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ON THE CLASSIFICATION OF AF-ALGEBRAS AND THEIR DIMENSION GROUPS(Ⅱ)

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Chinese Annals of Mathematics,Series B 1995年第3期16卷 391-398页

作者： HUANG ZHAOBO(InStitute of Mathematics, fudan univer.ityt shanghai 200433, china.) fudan UNIV INST MATHSHANGHAI 200433PEOPLES R CHINA

This paper is a continuation of [1]. It gives some applications of the results in [1], containing some examples of pure-infinite AF-algebras and the invariant properties of the types of the C-extensions by two AF-alge... 详细信息

关键词： AF-algebra Dimension group C-extension.

THE GAUSS MAP OF TIMELIKE SURFACES IN R1^n

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Chinese Annals of Mathematics,Series B 1995年第3期16卷 361-370页

作者： HONG JIANQIAO(Institute of Mathematics, fudan univer.ity, shanghai 200433, china.) fudan UNIV INST MATHSHANGHAI 200433PEOPLES R CHINA

Gauss maps of oriented timelike 2-surfaces in are characterized, and it is shown that Gallss maps can determine surfaces locally as they do in case. Moreover, some essential differences are discovered between the properties of the Gauss maps of surfaces in Rn and those of the Gauss maps of timelike surfaces in. In particular, a counterexample shows that a nonminimal timelike surface in cannot be essentially determined by its Gauss map.

关键词： Timelike surface Gauss map External surface.

Biomarkers of neurodegenerative disorders: How good are they?

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Cell Research 2004年第5期14卷 347-358页

作者： Varun RACHAKONDA Department of Neurology Baylor College of Medicine Houston TX USA

Biomarkers are very important indicators of normal and abnormal biological processes. Specific changes in pathologies, biochemistries and genetics can give us comprehensive information regarding the nature of any particular disease. A good biomarker should be precise and reliable, distinguishable between normal and interested disease, and differential between different diseases. It is believed that biomarkers have great potential in predicting chances for diseases, aiding in early diagnosis, and setting standards for the development of new remedies to treat diseases. New technologies have enabled scientists to identify biomarkers of several different neurodegenerative diseases. The followings, for instance, are only a few of the many new biomarkers that have been recently identified: the phosphorylated tau protein and aggregated β-amyloid peptide for Alzheimer’s disease (AD), α-synuclein contained Lewy bodies and altered dopamine transporter (DAT) imaging for Parkinson’s disease (PD), SOD mutations for familial amyotrophic lateral sclerosis (ALS), and CAG repeats resulted from Huntington’s gene mutations in Huntington’s disease (HD). This article will focus on the most-recent findings of biomarkers belonging to the four mentioned neurodegenerative diseases.

关键词： Alzheimer’s disease Parkinson’s disease Amyotrophic Lateral Sclerosis Huntington’s disease biomarkers.

Global Exact Boundary Controllability for Cubic Semi-linear Wave Equations and Klein-Gordon Equations

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Chinese Annals of Mathematics,Series B 2010年第1期31卷 35-58页

作者： Yi ZHOU Wei XU Zhen LEI Key Laboratory of Mathematics for Nonlinear sciences School of Mathematical Sciences Fudan University Shanghai 200433 China School of Mathematical sciences Fudan University Shanghai 200433 China

The authors prove the global exact boundary controllability for the cubic semilinear wave equation in three space dimensions,subject to Dirichlet,Neumann,or any other kind of boundary controls which result in the well-posedness of the corresponding initial-boundary value *** exponential decay of energy is first established for the cubic semi-linear wave equation with some boundary condition by the multiplier method,which reduces the global exact boundary controllability problem to a local *** proof is carried out in line with [2,15].Then a constructive method that has been developed in [13] is used to study the local *** when the region is star-complemented,it is obtained that the control function only need to be applied on a relatively open subset of the *** the cubic Klein-Gordon equation,similar results of the global exact boundary controllability are proved by such an idea.

