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Gene expression profile induced by oral administration of baicalin and gardenin after focal brain ischemia in rats

Acta Pharmacologica Sinica 2005年第3期26卷 307-314页

作者： Zhan-jun ZHANG~2 Zhong WANG~3 Xiao-yan ZHANG~4 Kang YING~5 Jian-xun LIU~3 Yong-yan WANG~62 The Clinical School of beijing university of Traditional Chinese Medicine,beijing 100029,china 3 Xi-yuan Hospital of the Academy o] Traditional Chinese Medicine,beijing 100089,china 4 beijing normal university,beijing 100036,china 5 BioStar Genechip Incorporated,Shanghai 200012,china 6 The Academy of Traditional Chinese Medicine,beijing 100059,china TheClinicalSchoolofbeijinguniversityofTraditionalChineseMedicine Beijing100029China

Aim:To investigate differential gene expression and the pharmacological mecha-nism of baicalin and gardenin in focal cerebral ischemia in rats with high-densitycDNA ***:Rat left middle cerebral arteries were occluded andtreated with either baicalin or *** pharmacological effects were inves-tigated using the difference in infarction areas before and after treatment,whichwere determined by 2,3,5-triphenyltetrazolium chloride (TTC) *** ex-pression was demonstrated using a"Biostar40S"gene *** transcription-polymerase chain reaction (RT-PCR) was used to verify theresult of the selected ***:Both baicalin and gardenin reduced theinfarction areas in focal cerebral ischemia rats (P<0.05).The differential geneswere 211,177,and 70 (upregulated or downregulated) in the model group,baicalin,and gardenin treatment groups compared with the sham-operated group,*** expression of RpL19 and Csnk2 underwent an approximately1.9 and 2.1-fold increase,respectively,verified by semiquantitative RT-PCR,whichwas the same trend as the cDNA ***:Differential gene ex-pression with respect to the pharmacological effects of baicalin and gardenin onfocal cerebral ischemia by cDNA microarray revealed a number of clues with re-spect to the therapeutic mechanisms of Chinese traditional *** additionthe present study provided theoretical and experimental evidence that will aidfuture studies examining cerebral ischemia.

关键词： microarray gene expression baicalin gardenin brain ischemia

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Recommendation Method for Contrastive Enhancement of Neighborhood Information

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Computers, Materials & Continua 2024年第1期78卷 453-472页

作者： Hairong Wang beijing Zhou Lisi Zhang He Ma School of Computer Science and Engineering North Minzu UniversityNingxia750021China

Knowledge graph can assist in improving recommendation performance and is widely applied in various person-alized recommendation ***,existing knowledge-aware recommendation methods face challenges such as weak user-item interaction supervisory signals and noise in the knowledge *** tackle these issues,this paper proposes a neighbor information contrast-enhanced recommendation method by adding subtle noise to construct contrast views and employing contrastive learning to strengthen supervisory signals and reduce knowledge ***,first,this paper adopts heterogeneous propagation and knowledge-aware attention networks to obtain multi-order neighbor embedding of users and items,mining the high-order neighbor informa-tion of users and ***,in the neighbor information,this paper introduces weak noise following a uniform distribution to construct neighbor contrast views,effectively reducing the time overhead of view *** paper then performs contrastive learning between neighbor views to promote the uniformity of view information,adjusting the neighbor structure,and achieving the goal of reducing the knowledge noise in the knowledge ***,this paper introduces multi-task learning to mitigate the problem of weak supervisory *** validate the effectiveness of our method,experiments are conducted on theMovieLens-1M,MovieLens-20M,Book-Crossing,and Last-FM *** results showthat compared to the best baselines,our method shows significant improvements in AUC and F1.

关键词： Contrastive learning knowledge graph recommendation method

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Functional central limit theorem for super α-stable processes

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Science china Mathematics 2004年第6期47卷 874-881页

作者： HONG WenmingDepartment of Mathematics, beijing normal university, beijing 100875, china 1. Department of Mathematics Beijing Normal University 100875 Beijing China

A functional central limit theorem is proved for the centered occupation time process of the super α-stable processes in the finite dimensional distribution sense. For the intermediate dimensions α < d < 2α (0 < α ≤ 2), the limiting process is a Gaussian process, whose covariance is specified; for the critical dimension d= 2α and higher dimensions d < 2α, the limiting process is Brownian motion.

关键词： super α-stable processes occupation time central limit theorem evolution equation

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On asymptotics of t-type regression estimation in multiple linear model

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Science china Mathematics 2004年第4期47卷 628-639页

作者： GUI HengjianDepartment of Mathematics, beijing normal university, beijing 100875, china 1. Department of Mathematics Beijing Normal University 100875 Beijing China

We consider a robust estimator (t-type regression estimator) of multiple linear regression model by maximizing marginal likelihood of a scaled t-type error *** marginal likelihood can also be applied to the de-correlated response when the withinsubject correlation can be consistently estimated from an initial estimate of the model based on the independent working assumption. This paper shows that such a t-type estimator is consistent.

关键词： t-type regression estimator, M-estimator, one-step estimate, consistency, asymptotic normality.

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THE HAUSDORFF MEASURE FOR THE SAMPLE PATH OF THE WESTWATER PROCESS

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Chinese Annals of Mathematics,Series B 1996年第3期17卷 375-388页

作者： ZHOU XIANYIN(Depatment of Mathematics, beijing normal university beijing 100875, china) beijing normal UNIV DEPT MATHBEIJING 100875PEOPLES R CHINA

It is proved that φ(s) = s2 log |logs| is the correct function to give the Hausdorff measureof a sample path of the Westwater process.

