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Role of inositol 1,4.5-trisphosphate receptors in α1-adrenergic receptorinduced cardiomyocyte hypertrophy

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Acta Pharmacologica Sinica 2006年第7期27卷 895-900页

作者： Da-li LUO~(2,3,5) Jian GAO~2 Xiao-mei LAN~3 Gang WANG~4.Sheng WEI~4.Rui-ping XIAO~4.Qi-de HAN~32 Department of Pharmacology,school of Chemical Biology & Pharmaceutical sciences,Capital university of Medical sciences,Beijing 100069,China 3 Institute of Cardiovascular Science at Health Science Center,Peking university Beijing 100083,China 4.Institute of Molecular Medicine and College of Life Science,Peking university,Beijing 100871,China Department of Pharmacology School of Chemical Biology & Pharmaceutical Sciences Capital University of Medical Sciences Beijing 100069 China Institute of Cardiovascular Science at Health Science Center Peking University Beijing 100083 China Institute of Molecular Medicine and College of Life Science Peking University Beijing 100871 China

Aim:Intracellular Ca2+plays pivotal roles in diverse cellular functions,includinggene transcription that underlies cardiac remodeling during stress ***,the role of inositol 1,4.5-trisphosphate receptors（IP3Rs）in the media-tion of cardiac intracellular Ca2+and hypertrophic growth remains *** with neonatal rat ventricular myocytes suggests that activation of IP3Rsmay be linked to α1adrenergic receptor（α1AR）increased stereotyped Ca2+sparkoccurrence and global Ca2+***,we hypothesized that Ca2+releasethrough IP3Rs was necessary for α1AR-stimulated cardiac ***:We used myoinositol 1,4.5-trisphosphate hexakis（butyryloxymethyl）ester（IP3BM）,a membrane-permeant ester of IP3,to activate IP3Rs directly,and Fluo 4.AM tomeasure intracellular Ca2+***:IP3BM(10μmol·L-1)mimicked theeffects of phenylephrine,a selective agonist of α1AR,in increments in local Ca2+spark release（especially in the perinuclear area）and global Ca2+*** importantly,IP3R inhibitors,2-aminoethoxydiphenyl borateand Xestospongin C,abolished the IP3BM-induced Ca2+responses,and signifi-cantly suppressed α1AR-induced cardiomyocyte hypertrophy assayed by cellsize,[3H]leucine incorporation and atrial natriuretic factor gene expression,dur-ing sustained（4. h）phenylephrine ***:These results,therefore,provide cellular mechanisms that link IP3R signaling to α1AR-stimulatedgene expression and cardiomyocyte hypertrophy.

关键词： inositol 1,4.5-trisphosphate receptors Ca2+sparks α1 adrenergic stimulation cardiac hypertrophy

Weighted estimation of single index models with right censored responses

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Science China Mathematics 2011年第3期54卷 479-514页

作者： WANG YanHua1, LI XiaYan2, WANG QiHua3 & HE ShuYuan4.1school of sciences, Beijing Institute of Technology, Beijing 100081, China 2Department of Mathematics, university of Science and Technology of China, Hefei 230026, China 3Chinese Academy of Mathematics and System Science, Beijing 100080, China 4.0} of Mathematical sciences, Capital Normal university, Beijing 10004., China 1. school of sciences Beijing Institute of Technology Beijing 100081 China2. Department of Mathematics University of Science and Technology of China Hefei 230026 China3. Chinese Academy of Mathematics and System Science Beijing 100080 China4. School of Mathematical Sciences Capital Normal University Beijing 100048 China

In this paper, the unknown link function, the direction parameter, and the heteroscedastic variance in single index models are estimated by the random weight method under the random censorship, respectively. The central limit theory and the convergence rate of the law of the iterated logarithm for the estimator of the direction parameter are derived, respectively. The optimal convergence rates for the estimators of the link function and the heteroscedastic variance are obtained. Simulation results support the theoretical results of the paper.

