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Long-term functional maintenance of primary hepatocytes in vitro using macroporous hydrogels engineered through liquid-liquid phase separation

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Nano Research 2024年第3期17卷 1725-1736页

作者： Yang Sun Sheng Yin Jian Cui Zhongxia Wang Yueying Han Ding ma Shuo Wang Junhua Wu Yi Cao Chunping Jiang Xiaosong Gu Jinan Microecological Biomedicine Shandong Laboratory Jinan 250021China Collaborative Innovation Center of Advanced Microstructures National Laboratory of Solid State MicrostructureKey Laboratory of Intelligent Optical Sensing and ManipulationMinistry of EducationDepartment of PhysicsNanjing UniversityNanjing 210093China department of Hepatobiliary Surgery The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210093China National Institute of Healthcare Data Science at Nanjing university Nanjing UniversityNanjing 210093China

Preserving the functionality of hepatocytes in vitro poses a significant challenge in liver tissue engineering and bioartificial liver,as these cells rapidly lose their metabolic and functional characteristics after *** by the macroporous structures found in native liver tissues,here we develop synthetic hydrogel scaffolds that closely mimic the liver’s structural organization through the phase separation between polyethylene glycol(PEG)and *** hydrogels exhibit interconnected macroporous structures and appropriate mechanical properties,providing an optimal microenvironment conducive to hepatocyte adhesion and the formation of sizable *** to two-dimensional hepatocyte cultures,enhanced functionalities of hepatocytes cultured in our macroporous hydrogels were observed for 14.days,as evidenced by quantitative reverse-transcription–polymerase chain reactions(qRT-PCR),immunofluorescence,and enzyme linked immunosorbent assay(ELISA)*** sequencing data further confirmed the establishment of cell–cell interactions among hepatocytes when cultured in our ***,these hepatocytes maintained a protein expression lineage that closely resembled freshly isolated hepatocytes,particularly in the Notch and tumor necrosis factor(TNF)signaling *** results suggest that the macroporous hydrogels are attractive scaffolds for liver tissue engineering.

关键词： liver tissue engineering phase separation hepatocytes macroporous hydrogel

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High-throughput structure determination of polycrystalline functional materials: a platform for automated 3DED/MicroED data collection

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Science China Chemistry 2024年

作者： Zhenghan Zhang Zhengyin Liang Chao ma Cong Lin Jian Li State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Nanjing University department of mechanical engineering The Hong Kong Polytechnic University

Structure determination plays the most crucial role in the discovery of novel functional materials, because only by knowing the intrinsic structures can we accurately and completely understand their properties and applications. However, most new materials are obtained in polycrystalline form or even as mixtures with multiple phases when first synthesized, presenting significant challenges in their structure determination and phase elucidation. Fortunately, the developed three-dimensional electron diffraction (3DED/MicroED) has provided a promising solution to overcome these challenges. In this study, we have constructed a state-of-the-art 3DED/MicroED data acquisition equipment by integrating a hybrid-pixel detector with a script developed for SerialEM, and thus successfully developed an automated 3DED/MicroED method for the high-throughput structure determination. To demonstrate its effectiveness, a multiphase sample with complex porous structures is employed, showcasing that individual phases and their structures can be identified and determined, respectively. One remarkable finding is the identification of an impurity metal-organic framework (MOF) that is completely invisible to traditional powder X-ray diffraction in a supposedly “pure” commercial MOF sample. Additionally, our method also enables the atomic-resolution structure determination of flexible covalent organic framework materials, which are highly sensitive to electron beams. Moreover, a new microporous aluminoborate is discovered using this rapid structure determination method. These experimental results highlight the enormous potential of our 3DED/MicroED method in the field of new materials discovery, offering a powerful tool for the structure determination of polycrystalline functional materials.

