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Comparison of the SchirmerⅠtest with and without topical anesthesia for diagnosing dry eye

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International Journal of Ophthalmology(English edition) 2012年第4期5卷 478-481页

作者： Na Li, Xin-Guo Deng, Mei-Feng He State Key Laboratory of Ophthalmology, zhongshan Ophthalmic center, Sun Yat-sen university, guangzhou 510060, Guangdong Province,{4.

·AIM:To determine the value of Schirmer Ⅰtest (SⅠt) without anesthesia and with topical anesthesia for diagnosing dry eye (DE). ·METHODS:Totally 220 eyes in 110 patients, male (4.) and female (66), (39.56±12.67) years old diagnosed with DE were examined. SⅠt without anesthesia was performed firstly, and 15 minutes later, it was applied again in the same person after topical anesthesia with 0.5% proparacaine hydrochloride eye drops. The wetting strips counted <10mm per 5 minutes were defined positive, while ≤5mm per 5 minutes were defined strong positive. ·RESULTS:The wetting length in SⅠt after topical anesthesia was significantly lower than that in SⅠt without anesthesia(P < 0.001). The positive rate and strong positive rate of SⅠt after topical anesthesia were significantly higher than that of SⅠt without anesthesia (P <0.001). The positive rate and strong positive rate of SⅠt without anesthesia and the strong positive rate of SⅠt after topical anesthesia in patients with aqueous-deficiency dry eye (ADDE) were significantly higher than those in total patients whereas those in patients with evaporative dry eye (EDE) were significantly lower than those in total patients (P <0.001). ·CONCLUSION:SⅠt after topical anesthesia with 0.5% proparacaine hydrochloride eye drops is more objective and reliable than that without anesthesia in reflecting the status of DE, and its diagnostic value in patients with ADDE was even higher, making itself a meaningful evidence for the diagnosis and treatment of DE.

关键词： dry eye SchirmerⅠtest tears topical anesthesia

HUMORAL AND CELLULAR IMMUNE RESPONSES TO LENS PROTEIN IN PATIENTS WITH CONGENITAL CATARACT

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Eye Science 1989年第Z1期14卷 24-25页

作者： Chufang Xie Shaozhen Li Xiangkun Huang Wenshu Mao (Winifred Mao) Eye Research Institute, zhongshan Ophthalmic center Sun Yat-sen university of Medical Sciences guangzhou,{4.

In order to understand the immune responses to lens protein in patients with congenital cataract, the passive hemagglutination assay for humoral immunity and the leukocyte migration test for cellular immunity to lens protein were performed on 4. patients with congenital cataract and 30 healthy persons served as *** results showed that there was no significant difference in the incidence of humoral immune responses to lens protein between patients with congenital cataract and the controls (P>0.05), but the incidence of cellular immune responses tolensprotein in patients with congenital cataract was higher than that of the controls (P<0.005).The results of this study suggested that during the development of congenital cataract, lens protein leaked into the aqueous humour and entered the systemic circulation, sensitizing lymphocytes and producing cellular mediated immune responses. Further investigation is neceessary to determine whether there is any relationship between the immune responses to lens protein and the formation of congenital cataract.

关键词： cataract congenital immunity incidence leukocyte producing migration immunized served Ophthal

POINTS THAT MERIT CONSIDERATION IN THE DIAGNOSIS OF RETINOBLASTOMA

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Eye Science 1989年第Z1期14卷 3-6页

作者： Wenshu Mao Qiaoyun Ma Linghua Zeng Xianghong Lin Youzhao Chen Xinyuan Cao Zuyou Dai zhongshan Ophthahnic center Sun Yat-sen university of Medical Sciences guangzhou,{4.

According to the clinical appearances and the characteristics of the onset of 86 Rb cases, some points in the diagnosis merit consideration:1) Since the average symptomatic age was 21.75 months and the mean diagnostic age was 24.32 months, children under 3 years with leukocoria should be carefully examined, while adult Rb should not be neglected.2) The primary symptom of Rb is mostly leukocoria, but Rb eyes without any symptoms or leukocoria(26 out of 105 eyes in our groups) might also be encountered.3) 4.out of the 86 cases were retinocytoma which is supposed to be a type of Rb degeneration or *** Rh.4. Attention should be paid to abnormalities and second primary tumors in Rb patients.5) The pedigree investigations, twin method and laboratory studies in Rb such as chromosome analysis, EsD, LDH measurement and RFLP technique are useful in the prenatal diagnosis,early diagnosis and the diagnosis of the carriers.