关键词： single index models random censorship central limit theorem law of the iterated logarithm weighted least squares unknown link function

Molecular dynamics simulation of kink in 〈100〉 edge dislocation in body centred cubic iron

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Chinese Science Bulletin 2007年第16期52卷 2291-2296页

作者： CHEN LiQun1,2,WANG ChongYu2,3,4.& YU Tao2 1 College of sciences,Central South university of forestry & Technology,Changsha 4.0004.China 2 Central Iron and Steel Research Institute,Beijing 100081,China 3 Department of Physics,Tsinghua university,Beijing 100084.China 4.International Center for Materials Physics,Chinese Academy of sciences,Shenyang 110016,China College of sciences Central South University of Forestry and Technology Changsha 410004 China

Using the molecular dynamics method,we have constructed two kink models corresponding to the 〈100〉{010} and 〈100〉{011} edge dislocations (EDs) in body centred cubic (bcc) Fe. It is found that the geometric structure of a kink depends on the type of edge dislocation and the structural energies of the atoms sites in the dislocation core region. The formation energies,migration energies and widths of the kinks in different types of EDs are calculated. The results show that formation and migration of the kink in the 〈100〉{010} edge dislocation are difficult. The 〈100〉{011} edge dislocation moves primarily through kink nucleation,rather than kink migration.

关键词：分子动力学边缘位移铁纽结结构

Vision navigation algorithm for mine agent based on quaternion

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中国有色金属学会会刊：英文版 2011年第S3期21卷 610-615页

作者： LI Ke-zhao1, 4. LEI Wei-wei1, 2, GUO Zeng-zhang1, 2, WU Li-xin3, ZHANG Qin4.1. school of Survey and Land Information Engineering, Henan Polytechnic university, Jiaozuo 4.4.03, China 2. Key Laboratory of Mine Spatial Information Technologies of State Bureau of Surveying and Mapping, Henan Polytechnic university, Jiaozuo 4.4.03, China 3. College of Resources and Civil Engineering, Northeastern university, Shenyang 110819, China 4. College of Geology Engineering and Geomatics, Chang’an university, Xi’an 710054. China [a] school of Survey and Land Information Engineering Henan Polytechnic University Jiaozuo 454003 China [b] Key Laboratory of Mine Spatial Information Technologies of State Bureau of Surveying and Mapping Henan Polytechnic University Jiaozuo 454003 China [c] College of Resources and Civil Engineering Northeastern University Shenyang 110819 China [d] College of Geology Engineering and Geomatics Chang'an University Xi'an 710054 China

Autonomous relative navigation is the key technology in mining or rescuing. On the basis of mine requirement and the theories of machine vision, an autonomous relative navigation algorithm for mine agent based on quaternion was proposed. In rotation transformation, this algorithm was represented by using quaternion. Because the Jacobi matrix of this method is lower than that of Hall algorithm, the calculation efficiency is improved by using this algorithm. The results of these experiments show that the computation burden of this algorithm based on quaternion is about half that of Hall algorithm. This algorithm based on quaternion is improved as a valid way to solve the problem of mine real-time navigation.

关键词： quaternion mine agent vision navigation

AN ATTRIBUTION OF CAVITATION RESONANCE:VOLUMETRIC OSCILLATIONS OF CLOUD

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Journal of Hydrodynamics 2009年第2期21卷 152-158页

作者： ZUO Zhi-gang LI Sheng-cai LIU Shu-hong LI Shuang CHEN Hui school of Engineering University of Warwick Coventry CV4 7AL UK Department of Thermal Engineering Tsinghua University Beijing 100084 China school of Engineering University of Warwick Coventry CV4 7AL UK school of Power and Energy Northwestern Polytechnical University Xi＇ an 710072 China

In order to further verify the proposed theory of cavitation resonance, as well as to proceed the investigations into microscopic level, a series of studies are being carried out on the Warwick venturi. The analysis of the oscillation characteristics of the cavitation resonance has conclusively verified the macro-mechanism proposed through previous studies on other cavitating flows by the authors. The initiai observations using high-speed photographic approach have revealed a new attribution of cavitation resonance. That is, the volumetric oscillation of cavitation cloud is associated with the cavitation resonance, which is a collective behaviour of the bubbles in the cloud.

