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EZH2 inhibitors promote β-like cell regeneration in young and adult type 1 diabetes donors

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Signal Transduction and Targeted Therapy 2024年第2期9卷 679-692页

作者： Keith al-Hasani Safiya Naina Marikar Harikrishnan Kaipananickal Scott Maxwell Jun Okabe Ishant Khurana Thomas Karagiannis Julia J.Liang Lina Mariana Thomas Loudovaris Thomas Kay Assam El-Osta Epigenetics in Human Health and Disease Program Baker Heart and Diabetes Institute75 Commercial RoadMelbourne 3004 VICAustralia Department of Diabetes Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia Epigenetics in Human Health and Disease Laboratory Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia school of Science STEM CollegeRMIT UniversityMelbourne 3001 VICAustralia Immunology and Diabetes Unit St Vincent’s Institute of Medical ResearchFitzroy 3065 VICAustralia Department of Medicine and Therapeutics The Chinese University of Hong KongSha TinHong Kong SAR Hong Kong Institute of Diabetes and Obesity Prince of Wales HospitalThe Chinese University of Hong Kong3/F Lui Che Woo Clinical Sciences Building30-32-Ngan Shing StreetSha TinHong Kong SAR Li Ka Shing Institute of Health sciences The Chinese University of Hong KongSha TinHong Kong SAR Biomedical Laboratory Science Department of TechnologyFaculty of HealthUniversity College CopenhagenCopenhagenDenmark

β-cells are a type of endocrine cell found in pancreatic islets that synthesize,store and release *** type 1 diabetes(T1D),T-cells of the immune system selectively destroy the insulin-producingβ-*** of these cells leads to a lifelong dependence on exogenous insulin administration for ***,there is an urgent need to identify novel therapies that stimulateβ-cell growth and induceβ-cell *** and others have shown that pancreatic ductal progenitor cells are a promising source for regeneratingβ-cells for T1D owing to their inherent differentiation *** transcriptional suppression is refractory to exocrine reaction and tightly controls the regenerative potential by the EZH2 *** the present study,we show that transient stimulation of exocrine cells,derived from juvenile and adult T1D donors to the FDAapproved EZH2 inhibitors GSK126 and Tazemetostat(Taz)influence a phenotypic shift towards aβ-like cell *** transition from repressed to permissive chromatin states are dependent on bivalent H3K27me3 and H3K4.e3 chromatin *** EZH2 is fundamental toβ-cell regenerative *** pancreatic ductal cells exhibit insulin production and secretion in response to a physiological glucose challenge ex *** pre-clinical studies underscore the potential of small molecule inhibitors as novel modulators of ductal progenitor differentiation and a promising new approach for the restoration ofβ-like cell function.

关键词： EZH2 struction inhibitors

Perceptual video hashing robust against geometric distortions

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Science China(Information sciences) 2012年第7期55卷 1520-1527页

作者： XIANG ShiJun 1,4.,YANG JianQuan 2 & HUANG JiWu 3 1 school of Information Science and Technology,Jinan University,Guangzhou 510632,China 2 Shenzhen Institutes of Advanced Technology,Chinese Academy of sciences,Shenzhen 518055,China 3 school of Information Science and Technology,Sun Yat-sen University,Guangzhou 510275,China 4.State Key Laboratory of Information Security,Institute of Software,Chinese Academy of sciences,Beijing 10004.,China 1. school of Information Science and Technology Jinan University Guangzhou 510632 China4. State Key Laboratory of Information Security Institute of Software Chinese Academy of Sciences Beijing 100049 China2. Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 China3. School of Information Science and Technology Sun Yat-sen University Guangzhou 510275 China

In this paper,we propose a robust perceptual hashing algorithm by using video luminance histogram in *** underlying robustness principles are based on three main aspects:1) Since the histogram is independent of position of a pixel,the algorithm is resistant to geometric deformations; 2) the hash is extracted from the spatial Gaussian-filtering low-frequency component for those common video processing operations such as noise corruption,low-pass filtering,lossy compression,etc.; 3) a temporal Gaussian-filtering operation is designed so that the hash is resistant to temporal desynchronization operations,such as frame rate change and *** a result,the hash function is robust to common geometric distortions and video processing *** results show that the proposed hashing strategy can provide satisfactory robustness and uniqueness.