关键词： carefully degeneration retinoblastoma chromosome neglected mostly supposed children diagnostic deletion

A Model for Blindness Prevention

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眼科学报 1997年第3期13卷 162-163,147页

作者： Jingjing Xu, Wenshu Mao, Shaozhen Li, Lezheng Wu, Zhongyao Wu Siping Zhu, Qiang Yu, Mingguang Hezhongshan Ophthalmic center, Sun Yat-sen university of Medical Sciences, guangzhou 510060,{4. zhongshan Ophthalmic center Sun Yat-sen University of Medical Sciences Guangzhou 510060 China

Objective :To introduce the work of the prevention and treatment of blindness of zhongshan Ophthalmic center, to find out the effective model of blindness prevention and treatment in ***; 1. To provide high quality clinical service to rural people. 2. To conduct epidemio-logical survey *** train local ophthalmic professionals *** promote international ***:4. 000 outpatients cases, 4.500 cataract surgeries have been accomplished. Thousands cataract blind have been rehabilitated. 9 papers concerning epidemiological survey have been published. After the international training courses, 50 local ophthalmic workers have been trained and 4.cataract surgery rehabilitation centers have been founded. Conclusion : An effective model for blindness prevention and treatment should be based on clinical service, population based epidemiological survey and local ophthalmic professionals training. International cooperation is also an important promoter. Eye Science 1997; 13 : 162 -163.

关键词：失明预防方法白内障

Peripheral nerve injury impairs working memory and hippocampal LTP via up-regulation of TNF-α

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Peripheral nerve injury impairs working memory and hippocamp...

Pioglitazone Ameliorate Lipid Metabolic Disorder in KKAy Mice

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Wen-Jie REN,Yong LIU,Xian-Guo LIU~* Pain Research center,zhongshan School of Medicine,Sun Yat-sen university,510080 guangzhou,{4.

＜正＞Abundant clinical data have demonstrated that about 2/3 of patients with chronic pain suffer from working memory deficit,but the mechanism is *** the most common cause of chronic pain is peripheral nerve injury,in the present work we investigated whether and how peripheral nerve injury may impair the memory *** found that working memory（a short-term memory） but not reference memory（a long-term memory） was impaired in animals with spared nerve injury（SNI）,in which two branches of the sciatic nerve（the common peroneal nerve and the tibial nerve） were *** memory deficit lasted about three *** investigate the underlying mechanisms,long-term potentiation （LTP） in vivo in hippocampus were compared in SNI animals and sham-operated *** results showed that peripheral nerve injury（SNI） inhibited CA1 LTP in a time-dependent manner,that is,acute transection of two branches of the sciatic nerve affected neither the baseline of field EPSPs in CA1 evoked by stimulation of Schaffer fiber nor LTP induction by high frequency stimulation（4.trains of 100 pulses of 100 Hz,intertrain interval of 15 s）;Eighteen hours after nerve injury LTP lasted for only 1.5 h,indicating that the late-phase LTP is blocked;Four days after nerve injury the potentiation lasted for only 15 min,suggesting that early-phase LTP is also *** impairment of hippocampal LTP persisted for around 3 ***,we found that tumor necrosis factor（TNF-α） was increased in cerebrospinal fluid and in hippocampus tissue following *** of TNF-αsynthesis by thalidomide prevented the working memory deficit and inhibition of LTP produced by *** failed to impair the working memory performance and hippocampal LTP in TNF-αreceptor 1 knockout *** results suggest that peripheral nerve injury,which produces chronic pain,may disrupt CA1 LTP and working memory via up-regulation of TNF-αin central nervous system.

关键词： chronic pain peripheral nerve injury working memory performance LTP TNF-α hippocampus

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Pioglitazone Ameliorate Lipid Metabolic Disorder in KKAy Mic...

Interaction between CI~- channels and CRAC-related Ca2+signaling during T lymphocyte activation and proliferation

广东省环境诱变剂学会、广东省预防医学会卫生毒理专业委员会2010年学术会议

作者： Sifan Chen~(1,2),Yanshuang Sun~(1,2),Xincai Xiao~(1,2,3),Zili Zhang~(1,2),Liangru Ke~4.Niman Zhou~4. Zhiming Shan~4.Xiang Feng~(1,2*),Wei Zhu~(3*) 1 Guangdong Provincial Key Laboratory of Food,Nutrition and Health 2 School of Public Health,Sun Yat-Sen university,guangzhou,Guangdong,P.R.china 3 guangzhou {4. for Disease Control and Prevention,guangzhou,Guangdong,P.R.china 4.zhongshan School of Medicine,Sun Yat-Sen university,guangzhou,Guangdong,P.R.china

To explore the effects of pioglitazone on serum and liver lipid level and antioxidant ability of mice with lipid metabolic disorder and the underlying mechanism,KKA mice were treated with pioglitazone based on their body weights for 12 weeks and their lipid and antioxidant indices were compared to those of KKA mice without pioglitazone treatment as well as those of C57BL/6J *** results show that pioglitazone treatment reduces serum and liver TG,elevates serum HDL-C level,increases serum and liver SOD activity,attenuates serum MDA content,ameliorates liver steatosis,induces liver PPARγexpression and enhances AMPKαphosphorylation level. In conclusion,the results indicate that pioglitazone can regulate blood lipid level,reduce liver lipid deposition and enhance antioxidant capacity of mice with lipid metabolic disorder possibly through increasing AMPK phosphorylation.