关键词： cavitation resonance volumetric oscillation macro-mechanism

On the new results of global attractive set and positive invariant set of the Lorenz chaotic system and the applications to chaos control and synchronization

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Science in China(Series F) 2005年第3期48卷 304-321页

作者： LIAO Xiaoxin 1, 2, 3 , FU Yuli 4.& XIE Shengli 4.1. Department of Control Science & Control Engineering, Huazhong university of Science & Technology, Wuhan 4.0074. China 2. school of Automation, Wuhan university of Science & Technology, Wuhan 4.0070, China 3. school of Information, Central South university of Economy, Politics and Law, Wuhan 4.0064. China 4. school of Electronics & Information Engineering, South China university of Technology, Guangzhou 51064., China Correspondence should be addressed to Liao Xiaoxin (email: xiaoxin_liao@***) 1. Department of Control Science & Control Engineering Huazhong University of Science & Technology 430074 Wuhan China 2. school of Automation Wuhan University of Science & Technology 430070 Wuhan China 3. school of Information Central South University of Economy Politics and Law 430064 Wuhan China 4. school of Electronics & Information Engineering South China University of Technology 510640 Guangzhou China

Constructing a family of generalized Lyapunov functions, a new method is proposed to obtain new global attractive set and positive invariant set of the Lorenz chaotic system. The method we proposed greatly simplifies the complex proofs of the two famous estimations presented by the Russian scholar Leonov. Our uniform formula can derive a series of the new estimations. Employing the idea of intersection in set theory, we extract a new Leonov formula-like estimation from the family of the estimations. With our method and the new estimation, one can confirm that there are no equilibrium, periodic solutions, almost periodic motions, wandering motions or other chaotic attractors outside the global attractive set. The Lorenz butterfly-like singular attractors are located in the global attractive set only. This result is applied to the chaos control and chaos synchronization. Some feedback control laws are obtained to guarantee that all the trajectories of the Lorenz systems track a periodic solution, or globally stabilize an unstable (or locally stable but not globally asymptotically stable) equilibrium. Further, some new global exponential chaos synchronization results are presented. Our new method and the new results are expected to be applied in real secure communication systems.

关键词： Lorenz chaotic system global attractive set positive invariant set globally exponential tracking globally exponential synchronization.

Characterization of a novel developmentally retarded mutant (drm1) associated with the autonomous flowering pathway in Arabidopsis

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Cell Research 2005年第2期15卷 133-140页

作者： Yong ZHU1,2,*, Hui Fang ZHAO1,3,*, Guo Dong REN1, Xiao Fei YU1, Shu Qing CAO1, Ben Ke KUAI1,4.**1Department of Biochemistry, Ministry of Education Key laboratory for Biodiversity Science and Ecological Engineering, school of Life sciences, Fudan university, 220 Handan Road, Shanghai 2004.3, China 2school of Horticulture and Gardening, Southwest {4. College, Kun Ming 650224. China 3Department of biology, school of Life and Environment Science, Shanghai Normal university, Shanghai 200234. China4.udan Centre for Genetic Diversity and designed Agriculture, Fudan university, 220 Handan Road, Shanghai 2004.3, China Department of Biochemistry Ministry of Education Key laboratory for Biodiversity Science and Ecological Engineering School of Life Sciences Fudan University 220 Handan Road Shanghai 200433 China.

A developmentally retarded mutant (drm1) was identified from ethyl methanesulfonate (EMS)-mutagenized M2 seedsin Columbia (Col-0) genetic background. The drm1 flowers 109 d after sowing, with a whole life cycle of about 160 *** also shows a pleiotropic phenotype, e.g., slow germination and lower germination rate, lower growth rate, curlingleaves and abnormal floral organs. The drm1 mutation was a single recessive nuclear mutation, which was mapped tothe bottom of chromosome 5 and located within a region of 20-30 kb around MXK3.1. There have been no mutantswith similar phenotypes reported in the literature, suggesting that DRM1 is a novel flowering promoting locus. Thefindings that the drm1 flowered lately under all photoperiod conditions and its late flowering phenotype was significantlyrestored by vernalization treatment suggest that the drm1 is a typical late flowering mutant and most likely associatedwith the autonomous flowering pathway. The conclusion was further confirmed by the revelation that the transcriptlevel of FLC was constantly upregulated in the drm1 at all the developmental phases examined, except for a very earlystage. Moreover, the transcript levels of two other important repressors, EMF and TFL1, were also upregulated in thedrm1, implying that the two repressors, along with FLC, seems to act in parallel pathways in the drm1 to regulateflowering as well as other aspects of floral development in a negatively additive way. This helps to explain why the drm1exhibits a much more severe late-flowering phenotype than most late-flowering mutants reported. It also implies that theDRM1 might act upstream of these repressors.

