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fMRI time series analysis based on stationary wavelet and spectrum analysis

Progress in Natural science:Materials International 2006年第11期16卷 1171-1176页

作者： ZHI Lianhe~ 1,2,3 , ZHAO Xia~4. SHAN Baoci~1**, PENG Silong~5, YAN Qiang~1, YUAN Xiuli~1 and TANG Xiaowei~ 1,6 (1. Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of sciences, Beijing 10004., China 2. Graduate School of Chinese Academy of sciences, Beijing 10004., China 3. Department of Physics, Zhoukou Normal university, Zhoukou 4.6100, China 4. research imaging center,{4., san antonio, texas 78229, USA 5. National ASIC Design and Engineering center, Institute of Automation, Chinese Academy of sciences, Beijing 10004., China 6. Department of Physics, Zhejiang university, Hangzhou 310027, China) [a]Key Laboratory of Nuclear Analysis Techniques Institute of High Energy Physics Chinese Academy of Sciences Beijing China [b]Graduate School of Chinese Academy of sciences Beijing China [c]Department of Physics Zhoukou Normal University Zhoukou China [d]research imaging center University of Texas Health Science Center San Antonio Texas USA [e]National ASIC Design and Engineering center Institute of Automation Chinese Academy of Sciences Beijing China [f]Department of Physics Zhejiang University Hangzhou China

The low signal to noise ratio (SNR) of functional MRI (fMRI) prefers more sensitive data analysis methods. Based on stationary wavelet transform and spectrum analysis, a new method with high detective sensitivity was developed for analyzing fMRI time series, which does not require any prior assumption of the characteristics of noises. In the proposed method, every component of fMRI time series in the different time-frequency scales of stationary wavelet transform was discerned by the spectrum analysis, then the components from noises were removed using the stationary wavelet transform, finally the components of real brain activation were detected by cross-correlation analysis. The results obtained from both simulated and in vivo visual experiments illustrated that the proposed method has much higher sensitivity than the traditional cross-correlation method.

关键词： fMRI stationary wavelet transform spectrum analysis data analysis.

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Molecular regulation of cardiovascular cell growth and apoptosis in atherosclerotic coronary artery disease

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中国病理生理杂志 2010年第A10期26卷 1947-1948页

作者： Yong-Jian Geng(The center for Cardiovascular Biology and Atherosclerosis research,university of texas {4. science center at Houston,and texas Heart Institute,Houston,USA.)

A balance between growth and apoptosis plays a critical role in maintaining the homeostasis of cardiovascular *** the development of atherosclerosis and atherosclerosis-associated coronary heart disease,many environmental factors exert regulatory effects on cardiovascular cells and their *** have recently investigated several proteins known to protect cells against ischemic damages.

关键词： cardiovascular homeostasis exert maintaining apolipoprotein damages Glucose blocked caspase protect

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Molecular signal transduction in vascular cell apoptosis

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Cell research 2001年第4期11卷 253-264页

作者： GENG YONG JIAN center for Cardiovascular Biology and Atherosclerosis research, Division of Cardiology, Department of Internal Medicine, university of texas Houston {4. science center Medical School, 64.1 Fannin Street, MSB 6.04., Houston, TX 77030, USA 1center for Cardiovascular Biology and Atherosclerosis research Division of Cardiology Department of Internal Medicine University of Texas Houston Health Science Center Medical School 6431 Fannin Street MSB 6.045 Houston TX 77030 USA

Apoptosis is a form of genetically programmed cell death, which plays a key role in regulation of cellularity in a variety of tissue and cell types including the cardiovascular tissues. Under both physiological and pathophysiological conditions, various biophysiological and biochemical factors, including mechanical forces, reactive oxygen and nitrogen species, cytokines, growth factors, oxidized lipoproteins, etc., ma influence apoptosis of vascular cells. The Fas/Fas ligand/caspase death-signaling pathway, Bcl-2 protein family/mitochondria, the tumor suppressive gene p53, and the proto-oncogene c-myc may be activated in atherosclerotic lesions, and mediates vascular apoptosis during the development of atherosclerosis. Abnormal expression and dysfunction of these apoptosis-regulating genes may attenuate or accelerate vascular cell apoptosis and affect the integrity and stability of atherosclerotic plaques. Clarification of the molecular mechanism that regulates apoptosis may help design a new strategy for treatment of atherosclerosis and ii major complication, the acute vascular syndromes.

关键词： Apoptosis vascular cells caspases atherosclerosis cytokines.

