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THE　ISOlATION　AND　CHEMICAl　STRUCTURE　OF　ISOANNONARETICINS，A　PAIR　OF　2－EPIMERS　FROM　ANNONA　RETICUlATA（ANNONACEAE）

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chinese Chemical letters 1996年第1期7卷 19-22页

作者： Jing’Guang YU and Dong lIU(institute of medicinal plant development, chinese academy of Medical sciences andpeking union Medical college, beijing 100094) Inst. of medicinal plant development Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100094

A new acetogenin 2,4ets-cis-isoannonareticin (2-1) (2,4-cis-bullatacinone) and a known bullatacinone (2,4--trans-isoannonareticin) (2-2) were a pair of isomersepimeric at C-2 which were isolated as two pure natural compounds from Annonareticulata l. by using preparative TlC. Their structures and the relativestereochemistry were elucidated on the basis of the spectral analysis.

关键词： DENSICOMA ANNONACEAE ACETOGENINS POlYKETIDES BUllATA

DNA barcoding provides distinction between Radix Astragali and its adulterants

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Science china(life sciences) 2010年第8期53卷 992-999页

作者： GUO HaiYan1,2, WANG WeiWei2, YANG Ning2, GUO Baolin3, ZHANG Sun2, YANG RuiJing2, YUAN Ye2, YU Junlin4, HU SongNian2, SUN QiShi1 & YU Jun2 1School of Traditional chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, china 2Key laboratory of Genome sciences and Information, beijing institute of Genomics, chinese academy of sciences, beijing 101300, china 3chinese academy of Medical sciences, peking union Medical college institute of medicinal plant development, beijing 100094, china 4Department of Chemistry, Tonghua Normal college, Tonghua 134002, china 1. School of Traditional chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China2. Key Laboratory of Genome Sciences and Information Beijing Institute of Genomics Chinese Academy of Sciences Beijing 101300 China3. Peking Union Medical College Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Beijing 100094 China4. Department of Chemistry Tonghua Normal College Tonghua 134002 China

Based on variable nuclear and/or organellar DNA sequences among vastly divergent species as well as morphologically indistinguishable species, DNA barcoding is widely applicable in species identification, biodiversity studies, forensic analyses, and authentication of medicinal plants. The roots of Astragalus membranaceus and A. membranaceus var. mongholica are commonly used as Radix Astragali in several Asian countries, including china, Japan, and Korea. However, in addition to the two species recorded in the chinese Pharmacopoeia, there are twenty-three species from different genera including Astragalus, Oxytropis, Hedysarum, and Glycyrrhiza, which have been used as adulterants not only in trading markets but also by the herbal medicine industry. Therefore, a simple, reliable, and accurate classification method is important for distinguishing authentic Radix Astragali from its adulterants. In this study, we acquired data for 37 samples from four related genera within the family Fabaceae. Then we compared four candidate DNA barcoding markers using ITS, matK, rbcl, and coxI sequences from nuclear, chloroplast, and mitochondrial genomes, all commonly used for plants to identify genetic variations among genera, intraspecies, and interspecies. We observed higher divergences among genera and interspecies for ITS, which have the average Kimura 2-parameter distances of 4.5% and 14.1%, respectively, whereas matK was found to have sufficient divergence at the intraspecific level. Moreover, two indels detected in the matK sequence are useful for PCR studies in distinguishing Radix Astragali from its adulterants. This study suggests that the combined barcoding regions of ITS and matK are superior barcodes for Radix Astragali and further studies should focus on evaluating the applicability and accuracy of such combined markers for a wide range of traditional chinese herbs.

关键词： Radix Astragali DNA barcode Astragalus adulterant identification

Molecular pharmacognosy

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Science china(life sciences) 2010年第6期53卷 643-652页

作者： HUANG luQi1,XIAO PeiGen2,GUO lanPing1 & GAO WenYuan3 1institute of chinese Materia Medica,china academy of chinese Medical sciences,beijing 100700,china 2institute of medicinal plant development,chinese academy of Medical sciences,peking union Medical college,beijing 100094,china 3School of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300072,china 1. institute of chinese Materia Medica China Academy of Chinese Medical Sciences Beijing 100700 China2. Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100094 China3. School of Pharmaceutical Science and Technology Tianjin University Tianjin 300072 China

This article analyzes the background and significance of molecular pharmacognosy,including the molecular identification of medicinal raw materials,phylogenetic evolution of medicinal plants and animals,evaluation and preservation of germplasm resources for medicinal plants and animals,etiology of endangerment and protection of endangered medicinal plants and animals,biosynthesis and bioregulation of active components in medicinal plants,and characteristics and the molecular bases of top-geoherbs.

关键词： molecular pharmacognosy pharmacognosy borderline subject

Cypripediquinone A, a new phenanthraquinone from Cypripedium macranthum (Orchidaceae)

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chinese Chemical letters 2000年第1期11卷 37-38页

作者： Jian Hua JU Jun Shan YANG Jin lI Pei Gen XIAO (institute of medicinal plant development. chinese academy of Medical sciences and peking union Medical college, beijing 100094) chinese Acad Med Sci Inst Med Plant Dev Beijing 100094 Peoples R China peking union Med Coll Beijing 100094 Peoples R China

A new phenanthraquinone, cypripediquinone A, was isolated from the rhizome of Cypripedium macranthum ( Orchidaceae ) and its structure was established as 2,4,7-trimethoxy-9, 10- phenanthraquinone mainly by spectroscop... 详细信息

关键词： Cypripedium macranthum cypripediquinone A

A new Kaurane Derivative from Aralia Fargesii

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chinese Chemical letters 1999年第8期10卷 673-674页

作者： Yu Mei ZHANG Jun Shan YANG Xu Dong XU (institute of medicinal plant development, chinese academy of Medical Science peking union Medical college, beijing 100094) peking union Med Coll Chinese Acad Med Sci Inst Med Plant Dev Beijing 100094 Peoples R China

A new ent-kaurane diterpene was isolated from the rhizome of Aralia fargesii. On the basis of chemical and spectral evidences, its structure was established as 16 alpha-hydroxy-17-isovaleroyloxy-ent-kauran-19-oic acid.

