检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

中建滨湖设计总部,成都,四川,中国

世界建筑 2024年第4期 16-19页

作者： china Southwest Architectural Design and Research institute Corp. Ltd. 中国建筑西南设计研究院有限公司

作为西南地区首个近零能耗建筑项目,中建滨湖设计总部从地域气候适应性的节能研究出发,考虑冬夏不同工况,突破体型系数的限制,提出了夏热冬冷地区超低能耗建筑设计的理论及方法。项目综合运用被动式策略、主动式技术与可再生能源,结合... 详细信息

作为西南地区首个近零能耗建筑项目,中建滨湖设计总部从地域气候适应性的节能研究出发,考虑冬夏不同工况,突破体型系数的限制,提出了夏热冬冷地区超低能耗建筑设计的理论及方法。项目综合运用被动式策略、主动式技术与可再生能源,结合工业化技术与新材料研发,最终实现形式空间、建筑技术与能耗性能的良好匹配。

关键词：可再生能源工业化技术体型系数气候适应性新材料研发西南地区

FORM AND EFFECT OF Zr IN CuCoBeZr ALLOY

在线全文

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 1993年第3期6卷 153-156页

作者： LIU Hefa SUN Naizhen DAI Xueli REN He Zhenjiang Shipbuilding institute,Zhenjiang,jiangsu,chinaLI Lijun Shanghai,Electrical Machinery Plant.Shanghai.china professor.institute of Metallic Materials Research,Zhenjiang Shipbuilding institute,Zhenjiang,jiangsu 212003,china Zhenjiang Shipbuilding Inst Zhenjiang China

Precipitation form of Zr in CuCoBeZr alloy during *** and final aging,as well as its effect on the high temperature properties have been studied and *** show that during solidificotion and *** precipitates as fine ***_3Zr,which pre- vents X-Cu grains from growing and provides more nuclei for CoBe and hence leads to finer primary *** Cu_3Zr partrticles also precipitate during aging. Because Co_3Zr is difficult to coalesce at high temperatures,the recrystallization temper- uture increases and the high temperature mechanical properties improve.

关键词： CuCoBeZr alloy Zr

Molecular Analysis of the Huntington's Disease with Expanded CAG Trinucleotide Repeat in Chinese

在线全文

学校读者我要写书评

暂无评论

High Technology Letters 1995年第1期1卷 5-9页

作者： Zeng Yitao Mao Yuehua Chen Meijue Ren Zhaorui Zhou Gang Huang Shuzhen (Shanghai institute of Medical Genetics,Shanghai Children’s Hospital,Shanghai 200040,P.R.china) Wang Xiuying~① Yie Wenghu~② Zhao Xiangzhi~③ (①xuzhou Medical College,xuzhou,jiangsu,P.R.china) (②Anhui Medical University,Aanhui,P.R.china) (③Henan Psychiatrical institute,Zhengzhou,P.R.china) Shanghai Inst of Medical Genetics Shanghai China

The polymorphic CAG repeats in the IT15 gene in Chinese normal and Huntington’s dis-ease(HD)chromosomes were determined by using nested PCR and denaturing polyacry-lamide gel electrophoretic autoradiography as well as direct sequencing analysis.A total of40 normal individuals and 122 members of 13 unrelated HD families originating from Shang-hai,jiangsu,Zhejiang,Anhui,Shandong,Guangdong and Henan,respectively,were in-volved in this *** results showed that the(CAG)n repeat numbers in 270 normal al-leles ranged from 13 to 26 but most in 16;while in 54 HD alleles,the CAG repeats from 40to 94,with an unstable inheritance of expanded repeats in some *** was no over-lap between the normal and affected ***,the presymptomatic diagnosis in103 family members at risk for HD disclosed that 35 individuals had HD alleles,which were-in accordance with the pedigree analysis and clinical *** these results indicatedthat the dynamic mutation in IT15 gene was responsible for the genetic defect in the ChineseHD patients and that a correlation existed between the numbers of(CAG)n repeat and theonset age of the ***-of these provide valuable data for HD molecular diagnosis,ge-netic counselling and genetic health.

关键词： Huntington’s disease (HD) IT15 gene trinucleotide repeat.

Report on Cardiovascular Health and Diseases in china 2023:An Updated Summary

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2024年第9期37卷 949-992页

作者： National Center for Cardiovascular Diseases The Writing Committee of the Report on Cardiovascular Health and Diseases in china Shengshou Hu .

