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洛沙坦对兔静脉移植物内膜增生的影响

复旦学报（医学版） 2003年第3期30卷 285-286,i001页

作者：尤文俊萧明第袁忠祥徐根兴上海市第一人民医院心血管外科上海200080

目的探讨血管紧张素Ⅱ受体拮抗剂洛沙坦对静脉移植物内膜增生的影响。方法新西兰大白兔20只,随机分为治疗组和对照组。术后治疗组即给予洛沙坦纯粉25mg/(kg·d),对照组常规喂养,共4.。术前及处死动物前分别测定基础血压和治疗后血压... 详细信息

目的探讨血管紧张素Ⅱ受体拮抗剂洛沙坦对静脉移植物内膜增生的影响。方法新西兰大白兔20只,随机分为治疗组和对照组。术后治疗组即给予洛沙坦纯粉25mg/(kg·d),对照组常规喂养,共4.。术前及处死动物前分别测定基础血压和治疗后血压;术后4.测定新生内膜面积、内膜中膜比。结果治疗组新生内膜面积(0.51±0.05)mm^2较对照组(1.02±0.10)mm^2明显减少,P<0.01。治疗前后血压无显著变化。结论洛沙坦对静脉移植物内膜增生有明显的抑制作用。

关键词：洛沙坦静脉移植物内膜增生对照组新生内膜治疗组血压动物变化

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喉鳞癌中c-myc和nm23表达与意义

复旦学报（医学版） 2003年第1期30卷 28-40,F003页

作者：黄新生吴钦苏周娴王正敏复旦大学附属中山医院耳鼻喉科上海200032 复旦大学眼耳鼻喉科医院耳鼻喉科上海200031

目的　研究喉鳞癌中c myc和nm2 3表达与意义。方法　应用免疫组织化学ABC法检测 64.喉鳞癌、10例喉乳头状瘤、6例喉正常黏膜组织中c myc和nm2 3的表达。结果　 ( 1)c myc在上述 3种组织中表达率分别为 70 %、3 0 %、0 % ,差别有统计... 详细信息

目的　研究喉鳞癌中c myc和nm2 3表达与意义。方法　应用免疫组织化学ABC法检测 64.喉鳞癌、10例喉乳头状瘤、6例喉正常黏膜组织中c myc和nm2 3的表达。结果　 ( 1)c myc在上述 3种组织中表达率分别为 70 %、3 0 %、0 % ,差别有统计学意义 (P 4.nm2 3表达与喉鳞癌颈淋巴结转移呈负相关 (P <0 .0 5 ) ;( 5 )在c myc和nm2 3联合表达与颈淋巴结转移的关系中 ,c myc阳性而nm2 3阴性表达者易发生颈淋巴结转移。结论　c myc和nm2 3在喉上皮中的表达与其恶变程度相关 ;c myc表达可作为喉鳞癌病情进展和预后不良的客观指标 ;检测喉鳞癌中c myc和nm2

关键词：喉鳞癌 nm23 c-myc 免疫组织化学肿瘤转移预后

氧化修饰低密度脂蛋白促进人单核细胞源树突状细胞的成熟及活化

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复旦学报（医学版） 2004年第5期31卷 441-444页

