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Asymmetric encryption and signature method with DNA technology

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science China(Information sciences) 2010年第3期53卷 506-514页

作者： LAI XueJia1, LU MingXin2, QIN Lei3, HAN Junsong4.& FANG XiWen11Department of Computer science & Engineering, shanghai Jiao Tong University, shanghai 200030, China 2school of National Information security, Nanjing University, Nanjing 210093, China 3BIOCOMPLEX, 4.15 Bathurst st. Unit# 209-366, ON M2R 1X9, Canada 4.ational Engineering center for BioChip at shanghai, shanghai 201203, China 1. Department of Computer science & Engineering Shanghai Jiao Tong University Shanghai 200030 China2. School of National Information Security Nanjing University Nanjing 210093 China3. BIOCOMPLEX 4915 Bathurst St. Unit# 209-366 Toronto ON M2R 1X9 Canada4. National Engineering Center for BioChip at Shanghai Shanghai 201203 China

This paper proposes DNA-PKC, an asymmetric encryption and signature cryptosystem by combining the technologies of genetic engineering and cryptology. It is an exploratory research of biological cryptology. similar to conventional public-key cryptology, DNA-PKC uses two pairs of keys for encryption and signature, respectively. Using the public encryption key, everyone can send encrypted message to a specified user, only the owner of the private decryption key can decrypt the ciphertext and recover the message; in the signature scheme, the owner of the private signing key can generate a signature that can be verified by other users with the public verification key, but no else can forge the signature. DNA-PKC differs from the conventional cryptology in that the keys and the ciphertexts are all biological molecules. The security of DNA-PKC relies on diffcult biological problems instead of computational problems; thus DNA-PKC is immune from known attacks, especially the quantum computing based attacks.

关键词： cryptology asymmetric encryption digital signature biological cryptology DNA

Cytoplasmic auxin signaling

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Cytoplasmic auxin signaling

从植物科学到农业发展——2012全国植物生物学大会

作者： Zhenbiao Yang Department of Botany and Plant sciences and center for Plant Cell Biology,University of California at Riverside,CA 92521,UsA shanghai Institute of Plant Physiology and Ecology,shanghai Institutes of{4. sciences,chinese academy of sciences,shanghai,China.

Auxin regulates the formation of various developmental and morphogenetic patterns in plants,but the molecular and cellular mechanisms for the auxin actions are not well *** investigate these mechanisms using Arabidopsis leaf epidermal pavement cells(PCs) as a model system,which form the jigsaw puzzle cell pattern with interdigitated lobes and *** have shown that pavement cell interdigitation is controlled by localized ROP GTPase signaling,which impinges on the organization of cortical actin microfilaments and microtubules to generate interdigitating lobes and *** recent studies indicate that auxin is a signal that activates the generation of multi-polarity to form lobes in pavement cells and coordinates lobe formation with indentation formation by activating ROP GTPase signaling through an Auxin-Binding Protein 1(ABP1) dependent auxin perception *** cytoplasmic auxin signaling system,which is distinct from the well-established TIR1-dependent nuclear auxin signaling system that regulates gene transcription,modulates local coordination of lobe and indentation formation within a PC and between adjacent PCs through its modulation of PIN protein *** ROP-based cytoplasmic auxin signaling also regulates the subcellular distribution of PINs in root cells,supporting a widespread role for this new auxin signaling system in plants 4. Recent findings of additional components in this new auxin signaling system will be discussed.

关键词： AUXIN sIGNALING ABP1 PIN1 PIN2

Recognition of Gene Acceptor site Based on Multi-objective Optimization

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Acta Biochimica et Biophysica sinica 2005年第7期37卷 435-439页

作者： Jing ZHAO~(1,3,4. Yue-Min ZHU~2 Pei-Ming sONG~1 Qing FANG~1 Jian-Hua LUO~(1,3) 1 school of Life science & Technology,shanghai Jiaotong University,shanghai 20024.,China 2 CREATIs,CNRs UMR 5515,INsA Lyon,69621 Villeurbanne Cedex,France 3 shanghai center for{4. and Technology,shanghai 200235,China 4.Logistical Engineering University,Chongqing 4.0016,China schoolofLifescience&Technology ShanghaiJiaotongUniversityShanghai200240China

A new method for predicting the gene acceptor site based on multi-objective optimization isintroduced in this *** models for the acceptor,branch and distance between acceptor site andbranch site were constructed according to the characteristics of the sequences from the exon-intron databaseand using common biological *** acceptor function,branch function and distance functionwere defined respectively,and the multi-objective optimization model was constructed to recognize thesplice *** test results show that the algorithm used in this study performs better than the splicePredictor,which is one of the leading acceptor site detectors.

