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Cytochrome P4.026A1 Contributes to the maintenance of Neuropathic Pain

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Neuroscience Bulletin 2024年第3期40卷 293-309页

作者： De-Li Cao Ling-Jie ma Bao-Chun Jiang Qiang Gu Yong-Jing Gao Institute of Pain Medicine and Special Environmental Medicine Co-innovation Center of NeuroregenerationNantong UniversityNantong226019China Nantong university Medical School Nantong226001China department of Pain management The Affiliated Hospital of Nantong UniversityNantong226001China

The cytochrome P4.0 proteins(CYP4.0s)have been implicated in catalyzing numerous important biological reactions and contribute to a variety of ***26A1,a member of the CYP4.0 family,carries out the oxidative metabolism of retinoic acid(RA),the active metabolite of vitamin *** we report that CYP26A1 was dramatically upregulated in the spinal cord after spinal nerve ligation(SNL).CYP26A1 was mainly expressed in spinal neurons and *** analysis displayed that the content of all-trans-RA(at-RA),the substrate of CYP26A1,was reduced in the spinal cord on day 7 after *** of CYP26A1 by siRNA or inhibition of CYP26A1-mediated at-RA catabolism by talarozole relieved the SNL-induced mechanical allodynia during the maintenance phase of neuropathic *** also reduced SNL-induced glial activation and proinflammatory cytokine production but increased anti-inflammatory cytokine(IL-10)*** RA receptors RARα,RXRβ,and RXRγwere expressed in spinal neurons and glial *** promoter of Il-10 has several binding sites for RA receptors,and at-RA directly increased Il-10 mRNA expression in ***,intrathecal IL-10 attenuated SNL-induced neuropathic pain and reduced the activation of astrocytes and ***,the inhibition of CYP26A1-mediated at-RA catabolism alleviates SNL-induced neuropathic pain by promoting the expression of IL-10 and suppressing glial ***26A1 may be a potential therapeutic target for the treatment of neuropathic pain.

关键词： CYP26A1 Microglia Astrocytes ERK P38 IL-10 Neuropathic pain

Multi-stable straw-like carbon nanotubes for mechanical programmability at microscale

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International Journal of Smart and Nano materials 2024年第1期15卷 95-109页

作者： Jia Liu Yong ma Wanjie Ren Fei Pan Shu Guo Yuli Chen Bin Ding National Key Laboratory of Strength and Structural Integrity Institute of Solid MechanicsBeihang University(BUAA)BejingPR China Institute of Extreme Mechanics Northwestern Polytechnical UniversityXi'anShaanxiPR China Fuselage department Shanghai Aircraft Design and Research InstituteShanghaiPR China School of Vehicle and Energy Yanshan UniversityQinhuangdaoPR China

Inspired by macroscale 3D pixel mechanical metamaterials and microscale straw-like carbon nanotube,we propose a design of multi-stable straw-like carbon nanotubes(MSCNT)via optimizing the structure of a unit to obtain multiple stable states under dis-placement loading by molecular *** unit of MSCNT is mirror-symmetrically connected two truncated graphene cones with specific apex *** switching the LJ term in AIREBO potential,we verify that the bistability of unit is co-determined by snap-through instability and microscale ***,we examine the validity of the multi-stability of the unit cells arranged in series and in *** results indicate that the MSCNT can achieve mechanical programmability in microscale,which triggers many potential applications in need of customizing nanos-cale mechanical behaviors.

关键词： Multi-stable state straw-shaped carbon nanotube microscale adhesions mechanical programmability

A new fourth order finite difference scheme for the heat equation

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Communications in Nonlinear Science and Numerical Simulation 2000年第4期5卷 151-157页

作者： Yuehong QIAN, Hudong CHEN, Raoyang ZHANG and Shiyi CHEN (Exa Corporation, 4.0 Bedford Street, Lexington, ma 024.0, usa e-mail.. qean＠*** Deportment of mechanical engineering, Johns Hopkins university, Baltimore, MD 21280, usa) (Received December 1, Exa Corporation 450 Bedford Street Lexington MA 02420 United States department of mechanical engineering Johns Hopkins University Baltimore MD 21280 United States

We propose and investigate a new simple fourth order finite difference scheme for the heat equation. Numerical simulations do confirm theoretical analysis of accuracy and stability condition.

