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中国(第七届)肿瘤微创治疗学术大会暨世界影像导引下肿瘤...

作者： ZHANG Fu-jun,JIAO De-chao,Zhang Nian-hua,LI Chuan-xing,WU Pei-hong,DUAN Guang-feng,WU Yue-xia State Key Laboratory of Oncology in South china,department of Imaging and Interventional Radiology,Cancer Center,Sun Yat-sen university,guangzhou,510060,china(Zhang FJ,Jiao DC,Li CX,Wu PH,Duan GF,Wu YX) department of Medical Oncology,guangdong second Provincial traditional chinese medicine hospital,guangzhou,510095, china(Zhang NH)

＜正＞Background To investigate the clinical value of CT guided 125iodine seed implantation in treating portal vein tumor thrombus in primary hepatocellular carcinoma patients. Methods 10 patients（9 males and 1 females,median age 51 years,range from 36 to 72） with portal vein tumor thrombus with hepatocellular carcinoma accepted CT guided 125iodine seed implantation were enrolled in this study. The portal vein tumor thrombus were not well controlled by hepatocellular carcinoma combined therapy,such as surgery,transcatheter arterial chemoembolization（TACE）,radiotherapy ablation（RFA）,microwave ablation（MA）,or percutaneous ethanol injection（PEI）.The average diameter of each tumor thrombus was 2.1×*** the guidance of CT,125I seeds of 0.8mCi were implanted under local anesthesia at a distance of 0.5cm along portal vein tumor thrombus according to *** spiral CT follow-up was performed 4 months post intervention. Results A total of 10 patients with portal vein tumor thrombus received CT-guided 125iodine seed implantation. The local control of the treated lesions was quite satisfactory with 4 months,and the overall response rate was 90.0% （9/10）,with observed complete response（CR） in 4 patients,partial response（PR） in 5 patients,and stable disease （SD） in 1 *** adverse effects mainly included aggravated abdominal dropsy and temporary increased hepatic aminopherase,which were controlled by medical ***,we have seen seeds migration to lung and left hepatic lobe in 1 *** other complications such as hemorrhoea,cholo-fistulase,hepatic abscess,pancreatic fistula and hepatic function failure were encountered in all patients. Conclusions CT-guided 125iodine seed implantation was proved safety and effectiveness in the treatment of portal vein tumor thrombus with hepatocellular carcinoma with minimal damage and few complications.

关键词： 125iodine seed implantation portal vein tumor thrombus brachytherapy primary hepatocellular carcinoma

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Biochemical mechanism studies of venlafaxine by metabonomic method in rat model of depression

Biochemical mechanism studies of venlafaxine by metabonomic ...

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共铸医药学术新文明——2012年广东省药师周大会

作者： Su Fenli~(1,2),Wang Feng~1,Zhu Ronghua~1,Li Huande~(1*) 1.Clinical Pharmacy & Pharmacology Research Institute,second Xiangya hospital, Central South university,Changsha 410011,P.R china 2.department of Pharmacy,First affiliated hospital,guangzhou university of traditional chinese medicine,guangzhou 510405,PR china

Backbround:Venlafaxine is a new antidepressant that has a chemical structure and neuropharmacologic profile distinct from those of existing *** studies about the mechanism of pharmacological action of venlafaxine mostly investigated the effects of venlafaxine on 5-HT,NE and DA levels,while only few studies examined the effects on the metabolites levels and ratio of these monoamines neurotransmitters. Aim:To study the biochemical mechanism of venlafaxine through determining the metabolism of monoamine neurotransmitters in brain tissues of rat model of depression after administration of venlafaxine using metabonomic method. Materials and methods:The rat model of depression was established by using the methods of separation and chronic unpredictable *** determination of 5-hydroxytryptamine (5-HT),norepinephrine(NE),dopamine(DA) and their metabolites,i.e., 5-hydroxyindole-3-acetic acid(5-HIAA),4-hrdroxy-3-methoxyphenylglycol(MHPG) sulfate, 3,4-dihydroxyphenylacetic acid(DOPAC) and homovanillic acid(HVA) in rat brain tissues by liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) following chronic administration of different venlafaxine doses(8,16,32 ***) and saline solution for 14 *** discriminant analysis(LDA) and principal components analysis(PCA) were used in data analysis of metabonomic. Results:Compared with saline,venlafaxine could significantly increase brain 5-HT and NE levels at middle dose(16 ***) or high dose(32 ***),especially at middle *** increases were greater than those seen with the comparable dose of SSRI,fluoxetine,under the same experimental conditions. Conclusion:Venlafaxine lower brain neurotransmitter metabolite levels by decreasing brain neurotransmitters *** could correct the disorder of neurotransmitters’ metabolism and coordinate the balance of 5-HT,NE and DA to reach the anti-depressed function.