关键词： Global exact boundary controllability Cubic semi-linear wave equations The exponential decay Star-shaped Star-complemented Cubic Klein- Gordon equations

PARAMETERS OF DARBOUX TRANSFORMATION FOR REDUCED AKNS,KAUP-NEWELL AND PCF SYSTEMS

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Chinese Annals of Mathematics,Series B 1999年第2期20卷 195-204页

作者： ZHOU ZIXIANG(Institute of Mathematics, fudan univer.ity, shanghai 200433) fudan Univ Inst Math Shanghai 200433 Peoples R China

FOr the integrable system with u(p, q) reduction, there is a well-known sufficient conditionto choose the parameters: the spectral parameters only take two mutually conjugate valuesand the solutions of the Lax pair should satisfy certain orthogonal relations. In this paper, theauthor proves that, for the AKNS system, the Kaup-Newed system and the principal chiralfield (PCF), this condition is also necessary for generic potentials with the u(p, q) *** some other reductions, sufficiency and necessity of more constraints are proved.

关键词： Darboux transformation Spectral parameters u(p q) reduction

TOEPLITZ C-ALGEBRA OVER THE L-SHAPED DOMAIN IN C^m

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Chinese Annals of Mathematics,Series B 1996年第3期17卷 325-334页

作者： XU SHENGZHI CHEN XIAOMAN YAN SHAOZONG(Institute of Mathematics, fudan univer.ity, shanghai 200433, china) Institute of Mathematics Fudan University Shanghai 200433 China

The authors investigate the Toeplitz C-algebra over the L-shaped domain in Cn by thegroupoid approach, and successfully parameterise the unit space of the groupoid associated tothe Toeplitz C-algebra.

关键词： L-shaped domain Toeplitz C-algebra Parameterization

Phylogeographic analysis of human papillomavirus 58

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Science china(Life sciences) 2009年第12期52卷 1164-1172页

作者： LI YanYun1, LI ZuoFeng2, HE YiFeng1, KANG Yu1, ZHANG XiaoYan1, CHENG MingJun1, ZHONG Yang2, 3· & XU CongJian1· 1 Obstetrics and Gynecology Hospital of fudan univer.ity, shanghai 200011, china 2 shanghai Bioinformation Research Center, shanghai 200235, china 3 School of Life sciences, fudan univer.ity, shanghai 200433, china Obstetrics and Gynecology Hospital of fudan univer.ity Shanghai 200011 China shanghai Bio-information Research Center Shanghai 200235 China School of Life sciences Fudan University Shanghai 200433 China

Human papillomavirus 58 (HPV58) is one type of HPV with high risk of causing cervical cancer. Unusually high prevalence of HPV58 has been reported in Asia, Africa and some other areas. However, due to the scattered distribution of global data, in addition to the lack of data of some HPV58 high-incidence nations and regions, like china's Mainland, a comprehensive analysis of the global geographical distribution of HPV58 remains blank so far. In this study, HPV58 from the human cervical cancer tissue was detected in china's Mainland, and 14 new HPV58-E6/L1 gene sequences were obtained. Moreover, phylogeographic analysis has been conducted combining the HPV58 sequences that have been deposited in GenBank since 1985. The study result shows that the sequences detected from the shanghai, Jiangsu and Sichuan areas are homologous with those found in the past from Hong Kong and Xi'an, china, as well as Japan and other Southeast Asian areas. Furthermore, Western Africa is considered to be the "root" source of the HPV58 variant, while china's Mainland and Southeast Asia are "transit points" and the new sources of HPV58 after receiving the isolates from the "root" source; like HPV16 and HPV18, the HPV58 might also be one of the major HPV types associated with the development and spread of cervical cancer.