关键词： Aralia fargesii ent-kaurane 16 alpha-hydroxy-17-isovaleroyloxy-ent-kauran-19-oic acid

New Flavonoid Glycoside from Thalictrum przewalskii

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chinese Chemical letters 1999年第4期10卷 295-296页

作者： Shi Chun YU Qing li WU li Wei WANG Pei Gen XIAO(institute of medicinal plant development, chinese academy of Medical sciences and peking union Medical college, beijing 100094.) chinese Acad Med Sci Inst Med Plant Dev Beijing 100094 Peoples R China peking union Med Coll Beijing 100094 Peoples R China

A new flavonoid glycoside, 5, 7-dihydroxy-4'-methoxyflavonoid 7-Q-[6-O-(4-O-acetyl-alpha-l-rhamnosyl)-3-O-beta-D-glucosyl]-6-O-acetyl-beta-D-glucoside was isolated from Thalictrum przewalskii. Its structure was determ... 详细信息

关键词： Thalictrum Thalictrum przewalskii flavonoid glycoside 5, 7-dihydroxy-4 '-methoxyflavonoid 7-O-[6-O-(4-O-acetyl-alpha-l-rhamnosyl)-3-O-beta-D-glucosyl]-6-O-acetyl-beta-D-glucoside

Erythrinarbine,a Novel nor-A ring Erythrina Alkaloid from Erythrina arborescens

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chinese Chemical letters 1999年第2期10卷 139-142页

作者： Dong lei YU Jian GUO li Zhen XU Shi lin YANG(institute of medicinal plant development, chinese academy of Medical sciencesand peking union Medical college, beijing 100094) chinese Acad Med Sci Inst Med Plant Dev Beijing 100094 Peoples R China peking union Med Coll Beijing 100094 Peoples R China

Erythrinarbine 2, a novel alkaloid was isolated from the stem of Erythrina arborescens Roxb. Its structure and stereochemistry were elucidated on the basis of the spectral analysis (C-13 - H-1 COSY, H-1-H-1 COSY, NOES... 详细信息

关键词： Erythrina arborescens erythrinarbine nor-A ring erythrina alkaloid

Muricatenol, a linear Acetogenin from Annona muricata (Annonaceae)

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chinese Chemical letters 2000年第3期11卷 239-242页

作者： De Yu lI Jing Guang YU Xiu Zhen lUO lan SUN Shi lin YANG (institute of medicinal plant development. chinese academy of Medical sciences and peking union Medical college. beijing 100094) chinese Acad Med Sci Inst Med Plant Dev Beijing 100094 Peoples R China peking union Med Coll Beijing 100094 Peoples R China

Muricatenol 1, a new acetogenin, has been isolated from the seeds of Annona muricata l.. Compound 1 is a C-37 acetogenin without any THF rings. with four hydroxyls and one double bond in the long aliphatic chain. The hydroxyls of 1 are located at C-4, C-10, C-18 and C-19. respectively. The vicinal diet at C-18/C-19 is threo-configuration, and the double bond at C-14/C-15 is cis-configuration.

关键词： Annona muricata Annonaceae acetogenins muricatenol

Size-dependent hydroxyl radicals generation induced by SiO_2 ultra-fine particles: The role of surface iron

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Science china Chemistry 2009年第7期52卷 1033-1041页

作者： SHANG Yu1, ZHU Tong1, lI Yi1,2 & ZHAO JinCai3 1 college of Environmental sciences and Engineering, peking University, beijing 100871, china 2 chinese academy of Meteorological sciences, beijing 100871, china 3 institute of Chemistry, chinese academy of sciences, beijing 100871, china 1. college of Environmental sciences and Engineering Peking University Beijing 100871 China 2. chinese academy of Meteorological sciences Beijing 100871 China 3. institute of Chemistry Chinese Academy of Sciences Beijing 100871 China

Oxidative stress and hydroxyl radicals (·OH) play important roles in adverse health effects caused by inhalable ambient air particles (PM10). The ultra-fine fraction of PM10 has been hypothesized as one of the critical contributors to ·OH generation. Both in vivo and in vitro studies have shown that ultra-fine particles (UFPs) or nano-particles generate more ·OH than larger particles with identical mass and composition. Both the surface area and surface-adsorbed redox-active metals have been suggested as factors to determine the oxidative capacity of UFPs. In this study, the ·OH-generating capability of dif-ferent sizes of SiO2 particles was investigated in order to determine which factor influences particle-induced ·OH generation. The amount of ·OH generated in both acellular and cellular systems was quantified using a capillary electrophoresis method following exposure to SiO2 particles with diameters of 14, 100, and 500 nm. The amount of ·OH was strongly dependent on particle size, and a significant enhancement was observed only with 14 nm particles. Further studies indicated a close association between ·OH and iron ion concentration (R2 = 0.812, ples, with their surface iron being removed, did not generate ·OH. The iron-containing leachate from these washings was able to enhance ·OH production as untreated particles did. Therefore, the presence of adsorbed iron on the surface of the SiO2 particles is presented as a possible mechanism of UPFs-induced ·OH generation. The SiO2 acted as an inert substrate, and the surface of ultra-fine SiO2 particles acted as a carrier for iron.

关键词： ultra-fine particles nano-particles ·OH oxidative stress size-effect