关键词： heat equation CFL condition stability high-order scheme

An exact, closed-form solution for equilibrium of trveling, sagged, elastic cables under uniformly distributed loading

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Communications in Nonlinear Science and Numerical Simulation 2000年第1期 6-11页

作者： Albert C. LUO and.C.DMOTE,Jr department of mechanical and Industrial engineering, Southern Illinois university Edwardsville, Edwardsville, IL 62034.1805,{4. e-mall:aluo @siue.edu Office of the President, main Administration. Building, university of ma

The exact, closed-form solution for equilibrium of traveling, sagged, elastic cables uniformly-distributed loading is derived. Three components of displacement describing two equilibria of an extensible, traveling, elastic cable are also obtained. Illustrations of equilibrium configuration, tension distribution and displacements of cables are given.

关键词： sagged cables equilibrium configuration tension distribution

Unveiling an S-scheme F–Co_(3)O_(4.@Bi_(2)WO_(6) heterojunction for robust water purification

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eScience 2024年第1期4卷 104-113页

作者： Linhan Jian Guowen Wang Xinghui Liu Hongchao ma School of Light Industry&Chemical engineering Dalian Polytechnic UniversityNo.1 QinggongyuanGanjingzi DistrictDalian 116034People's Republic of China department of Chemistry Sungkyunkwan University(SKKU)Jangan-GuSuwon 16419Republic of Korea Division of Research and Development Lovely Professional UniversityPhagwaraIndia Science and Technology on aerospace Chemical Power Laboratory Xiangyang 441003People's Republic of China Hubei Institute of aerospace Chemotechnology Xiangyang 441003People's Republic of China

Devising a desirable nano-heterostructured photoelectrode based on the charge transfer kinetics mechanism is a pivotal strategy for implementing efficient photoelectrocatalytic(PEC)technology,since the charge separation and utilization efficiency of a photoelectrode is critical to its PEC ***,we fabricate a F–Co_(3)O_(4.@Bi_(2)WO_(6) core–shell hetero-array photoanode by coupling Bi_(2)WO_(6) nanosheets with F–Co_(3)O_(4. nanowires using a simple solvothermal solution *** three-dimensional hierarchical heterostructure has a homogeneous chemical interface,helping it to promote an S-scheme-based carrier transport kinetics and maintain excellent cycling *** density difference calculations verify the electron migration trend from F–Co_(3)O_(4. to Bi_(2)WO_(6) upon hybridization and the formation of an internal electric field in the heterojunction,consistent with the S-scheme mechanism,which is identified by in situ irradiation X-ray photoelectron spectroscopy and by ultraviolet photoelectron *** optimized F–Co_(3)O_(4.@Bi_(2)WO_(6)-2 photoelectrode achieves high carrier utilization efficiency and exhibits superior PEC degradation performance for various organic pollutants,including reactive brilliant blue KN-R,rhodamine B,sulfamethoxazole,and bisphenol *** work not only reveals that F–Co_(3)O_(4.@Bi_(2)WO_(6)-2 is effective for PEC water remediation but also provides a strategy to enhance carrier transport kinetics by designing binary oxides.

关键词： S-scheme Internal electric field Bi_(2)WO_(6) Water purification Photoelectrocatalysis

An omnidirectional mobile robot

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Science China(Information Sciences) 2011年第12期54卷 2651-2658页

作者： YE ChangLong 1,2 , ma ShuGen 2,3 & HUI Li 1 1 School of Mechatronics engineering, Shenyang aerospace university, Shenyang 110136, China 2 State Robotics Laboratory, Shenyang Institute of Automation, Shenyang 110016, China 3 department of Robotics, Ritsumeikan university, Kusatsu 525-8577, Japan 1. School of Mechatronics engineering Shenyang Aerospace University Shenyang 110136 China2. State Robotics Laboratory Shenyang Institute of Automation Shenyang 110016 China3. Department of Robotics Ritsumeikan University Kusatsu 525-8577 Japan

A novel omnidirectional wheeled mobile robot, mainly composed of three special wheeled structures-MY wheel, is developed in this paper. Based on the movement principle of sphere, the sphere of the special wheel is divided into contact part and non-contact part. The function of the omnidirectional wheel is realized utilizing the mutual complementarities of the two parts of the sphere. The passive rotational axes of two parts of the sphere are in staggered arrangement to each other at an angle of 4. degrees to realize continuous contact with the ground. At the same time, this structure also improves the strength of omnidirectional wheel. It is verified by the kinematic analysis and simulation of the wheeled mobile mechanism that the mechanism can achieve the omnidirectional movement. It is also proved by the movement experiment of the mobile robot that the omnidirectional mechanism can not only achieve the omnidirectional movements but also step over obstacles.