Since 1990,china has made considerable progress in resolving the problem of“treatment difficulty”of cardiovascular diseases(CVD).The prevalent unhealthy lifestyle among Chinese residents has exposed a massive proportion of the population to CVD risk factors,and this situation is further worsened due to the accelerated aging population in *** remains one of the greatest threats to the health of Chinese *** terms of the proportions of disease mortality among urban and rural residents in china,CVD has persistently ranked *** 2021,CVD accounted for 48.98%and 47.35%of deaths in rural and urban areas,*** out of every five deaths can be attributed to *** implement a national policy“focusing on the primary health institute and emphasizing prevention”and truly achieve a shift of CVD prevention and treatment from hospitals to communities,the National Center for Cardiovascular Diseases has organized experts from relevant fields across china to compile the“Report on Cardiovascular Health and Diseases in china”annually since *** 2024 report is established based on representative,published,and high-quality big-data research results from cross-sectional and cohort population epidemiological surveys,randomized controlled clinical trials,large sample registry studies,and typical community prevention and treatment cases,along with data from some projects undertaken by the National Center for Cardiovascular *** firsthand data not only enrich the content of the current report but also provide a more timely and comprehensive reflection of the status of CVD prevention and treatment in china.

关键词： Cardiovascular disease Risk factor Prevalence Mortality Rehabilitation Basic research Medical device development Health economics

Gene flow from genetically modified herbicide-resistant rapeseed to cruciferous weeds

在线全文

学校读者我要写书评

暂无评论

Progress in Natural Science:Materials International 2006年第9期16卷 936-941页

作者： ZHAO Xiangxiang, XIA Qiuxia, LU Dalei, LU Weiping , QI Cunkou, PU Huiming, LIU Geshan, ZHAO Jian and WANG Youping ( jiangsu Provincial Key Laboratory of Crop Genetics and Physiology, Yangzhou University, Yangzhou 225009, china institute of Industrial Crops, jiangsu Academy of Agricultural Sciences, Nanjing 210014, china jiangsu Entry-Exit Inspection and Quarantine Bureau of People's Republic of china, Nanjing 210001, china College of Bioscience and Biotechnology, Yangzhou University, Yangzhou 225009, china) jiangsu Provincial Key Laboratory of Crop Genetics and Physiology Yangzhou University Yangzhou 225009 China institute of Industrial Crops Jiangsu Academy of Agricultural Sciences Nanjing 210014 China jiangsu Entry-Exit Inspection and Quarantine Bureau of People's Republic of china Nanjing 210001 China College of Bioscience and Biotechnology Yangzhou University Yangzhou 225009 China

The sexual compatibility between genetically modified (GM) glyphosate-resistam rapeseed variety Q3 (Brassica napus L. ) and 5 cruciferous weeds is studied through the observation of fluorescence microscopy and cross-fertility after manual pollination. The results indicated that Q3 (as male) was highly incompatible with Thlaspi arvense L., Capsella bursa-pastoris (L. ) Medic, Cardamine hirsuta L. and Rorippa palustris (L. ) Besser (as female). Fluorescence microscopic observation showed that growing of pollen tubes terminated on the stigma surface or at the upper 1/3 part of the style. However, B. juncea×Q3 was compatible, and the compatibility index was 1.65. Under the neighboring growth and natural pollination conditions, the rates of gene flow from Q3 to T. arvense, C. bursa-pastoris, C. hirsute and R. palustris were all 0, while it was 0.86 % for B. juncea. These results indicate that there is difference in the rate of gene flow between GM rapeseed and cruciferous wild weeds, and frequency of gene flow is highly correlated with sexual compatibility.

关键词： herbicide-resistant rapeseed craciferous weeds aniline blue fluorescence interspecific hybridization sexual compatibility gene flow.

SLIP SYSTEMS AND DISLOCATION DISTRIBUTION IN α-PHASE OF SUPERPLASTICALLY DEFORMED Ti-6AI-4V ALLOY

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 1990年第4期3卷 256-261页

作者： ZHAO Linruo ZHANG Shaoqing YAN Minggao institute of Aeronautical Materials,Beijing,china Lab.No.4,Beijing institute of Aeronautical Materials,Beijing 100095,china

The activated slip systems in the α-phase of the superplastically deformed Ti-6Al-4V alloy were analyzed by systematic operation method with *** results show that the dominately activated slip systems in the α-phase are{01(?)0}〈2(?)0〉and{01(?)}2(?)0〉, The{0001}〈2(?)0〉system as well as the c+a dislocalions of b=[1/3]〈11(?)3〉will be acti- vated when the deformation temperature is *** amounts of TEM observations in- dicate that the dislocations in the α-phase were mainly activated near the triple grain bounda- ry junctions,α/α grain boundaries and α/β interlaces.

关键词： titanium alloy superplastic deformation dislocation

林克明旧居修缮与活化利用,广州,广东,中国

在线全文

学校读者我要写书评

暂无评论

世界建筑 2024年第8期 64-69页

作者： Guangdong Architectural Design and Research institute Group Co.,Ltd. Architectural Design and Research institute of South china University of Technology 广东省建筑设计研究院集团股份有限公司华南理工大学建筑设计研究院有限公司

街区断点更新林克明旧居(简称旧居)1935年由中国第一代著名建筑师林克明设计建造。旧居所在的越秀北路原为民国初年广州城墙拆除后的城基路,城外即东濠涌,前后高差达8m。林克明巧妙地利用地形组织功能与空间,并采用摩登建筑理念,使建筑... 详细信息