作者：罗育坤梁春黄东许从峰贾庆哲王克强葛均波复旦大学附属中山医院心内科-上海市心血管病研究所上海200032 第二军医大学附属长征医院心内科上海200003

目的　探讨氧化修饰低密度脂蛋白 (oxidized lowdensitylipoprotein ,oxLDL)和低密度脂蛋白 (lowdensi tylipoprotein ,LDL)对人单核细胞源的树突状细胞 (monocytederiveddendriticcells,MDCs)免疫功能的影响。方法　采用免疫磁珠法分离人外周血CD14.+ 单核细胞 ,经含rhGM CSF(10 0ng/mL)和rhIL - 4.(2 0ng/mL)的Cell gro培养 ,使其分化为MDCs。分别以PBS和LPS(5 0 0 μg/mL)作阴性和阳性 (成熟 )对照 ,观察经5 0 μg/mL的oxLDL和LDL干预 4.8h后 ,流式细胞术检测MDCs表型 (CD1a、CD4.0、CD86、HLA DR) ,混合T淋巴细胞反应检测MDCs对淋巴细胞增殖的影响 ,FITC Dextran检测MDCs吞噬功能 ,ELISA检测细胞培养上清细胞因子 (IL -12、IL - 10和TNF α)浓度。结果　与PBS相比 ,5 0 μg/mLoxLDL干预的MDCs,不但可明显上调共刺激分子CD86的高表达 ,而且反映MDCs成熟程度的CD1a也表达增强 ,与此同时经oxLDL处理的MDCs吞噬作用却明显减弱 ,进一步的混合T淋巴细胞反应显示经过oxLDL刺激的MDCs促T细胞增殖作用明显增强 (P <0 .0 5 ) ;此外 ,oxLDL可明显促进MDC分泌细胞因子TNF α、IL - 10和IL - 12 (P <0 .0 5 ) ,但明显弱于LPS组 ,而LDL无此作用。结论　oxLDL在促进DCs成熟的同时。

关键词： LDL 人单核细胞氧化修饰低密度脂蛋白 MDC T淋巴细胞树突状细胞 CD86 增强混合活化

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尿囊素系列制剂治疗手足皲裂病人1799例

新药与临床 1989年第2期8卷 82-84页

作者：秦万章上海医科大学附属中山医院皮肤科上海200032

本文报道以尿囊素为主的系列制剂防治1799例皮肤皲裂的资料,并与4.9例皮肤皲裂病人作对照比较取得较好疗效。4.愈裂贴膏和尿囊素脂或复方尿囊素脂均分别优于其相应的对照组。研究结果表明尿囊素系列制剂对皲裂的疗效都比目前治疗皲裂... 详细信息

本文报道以尿囊素为主的系列制剂防治1799例皮肤皲裂的资料,并与4.9例皮肤皲裂病人作对照比较取得较好疗效。4.愈裂贴膏和尿囊素脂或复方尿囊素脂均分别优于其相应的对照组。研究结果表明尿囊素系列制剂对皲裂的疗效都比目前治疗皲裂最佳制剂(15％尿素脂)为佳(p<0.01)。

关键词：尿囊素皮肤病皲裂局部投药

Treatment effect of immunosuppressive therapy on endomyocardial biopsy proved myocarditis:a meta-analysis and hints for future trials

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Treatment effect of immunosuppressive therapy on endomyocard...

第十三次全国心血管病学术会议

作者： XIE Ye-qing,LI Ming-hui,ZHANG Chun-yu,YANG Ying-zhen,CHEN Rui-zhen,CHEN Hao-zhu Key Laboratory of Viral Heart Diseases,Ministry of Public Health,shanghai institute of cardiovascular Diseases,zhongshan {4.,Fudan University,shanghai 20003.,china

Objective Treatment of myocarditis has always been conservative and mainly restricted to expectant treatment dealing with the corresponding clinical *** the notice of the immune system’s role in the pathogenesis,immunosuppressive therapies have been studied in a series of clinical trials from 1980’s,of which the results were conflicting with each other. In order to get a more convincing result,we conducted this system review of the related randomized controlled trials

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小鼠微小残留白血病模型的建立

复旦学报（医学版） 2002年第5期29卷 383-386页

作者：史剑慧许小平程文英李林牛玉宏葛均波复旦大学附属中山医院-上海市心血管病研究所上海200032 第二军医大学长海医院血液科上海200433 复旦大学放射医学研究所上海200032