关键词： multi-objective optimization acceptor site recognition

香樟树种子中两种Ⅱ型核糖体失活蛋白凝集素活性的研究

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生物化学与生物物理进展 2004年第7期31卷 650-654页

作者：杨海燕李荣秀刘望夷中国科学院上海生命科学研究院生物化学与细胞生物学研究所中国科学院上海生命科学研究院生物工程研究中心

从香樟树成熟的种子分离到两种新的Ⅱ型核糖体失活蛋白 :新丰毒蛋白和辛纳毒蛋白 .两者A链的分子质量虽然相差近一倍 ,但B链的分子质量相同 .Ⅱ型核糖体失活蛋白的A链是RNAN 糖苷酶 ,B链是凝集素 ,A链进入细胞表现毒性在很大程度上依赖... 详细信息

从香樟树成熟的种子分离到两种新的Ⅱ型核糖体失活蛋白 :新丰毒蛋白和辛纳毒蛋白 .两者A链的分子质量虽然相差近一倍 ,但B链的分子质量相同 .Ⅱ型核糖体失活蛋白的A链是RNAN 糖苷酶 ,B链是凝集素 ,A链进入细胞表现毒性在很大程度上依赖于B链的糖结合活性和特异性 .对辛纳毒蛋白和新丰毒蛋白B链的凝集素活性进行了测定和比较 .红细胞凝集实验显示辛纳毒蛋白和新丰毒蛋白具有相同的细胞凝集活性 ,半抗原抑制实验发现它们都属于半乳糖型核糖体失活蛋白 ,荧光光谱法显示它们的糖结合常数也相同 .

关键词：新丰毒蛋白辛纳毒蛋白凝集素荧光光谱法

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structure-based drug design of a novel family of chalcones as PPARα agonists:virtual screening,synthesis,and biological activities in vitro

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Acta Pharmacologica sinica 2007年第12期28卷 2040-2052页

作者： Xiang-hua LI~(2,3),Han-jun ZOU~(2,3),An-hui WU~2,Yang-liang YE~2,Jian-hua sHEN~(2,4.~2 Drug Discovery and Design center,state Key Laboratory of Drug Research,shanghai Institute of Materia Medica,chinese academy of{4.,shanghai 201203,China Drug Discovery and Design center State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy oj SciencesShanghai 201203China

Aim:To design and synthesize a novel class of peroxisome proliferator-activatedreceptors (PPAR)α agonists,which is obtained by the combination of the classi-cal fibrate"head group",a linker with appropriate length and a ***:Thirty seven compounds were designed and identified employing the virtualscreening *** compounds were then selected for synthesis and bioas-say according to the virtual screening results,structural similarity,and ***:six new compounds (4. and 4.-h) were synthesized *** were found to be potent PPARα agonists,compound 4.h being themost prominent with a 50% effective concentration value of 0.06 μmol/***:This study provides a promising novel family of chalcones with a potentialhypolipidemic effect.

关键词： peroxisome proliferator-activated receptors drug design virtual screening

Characterization of structural Genes Involved in Anthocyanin Biosynthesis in sweet Potato(Ipomoea batatas Lam.)

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Characterization of Structural Genes Involved in Anthocyanin...

2011全国植物生物学研讨会

作者： Hongxia Wang~a,Peng Zhang~(a,b) a Institute of Plant Physiology & Ecology,shanghai Institutes for biological sciences,chinese{4. of sciences,300 Fenglin Road,shanghai 200032,China b Chenshan Plant science Research center,chinese{4. of sciences,Chenshan Botanical Garden,3888 Chenhua Road,shanghai 201602,China

Purple sweet potato accumulates a high amount of anthocyanins,which are mainly composed of non-,mono-,and diacylated gluocosides of cyanidin and *** the function of anthocyanins from purple sweet potato has been well studied in food and pharmaceutical products,the biosynthesis of anthocyanins in the crop is still largely *** this study,four structural genes involved in anthocyanin biosynthesis,flavanone 3-hydroxyrase(F3H), dihydroflavonol 4.reductase(DFR),anthocyanidin synthase(ANs),and glucosyltransferase(GT),were cloned from the purple cultivar Ayamurasaki and intensively ***-expression of the full-length cDNAs of DFR,F3H,ANs

关键词： sweet potato anthocyanin biosynthesis expression regulation flavonoids

Refined Phylogenetic Profiles Method for Predicting Proteinprotein Interaction

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Refined Phylogenetic Profiles Method for Predicting Proteinp...