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Immunization with chlamydial plasmid protein pORF5 DNA vaccine induces protective immunity against genital chlamydial infection in mice

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science China(Life sciences) 2008年第11期51卷 973-980页

作者： LI ZhongYu1,2, WANG ShiPing1, Wu YiMou2, ZHONG GuangMing3 & CHEN Ding3 1 Xiangya School of Medicine, Central South university, Changsha 4.0078, China 2 Department of Microbiology and Immunology, university of South China, Hengyang 4.1001, China 3 university of texas health science center at san antonio, TX {4., USA Xiangya School of Medicine Central South University Changsha 410078 China Department of Microbiology and Immunology University of South China Hengyang 421001 China university of texas health science {4. at san antonio San Antonio TX 78229 USA

To validate the immune protective efficacy of pORF5 DNA vaccine and to analyze potential mechanisms related to this protection. In this study, pORF5 DNA vaccine was constructed and evaluated for its protective immunity in a mouse model of genital chlamydial infection. Groups of BALB/c mice were immunized intranasally with pORF5 DNA vaccine. Humoral and cell mediated immune responses were evaluated. The clearance ability of chlamydial challenge from the genital tract and the chlamy- dia-induced upper genital tract gross pathology and histopathological characterization were also de- tected. The results showed that the total and the IgG2a anti-pORF5 antibody levels in serum were sig- nificantly elevated after pcDNA3.1-pORF5 vaccination, as were the total antibody and IgA levels in vaginal fluids. pcDNA3.1-pORF5 induced a significantly high level of Th1 response as measured by robust gamma interferon (IFN-γ). Minimal IL-4.was produced by immune T cells in response to the re-stimulation with pORF5 protein or the inactive elementary body in vitro. pcDNA3.1-pORF5-vacci- nated mice displayed significantly reduced bacterial shedding upon a chlamydial challenge and an accelerated resolution of infection. 100% of pcDNA3.1-pORF5 vaccinated mice successfully resolved the infection by day 24. pcDNA3.1-pORF5-immunized mice also exhibited protection against patho- logical consequences of chlamydial infection. The stimulated index was significantly higher than that of mice immunized with pcDNA3.1 and PBS (P<0.05). Together, these results demonstrated that immu- nization with pORF5 DNA vaccine is a promising approach for eliciting a protective immunity against a genital chlamydial challenge.

关键词： Chlamydia trachomatis pORF5 DNA vaccine immune protection Th1 immune response

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Gravity Changes Before Large Earthquakes in China: 1998-2005

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地球空间信息科学学报（英文） 2011年第1期14卷 1-9页

作者： ZHAN F. Benjamin ZHU Yiqing NING Jinsheng ZHOU Jiangcun LIANG Weifeng XU Yunma School of Resource and Envirorunental science Wuhan University 129 Luoyu Road Wuhan 430079 China texas center for Geographic Information science Texas State University San Marcos TX 78666 USA Institute of Geodesy and Geophysics Chinese Academy of Sciences 340 Xudong Street Wuhan 430077 China Second Crust Monitoring and Application center China Earthquake Administration Xi'An 710054 China School of Geodesy and Geomatics Wuhan University 129 Luoyu Road Wuhan 430079 China

Although it is well known that coseismic gravity changes take place during an earthquake, previous research has not yielded convincing evidence demonstrating that significant gravity changes occur before large earthquakes. Furthermore, even if we suspect that gravity changes occur before large earthquakes, we have yet to demonstrate how to consistently observe these changes for useful earthquake forecast that would bring benefits to society. We analyzed ground gravity survey data obtained in 1998, 2000, 2002, and 2005 at stations of the Crustal Movement Observation Network of China (CMONOC) and examined gravity changes be-fore the occurrence of nine large (Ms≥6.8) earthquakes that ruptured within or near China's Mainland and Taiwan from November 2001 to August 2008. Results from this analysis show that significant gravity changes occurred across a large region before each of these nine large earthquakes, and these changes were detected by repeated ground gravity surveys through CMONOC. Although these gravity changes were significant, more research is needed to investigate whether these gravity changes could be viewed as precursors of large earthquakes. Limitations and uncertainties in the data include sparseness of the gravity monitoring network, long time intervals between consecutive gravity surveys, inevitable measurement errors, hydrological effects on gravity, and effects of vertical crustal movements on gravity. Based on these observations, we make several recommendations about possible future direc-tions in earthquake-related research using gravity monitoring data.

关键词： earthquake gravity seismology China Wenchuan geodesy GIS

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A general phase retrieval algorithm based on a ptychographical iterative engine for coherent diffractive imaging

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Chinese Physics B 2013年第1期22卷 243-248页

作者：傅健李鹏 research center of Digital Radiation imaging and Biomedical imaging Beijing University of Aeronautics and Astronautics

Coherent diffractive imaging （CDI） is a lensless imaging technique and can achieve a resolution beyond the Rayleigh or Abbe limit. The ptychographical iterative engine （PIE） is a CDI phase retrieval algorithm that uses multiple diffraction patterns obtained through the scan of a localized illumination on the specimen, which has been demonstrated successfully at optical and X-ray wavelengths. In this paper, a general PIE algorithm （gPIE） is presented and demonstrated with an He-Ne laser light diffraction dataset. This algorithm not only permits the removal of the accurate model of the illumination function in PIE, but also provides improved convergence speed and retrieval quality.