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Research on the Formation of Metal-Ceramic Surface Composite Coating by Wide-Band Laser Cladding

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材料热处理学报 2004年第5B期25卷 1025-1028页

作者： LIUShuo ZHANGWei-ping maYu-tao departmentofmaterialsengineering DatianUniversityofTechnologyDafianPeopte＇sRepublicofChina

Large-area in-situ synthesized TiB2(TiB, Fe2B)—Fe metal-ceramic composite coating has been fabricated on medium carbon steel by laser cladding with the optimal laser parameters and overlapping coefficient. The bonding interfaces between the cladding layer and the matrix and among different tracks are excellent. Microanalysis on the cladding layer shows that the morphology is a little different from each other and the element distribution and the mechanical properties are unanimous in each track while the mechanical property of the cladding layer shows a gradual change from the surface to the matrix. The in-situ separating out thin ceramic phases in the coating contribute to the improving of its properties greatly.

关键词：宽带激光包覆金属陶瓷显微结构机械性质

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超精密微量进给刀架的研制

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同济大学学报（自然科学版） 1999年第5期27卷 621-624页

作者：马淑梅同济大学机械工程系上海200092

介绍一种新型超精密微量进给刀架，该刀架采用双簧片铰链结构的弹性变形体，刀尖高度可实现０～０．３ｍｍ微量调整．实验结果表明，该刀架具有良好的静、动态特性，其轴向静刚度为１００Ｎ·μｍ(－１)，行程为０～５ｍｍ，重复定位精... 详细信息

介绍一种新型超精密微量进给刀架，该刀架采用双簧片铰链结构的弹性变形体，刀尖高度可实现０～０．３ｍｍ微量调整．实验结果表明，该刀架具有良好的静、动态特性，其轴向静刚度为１００Ｎ·μｍ(－１)，行程为０～５ｍｍ，重复定位精度不超过±０．０２μｍ．ｘ方向、ｙ方向的固有频率最低为４．３６ｋＨｚ和４．０５ｋＨｚ．能够满足超精密加工的需要．

关键词：超精密加工微量进给刀架压电陶瓷弹性变形体

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NANOSCALE HEAT TRANSFER FOR ENERGY CONVERSION APPLICATIONS

NANOSCALE HEAT TRANSFER FOR ENERGY CONVERSION APPLICATIONS

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国际能源转换及利用学术会议

作者： Gang Chen Bao Yang Weili Liu Taofang Zeng Nanoscale Heat Transfer and Thermoelectrics Laboratory mechanical and aerospace engineering department {4. of California, Los Angeles, CA 90095-1597 usa

Solid-state energy conversion technologies such as thermoelectric and thermionic refrigeration and power generation require materials with low thermal conductivity but high electrical conductivity and Seebeck coefficient, which are difficult to realize in bulk semiconductors. Nanostructures such as superlattices and quantum wires provide alternative approaches to improve the solid-state energy conversion efficiency through size and interface effects on the electron and phonon transport. In this review, we discuss recent research progresses using nanostructures for solid-state energy conversion, with the emphases on fundamental issues that distinguish energy transport and conversion between nanoscale and macroscale.

关键词： nanoscale heat conduction thermoelectrics

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Strengthening strategy for high-performance friction stir lap welded joints based on 5083 Al alloy

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International Journal of Minerals,Metallurgy and materials 2024年第11期31卷 2498-2507页

作者： Yujia Shen Jijie Wang Beibei Wang Peng Xue Fengchao Liu Dingrui Ni Bolv Xiao Zongyi ma College of material Science and engineering Shenyang Aerospace UniversityShenyang 110136China Shi-changxu Innovation Center for Advanced materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China CAS Key Laboratory of Nuclear materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Binzhou Institute of Technology Shandong Key Laboratory of Advanced Aluminium Materials and TechnologyWeiqiao-UCAS Science and Technology ParkBinzhou 256606China Centre of Excellence for Advanced materials Dongguan 523808China

During aircraft,ship,and automobile manufacturing,lap structures are frequently produced among Al alloy skins,wall panels,and *** occurrence of welding defects severely decreases mechanical properties during friction stir lap welding(FSLW).This study focuses on investigating the effects of rotation rate,multipass welding,and cooling methods on lap defect formation,microstructural evolution,and mechanical *** defects were eliminated by decreasing welding speed,applying two-pass FLSW with a small welding tool,and introducing additional water cooling,thus leading to a remarkable increase in effective sheet thickness and lap *** above strategy yielded defect-free joints with an ultrafine-grained microstructure and increased tensile shear force from 298 to 551 N/*** fracture behavior of FSLW joints was systematically studied,and a fracture factor of lap joints was proposed to predict their fracture *** reducing the rotation rate,using two-pass welding,and employing additional water cooling strategies,an enlarged,strengthened,and defect-free lap zone with refined ultrafine grains was achieved with a quality comparable to that of lap welds based on 7xxx Al ***,this study provides a valuable FSLW method for eliminating hook defects and improving joint performance.