关键词： omnidirectional mobile robot mechanism design kinematics

VISIOMETRICS OF 2D SHOCK-PLANAR S/F/S CURTAIN INTERACTIONS: VORTEX DOUBLE LAYERS, VORTEX PROJECTILES AND DECAYING STRATIFIED TURBULENCE

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Transactions of Nanjing university of Aeronautics and Astronautics 2001年第Z1期18卷 32-38页

作者： Norman J. Zabusky Shuang ZhangLaboratory of Visiometrics and Modeling,department of mechanical and aerospace engineering Laboratory of Visiometrics and Modeling.department of mechanical and aerospace engineering Rutgers {4. P.O. Box 909. Piscataway New Jersey 08855

Vortex double layers (VDLs) and vortex projectiles (VPs) are the essential coherent structures which emerge in the shock excited (s/f/s) planar parallel "curtain" simulations of a 2D shock tube with PPM. These opposite signed layers, formed by shock induced baroclinic deposition of vorticity, "ind" and are strongly affected by secondary reflected shocks and vortex interactions. In our visiometric mode of working, we quantify several of these processes and introduce time epochs to discuss the emerging phenomena and normalizations to scale (collapse) the data at M =1.5 and 2.0. This versatile configuration, easily obtained in the laboratory, allows us to study the formation, evolution and reacceleration of VPs and stratified turbulence and mixing.

关键词： visiometrics accelerated inhomogeneous flows (aifs) Richtmyer Meshkov shock curtain baroclinic vorticity generation vortex double layers (VDLs) vortex projectiles (VPs) stratified turbulence

3D Printed Polyimide/Silica Composite Aerogels for Customizable Thermal Insulation from-50℃ to 1300℃

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Chinese Journal of Polymer Science 2024年第7期42卷 936-945,I0007页

作者： Dingyi Yu Tiantian Xue Zhuocheng ma Zaiyin Hu Lijuan Long Yue-E Miao Wei Fan Tianxi Liu State Key Laboratory for Modification of Chemical Fibers and Polymer materials College of Materials Science and EngineeringDonghua UniversityShanghai201620China Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi214122China Guizhou aerospace Wujiang Electro-mechanical Equipment Co. Ltd.Zunyi563000China School of materials and Architectural engineering Guizhou Normal UniversityGuiyang550025China

Aerogels are widely used as thermal insulation materials because of their high porosity and low bulk ***,the insulation performance of aerogels is limited to a narrow temperature ***,the preparation of aerogel materials with precisely controlled and complex architectures is still ***,we report 3D printed polyimide/silica aerogel particle(PI/SAP)composite aerogels for thermal insulation in a wide range of temperature with customized *** printability and shape fidelity of 3D printed composite aerogels is improved by adding hydrophilic SAP as a rheology *** resulting PI/SAP composite aerogel exhibits excellent flame-retardant properties and thermal insulation from-50℃ to 1300℃.Moreover,the PI/SAP composite aerogel with customized shape can be applied for battery insulation at subzero temperatures,promising to be used as customizable and stable insulating materials in a variety of complex and extreme applications.

关键词： 3D printing Polyimide Aerogel Silica Thermal insulation

A review of linear friction welding of Ni -based superalloys

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International Journal of Minerals,Metallurgy and materials 2024年第6期31卷 1382-1391页

作者： Xiawei Yang Tingxi Meng Qiang Chu Yu Su Zhenguo Guo Rui Xu Wenlong Fan Tiejun ma Wenya Li State Key Laboratory of Solidification Processing Shaanxi Key Laboratory of Friction Welding TechnologiesNorthwestern Polytechnical UniversityXi’an 710072China Xi’an aerospace Engine Co.Ltd. Xi’an 710100China

Ni-based superalloys are one of the most important materials employed in high-temperature applications within the aerospace and nuclear energy industries and in gas turbines due to their excellent corrosion,radiation,fatigue resistance,and high-temperature *** friction welding(LFW)is a new joining technology with near-net-forming characteristics that can be used for the manu-facture and repair of a wide range of aerospace *** paper reviews published works on LFW of Ni-based superalloys with the aim of understanding the characteristics of frictional heat generation and extrusion deformation,microstructures,mechanical proper-ties,flash morphology,residual stresses,creep,and fatigue of Ni-based superalloy weldments produced with LFW to enable future optim-um utilization of the LFW process.

关键词： Ni-based superalloys linear friction welding microstructures mechanical properties flash morphology