关键词： video hashing geometric distortion histogram Gaussian filtering

Molecular dynamics simulation of kink in 〈100〉 edge dislocation in body centred cubic iron

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Chinese Science Bulletin 2007年第16期52卷 2291-2296页

作者： CHEN LiQun1,2,WANG ChongYu2,3,4.& YU Tao2 1 College of sciences,Central South University of forestry & Technology,Changsha 4.0004.China 2 Central Iron and Steel Research Institute,Beijing 100081,China 3 Department of Physics,Tsinghua University,Beijing 100084.China 4.International Center for Materials Physics,Chinese Academy of sciences,Shenyang 110016,China College of sciences Central South University of Forestry and Technology Changsha 410004 China

Using the molecular dynamics method,we have constructed two kink models corresponding to the 〈100〉{010} and 〈100〉{011} edge dislocations (EDs) in body centred cubic (bcc) Fe. It is found that the geometric structure of a kink depends on the type of edge dislocation and the structural energies of the atoms sites in the dislocation core region. The formation energies,migration energies and widths of the kinks in different types of EDs are calculated. The results show that formation and migration of the kink in the 〈100〉{010} edge dislocation are difficult. The 〈100〉{011} edge dislocation moves primarily through kink nucleation,rather than kink migration.

关键词：分子动力学边缘位移铁纽结结构

Insulin-sensitizing effects of a novel α-methyl-α-phenoxylpropionate derivative in vitro

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Acta Pharmacologica Sinica 2007年第3期28卷 417-422页

作者： Hao-shu WU~(2,4. Juan-hong YU~(3,4. Ying-yin LI~2 Yu-she YANG~3 Qiao-jun HE~2 Yi-jia LOU~(2,5) Ru-yun JI~3 ~2Department of Pharmacology and Toxicology,College of Pharmaceutical sciences,Zhejiang University,Hangzhou 310058,China ~3State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological sciences,Graduate school of the Chinese Academy of sciences,Shanghai 201203,China Department of Pharmacology and Toxicology College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China Department of State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Graduate School of the Chinese Academy of Sciences Shanghai 201203 China

Aim:To examine the insulin sensitizing effects of a novel α-methyl-α-phenoxylpropionate derivative YY20 in insulin-sensitive cell ***:Theperoxisome proliferator-activated receptor γ（PPARγ）agonist bioactivities of YY20were detected by a preadipocyte differentiation ***-PCR and Westernblotting analysis were used to detect the expression of the target gene or *** effects of YY20 on insulin-mediated glucose consumption were determined inthe HepG2 human hepatocellular carcinoma ***:YY20 could enhancethe differentiation of preadipocytes to adipocytes and upregulate the gene ex-pression of PPARγ2,as well as the protein expression of insulin receptor sub-strate-1（IRS-1）,glucose transporter-4.GLUT4.,and adiponectin（ACRP30）.Theeffects on GLUT4.and ACRP30 could be reversed by the PPARγ inhibitor ***,YY20 efficiently reduced glucose consumptions in HepG2 cells after24.h culture,and the effects were related to insulin and YY20 ***:YY20,a potential insulin-sensitizing agent like rosiglitazone,couldenhance glucose consumption in HepG2 cells in a concentration-and insulin-dependent *** may improve the insulin resistance associated with type 2diabetes.

关键词： YY20 peroxisome proliferator-activated receptor y insulin sensitivity glucose consumption

Studies and advances on joint source-channel encoding/decoding techniques in flow media communications

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Science China(Information sciences) 2010年第1期53卷 1-17页

作者： TU GuoFang1, LIU JianJun1, ZHANG Can1,2, GAO ShaoShuai3 & LI ShiDong4.1school of Information Science and Engineering, Graduate University of Chinese Academy of sciences, Beijing 10004., China 2State Key Laboratory of Information Security, Graduate University of Chinese Academy of sciences, Beijing 10004., China 3National Institute of Standards and Technology, Gaithersburg, MD 20899, usa, 4.epartment of Mathematics, San Francisco State University, San Francisco, CA 94.4., usa 1. school of Information Science and Engineering Graduate University of Chinese Academy of Sciences Beijing 100049 China2. State Key Laboratory of Information Security Graduate University of Chinese Academy of Sciences Beijing 100049 China3. National Institute of Standards and Technology Gaithersburg MD 20899 USA4. Department of Mathematics San Francisco State University San Francisco CA 94132 USA