关键词： friction stir lap welding defect control microstructure fracture mechanisms mechanical properties

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An early scoring system to predict mechanical ventilation for botulism: a single-center-based study

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World Journal of Emergency Medicine 2024年第5期15卷 365-371页

作者： Yaqing An Tuokang Zheng Yanling Dong Yang Wu Yu Gong Yu ma Hao Xiao Hengbo Gao Yingping Tian Dongqi Yao Emergency department the Second Hospital of Hebei Medical UniversityShijiazhuang 050051China

BACKGROUND: Early identification of patients requiring ventilator support will be beneficial for the outcomes of botulism. The present study aimed to establish a new scoring system to predict mechanical ventilation(MV) for botulism ***: A single-center retrospective study was conducted to identify risk factors associated with MV in botulism patients from 2007 to 2022. Univariate analysis and multivariate logistic regression analysis were used to screen out risk factors for constructing a prognostic scoring system. The area under the receiver operating characteristic(ROC) curve was ***: A total of 153 patients with botulism(66 males and 87 females, with an average age of 4. years) were included. Of these, 4. patients(32.0%) required MV, including 21(13.7%) with invasive ventilation and 28(18.3%) with non-invasive ventilation. Multivariate analysis revealed that botulinum toxin type, pneumonia, incubation period, degree of hypoxia, and severity of muscle involvement were independent risk factors for MV. These risk factors were incorporated into a multivariate logistic regression analysis to establish a prognostic scoring system. Each risk factor was scored by allocating a weight based on its regression coefficient and rounded to whole numbers for practical utilization([botulinum toxin type A: 1], [pneumonia: 2], [incubation period ≤1 day: 2], [hypoxia mal threshold of 9, the scoring system achieved a sensitivity of 83.7% and a specificity of 70.2%.CONCLUSION: Our study identified botulinum toxin type, pneumonia, incubation period, degree of hypoxia, and severity of muscle involvement as independent risk factors for MV in botulism patients. A score ≥9 in our scoring system is associated with a higher likelihood of requiring MV in botulism patients. This scoring

关键词： Botulism Scoring system Botulinum toxin type Incubation period Hypoxia Pneumonia Severity of muscle involvement

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Unraveling the coordination behavior and transformation mechanism of Cr^(3+) in Fe–Cr redox flow battery electrolytes

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materials Reports(Energy) 2024年第2期4卷 54-63页

作者： Xiaojun Zhao Xinwei Niu Xinyuan Liu Chongchong Wu Xinyu Duan Zhiqi ma Yan Xu Hao Li Weijie Yang department of Electrical engineering North China Electric Power UniversityBaoding071003PR China department of Energy Power and mechanical engineering North China Electric Power UniversityBaoding071003PR China CNOOC Institute of Chemicals&Advanced materials Beijing102200PR China Shanghai LongVault Energy Technology Co. Ltd.Shanghai201615PR China Advanced Institute for materials Research(WPI-AIMR) Tohoku UniversitySendai980-8577Japan

Currently,the iron chromium redox flow battery(ICRFB)has become a research hotspot in the energy storage field owing to its low cost and ***,the activity of electrolyte is still ambiguous due to its complicated solution ***,we performed a pioneering investigation on the coordination behavior and transformation mechanism of Cr^(3+)in electrolyte and prediction of impurity ions impact through quantum chemistry *** on the structure and symmetry of electrostatic potential distribution,the activity of different Cr^(3+)complex ions is confirmed as[Cr(H2O)5Cl]^(2+)>[Cr(H2O)4.l2]+>[Cr(H2O)6]^(3+).The transformation mechanism between[Cr(H2O)6]^(3+)and[Cr(H2O)5Cl]^(2+)is *** find the metal impurity ions(especially Mg^(2+))can exacerbate the electrolyte deactivation by reducing the transformation energy barrier from[Cr(H2O)5Cl]^(2+)(24.38 kcal mol^(−1))to[Cr(H2O)6]^(3+)(16.23 kcal mol^(−1)).The solvent radial distribution and mean square displacement in different solvent environments are discussed and we conclude that the coordination configuration limits the diffusivity of Cr^(3+).This work provides new insights into the activity of electrolyte,laying a fundamental sense for the electrolyte in ICRFB.

