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Cell research 2004年第5期14卷 347-358页

作者： Varun RACHAKONDA Department of Neurology Baylor College of Medicine Houston TX USA

Biomarkers are very important indicators of normal and abnormal biological processes. Specific changes in pathologies, biochemistries and genetics can give us comprehensive information regarding the nature of any particular disease. A good biomarker should be precise and reliable, distinguishable between normal and interested disease, and differential between different diseases. It is believed that biomarkers have great potential in predicting chances for diseases, aiding in early diagnosis, and setting standards for the development of new remedies to treat diseases. New technologies have enabled scientists to identify biomarkers of several different neurodegenerative diseases. The followings, for instance, are only a few of the many new biomarkers that have been recently identified: the phosphorylated tau protein and aggregated β-amyloid peptide for Alzheimer’s disease (AD), α-synuclein contained Lewy bodies and altered dopamine transporter (DAT) imaging for Parkinson’s disease (PD), SOD mutations for familial amyotrophic lateral sclerosis (ALS), and CAG repeats resulted from Huntington’s gene mutations in Huntington’s disease (HD). This article will focus on the most-recent findings of biomarkers belonging to the four mentioned neurodegenerative diseases.

关键词： Alzheimer’s disease Parkinson’s disease Amyotrophic Lateral Sclerosis Huntington’s disease biomarkers.

Biological networks to the analysis of microarray data

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Progress in Natural science:Materials International 2006年第12期16卷 1242-1251页

作者： FANG Zhuo~1, LUO Qingming~1**, ZHANG Guoqing~1 and LI Yixue~2**(1. Hubei Bioinformatics and Molecular imaging Key Laboratory,Huazhong university of science and Technology, Wuhan 4.0074. China 2. Shanghai center for Bioinformation and Technology, Shanghai 200235, China) [a]Hubei Bioinformatics and Molecular imaging Key Laboratory Huazhong University of Science and Technology Wuhan China [b]Shanghai center for Bioinformation and Technology Shanghai China

Microarray technology, which permits rapid and large-scale screening for patterns of gene expressions, usually generates a large amount of data. How to mine the biological meanings under these data is one of the main challenges in bioinformatics. Compared to the pure mathematical techniques, those methods incorporated with some prior biological knowledge generally bring better interpretations. Recently, a new analysis, in which the knowledge of biological networks such as metabolic network and protein interaction network is introduced, is widely applied to microarray data analysis. The microarray data analysis based on biological networks contains two main research aspects: identification of active components in biological networks and assessment of gene sets significance. In this paper, we briefly review the progress of these two categories of analyses, especially some representative methods.

关键词： biological networks microarray data analysis subnetwork gene set.

Oxides for High Temperature Superconductivity and Beyond

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Tsinghua science and Technology 1998年第1期3卷 57-78页

作者： Ching Wu Chu Department of Physics and texas center for Superconductivity, university of Houston, Houston, TX 77204. USA Department of Physics and texas center for Superconductivity University of Houston TX 77204 USA

In this paper, I shall briefly summarize the present state of high temperature superconductivity research and development together with an assessment of the prospect of yet a higher transition temperature and an outline of challenges facing today's practitioners of high temperature super conductivity science and technology. The extensive knowledge acquired in the last decade in high temperature superconducting science and materials may usher in a new era of material engineering, which I would like to call mesomaterial engineering for the fabrication of perovskite and related oxide superlattices, a new class of materials for science and technology. Therefore, I shall also present the rationale behind this effort and the promises of the new materials, together with a list of several preliminary successful examples.

关键词： high temperature superconductivity oxide mesomaterial engineering

STABILITY　OF　WHISKERS　AND　INTERFACIAL　MICROSTRUCTURE　IN　ALUMINUM　MATRIX　COMPOSITES　REINFORCED　BY　K_2O·8TiO_2　WHISKERS

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Acta Metallurgica Sinica(English Letters) 1995年第3期8卷 167-173页

作者： LI Jihong NING Xiaoguang YE Hengqiang (Laboratory of Atomic imaging of Solids,Institute of Metal research, Chinese Academy of sciences, Shenyang) SHEN Baoluo LI Wei TU Mingjing (Chengdu university of science and Technology, Chengdu, China) Inst of Metal research Chinese Acad of Sciences Shenyang China

The stability of K_2O·8TiO_2 whiskers and the microstructures of the interfaces in K_2O·8TiO_2 whisker reinforced ZL109 aluminum composites under different heat treatment conditions were investigated by means of transmission electron microscopy(TEM) , mostly by high resolution TEM( HRTEM). It was found that K_2O·8TiO_2 whiskers were not very *** edge of the whiskers decomposed and a TiO interfacial layer formed during the process of fabricating K_2O·8TiO_2/ ZL109Al composite,and so the interior with increasing temperature and time of heatreatment. Two kinds of interfacial microstructures between the whiskers and the matrix were characterized; one was the TiO layer and the other was a nano scale amorphous transition layer. A few MgAl_2O_4.particles were also observed at the whisker/ matrix interfaces.