关键词： Hausdorff measure Wiener process Westwater process Sojourn time

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SINGLE BIRTH PROCESSES

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Chinese Annals of Mathematics,Series B 1999年第1期20卷 77-82页

作者： CHEN MUFA(Department of Mathematics,beijing normal university,beijing 100875,china) beijing normal Univ Dept Math Beijing 100875 Peoples R China

The single birth process is a Markov chain, either time-continuous or time-discrete, valuedin the non-negative integers: the system jumps with positive rate from k to k + 1 but not tok +j for all j 2 (this explains the meaning of 'single birth') . However, there is no restrictionfor the jumps from k to k - j(1 j< k). This note mainly deals with the uniqueness problemfor the time-continuous processes with an extension: the jumps from k to k + 1 may also beforbidden for at most finite number of k. In both cases (time-continuous or -discrete), thehitting probability and the first moment of the hitting time are also studied

关键词： Markov chains Single birth process Uniqueness criterion

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Quasi-critical ring of a primitive ring with nonzero socle

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Chinese Science Bulletin 1997年第3期42卷 189-192页

作者： JIANG ZimeiDepartment of Mathematics, beijing normal university, beijing 100875, china Department of Mathematics Beijing Normal University Beijing China

IN ref. [1] Jacobson proved the structure theorem for primitive rings with nonzero socles that R is a primitive ring withsocle S≠{0} if and only if there is a pair of dual vector spaces (M,M’) over a division ring Δ such that S=F(M, M’)(?) R(?)(?)(M, M’), where (?)(M, M’)-{ω∈Ω|ωM’(?)M’, Ω is the complete ring of linear transformations of M over Δ}, F(M, M’) is the set of all linear transformations of (?)(M, M’) of finite rank. After that, some people reproved this theorem by using different methods such as those in refs. [2, 3]. In

关键词： primitive ring socle conjugate space total subspace of conjugate space.

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Study on Green Residential Space Design

IJLAI Transactions on Science and Engineering

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IJLAI Transactions on Science and Engineering 2024年第1期2卷 32-37页

作者： Yu Jiang Shenyang normal university No.253 Huanghe North Street Shenyang 110034China

With the ever-changing nature,green ecology has become an international trend of ***,the green ecological design of residential space has become the main melody of people’s *** always implement the concept of ecological and environmental protection in the design process,attach importance to the ecological effect of residential space,carry out reasonable budget and use of environmentally friendly decorative materials,reduce the waste of materials,save money and save resources at the same time,and protect the *** the same time,people began to put their hopes on the residential space design,which made the green residential space design began to *** the bold exploration and practice of designers,the design of green residential space will be endowed with more distinctive characteristics and unique *** from the concept of green design,this paper explores the method of green space design through typical analysis.

关键词： Green Residential space Haze

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Reaction-diffusion processes

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Chinese Science Bulletin 1998年第17期43卷 1409-1420页

作者： CHEN Mufa beijing normal university beijing 100875, china beijing normal university Beijing China

The main progress made in the past dozen years or more in the study of reaction-diffusion (abbrev. RD) processes is surveyed. The processes are motivated from some typical models in the modern non-equilibrium statistical physics and consist of an important class of interacting particle systems which is currently an active research field in probability and mathematical physics. The models are concrete but as a part of the infinite-dimensional mathematics, the topic is quite hard. It is explained how new problems arise, and how some new ideas and new mathematical tools are introduced. Surprisingly, the mathematical tools produced from the study on the simple models then turn to have a lot of powerful applications not only in probability theory but also in other branches of mathematics. Nevertheless, the story is still far from finished, and some important open problems are proposed for further study.

关键词： Reaction-diffusion process ergodicity phase transitions coupling.

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Development and application of ergodicity model with FRCM and FLAR for hydrological process

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Science china(Technological Sciences) 2009年第2期52卷 379-386页

作者： WANG HongRui1, FENG QiLei2, LIN Xin3 & ZENG WenYi4 1 College of Water Science, Key Laboratory for Water and Sediment Sciences of the Ministry of Education, beijing normal university, beijing 100875, china 2 School of Science, beijing Institute of Education, beijing 100011, china 3 School of Mathematical Sciences, beijing normal university, beijing 100875, china 4 College of Information Science and Technology, beijing normal university, beijing 100875, china 1. College of Water Science Key Laboratory for Water and Sediment Sciences of the Ministry of Education Beijing Normal University Beijing 100875 China 2. School of Science Beijing Institute of Education Beijing 100011 China 3. School of Mathematical Sciences Beijing Normal University Beijing 100875 China 4. College of Information Science and Technology Beijing Normal University Beijing 100875 China

In this paper, a new ergodic property analysis model of hydrological process is proposed based on fuzzy-rough c-means clustering (FRCM), autocorrelogram, and fuzzy least absolute regression (FLAR). A precipitation time series (1951―2004) from Shanghai Hydrology Station is then analyzed with the model. The results show that the precipitation time series of April, May, June, and September has er-godic property. We conclude that in the long run, the precipitation of April, May, June, and September will not keep decreasing; it will converge to its mean value in some period.

关键词： hydrological process ergodic autocorrelogram fuzzy-rough c-means clustering fuzzy least absolute regression

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