关键词： Fe-Cr redox flow battery Coordination Electrolyte Quantum chemistry computation

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Triazine-based multicomponent metallacages with tunable structures for SO_(2) selective capture and conversion

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Aggregate 2024年第1期5卷 270-279页

作者： Ruoqian Zhang Dingyue Hu Yu Fu Qian Feng Chaoqun Mu Kai Gao Heping ma Ming Liu Mingming Zhang State Key Laboratory for mechanical Behavior of materials Shaanxi International Research Center for Soft MatterSchool of Materials Science and EngineeringXi’an Jiaotong UniversityXi’anP.R.China department of Chemistry Hangzhou Global Scientific and Technological Innovation Center(HIC)Zhejiang UniversityHangzhouP.R.China School of Chemical engineering and Technology Xi’an Jiaotong UniversityXi’anP.R.China

The design of novel materials for sulfur dioxide(SO_(2))capture and conversion with considerable efficiency under mild conditions is of great significance for human health and environmental protection yet highly ***,we report a series of triazine-based multicomponent metallacages via coordination-driven self-assembly of 2,4.6-tri(4.pyridyl)-1,3,5-triazine,cis-Pt(PEt3)2(OTf)2 and different tetracarboxylic *** the increase of the length of the tetracarboxylates,the structures of the metallacages change from pyramids to extended *** to their N-rich structure,these metallacages are further used for selective SO_(2)capture,showing good adsorption capacity and remarkable SO_(2)/CO_(2)selectivity in ambient conditions,suggesting their potential applications toward real flue gas *** metallacages are further employed for the conversion of SO_(2)into value-added compounds,showing exceptional efficiency even dilute SO_(2)is used as the *** study represents a type of structure-tunable triazinebased metallacages for SO_(2)capture and conversion,which will pave the way on the applications of metal-organic complexes for gas adsorption.

关键词： multicomponent metallacages self-assembly SO_(2) adsorption SO_(2) conversion tunable structures

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Bearing Fault Diagnosis Based on Deep Discriminative Adversarial Domain Adaptation Neural Networks

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Computer Modeling in engineering & Sciences 2024年第3期138卷 2619-2640页

作者： Jinxi Guo Kai Chen Jiehui Liu Yuhao ma Jie Wu Yaochun Wu Xiaofeng Xue Jianshen Li School of mechanical and Equipment engineering Hebei University of EngineeringHandan056000China College of mechanical engineering Anyang Institute of TechnologyAnyang455000China department of mechanical and Electrical engineering Yuncheng UniversityYuncheng044000China

Intelligent diagnosis driven by big data for mechanical fault is an important means to ensure the safe operation ofequipment. In these methods, deep learning-based machinery fault diagnosis approaches have received increasingattention and achieved some results. It might lead to insufficient performance for using transfer learning alone andcause misclassification of target samples for domain bias when building deep models to learn domain-invariantfeatures. To address the above problems, a deep discriminative adversarial domain adaptation neural networkfor the bearing fault diagnosis model is proposed (DDADAN). In this method, the raw vibration data are firstlyconverted into frequency domain data by Fast Fourier Transform, and an improved deep convolutional neuralnetwork with wide first-layer kernels is used as a feature extractor to extract deep fault features. Then, domaininvariant features are learned from the fault data with correlation alignment-based domain adversarial ***, to enhance the discriminative property of features, discriminative feature learning is embeddedinto this network to make the features compact, as well as separable between classes within the class. Finally, theperformance and anti-noise capability of the proposedmethod are evaluated using two sets of bearing fault *** results demonstrate that the proposed method is capable of handling domain offset caused by differentworkingconditions and maintaining more than 97.53% accuracy on various transfer tasks. Furthermore, the proposedmethod can achieve high diagnostic accuracy under varying noise levels.

关键词： Fault diagnosis transfer learning domain adaptation discriminative feature learning correlation alignment

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