目的　研究小鼠微小残留白血病模型的建立方法。方法　采用P388白血病细胞系和DBA小鼠建立P388/DBA小鼠微小残留白血病模型。结果　P388细胞腹腔接种DBA小鼠 ,白血病的发病率为 10 0 % ,无自发缓解。P388白血病模型对环磷酰胺 (Cy)敏感 ... 详细信息

目的　研究小鼠微小残留白血病模型的建立方法。方法　采用P388白血病细胞系和DBA小鼠建立P388/DBA小鼠微小残留白血病模型。结果　P388细胞腹腔接种DBA小鼠 ,白血病的发病率为 10 0 % ,无自发缓解。P388白血病模型对环磷酰胺 (Cy)敏感 ,有较好的药物剂量生存时间关系 ,接种细胞数量与Cy剂量间有良好回归关系 ,是研究微小残留白血病的理想模型。移植生物试验提示 ,当微小残留白血病细胞数量在 10 1左右时 ,其分布可能局限于肝、脾及股骨骨髓以外的器官和组织中。

关键词：白血病细胞微小残留白血病小鼠

Trends in the prevalence of heart diseases over a ten-year period from single-center observations based on a large echocardiographic database

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2016年第1期17卷 54-59页

作者： Hao LU Wen-zhi PAN Quan WAN Lei-lei CHENG Xian-hong SHU Cui-zhen PAN Ju-ying QIAN Jun-bo GE Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular Diseases Department of Echocardiography Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular Diseases

There is a paucity of data regarding trends in the incidence of heart disease in china during recent years. Using a large echocardiography database in our center, we analyzed trends in the prevalence of several common heart diseases from Dec. 2003. This study retrospectively analyzed the echocardiographic database in our Department from 2003 to 2012. A total of 385 682 cases were included in the study. The prevalence of rheumatic heart disease decreased over the 10-year period, from 4.04. in 2003 to 3.06% in 2012 （P〈0.01）. Infective endocarditis also decreased, from a mean prevalence of 0.37% in July 2003 to 0.27% in Dec. 2008 （P〈0.001）. The prevalence of hy- pertrophic cardiomyopathy, which includes 20% apical hypertrophic cardiomyopathy and 20% hypertrophic obstructive cardiomyopathy, was about 1.8%. The prevalence of the three most common adult congenital heart diseases （CHDs） decreased by about 10% from July 2003 to Dec. 2008 （all P〈0.001）. The prevalence of moderate pulmonary arterial hypertension （PAH） or left ventricular systolic dysfunction （LVSD） decreased during the 10-year period （P〈0.001）, but there was no change in the prevalence of severe PAH or LVSD （P〉0.05）. The present study indirectly demonstrates that the prevalence of several common heart diseases in china has declined in recent years.

关键词： Prevalence Trends Heart diseases Epidemiology

Budd-Chiari syndrome:Diagnosis with three-dimensional contrast-enhanced magnetic resonance angiography

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World Journal of Gastroenterology 2003年第10期9卷 2317-2321页

作者： Jiang Lin Xiao-Hai Chen Kang-Rong Zhou Zu-Wang Chen Jian-Hua Wang Zhi-Ping Yan Ping Wang, Department of Radiology, Affiliated zhongshan hospital, Fudan University, shanghai 20003., china Department of Radiology Affiliated Zhongshan Hospital Fudan University Shanghai 200032 China. linjiang@***

