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Overcoming multidrug resistance(MDR) in cancer by nanotechnology

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Science china Chemistry 2010年第11期53卷 2226-2232页

作者： BU HuiHui,GAO Yu & LI YaPing shanghai institute of Materia Medica,chinese academy of sciences,shanghai 201203,china 1. shanghai institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China

The emerging nanotechnology-based drug delivery holds tremendous potential to deliver chemotherapeutic drugs for treatment of multidrug resistance(MDR) *** drug delivery system could improve the pharmacokinetic behavior of antitumor drugs,deliver chemotherapeutic drugs to target sites,control release of drugs,and reduce the systemic toxicity of drugs in MDR *** review addresses the use of nanotechnology to overcome MDR classified on the bases of the fundamental mechanisms of MDR and various approaches to deliver drugs for treatment of MDR cancer.

关键词： nanotechnology nanoparticles multidrug resistance chemotherapeutic drugs cancer drug delivery system

Entropy of Dilatonic Black Hole due to Arbitrary Spin Fields

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chinese Journal of Astronomy and Astrophysics 2001年第4期1卷 357-364页

作者： You-Gen Shen and Chang-Jun Gao (shanghai Astronomical Observatory, chinese academy of sciences, shanghai 200030 National Astronomical Observatories, chinese academy of sciences, Beijing 100012 institute of Theoretical physics, chinese academy of Scienc institute of Theoretical physics Chinese Academy of Sciences Beijing 100080

Using the membrane model based on the brick-wall model, we calculate the free energy and entropy of dilatonic black hole due to arbitrary spin fields. The result shows that the entropy of scalar field and the entropy ... 详细信息

关键词： black hole physics - entropy - spin

Central simple Poisson algebras

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Science china Mathematics 2004年第2期47卷 245-263页

作者： SU Yucai & XU XiaopingDepartment of Mathematics, shanghai Jiaotong University, shanghai 200030, china institute of Mathematics, academy of Mathematics and System sciences, chinese academy of sciences, Beijing 100080, china 1.Department of Mathematics Shanghai Jiaotong University 200030 Shanghai China 2.Institute of Mathematics Academy of Mathematics and System Sciences Chinese Academy of Sciences 100080 Beijing China

Poisson algebras are fundamental algebraic structures in physics and symplectic geometry. However, the structure theory of Poisson algebras has not been well developed. In this paper, we determine the structure of the central simple Poisson algebras related to locally finite derivations, over an algebraically closed field of characteristic *** Lie algebra structures of these Poisson algebras are in general not finitely-graded.

关键词： Poisson algebra, locally-finite operator, derivation, finitely-graded, isomorphism class.

Microstructure and Properties of Plasma Spraying Boron Carbide Coating

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Journal of Materials Science & Technology 2000年第1期16卷 63-66页

作者： Yi ZENG, Jingwei FENG and Chuanxian DING (shanghai institute of Ceramics, chinese academy of sciences, 1295 Dingxi Road, shanghai 200050, china) shanghai institute of Ceramics Chinese Academy of Sciences 1295 Dingxi Road Shanghai 200050 China

Microstructure of plasma spray boron carbide coating was studied by SEM and TEM. Its physical, mechanical and electrical properties were measured. The results showed that high microhardness, modulus and low porosity of B4C coating were manufactured by plasma spray. It was lamellar packing and dense. The B4C coating examined here contained two principal structures and two impurity phase besides major phase. The relatively small value of Young's modulus, comparing with that of the bulk materials, is explained by porosity . The Fe impurity phase could account for the relatively high electrical conductivity of boron carbide coating by comparing with the general boron carbide materials.

关键词： Microstructure and Properties of Plasma Spraying Boron Carbide Coating

Morphological characteristics of α-Al_2O_3 crystallites obtained directly from hydro/solvothermal solvents

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chinese Science Bulletin 1998年第2期43卷 163-166页

作者： WANG Buguo, TIAN Mingyuan, SHI Erwei, ZHONG Weizhuoand GUO Jingkun shanghai institute of Ceramics, chinese academy of sciences, shanghai 201800, china shanghai institute of Ceramics Chinese Academy of Sciences Shanghai China

The morphological characteristics of α_Al-2O-3 crystallites obtained directly from hydro/solv othermal solvents are reported and the formation mechanisms of corundum morphology are discussed from crystal growth and crystal chemistry principles. The crystal growth process is considered as a process of incorporation of growth units on the growth interfaces, and the crystal morphology is determined by the linkage of the coordinated polyhedra.