中国蛋白质组学第二届学术大会

作者： Jingchun sun, Zhen Liu, Qi Liu, Jinlin Xu, Tieliu shi, Yixue Li (school of Life science & Technology, shanghai Jiaotong University, shanghai, 20024., China Departments of Biology, Hunan Normal University, Changsha, 4.0081, China bioinformation center, shanghai Institutes for biological sciences, chinese academy of sciences, shanghai 2.0031, China)

Many aspects of cellular biology involve protein-protein interactions and comprehensively identifying them is important to systematically understand the biological mechanisms such as molecular mechanisms of metabolic or signal pathway and the construction of complexes. The availability of increasing completely sequenced genomes makes the in silico or experiment based reverse proteomics methods to detect protein-protein interaction popular, such as widely used yeast two-hybrid test, gene neighbor method, gene fusion method and the phyloge netic profiles method and so on.

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Neuron-specific knockout of NRsF mouse is more vulnerable to the dopaminergic neurotoxin MPTP

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Neuron-specific knockout of NRSF mouse is more vulnerable to...

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Mei YU~(1,#),Ming LIU~(2,#),Hai-Yun sUO~1,Lei CAI~2,Jian FEI~(3,4.*) Fang HUANG~(1,*) 1 National Key Laboratory of Medical Neurobiology,shanghai Medical College,Fudan University,shanghai 200032, China 2 Institutes of Biochemistry and Cell Biology,shanghai Institutes for biological{4.,chinese academy of{4. 3 school of Life science and Technology,Tongji Universities,shanghai 200092,China 4.shanghai Nan Fang Model Organism Research center,shanghai 201203,China

Recent studies on neuron-restrictive silencer factor(NRsF) / neuronal repressor element-1 silencing transcription factor(REsT) have revealed that NRsF participates in the pathological processes of nervous system diseases,such as global ischemia,epilepsy and Huntington *** l-methyl-4.phenyI-pyridinium ion(MPP) treatment triggers the mRNA and protein expression of NRsF in human dopaminergic sH-sY5Y cells,and alteration of NRsF expression exacerbates MPP-induced cell ***,we generated a neuron-specific conditional knockout mice of NRsF(cKO) by crossing NRsF floxed mice with the neuron-specific enolase(NsE)-Cre transgenic *** or wild type mice were injected with l-methyl-4.phenyl-l,2,3,6-tetrahydropyridine(MPTP) at a dose of 15mg/kg,four times within two days,and behavioral assays were performed respectively on 1,3,7,14.21 and 28 days after the last MPTP *** were sacrificed one day after the last behavioral *** levels of DA,its metabolite 3,4.dihydroxiphenylacetic acid (DOPAC),and 5-hydroxytryptamine(5-HT) or non-relevant 5-hydroxyindoleacetic acid(5-HIAA) in striatum were analyzed by ***,the protein level of tyrosine hydroxylase(TH) in striatum was detected by Western blotting *** results showed that in the experiment of swim test,the force swimming time in both cKO and wild type mice was obviously decreased after MPTP administration,but the rate of decline in the cKO mice was higher than that in the wild type *** intoxication reduced the levels of DA,DOPAC and 5-HT in cKO and wild type mice significantly. The ratio of decrease in the cKO mice was more dramatic than that in the wild type *** the same situation happened at the level of TH in *** results suggested that neuron-specific knockout of NRsF mouse is more vulnerable to the dopaminergic neurotoxin MPTP.

关键词： NRsF MPTP conditional knockout mouse NsE promoter Parkinson’s disease

QTL Mapping for 1,000- Grain Weight in RILs of Rice

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QTL Mapping for 1,000- Grain Weight in RILs of Rice

第十二届全国植物基因组学大会

作者： Junping shi,Lu Wang,Bin Han~*,Ahong Wang National center For Gene Research and Institute of Plant Physiology and Ecology,shanghai Institutes of biological sciences,{4.,shanghai 200233,China

Rice(Orvza sativa L.) is one of human’s major food staples,and 1,000-grain weight(TGW) which is determined by grain length,width,thickness and filling rate is a vital component of grain *** identify the genes conditioning this trait and reveal the molecular mechanism of them,we carried out a quantitative trait locus(QTL) mapping with 150 rice recombinant inbred lines(RILs) which were developed from a cross between Nipponbare(japonica,low TGW) and 93-11(indica,high TGW).4.QTLs were detected;two localized on chromosome 5,the other two localized on chromosome 8 and 10,*** we focused on a ma-

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