关键词： Pioglitazone lipid metabolic disorder AMP-activated protein kinase

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Acta Pharmacologica Sinica 2006年第4期 437-446页

作者： Guan-lei WANG Yan QIAN Qin-ying QIU Xiu-jian LAN Hua HE Yong-yuan GUAN~2 Department of Pharmacology,zhongshan Medical College,Sun Yat-Sen university,guangzhou 510089.china

Aim:To test the hypothesis that Cl~- channel blockers affect T cell proliferationthrough Ca2+-release-activated Ca2+(CRAC)signaling and examine the effects ofthe combination of a CRAC channel blocker and a Cl~- channel blocker on con-canavalin A(ConA;5 mg/mL)-induced Ca2+signaling,gene expression and cellu-lar proliferation in human peripheral T ***:[~3H]Thymidineincorporation,Fura-2 fluorescent probe,RNase protection assay,and reversetranscription-polymerase chain reaction were ***:The Cl~- channelblocker 4.4.-diisothiocyanostilbene-2,2’-disulfonic acid(DIDS)inhibited ConA-induced Ca2+influx,interleukin-2 mRNA expression and T lymphocyte prolifera-tion in a concentration-dependent manner,and also enhanced the inhibitory ef-fects of 1-{beta-[3-(4.methoxyphenyl)propoxyl]-4.methoxyphenethyl}-1H-imida-zole(SK&F96365)on the above key events during T cell activation.A combina-tion of DIDS(1 μmol/L)and SK&F96365(1 μmol/L)significantly diminished ConA-induced ClC-3 mRNA expression by 64.,whereas DIDS(1 μmol/L)or SK&F96365(1 μmol/L)alone decreased ConA-induced ClC-3 mRNA expression by only 16%and 9%,***:These results suggest that there is an interac-tion between CRAC-mediated Ca2+signaling and DIDS-sensitive Cl~- channelsduring ConA-induced T cell activation and ***,the DIDS-sensitive Cl~- channels may be related to the C1C-3 Cl~- channels.

关键词： T lymphocTytes lymphocyte activation chloride channels calcium ion channels interleukin-2

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门诊小梁切除术的临床观察

眼科学报 1998年第4期14卷 245-248页

作者：敖晶晶刘杏中山医科大学中山眼科中心广州510060

目的:探讨门诊开展小梁切除术的可行性。方法:将27例38眼门诊小梁切除术的病例与同期由相同手术医师施行的30例38眼住院小梁切除术病例进行比较,观察其疗效及并发症。结果:观察组术后1周、1月、3月或以上眼压分别为1.4.00±0.5977 kPa、... 详细信息

目的:探讨门诊开展小梁切除术的可行性。方法:将27例38眼门诊小梁切除术的病例与同期由相同手术医师施行的30例38眼住院小梁切除术病例进行比较,观察其疗效及并发症。结果:观察组术后1周、1月、3月或以上眼压分别为1.4.00±0.5977 kPa、1.8379±0.5517kPa、1.9650±0.4.79 kPa。对照组术后1周、1月、3月或以上眼压分别为1.34.8±0.5994.Pa、1.7737±0.5177 kPa、2.014.±0.54.7 kPa。经t检验,两组术后眼压、疗效、视力改变及并发症差异无统计学意义。结论:在条件成熟的医院选择性地开展门诊小梁切除术是有效、安全可行的。眼科学报1998;14.24.～24.。

关键词：小梁切除术门诊青光眼

Comparison of the Accuracy of Canon KU-1 IOL Measurer and VPLUS A/B Scanner in Axial Length Measurement

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Eye Science 2003年第3期19卷 150-152,183页

作者： Chuyin Chen, Zhende Lin, Bo Feng, Yonghua Li zhongshan Ophthalmic center, Sun Yat-sen university, guangzhou 510060,{4. zhongshan Ophthalmic center Sun Yat-sen University Guangzhou 510060 China.

Purpose: To evaluate the accuracy of Canon KU-1 IOL measurer (Japanese Canon Company) and VPLUS A/B scanner (French Quantel Company) in axial length (AL)***:Canon KU-1 IOL measurer and VPLUS A/B scanner were used to measure axial length of human cataractous eyes before cataract surgery. Two hundred and twentytwo cases (4.3 eyes) were involved. The results were compared and the postoperative visual acuity, refractive results were recorded during the follow-ups to evaluate the accuracy of the two ***:In the 222 cases (4.3 eyes), the absolute value of the measurement differences was 0.4.mm or above in 35 eyes, 0.8 mm or above in 17 eyes, 1.2 mm or above in 12 eyes,2.0mm or above in 5 eyes. The refractive error was less than 2.0D in all patients. The mean values of ocular axial length by the two methods were 23.82 mm and 23.83 mm respectively and the difference had no statistic significance with compared t test ( P=0.902, two tail, or=0.01).Conclusion:The accurate AL measurements can be obtained with the two instruments and the measurement results should be analyzed comprehensively to obtain accurate values in the complicated cases.

关键词：白内障轴向长度测量法 KU-1IOL测量器 VPLUSA/B扫描仪