关键词： potassium titanate whisker,aluminium alloy composite interface heat treatment

^(234.Th/^(238)U disequilibrium and particulate organic carbon export in the northwestern South China Sea

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Acta Oceanologica Sinica 2011年第3期30卷 55-62页

作者： MA Hao ZENG Zhi YU Wen HE Jianhua CHEN Liqi CHENG Jianping YIN Mingduan ZENG Shi Department of Engineering Physics Tsinghua University Beijing 100084 China Key Laboratory of Global Change and Marine-Atmospheric Chemistry State Oceanic Administration Xiamen 361005 China Key Laboratory of Particle ＆ Radiation imaging （Tsinghua university） Ministry of Education Beijing 100084 China Key Laboratory of High Energy Radiation imaging Fundamental science for National Defense Beijing 100084 China

234.h was utilized as a tracer of particulate organic carbon （POC） export in the northwestern South China Sea （SCS） on the basis of the data collected at four stations during a spring cruise. Depth profiles of dissolved and particulate 234.h activities were measured in the upper 60m, showing a significant deficit relative to 23Su over the investigated stations. A stratified structure of 234.h-23su disequilibrium was in general observed in the upper 60 m water column, indicating that the euphotic zone of the northwestern SCS in this reason can be divided into two layers, an upper and lower layer, with different export rates. POC export fluxes were estimated from a one-dimensional steady state model of 234.h fluxes in combination with the measurement of POC/234.h ratios on suspended particles. The POC export in this region ranged from 8.2 to 20.0 mmol/（m2.d）, with an average of 16.0 mmol/（m2-d）, and was slightly higher than those previously reported in the southern SCS.

关键词： 234.h 23su disequilibrium POC export South China Sea

Nanotechnology for bioseparations

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Nanotechnology for bioseparations

Tunable negative-index photonic crystals using colloidal magnetic fluids

30th International Symposium on Capillary Chromatography、4.h GC×GC Symposium、16th National Symposium and Exhibition on Chromatography,i.e. 1st Dalian International Symposium and Exhibition on Chromatography

作者： Baba Y.~(1-5 *) 1.Department of Applied Chemistry Graduate School of Engineering Nagoya university 2.MEXT Innovative research center for Preventive Medical Engineering Nagoya university 3.Plasma Nanotechnology research center Nagoya university 4.health Technology research center National Institute of Advanced Industrial science and Technology (AlST) 5.Institute for Molecular science National Institute for Natural sciences

＜正＞This lecture will describe the recent development of nanobiotechnologies based on the nanofabrication, molecular nanotechnoiogy,and nanomaterials for bioanalysis and biomedical *** technologies allow us to develop novel methods to analyze several biomolecules,including DNA,RNA,protein,peptide, polysaccharide,and *** of nano-pillar,which is 200 nm wide and 4.00 nm tall,is successfully applicable to fast separation of DNA within 10-25 ***-ball,fabricated by molecular nanotechnology,of which diameter is 50 nm,is developed and successfully applied for fast separation of DNA fragments from 100 bp to 15 *** cellulose,which is 50 nm diameter biofiber,is found to be useful high sensitive detection of biomolecule based on the optical confined effect as well as fast analysis of *** nano-biodevice is extremely useful for fast separation of protein samples from several kDa to 200 kDa within 15 seconds. Utilizing this technique,complex protein mixture extracted from human T cell line,lymphoblastic Jurkat cells, were separated within 15s with high *** methods we have taken appear suitable for biomedical and clinical applications,including SNPs analysis,mutation analysis,haplotyping,DNA diagnosis,protein expression analysis,immunoassay,protein disease marker detection,point-of-care *** methods are also applicable to molecular imaging of cancer cell and possible photodynamic therapy of cancer.

关键词： Nanotechnoiogy Biodevice Protein DNA Cell

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Chinese Physics B 2015年第12期24卷 352-357页

作者：耿滔王新王岩董祥美 Engineering research center of Optical Instrument and System Ministry of Education Shanghai Key Laboratory of Modern Optical SystemUniversity of Shanghai for Science and Technology

The model of using colloidal magnetic fluid to build tunable negative-index photonic crystal is established. The effective permittivity εe and permeability μe of the two-dimensional photonic crystal are investigated in detail. For transverse magnetic polarization, both εe and μe exhibit a Lorentz-type anomalous dispersion, leading to a region where εe and μe are simultaneously negative. Then, considering a practical case, in which the thickness of photonic crystal is finite, the band structures for odd modes are calculated by the plane wave expansion method and the finite-difference time-domain method. The results suggest that reducing the external magnetic field strength or slab thickness will weaken the periodic modulation strength of the photonic crystal. Simulation results prove that the negative-index can be tuned by varying the external magnetic field strength or the slab thickness. The work presented in this paper gives a guideline for realizing the flat photonic crystal lens with tunable properties at optical frequencies, which may have potential applications in tunable near-field imaging systems.

