6 mRNA in mouse liver were significantly elevated afteradministration of BCg plus LPS(P4 mRNA inmouse liver were markedly upregulated after treatment with BCg and LPS,andtreatment with BCg alone led to an increase in CD14 InRNA in mouse ***,immunoreactivity for NF-κB p65 was predominantly detected in hepatocyte nucleifrom mice treated with BCg plus LPS,compared with the normal *** of IκB-α were strikingly decreased by LPS or BCg plus LPS treatment,compared with the normal group or BCg ***:TNF-α and IL-6mRNA were partially involved in early immunological liver injury induced by chal-lenge with small doses of LPS after BCg *** of TNF-α and IL-6 mRNA might be related to increases in LBP and CD 14 mRNA expression andactivation of NF-κ***,BCg priming in immunological liver injury mayoccur via upregulation of CD 14 mRNA expression in monon uclear cell infiltrationinto t

关键词： liver injury lipopolysaccharide binding protein CD14 tumor necrosis factor-alpha interleukin-6 NF-kappa B

On Metallogenic Conditions and Regularities of the Lower and Middle Reaches of the Changjiang River

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Acta g.olog.ca Sinica(English Edition) 1988年第4期1卷 435-449页

作者： Liu Xiangpei Chang Yinfo Wu Yenchang anhui Bureau of g.olog. and Mineral Resources, hefei, anhui anhui institute of g.olog.cal Sciences, hefei, anhui 1Du Xun Lu Jingyuan Chen Xunxiong Liang Shanrong Xu Xin Wang Yingchun et al. also participated in the study.

The paper deals with the metallogenic conditions and regularities of the region ol the lower-middle reachesof the Changjiang River in china. The complicated structural network with the Changjiang (Yangtse) deepfracture as its trunk is the leading rock-and ore-controlling structure of the metallogenic belt. Thehigh-potassium granodiorites of the first magmatic sequence of the Mesozoic Yangtse syntexis type and thesodium-rich diorites of the second sequence are genetically related to the copper ore series and the iron ore se-ries respectively. and occur respectively in the block-faulted and-folded uplift area and the down-faulted vol-canic basin as well as the transitional zone between the two. The ore-hosting horizons show specific associa-tions of rocks and often contain ore beds basically of stratabound nature.

关键词： Cu In On Metallogenic Conditions and Regularities of the Lower and Middle Reaches of the Changjiang River

Thrombin-like enzymes from venom gland of Deinagkistrodon acutus:cDNA cloning,mechanism of diversity and phylogenetic tree construc-tion

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Acta Pharmacologica Sinica 2006年第2期27卷 184-192页

作者： Xiang-dong ZHA~(2,3,7) He-sheng HUANg~(4,7) Li-zhi ZHOU~(2,3) Jing LIU~5 Kang-sen XU~6 ~2School of Life Sciences,anhui University,hefei 230039,china ~3anhui Key Laboratory of Eco-Engineering and Bio-techniques,hefei 230039,china ~4Department of Pharmacology,anhui Medical University.hefei 230022,china ~5School of Life Sciences,University of Science and Technology of china,hefei 230026,china ~6institute for Control of Pharmaceuticals and Biological Products,Beijing 100050,china School of Life Sciences Anhui University Hefei China anhui Key Laboratory of Eco-Engineering and Bio-techniques Hefei China Department of Pharmacology Anhui Medical University Hefei China School of Life Sciences University of Science and Technology of China Hefei China institute for Control of Pharmaceuticals and Biological Products Beijing China

Aim:To clone cDNAs of thrombin-like enzymes(TLEs)from venom gland ofDeinagkistrodon acutus and analyze the mechanisms by which their structuraldiversity ***:Reverse transcription-polymerase chain reaction andgene cloning techniques were used,and the cloned sequences were analyzed byusing bioinformatics ***:Novel cDNAs of snake venom TLEs *** possibilities of post-transcriptional recombination and horizontalgene transfer are discussed.A phylogenetic tree was ***:The cDNAs of snake venom TLEs exhibit great *** are severaltypes of structural *** variations may be attributable to certainmechanisms including recombination.

关键词： thrombin-like enzymes structural diversity RNA recombination phylogenetic tree

BIVARIATE RATIONAL IN TERPOLANTS WITHRECTANgLE-HOLE-STRUCTURE

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Journal of Computational Mathematics 1999年第1期17卷 1-14页

作者： Jie-qing Tan(institute of Applied Mathematics, hefei University Of Technology, hefei 230009, china) 合肥工业大学应用数学系安徽合肥

Bivariate vector valued rational interpolants are established by means of Thiele-type branched continued fractions and Samelson inverse over rectangular grids with holes, characterisation theorem with topologic struct... 详细信息

关键词： branched continued fraction interpolation vector-grid

Discovery of low grade metamorphic volcanic rock sheets within UHP in Dabie Mts. and its implications

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Chinese Science Bulletin 1997年第14期42卷 1199-1203页

作者： DONg Shuwen, WANg Xiaofeng and HUANg Dezhi1. Chinese Academy of g.olog.cal Sciences (CAgS), Beijing 100037, china 2. institute of geomechanics of CAgS, Beijing 100081 china 3. anhui institute of g.olog.cal Sciences, hefei 230001 Chinese Academy of g.olog.cal Sciences (CAgS) Beijing China institute of geomechmics of CAgS Beijing China anhui institute of g.olog.cal Sciences Hefei

THE ultrahigh-pressure metamorphic zone (UHP), outcropping in the central and southernDabie Mts. with an area of about 1000 km^2, may be the largest one in the world. The forma-tion and exhumation mechanism of the UHP rocks become a hot point in the study of continen-tal orogen. The first finding of the Shiqiao structural window, which is composed of low

关键词： ultrahigh-pressure metamorphic zone (UHP) low grade metamorphic rock sheets Dabie Mts.