关键词： phase retrieval algorithm coherent diffractive imaging ptychography

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Limbic leptin signaling and depression

Limbic leptin signaling and depression

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xin-Yun LU Departments of Pharmacology and Psychiatry,university of texas health science {4. at san antonio,7703 Floya Curl Drive,san antonio,TX 78229,USA

＜正＞Major depressive disorder is the most common mental illness,affecting roughly 20%of the general population at some point during their *** approximately half of patients respond to existing antidepressant ***,the mechanisms underlying the pathogenesis of depression remain poorly *** is often comorbid with medical conditions such as ***,an adipocyte-derived hormone,is well known for its role in the control of energy homeostasis and body *** research has provided evidence for a novel action of leptin in the regulation of mood and *** leptin levels are reduced in chronic stress models of *** treatment reverses chronic stress-induced depression-like behavioral deficits and impairment of hippocampal *** addition,we have explored limbic leptin signaling in mood-related *** implications of leptin and leptin receptor signaling in human depression will be discussed.

关键词： depression leptin stress hippocampus

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Plasmacytoid dendritic cells in antiviral immunity and autoimmunity

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science China(Life sciences) 2010年第2期53卷 172-182页

作者： TANG Fei1,2,DU Qiumei1,2 & LIU Yong-Jun3 1 center for Infection and Immunity,Institute of Biophysics,Chinese Academy of sciences,Beijing 100101,China 2 Graduate university of Chinese Academy of sciences,Beijing 10004.,China 3 Department of Immunology and center for Cancer Immunology research,university of texas,M.D.Anderson Cancer center,Houston,texas 77030,USA 1. center for Infection and Immunity Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China2. Graduate University of Chinese Academy of Sciences Beijing 100049 China3. Department of Immunology and Center for Cancer Immunology Research University of Texas M.D. Anderson Cancer Center Houston Texas 77030 USA

Plasmacytoid dendritic cells (pDCs) represent a unique and crucial immune cell population capable of producing large amounts of type I interferons (IFNs) in response to viral *** function of pDCs as the professional type I IFN-producing cells is linked to their selective expression of Toll-like receptor 7 (TLR7) and TLR9,which sense viral nucleic acids within the endosomal *** I IFNs produced by pDCs not only directly inhibit viral replication but also play an essential role in linking the innate and adaptive immune *** aberrant activation of pDCs by self nucleic acids through TLR signaling and the ongoing production of type I IFNs do occur in some autoimmune ***,pDC may serve as an attractive target for therapeutic manipulations of the immune system to treat viral infectious diseases and autoimmune diseases.

关键词： plasmacytoid dendritic cells type I interferon TLR7 TLR9 antiviral immunity autoimmune diseases

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Involvement of the crebellum in sequential finger movement learning:Evidence from functional magnetic resonance imaging

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science Bulletin 2005年第17期 73-77页

作者： ZHU Yihong1, DI Haibo1,2, YUAN Yi3, REN Jin’ge3, YU Wei4. ZHANG Zhaoqi4. GAO Jiahong5, WENG Xuchu3 & CHEN Yizhang1 1. Medical School, Zhejiang university, Hangzhou 310006, China 2. Medical School, Hangzhou Normal university, Hangzhou 310018, China 3. Laboratory for Higher Brain Function, Institute of Psychology, Chi-nese Academy of sciences, Beijing 100101, China 4. Department of Radiology, Beijing Anzhen Hospital of Capital Univer-sity, Beijing 100029, China 5. research {4. center, university of texas health science center, san antonio, texas, USA

Whether the cerebellum is involved in volun-tary motor learning or motor performance is the subject of a new debate. Using functional magnetic resonance imaging (fMRI), we examined cerebellar activation in eight volun-teers before and after an extended period of training. Activa-tion volume on both sides of cerebellum after learning was significantly reduced compared to that before learning even under the same motor frequency. Remarkably, while motor frequency for the training sequence was significantly higher than the control sequence after 4. d of learning, activation in the cerebellum for both sequences, with respect to activation loci and volumes, was very similar. These results suggest that the cerebellum was involved in motor learning but not motor performance. Changes of cerebellar activation from training thus appear to be associated with learning but not with im-provement on task performance.

关键词： cerebellum learning performance sequential movement fMRI.

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Molecular regulation of cardiovascular cell growth and apoptosis in atherosclerotic coronary artery disease

Molecular regulation of cardiovascular cell growth and apopt...

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中国病理生理学会第九届全国代表大会及学术会议

作者： Yong-Jian Geng (The center for Cardiovascular Biology and Atherosclerosis research,university of texas {4. science center at Houston, and texas Heart Institute,Houston,USA.)

＜正＞A balance between growth and apoptosis plays a critical role in maintaining the homeostasis of cardiovascular *** the development of atherosclerosis and atherosclerosis-associated coronary heart disease,many environmental factors exert regulatory effects on cardiovascular cells and their *** have recently investigated several proteins known to protect cells against ische-

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