关键词： hydrothermal crystallization α_Al-2O-3 crystallites morphology growth mechanisms.

Change of proton motive force across thylakoid membrane in soybean leaf during state transitions

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chinese Science Bulletin 2003年第7期48卷 652-657页

作者： SU Jihu & SHEN Yungang shanghai institute of Plant Physiology, chinese academy of sciences, shanghai 200032, china 1. shanghai institute of Plant Physiology Chinese Academy of Sciences Shanghai 200032 China

Change of proton gradient across thylakoid membrane in soybean leaves was studied with millisecond delayed light emission (ms-DLE) during the course of state transitions which were indicated by the chlorophyll fluores-cence at room temperature and 77 K. When dark-adapted leaves were induced to stateⅠ with far-red light, Fm/Fo, F685/F735 and the intensity of fast phase of ms-DLE were af-fected slightly. However, during the induction to stateⅡ with red light, both Fm/Fo and F685/F735 decreased immedi-ately and the former were quicker than the latter. In this interval, the intensity of fast phase of ms-DLE increased to a maximum and then decreased to a lower value during the transition to stateⅡ. Nigericin, an uncoupler which elimi-nates the proton gradient across thylakoid membrane, inhib-ited the increase in the intensity of fast phase of ms-DLE during the transition to stateⅡ. Another uncoupler, valino-mycin, which eliminates the membrane potential, did not affect the changes of the intensity of fast phase. These results suggest that the prompt increase in the intensity of fast phase of ms-DLE at the beginning of transitions to stateⅡ is cor-related mainly with the proton gradient released from water oxidation in photosystemⅡ.

关键词：大豆叶状态转换类囊体膜质子运动力量毫秒滞后光发射光合体系

Structural and microstructural transformations in Bi_2Sr_2Ca_(1-x)Y_xCu_2O_(8+y) system

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chinese Science Bulletin 1997年第3期42卷 192-196页

作者： SONG Chengyu, WEN Shulin and CHE Guangcan1. shanghai institute of Ceramics, chinese academy of sciences, shanghai 200050, china 2. State Key Laboratory of Supercon-ductivity, institute of physics, chinese academy of sciences, Beijing 100080, china shanghai institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China

SINCE the discovery of high-Tc superconductors, experiments have revealed that the phase diagrams of La2-xSrxCuO4 and YBa2Cu3O6+x resemble each other. The antiferromagnetic phase is commonly situated in the vicinity o... 详细信息

关键词： Bi2Sr2Ca1-xYxCu2Oy substitution structural transformation.

RADIAL BASIS FUNCTION INTERPOLATION IN SOBOLEV SPACES AND ITS APPLICATIONS

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Journal of Computational Mathematics 2007年第2期25卷 201-210页

作者： Manping Zhang (School of Mathematical sciences,Fudan University,shanghai 200433,china institute of Computational Mathematics,chinese academy of sciences,Beijing 100080,china School of Mathematical sciences Fudan University Shanghai 200433 China institute of Computational Mathematics Chinese Academy of Sciences Beijing 100080 China

In this paper we study the method of interpolation by radial basis functions and give some error estimates in Sobolev space H^k（Ω）（k 〉 1）. With a special kind of radial basis function, we construct a basis in H^k（Ω） and derive a meshless method for solving elliptic partial differential equations. We also propose a method for computing the global data density.

关键词： Sobolev space Radial basis function Global data density Meshless method

Production and measurement of Bose-Einstein condensate of ^(87)Rb atomic gas

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Science china(physics,Mechanics & Astronomy) 2008年第1期51卷 22-28页

作者： XU Zhen ,ZHOU ShuYu,ZHOU ShanYu&WANG YuZhu Key Laboratory for Quantum Optics,shanghai institute of Optics and Fine Mechanics,chinese academy of sciences,shanghai 201800,china 1. Key Laboratory for Quantum Optics Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Shanghai 201800 China

The research platform for Bose-Einstein condensate in 87 Rb atomic gas,which is composed of a double MOT configuration and a QUIC trap,was *** properties of the condensate were measured both in time-of-flight and in tight confinement by the absorption imaging *** measurements agreed with the criterions of Bose-Einstein condensation phase *** 2×10 5 atoms were pure condensed.

关键词： laser cooling and trapping Bose-Einstein condensate time-of-flight measurement