Joint source-channel coding/decoding (JSCC/JSCD) techniques in flow media communications have become a state-of-the-art and one of the challenging research subjects in the spatial communication area. They have great application prospective and deep impact in various manned space flights, satellite missions, mobile radio communications and deep-space explorations. In the last few years, there have been influential achievements in JSCC/JSCD studies. This paper aims at an introduction to the basic principles of joint source-channel optimal design. A general summarization and classification for various existing JSCC/JSCD methods is addressed. also presented is a JSCD scheme based on variable-length coding, capable of providing reliable resolutions for flow media data transmission in spatial communications.

关键词： joint source-channel coding/decoding rate allocation variable-length coding/decoding iterative decoding

Reconstruction of the most recent common ancestor sequences of SARS-Cov S gene and detection of adaptive evolution in the spike protein

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Chinese Science Bulletin 2004年第12期49卷 1311-1313页

作者： ZHANG Yuan1, ZHENG Nan2,3, HAO Pei4.5 & ZHONG Yang6 1. Laboratory of Systematic and Evolutionary Botany, Institute of Bot- any, Chinese Academy of sciences, Beijing 100093, China 2. College of Life sciences, Beijing Normal University, Beijing 100875, China 3. Institute of Viral Disease Control and Prevention, Chinese CDC, Beijing 100052, China 4. Bioinformation Center, Shanghai Institutes for Biological sciences, Chinese Academy of sciences, Shanghai 200031, China 5. Shanghai Center for Bioinformation Technology, Shanghai 200235, China 6. {4. of Life sciences, Fudan University, Shanghai 2004.3, China 1. Laboratory of Systematic and Evolutionary Botany Institute of Botany Chinese Academy of Sciences 100093 Beijing China 2. College of Life sciences Beijing Normal University 100875 Beijing China 3. Institute of Viral Disease Control and Prevention Chinese CDC 100052 Beijing China 4. Bioinformation Center Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 200031 Shanghai China 5. Shanghai Center for Bioinformation Technology 200235 Shanghai China 6. school of Life sciences Fudan University 200433 Shanghai China

The genome oiganization and expression strategy of severe acute respiratory syndrome coronavirus (SARS-CoV) have been described extensively. As a structural glycoprotein on the virion surface, the spike protein is responsible for binding to host cellular receptors and for the fusion between the viral envelope and the cellular membrane. It also induces neutralizing antibodies in the host and mediates cellular immunity. Previous studies suggested that amino acid replacements in the spike protein coulddramatically alter the pathogenesis and virulence of some coronaviruses. It is therefore reasonable to test the hypothesis that radical amino acid replacements in the spike protein, favored by environmental selective pressure during the process of SARS-CoV interspecific transmission, might make this pathogen adapt to a new host, In this study, we investigated a total of 108 complete sequences of the SARS-CoV S gene from Gen-Bank (until March 23, 2004.. After omission of those records containing frame-shift mutations or low quality sequences, e.g. ZJ01, and selection of one sequence for identical records, an alignment of 4. sequences was obtained using the program Clustal-X. Then, we reconstructed the most recent common ancestor (MRCA) sequences of theSARS-CoV S gene and detected the adaptive evolution in the spike protein.

关键词： SARS冠状病毒自适应进化基因表达糖蛋白分子免疫学波峰病毒

Anticoagulation property and security of artificial heart valve material

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Science China(Technological sciences) 2005年第2期48卷 145-162页

