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Chinese Journal of Structural Chemistry 2007年第12期26卷 1429-1434页

作者：胡学雷邱立赵元弟key laboratory of biomedical photonics of{4. - wuhan National laboratory for Optoelectronics - Hubei Bioinformatics and Molecular Imaging key laboratory - key laboratory of Molecular Biophysics of the{4. huazhong university of {14. and technology 潘志权 key laboratory of biomedical photonics of{4. - wuhan National laboratory for Optoelectronics - Hubei Bioinformatics and Molecular Imaging key laboratory - key laboratory of Molecular Biophysics of the{4. Huazhong University of Science and Technology Hubei key laboratory of Novel Chemical Reactor and Green Chemical technology Wuhan Institute of Technology

The title compound （13,27-dimethyl-3,6,9,17,20,23-hexaazatricyclo-[23.***.1.1^11.15]- triaconta-l（29）,2,9,11,13,15（30）,16,23,25,27-decaene-29,30-diol-N^3,N^6,N^9,O^29,O^30）-bis（nitrato-O,O＇）- holmium（m） nitrate hydrate has been prepared and characterized by elemental analysis, infrared spectra, and electrospray mass spectra. Its crystal and molecular structures were determined by X-ray diffraction methods. The crystal crystallizes in the monoclinic system, space group C2/c with a = 23.737（12）, b = 14.237（7）, c = 19.801（10） A, β = 91.36（1）^o, Mr = 831.57, V = 6690（6） A^3, Z = 8, Dc = 1.651 g/cm^3, F（000） = 334., R = 0.04.2 and wR = 0.0923. The holmium ion is located in one of the compartments of the macrocyclic ligand and presents a distorted tricapped trigonal prismatic coordination geometry. The macrocycle is coordinated with two oxygen and three nitrogen atoms. Two nitrates are chelated in the opposite positions of the macrocycle, and the third one is ionic.

关键词： crystal structure lanthanide macrocycle

Firing patterns of long-term cultured neuronal network on multi-electrode array

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Progress in Natural science:Materials International 2006年第12期16卷 1337-1342页

作者： LI Xiangning, ZHOU Wei, LIU Man, ZENG Shaoqun and LUO Qingming**(The key laboratory of biomedical photonics of{4.-wuhan National laboratory for Optoelectronics, huazhong university of science and technology, wuhan 4.0074. China) key laboratory of biomedical photonics of{4.-wuhan National laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 China

Spontaneous neuronal activity plays an important role in the development and plasticity of brain. To explore the developmental changes in the firing pattern of the neuronal networks in vitro, the hippocampal neurons were cultured on the multi-microelectrode array dish for over 14.weeks and the spontaneous activity was recorded. The results showed that random firing was observed in the 1st week and transformed into synchronized activity after two weeks, then tightly synchronized activity appeared in week 2 to 7 and finally the activities transformed into the random firing pattern. These results suggested three stages in the long-term development of neuronal network in vitro: the stage for connection, the stage of synchronized activity and the mature stage. Synchronized firing shown by spontaneous activity was an important phenomenon in high density cultured neuronal network and transformed patterns during development.

关键词： neuronal networks development multi-electrode array cultured neuron.

Large second-order optical nonlinearities of s-triazine derivatives: View from micro molecules to macro crystals

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science China Chemistry 2005年第3期48卷 203-209页

作者： FANG Qi1, LEI Hong2, CUI Yuezhi3, HUANG Zhenli4. XUE Gang1 & YU Wentao1 1. State key laboratory of Crystal Materials, Shandong university, Jinan 250100, China 2. School of Information science and Engineering, Shandong university, Jinan 250100, China 3. Department of Chemical Engineering, Light Industry College of Shandong, Jinan 250100, China 4. key laboratory of biomedical photonics, ministry of education, huazhong university of science and technology, wuhan 4.0074. China State key laboratory of Crystal Materials Shandong University Jinan China School of Information science and Engineering Shandong University Jinan China Department of Chemical Engineering Light Industry College of Shandong Jinan China key laboratory of biomedical photonics Ministry of Education Huazhong University of Science and Technology Wuhan China