关键词： human papillomavirus 58 (HPV58) cervical cancer phylogeography molecular evolution

Identification and Characterization of glnA Promoter and its Corresponding Trans-regulatory Protein GlnR in the Rifamycin SV Producing Actinomycete,Amycolatopsis mediterranei U32

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Acta Biochimica et Biophysica Sinica 2006年第12期38卷 831-843页

作者： Hao YU~(1&) Wen-Tao PENG~1 Yang LIU~1 Ting WU~2 Yu-Feng YAO~1 Ming-Xue CUI~1 Wei-Hong JIANG~1 Guo-Ping ZHAO~(1,3,4*) 1 Laboratory of Molecular Microbiology,Institute of Plant Physiology and Ecology,shanghai institutes for Biological sciences,Chinese Academy of sciences,shanghai 200032,china 2 Department of Medicinal Chemistry,School of Pharmacy,fudan univer.ity,shanghai 200032,china 3 State Key Laboratory of Genetic Engineering & Department of Microbiology,School of Life Science,fudan univer.ity,shanghai 200433,china 4 Laboratory of Disease and Health Genomics,Chinese National Human Genome Center at shanghai,shanghai 201203,china Laboratory of Molecular Microbiology Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200032 China Department of Medicinal Chemistry School of Pharmacy Fudan University Shanghai 200032 China State Key Laboratory of Genetic Engineering & Department of Microbiology School of Life Science Fudan University Shanghai 200433 China Laboratory of Disease and Health Genomics Chinese National Human Genome Center at Shanghai Shanghai 201203 China

The genetic requirements for the transcription of glnA,encoding the major glutaminesynthetase in a rifamycin SV-producing Amycolatopsis mediterranei strain,U32,were *** experiments showed that the promoter of U32 glnA （pglnA） was likely to have two transcriptioninitiation sites:P1and P2,located 157 and 45 nucleotides （nt） upstream of the translational start codon,*** mobility shift and DNase I footprinting analyses revealed a 30 bp cis-element locatedat 45 to 75 nt downstream of P1,or 38 to 68 nt upstream of *** sequence of the cis-element displayedhigh similarity to the corresponding regions of pglnA from Streptomyces coelicolor and *** as a reporter gene,the expression levels of U32 pglnA and its deletion derivatives under differentnitrogen-source conditions were analyzed by detecting the catechol dioxygenase activities in ***54,*** J508 and *** FS10 （glnR mutant）.These in vivo studies showed that theactivation of U32 pglnA in *** required GlnR,and its binding to the U32 pglnA was furtherconfirmed by the gel mobility shift *** and heterologous expression of the U32 glnR allowed usto detect the in vitro interaction between the U32 GlnR and the corresponding pglnA *** shown by in vivo glnR inactivation and complementation indicated that GlnR is essential for theactive transcription of glnA in U32.

关键词： glnA promoter cis-element glnR Amycolatopsis mediterranei

The contribution of cis-regulatory elements to head-to-head gene pairs' co-expression pattern

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Science china(Life sciences) 2009年第1期52卷 74-79页

作者： HAO Pei1,2,YU Yao2,3,ZHANG XiaoYan4,TU Kang2,FAN HaiWei2 & ZHONG Yang1 1 School of Life sciences,fudan univer.ity,shanghai 200433,china 2 Bioinformatics Center,Key Lab of Systems Biology,shanghai institutes for Biological sciences,Chinese Academy of sciences,shanghai 200031,china 3 shanghai Center for Bioinformation Technology,shanghai 200235,china 4 School of Life sciences,Tongji univer.ity,shanghai 200092,china 1. School of Life sciences Fudan University Shanghai 200433 China 2. Bioinformatics Center Key Lab of Systems Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China 3. shanghai Center for Bioinformation Technology Shanghai 200235 China 4. School of Life sciences Tongji University Shanghai 200092 China

Transcription regulation is one of the most critical pipelines in biological process,in which cis-elements play the role as gene expression *** attempt to deduce the principles underlying the co-expression of "head-to-head" gene pairs by analyzing activities or behaviors of the shared cis-elements.A network component analysis was performed to estimate the impact of cis-elements on gene promoters and their activities under different *** discoveries reveal how biological system uses those regulatory elements to control the expression pattern of "head-to-head" gene pairs and the whole transcription regulation system.

关键词： transcription regulation cis-elements "head-to-head" gene pairs