关键词： tunable negative-index photonic crystals colloidal magnetic fluids

TRPC3 is involved in flow- and bradykinin-induced vasodilation in rat small mesenteric arteries

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Acta Pharmacologica Sinica 2006年第8期27卷 981-990页

作者： Cui-ling LIU~(2,4. Yu HUANG~3 Ching-yuen NGAI~3 Yuk-ki LEUNG~3 Xiao-qiang YAO~3 ~2Department of Pathology,Peking university health science center,Beijing 100083,China ~3Department of Physiology Faculty of Medicine,the Chinese university of Hong Kong,Hong Kong,China DepartmentofPathology PekingUniversityHealthScienceCenterBeijing100083China DepartmentofPhysiology FacultyofMedicinetheChineseUniversityofHongKongHongKongChina

Aim:To test the possible involvement of TRPC3 in agonist-induced relaxationand flow-induced vasodilation in rat small mesenteric ***:MaleSprague-Dawley rats were used in the present *** 72 h-treatment ofantisense oligo via tail vein injection,isometric tension and isobaric diametermeasurement were carried out with isolated mesenteric artery segments by usingeither a Pressure Myograph or a Multi Myograph *** [Ca2+]ichanges were measured with a MetaFluor imaging system in response to flow orto 30 nmol/L ***:Immunohistochemical study showed that the72 h-treatment of antisense oligo via tail vein injection markedly decreased theTRPC3 expression in mesenteric arteries,indicating the effectiveness of theantisense *** tension and isobaric diameter measurement showedthat,although the antisense oligo treatment did not affect histamine-,ATP-,andCPA-induced relaxation,it did reduce the magnitude of flow-induced vasodilationby approximately 13% and decreased bradykinin-induced vascular relaxation withits EC50value raised by nearly *** [Ca2+]imeasurement revealedthat treatment of the arteries with antisense oligos significantly attenuated themagnitude of endothelial [Ca2+]irise in response to flow and to 30 nmol/L ***:The results suggest that TRPC3 is involved in flow-and bradykinin-induced vasodilation in rat small mesenteric arteries probably by mediating theCa2+influx into endothelial cells.

关键词： TRPC3 flow-induced vasodilation bradykinin-induced vasodilation antisense oligonucleotides

Biphasic firing response of nucleus accumbens neurons elicited by THPB-18 and its correlation with DA receptor subtypes

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Acta Pharmacologica Sinica 2004年第12期25卷 31-39页

作者： Yu FU2,3,4. Zi-tao ZHU2,5, Xing-zu ZHU2, Guo-zhang JIN2,6 2State KeyLaboratory of Drug research,Shanghai Institute ofMateria Medica, Shanghai Institutes for Biologicalsciences, ChineseAcademy of sciences, Graduate Schoolof the Chinese Academy of sciences, Shanghai 201203, ChinaNow in Department of Pharmacology and Toxicology, Univer-sity of {4. Medical Branch, USA.Now in Department of Physiology & Pharmacology, Oregonhealth sciences university, USA,5Now in Department of Physiology & Pharmacology, Oregonhealth sciences university, USA, State Key Laboratory of Drug research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201203 China

AIM: To investigate the possibility whether THPB-18 (l-12-shloroscoulerine) possesses the D1 agonist-D2 antago- nist action on meso-accumbens-mPFC DA system. METHODS: Single unit spontaneous firing activity was re- corded in the nucleus accumbens (NAc) neurons of na?ve and unilateral-6-hydroxydopamine (6-OHDA)-lesioned Sprague-Dawley rats. The effects of drugs applied intravenously or iontophoretically were determined by the change of firing rates. RESULTS: Under normal conditions, the systemic administration of THPB-18 produced a decrease-increase biphasic firing pattern in the NAc neurons during cumulative doses. High dose of THPB-18 was capable of reversing the inhibition induced by both D2 agonist LY171555 and D1/D2 agonist APO on NAc firing activity. Spiperone pretreatment could not block the high dose of THPB-18-induced firing rate increase, which was reversed by the D1 selective antagonist SCH23390. The tested NAc neurons were effectively inhibited by iontophoretically applied THPB-18 in 90 % of 6-OHDA-lesioned rats, while THPB-18 caused variable effects on the firing of NAc neurons in the neurons of unlesioned rats. The inhibitory effect of THPB-18 was blocked by iontophoretic application of SCH23390, but not D2 antagonist spiperone. CONCLUSION: Similar to l-stepholidine, THPB-18 also possesses the “D1 agonistic-D2 antagonistic” dual action on the VTA-NAc DA system.4.ow in Department of Pharmacology and Toxicology, Univer-sity of texas Medical Branch, USA.5Now in Department of Physiology & Pharmacology, Oregonhealth sciences university, USA,4.ow in Department of Pharmacology and Toxicology, Univer-sity of texas Medical Branch, USA.5Now in Department of Physiology & Pharmacology, Oregonhealth sciences university, USA,5Now in Department of Physiology & Pharmacology, Oregonhealth sciences university, USA,

关键词： berberine dopamine D1 receptors dopamine D2 receptors nucleus accumbens