Three s-triazine derivatives have been synthesized and their structures been de-termined. These are Compound I: 2,4.dimethyl-6-(p-N,N-dimethylaminostyryl)-s-triazine (abbre-viated to NMe-1), Compound II: 2,4.dimethyl-6-(p-N,N-diethylaminostyryl)-s-triazine (to NEt-1), and Compound III: 2-methyl-4.6-bis(p-N,N-dimethylaminostyryl)-s-triazine (NMe-2). NMe-1 and NEt-1 molecules belong to the D-π-A type with a one-dimensional charge-transfer character. NMe-1 crystallizes to centrosymmetric P1 space group, while NEt-1 to non-centrosymmetric polar Cc space group with all of the molecular charge-transfer axes taking the same orientation. Under the irradiation of 1064.nm fundamental laser, NEt-1 powder crystals radiate a 2-order harmonic light with an intensity 4..8 times that of urea. The Λ typed NMe-2 molecule, which has a two-dimensional charge-transfer character, crystallizes to polar P21 space group. Its powder crystals exhibit a 2-order harmonic intensity 4..2 times that of urea. The quantum chemical cal-culations and tensor analyses have been carried out to reveal the dependence of the macro 2-order nonlinear optical (NLO) efficiency on the micro 2-order NLO coefficients (β) and on the crystalline packing styles.

关键词： s-triazine derivatives, synthesis, structure, SHG intensities of crystals, βvalues of molecules.

The Role of Surfactant and Costabilizer in Controlling Size of Nanocapsules Containing TEGDMA in Miniemulsion

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Journal of wuhan university of technology(Materials science) 2009年第6期24卷 1004-1006页

作者：郭进新黄翠 School and Hospital of Stomatology Wuhan University key laboratory of Oral biomedical Engineering of ministry of education Wuhan University

Nanocapsules with triethylene glycol dimethacrylate （TEGDMA） as core material and polyurethane as wall material used for self-healing bonding resin were prepared by interfacial polycondensation in miniemulsion. The influence of surfactant and costabilizer concentration on nanocapsules size and stability of nanocapsules was investigated. The size and its polydispersity of the nanocapsules were measured by light-scattering particle size analyzer. When the concentration of SDS were increased from 2.5wt% to 10wt%,the size decreases from 34..5 nm to 258.3 nm, PDI decreased from 0.210 to 0.111. As the concentration of HD increased, the size and PDI were both decreased, When reaching 10wt%,the size was 258.0 nm,PDI was 0.130. SDS and HD play important effect in synthesis of Nanocapsules containing *** changing the surfactant and costabilizer concentration it was possible to synthesize a wide variety of nanocapsules sizes. The performance and technical parameters of nanocapsules had been researched preliminarily, which built the solid foundation for the application to the self-repairing bonding resin.

关键词： triethylene glycol dimethacrylate nanocapsules interfacial polycondensation miniemulsion

Optical dynamic imaging of the regional blood flow in the rat mesentery under the effect of noradrenalin

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Progress in Natural science:Materials International 2003年第5期 79-82页

作者： CHENG Haiying, LUO Qingming, ZENG Shaoqun, CEN Jian and LIANG Wenxi(The key laboratory of biomedical photonics of{4. of China, huazhong university of science and technology, wuhan 4.0074. China) The key laboratory of biomedical photonics of{4. of China Huazhong University of Science and Technology Wuhan 430074 China

The regional blood flow in the rat mesentery under the effect of noradrenalin is monitored using the laser speckle imaging method. The results show that at the third minute of application of noradrenalin, the blood flow begins to decrease, and the venule blood flow decreases more rapidly than that in the arteriole. Five minutes later blood flow in part of blood vessels begins to resume and the blood flow in the arteriole recovers more quickly than that in the venule. These suggest that laser speckle imaging can obtain the temporal-spatial characteristic of blood flow in mesentery without the need of scanning. It provides a new approach for investigating the change of regional blood flow in the mesentery in microcirculation studies.