作者： WANG Xianghui1, , LIU Xianghuai1,22, 3, ZHANG Feng2, LI Changrong2, YU Liujiang2, ZHENG Zhihong2, WANG Xi2, JIANG Zhenbin4. CHEN Anqing4.& XU Jingfang3 1. Department of Physics, East China Normal University, Shanghai 200062, China 2. Ion Beam Lab, Shanghai Institute of Mini-system and information, Chinese Academy of sciences,Shanghai 200050, China 3. Department of Electronics, school of Information Science and Technology, East China Normal Univer- sity, Shanghai 200062, China 4. Shanghai Cardiovascular Institute, Zhongshan Hospital, Shanghai 200032, China 1. Department of Physics East China Normal University 200062 Shanghai China 2. Ion Beam Lab Shanghai Institute of Mini-system and information Chinese Academy of Sciences 200050 Shanghai China 3. Department of Electronics School of Information Science and Technology East China Normal University 200062 Shanghai China 4. Shanghai Cardiovascular Institute Zhongshan Hospital 200032 Shanghai China

Heart valve diseases threaten human health. One reliable way to save lives of such patients is to replace the pathologically changed heart valves by artificial ones. Over 2 million patients have received LTI-carbon heart valve’s implantation. However, the thrombosis after the implantation is one of the difficulties that need to be solved. In order to improve the blood compatibility and security of mechanical heart valves, ion beam technology was used to modify the surface properties of the materials. The investigation results have been summarized in this paper.

关键词： artificial heart valve, ion implantation, plasma immersed ion implantation, ion beam enhanced deposition.

Second-order consensus in networks of dynamic agents with communication time-delays

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Journal of Systems Engineering and Electronics 2010年第1期21卷 88-94页

作者： Bo Yang1,2, Huajing Fang3, and Hua Wang4.1. school of Navigation, Wuhan University of Technology, Wuhan 4.0063, P. R. China 2. Wuhan Second Ship Design and Research Institute, Wuhan 4.0064. P. R. China 3. Department of Control Science and Engineering, Huazhong University of Science and Technology, Wuhan 4.0074. P. R. China 4. Department of Aerospace and Mechanical Engineering, Boston University, Boston MA02215, usa school of Navigation Wuhan University of Technology Wuhan 430063 P. R. China Wuhan Second Ship Design and Research Institute Wuhan 430064 E R. China Department of Control Science and Engineering Huazhong University of Science and Technology Wuhan 430074 P. R. China Department of Aerospace and Mechanical Engineering Boston University Boston MA02215 USA

This paper proposes second-order consensus protocols with time-delays and gives the measure of the robustness of the protocols to the time-delay existing in the network of agents with second-order dynamics. By employing a frequency domain method, it is proven that the information states and their time derivatives of all the agents in the network achieve consensus asymptotically, respectively, for appropriate communication timedelay if the topology of weighted network is connected. Particularly, a tight upper bound on the communication time-delay that can be tolerated in the dynamic network is found. The consensus protocols are distributed in the sense that each agent only needs information from its neighboring agents, which reduces the complexity of connections between neighboring agents significantly. Numerical simulation results are provided to demonstrate the effectiveness and the sharpness of the theoretical results for second-order consensus in networks in the presence of communication time-delays.

关键词： second-order consensus protocols dynamic networks algebraic graph theory frequency domain analysis com-munication constraints.

Study on Community Diversity of Coastal Shelter Forest in Jiaonan

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Chinese Journal of Population,Resources and Environment 2005年第3期3卷 42-47页

作者： Xu Jingwei 1,2, Li Chuanrong 3, Li Qi 4. Zheng Li 3, & Wang Weidong 1 1 Beijing forestry University,Beijing 100871,China 2 Shandong Acdemy of forestry, Jinan 250014. China 3 College of forestry, Shandong Agricultural University, Taian 271018, China 4.Shandong Normal University, Jinan 250014. China Beijing forestry University Beijing 100871 China Shandong Acdemy of forestry Jinan 250014 China College of forestry Shandong Agricultural University Tatan 271018 China Shandong Normal University Jinan 250014 China

Based on the research of the plots in coastal areas in Jiaonan city, Shandong Province, the indices of richness, evenness and diversity of different community types are analyzed. The results show that: The richness indices indicates that arbor layers are close to shrub layers, and both are lower than herbage layers; the ranges among communities vary a little except those of the arbor ones. Mostly the biodiversity indices reveal that herbage, the arbor, the shrub; Biodiversity of communities has great influences on microclimate to a certain extent and is under the control of regional environment.

关键词： coastalshelterforest richness biodiversity index microclimate