街区断点更新林克明旧居(简称旧居)1935年由中国第一代著名建筑师林克明设计建造。旧居所在的越秀北路原为民国初年广州城墙拆除后的城基路,城外即东濠涌,前后高差达8m。林克明巧妙地利用地形组织功能与空间,并采用摩登建筑理念,使建筑形体呈现出迷人的风采。

关键词：建筑形体建筑理念活化利用功能与空间著名建筑师林克明修缮城墙

Genistein stimulates osteoblastic differentiation via p38 MAPK-Cbfa1 pathway in bone marrow culture

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2007年第10期28卷 1597-1602页

作者： Qing-chuan LIAO~2,Zhou-sheng XIAO~(4,5),Yan-fang QIN~3,Hong-hao ZHOU~4~2 Affiliated Children's Hospital,Nanjing Medical University,Nanjing 210008,china,~3 Department of Pathology,School of Medicine,JinanUniversity,Guangzhou 510632,china ~4 institute of Clinical Pharmacology,Central South University,Changsha 410078,china Affiliated Children's Hospital Nanjing Medical University Nanjing China institute of Clinical Pharmacology Central South University Changsha China Department of Pathology School of Medicine Jinan University Guangzhou China

Aim:To test the hypothesis that genistein stimulates the osteoblastic differentia-tion through the p38 mitogen activated protein kinase (MAPK)-core-binding fac-tor 1 (Cbfa1) ***:The activation of p38 MAPK was detected byWestern *** phosphatase (ALP) activity and calcium depositionwere assessed for osteoblastic differentiation of bone marrow-derived mesenchy-mal stem cell (BMSC) *** expression of Cbfa1 was analyzed at both themRNA and protein *** activity of Cbfa1 was detected by electrophoreticmobility shift *** sialoprotein (BSP),ALP,osteocalcin (OC),andosteopontin (OPN) gene transcription were also evaluated by either RT-PCR orNorthern ***:Genistein (0.01-1 μmol/L) dose dependently led tothe rapid and sustained activation of the p38 MAPK pathway in mouse *** with genistein (1 μmol/L) resulted in increased ALP activityand calcium deposition of BMSC cultures as a function of *** alsoenhanced Cbfa1 DNA binding activity and promoted the expressions of Cbfa1itself as well as several Cbfa1-regulated genes,including ALP,BSP,OC,and *** treatment with p38 MAPK inhibitor (SB203580) diminished thegenistein-induced osteoblastic maturation and p38 MAPK-Cbfa1 activation inmouse BMSC ***:These results indicated that genistein couldstimulate the osteoblastic differentiation of BMSC cultures through the p38MAPK-Cbfa1 pathway.

关键词： bone marrow-derived mesenchymal stem cells core-binding factor 1 osteoblastic differentiation genistein mitogen-activated protein kinase

Expression,Characterization and Immunogenicity of a Major Outer Membrane Protein from Vibrio alginolyticus

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Biochimica et Biophysica Sinica 2007年第3期39卷 194-200页

作者： Ronghua QIAN~(1,2) Wuying CHU~3 Zhijuan MAO~(1,4) Chongwen ZHANG~(1,2) Yongwei WEI~2 Lian YU~2* 1 Department of Biomedical Engineering,Zhejiang University,Hangzhou 310027,china 2 institute of Preventive Veterinary Medicine,Zhejiang University,Hangzhou 310029,china 3 institute of Subtropical Agriculture,Chinese Academy of Sciences,Changsha 410125,china 4 Ningbo Oceanography and Fishery institute,Ningbo 315012,china Department of Biomedical Engineering Zhejiang UniversityHangzhou 310027 China institute of Preventive Veterinary Medicine Zhejiang UniversityHangzhou 310029 China institute of Subtropical Agriculture Chinese Academy of SciencesChangsha 410125 China Ningbo Oceanography and Fishery instituteNingbo 315012 China

Vibrio alginolyticus is one of the Vibrio pathogens common to humans and marine *** infection and induction of the host immune response,outer membrane proteins of bacteria play animportant *** this study,an outer membrane protein gene(ompW)was cloned from *** andexpressed in Escherichia *** 645 bp open reading frame(ORF)encodes a protein of 214 amino acidresidues with a predicted molecular weight of 23.3 *** amino acid sequence showed a high identitywith that of Photobacterium damselae(96.2%)and Vibrio parahaemolyticus(94.4%).The alignment analy-sis indicated that OmpW was highly *** dodecyl sulfate-polyacrylamide gel electrophoresisshowed that the gene was over-expressed in *** BL21(DE3).Western blot analysis revealed that theexpressed protein had *** recombinant protein was purified by affinity chromatographyon Ni-NTA Superflow *** yellow croaker vaccinated with the purified OmpW showed significantlyincreased antibody to OmpW,which could resist the infection by ***.A specific antibody wasdetected by enzyme-linked immunosorbent *** study suggested that the conserved OmpW could bean effective vaccine candidate against infection by ***.

关键词： Vibrio alginolyticus ompW expression characterization immunogenicity vaccine candidate