关键词： laser speckle imaging mesentery regional blood flow.

Blood flow activation in rat somatosensory cortex under sciatic nerve stimulation revealed by laser speckle imaging

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Progress in Natural science:Materials International 2003年第7期 44-49页

作者： WANG Zheng, LUO Qingming, CHENG Haiying, LUO Weihua, GONG Hui and LU Qiang(The key laboratory of biomedical photonics of{4. of China, huazhong university of science and technology, wuhan 4.0074. China) The key laboratory of biomedical photonics of{4. of China Huazhong University of Science and Technology Wuhan 430074 China

In many functional neuroimaging research the change of local cerebral blood flow (CBF) induced by sensory stimulation is regarded as an indicator of the change in cortical neuronal activity although a precise and full spatio-temporal description of local CBF response coupled to neural activity has still not been laid out. Using the laser speckle imaging technique a relatively large exposed area in so-matosensory cortex of rat was imaged for the observation of the variations of CBF during sciatic nerve stimulation. The results showed that cerebral blood flow activation was spatially localized and discretely distributed in the targeted microvasculature. Individual arteries, veins and capillaries in different diameters were activated with the time going. The response pattern of CBF related to the function of brain activity and energy metabolism is delineated exactly.

关键词： blood flow activation somatosensory cortex sciatic nerve stimulation laser speckle imaging.

Thermal induced effects on normal and tumor of mouse mesentery based on measuring microcirculation parameters and temperature

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Thermal induced effects on normal and tumor of mouse mesente...

Real-time detecting gelatinases activity in living cells by FRET imaging

photonics Asia 2004.Sensors and Imaging

作者： Dan Zhu Qingming Luo Ting Zhang The key laboratory of biomedical photonics of{4., huazhong university of science &technology, wuhan, P. R. China, 4.0074

Thermotherapy could be selective to cure tumor because tumor is sensitive to temperature rise. The tumor blood flow rate, the average blood perfusion of tissue or temperature during heating was invest

关键词： tumor, vessel diameter, flow rate, blood perfusion, temperature

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Real-time detecting gelatinases activity in living cells by ...

Synthesis and properties of quantum dots optical probes for bio-imaging

20th Congress of the International Commission for Optics

作者： Jie Yang a Zhihong Zhang a b Bifeng Liu b Qingming Luo a b * a key laboratory of biomedical photonics of{4. b Huibei Bioinformatic and Molecular Imaging key laboratory huazhong university of science and technology wuhan 4.0074.China

Degradation of the extracellular matrix by Matrix metalloproteinases (MMPs) not only enhances tumor invasion, but also affects tumor cell behaviour and leads to cancer progression. To monitor gelatina

关键词： Gelatinases MMP2 MMP9 fluorescence resonance energy transfer (FRET) MMP inhibitor Doxycycline ECFP Citrine

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Synthesis and properties of quantum dots optical probes for ...

基于Java和XML的系统生物学可视化建模系统

20th Congress of the International Commission for Optics

作者： Tian-Cai Liu Zhen-Li Huang Hai-Qiao Wang Yuan-Di Zhao* Qing-Ming Luo key laboratory of biomedical photonics of{4. School of life of science & technology huazhong university of science and technology wuhan 4.0074.P. R. China

A novel green synthesis of semiconductor nanoparticles was introduced and it was used as optical probes for bio-imaging. Quantum dots are known as <10nm scaled semiconductor nanoparticles, which could

关键词： Quantum dots Optical probes Fluorescence Bio-imaging.

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计算机工程与应用 2004年第6期40卷 202-204页

作者：董建坤鲁强骆清铭曾绍群华中科技大学生物医学光子学教育部重点实验室武汉430074

论文讨论了用系统生物学建模语言描述生化反应和基因调控网络模型的方法,设计并实现了系统生物学建模系统BioDesigner。最后利用BioDesigner有效地描述了最小钙振荡模型,并用仿真软件验证了模型的正确性。

关键词：系统生物学 Java XML