AIM:To evaluate the role of three-dimensional contrastenhanced magnetic resonance angiography (3D CE MRA) in the diagnosis of Budd-Chiari syndrome (BCS).METHODS: Twenty-three patients with BCS underwent 3D CE MRA examination, in which 13 cases were secondary to either hepatocellular carcinoma (11 cases), right adrenal carcinoma (1 case) or thrombophlebitis (1 case) and 10suffered from primary BCS. The patency of the inferior vena cava (IVC), hepatic and portal veins as well as the presence of intra- and extrahepatic collaterals, liver parenchymal abnormalities and porto-systemic varices were evaluated. Inferior vena cavography was performed in 10 cases. The diagnosis of IVC obstruction by 3D CE MRA was compared with that demonstrated by inferior vena ***: The major features of BCS could be clearly displayed on 3D CE MRA. Positive hepatic venous signs included tumor thrombosis (9 cases), tumor compression (2 cases), nonvisualization (4.cases) and focal stenosis (2 cases). Positive IVC findings were noted as severe stenosis or occlusion (10 cases), tumor invasion (2 cases), thrombosis (3 cases), thrombophlebitis (1 case) and septum formation (3 cases). Intrahepatic collaterals were shown in 9 patients,2 of them with 'spider web' sign. The displayed extrahepatic collaterals included dilated azygos and hemi-azygos veins (13 cases) and left renal-inferior phrenic-pericardiophrenic veins (2 cases). The occlusion of the left intrahepatic portal veins was found in 2 cases. Porto-systemic varices were detected in 10 patients. Liver parenchymal abnormalities displayed by 3D CE MRA were enlargement of the caudate lobe (7 cases), heterogenous enhancement (18 cases) and complicated tumors (13 cases). Compared with the inferior vena cavography performed in 10 cases, the accuracy of 3D CE MRA was 100% in the diagnosis of IVC ***: 3D CE MRA can display the major features of BCS and provide an accurate diagnosis.

关键词：布-加综合征核磁共振三维图像诊断肝血管

α_1-ANTITRYPSIN ATTENUATES ENDOTOXIN-INDUCED ACUTE LUNG INJURY IN RABBITS

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Journal of shanghai Second Medical University(Foreign Language Edition) 2003年第2期15卷 71-76页

作者：揭志军蔡映云杨文兰金美玲朱威祝慈芳 Department of Pulmonology Xinhua HospitalSSMUShanghai 200092 China Department of Pulmonology Zhongshan HospitalFudan UniversityShanghai 200032 China shanghai Biological Production Research institute Shanghai 200052 China

Objective To investigate whether pretreatment with α 1-AT can attenuate acute lung injury (ALI) in rabbits induced with endotoxin. Methods Thirty-two New Zealand rabbits were randomly assigned to four groups(n=8):*** of endotoxin(Lipopolysaccharide,LPS 500μg/kg)without α 1-AT (group LPS).*** α 1-AT 120mg/kg at 15min before challenge with LPS(group LAV).*** of α 1-AT 120mg/kg(group AAT).4.Infusion of saline 4.l/kg as control (group NS).Arterial blood gases,peripheral leukocyte counts and airway pressure were recorded every *** intrapulmonary shunting (Qs/Qt) was measured every *** 8h the bloods were collected for measurement of plasma concentration and activity of α *** bronchoalveolar lavage fluid (BALF)was collected for measurement of concentrations of total protein (TP),interleukin-8(IL-8),tumor necrosis factor(TNF-α),the activities of elastase-like and α 1-AT,total phospholipids(TPL) and disaturated phosphatidylcholine (DSPC).In addition,the wet-to-dry lung weight ratio(W/D) was measured. Results After infusion of endotoxin,it was observed that PaO 2,peripheral luekocyte counts,total respiratory compliance progressively decreased and P peak and Qs/Qt increased comparing with the baseline *** contrast to group NS,the increased plasma concentration but reduced activity of α 1-AT was found in group *** the BALF,the activity of α 1-AT,TPL,DSPC/TPL were lower,but the concentrations of albumin,IL-8,TNF-α,and the activity of NE were *** ratio of W/D also *** pretreatment of α 1-AT attenuated the deterioration of oxygenation,the reduction of compliance and the deterioration of other physiological,biochemical parameters mentioned above. Conclusion Pretreatment with α 1-AT could attenuate endotoxin-induced lung injury in *** beneficial effects of α 1-AT might be due in part to the inhibitory effect on neutrophil elastase.

关键词： acute lung injury α 1-antitrypsin neutrophil elastase endotoxin