关键词： drm1 late-flowering autonomous flowering pathway Arabidopsis thaliana.

Perceptual video hashing robust against geometric distortions

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Science China(Information sciences) 2012年第7期55卷 1520-1527页

作者： XIANG ShiJun 1,4.,YANG JianQuan 2 & HUANG JiWu 3 1 school of Information Science and Technology,Jinan university,Guangzhou 510632,China 2 Shenzhen Institutes of Advanced Technology,Chinese Academy of sciences,Shenzhen 518055,China 3 school of Information Science and Technology,Sun Yat-sen university,Guangzhou 510275,China 4.State Key Laboratory of Information Security,Institute of Software,Chinese Academy of sciences,Beijing 10004.,China 1. school of Information Science and Technology Jinan University Guangzhou 510632 China4. State Key Laboratory of Information Security Institute of Software Chinese Academy of Sciences Beijing 100049 China2. Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 China3. School of Information Science and Technology Sun Yat-sen University Guangzhou 510275 China

In this paper,we propose a robust perceptual hashing algorithm by using video luminance histogram in *** underlying robustness principles are based on three main aspects:1) Since the histogram is independent of position of a pixel,the algorithm is resistant to geometric deformations; 2) the hash is extracted from the spatial Gaussian-filtering low-frequency component for those common video processing operations such as noise corruption,low-pass filtering,lossy compression,etc.; 3) a temporal Gaussian-filtering operation is designed so that the hash is resistant to temporal desynchronization operations,such as frame rate change and *** a result,the hash function is robust to common geometric distortions and video processing *** results show that the proposed hashing strategy can provide satisfactory robustness and uniqueness.

关键词： video hashing geometric distortion histogram Gaussian filtering

Binding activity of H-Ras is necessary for in vivo inhibition of ASK1 activity

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Cell Research 2004年第2期14卷 148-154页

作者： Jun DU~(1,2*), Shao Hui CAI~(3,4., Zhe SHI~3, Fumihiko NAGASE~1 ~1Department of Medical Technology, Nagoya university school of Health sciences, Aichi 4.1-8673, Japan. ~2school of Pharmaceutical Science, Sun Yat-Sen university, Guangzhou, 510089, China. ~3Department of Immunology, Nagoya university Graduate and Faculty school of Medicine, Aichi, 4.6-8550, Japan. ~4.ollege of Pharmacy, Jinan university, Guangzhou, 510632, China. 2school of Pharmaceutical Science Sun Yat-Sen University Guangzhou 510089 China. 4.ollege of Pharmacy Jinan University Guangzhou 510632 China. 3Department of Immunology Nagoya University Graduate and Faculty School of Medicine Aichi 466-8550 Japan. 1Department of Medical Technology Nagoya University School of Health Sciences Aichi 461-8673 Japan.

H-Ras is well known as one of the essential components of Ras/Raf/MEK/ERK cascade, which is a critical prosurvival signaling mechanism in most eukaryotic cells. Ras targets Raf/MEK/ERK cascade by integrating and transmitting extracellular signals from growth factor receptors to Raf, leading to the propagation of signals to modulate a serious of cellular survival events. Apoptosis signal-regulating kinasel (ASK1) serves as a general mediator of cell death because it is responsive to a variety of death signals. In this study, we found that H-Ras interacted with ASK1 to cause the inhibition of both ASK1 activity and ASK1-induced apoptosis in vivo, which was reversed only partially by addition of RafS621A, an antagonist of Raf, whereas MEK inhibitor, PD98059, and PI3K inhibitor, LY294.02, did not disturb the inhibitory effect of H-Ras on ASK-1-induced apoptosis. Furthermore, by means of immunoprecipitate and kinase assays, we demonstrated that the interaction between H-Ras and ASK1 as well as the inhibition

关键词： H-Ras ASK1 apoptosis binding activity.