关键词： venlafaxine depression model neurotransmitter metabonomics

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糖尿病患者瘀血舌象与凝血功能相关性研究

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四川中医 2011年第5期29卷 26-28页

作者：罗振亮陈壮忠广州中医药大学广东广州510006 广州中医药大学第一附属医院广东广州510006

目的:对2型糖尿病患者瘀血舌象与PT、INR、APTT、FIB四项凝血指标之间的相关性进行探讨。方法:用Sysm ex CA1500全自动血凝分析仪检测136例2型糖尿病患者,77例正常人群体检者的凝血酶原时间(PT)、活化部分凝血酶时间(APTT)、国际标准化... 详细信息

目的:对2型糖尿病患者瘀血舌象与PT、INR、APTT、FIB四项凝血指标之间的相关性进行探讨。方法:用Sysm ex CA1500全自动血凝分析仪检测136例2型糖尿病患者,77例正常人群体检者的凝血酶原时间(PT)、活化部分凝血酶时间(APTT)、国际标准化比值(INR)、纤维蛋白原(FIB)。结果:瘀血舌象组、非瘀血舌象组的PT均比正常组显著缩短(P<0.017,P<0.001);瘀血舌象组、非瘀血舌象组的APTT均比正常组显著缩短(P<0.001,P<0.017);非瘀血舌象组FIB水平显著高于正常组(P<0.017);瘀血舌象组FIB水平显著高于非瘀血舌象组(P<0.001)。结论:糖尿病患者体内凝血功能增强、纤溶功能升高,而糖尿病血瘀证患者体内凝血功能增强、纤溶功能升高可能是其出现瘀血舌象的病理基础之一。

关键词：糖尿病血瘀证舌象凝血

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打造患者信赖的医院品牌

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中国医院 2005年第12期9卷 32-34页

作者： guangdong chinese traditional Medical hospital. No.111, Dadelu, guangzhou. 510120, PRC 广东省中医院 510120广州市大德路111号

论述了正确认识品牌建设的必要性,指出品牌是医院参与竞争的核心能力,品牌建设是推动医院内涵建设的重要载体,品牌建设的关键是形成医院能力与患者需求之间的独特匹配,良好的医院形象有助于医院品牌的形成,品牌形成必须依靠医院文化建设... 详细信息

论述了正确认识品牌建设的必要性,指出品牌是医院参与竞争的核心能力,品牌建设是推动医院内涵建设的重要载体,品牌建设的关键是形成医院能力与患者需求之间的独特匹配,良好的医院形象有助于医院品牌的形成,品牌形成必须依靠医院文化建设,其中价值观的确立在医院品牌建设中起着核心作用。

关键词：医院品牌医院形象医院文化

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Efficacy of intramuscular matrine in the treatment of chronic hepatitis B

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Hepatobiliary & Pancreatic Diseases International 2004年第1期3卷 69-72页

作者： Yao Long, Xiao-Tian Lin, Kun-Lun Zeng and Lian Zhang Zhanjiang, china department of Infectious Diseases, affiliated hospital of guangdong Medical College, Zhanjiang 524001, china Haibin Centre hospital, Zhanjiang 524005, china Centre of Hepatology of Nanfang hospital, First Military Medical university, Guang- zhou 510515, china department of Infectious Diseases Affiliated Hospital of Guangdong Medical College Zhanjiang 524001 China. zjlongyao@***

BACKGROUND: Hepatitis B virus (HBV) infection, a glo- bal public health problem, is the leading cause of cirrhosis and hepatocellular carcinoma (HCC) worldwide. There are more than 350 million HBV carriers in the world and up to one million die annually due to hepatitis B associated liv- er disease. So far no optimal treatment is available for pa- tients with chronic hepatitis B. In the paper we investigated the efficacy of intramuscular matrine in the treatment of chronic hepatitis B. METHODS: One hundred and twenty patients with chronic hepatitis B were randomly divided into matrine treatment group (n =60) and control group (n =60). The patients of the matrine group were given intramuscularly with matrine (an alkaloid extracted from a traditional chinese herb Radix Sophorae Flavescentis by guangzhou Ming Xing Pharmaceu cal Factory, guangzhou, china) of 100 mg daily for 90 days in addition to conventional liver-protective drugs in- cluding glucurone, inosine, compound vitamin B and caryophyllin. The control group received conventional liv- er-protective drugs alone. Clinical manifestations and labo- ratory parameters including liver biochemistry and serum hepatitis B virus markers were monitored before and after treatment in the two groups. RESULTS: Significant differences were seen between the two groups in terms of improvement of clinical symptoms and signs, recovery of liver functions, and serum conver- sion from hepatitis Be antigen to HBe antibody and from positive to negative serum HBV DNA (P <0.05-0.01). The result of the matrine group was more marked than that of the control group. Serious side-effects were not observed except mild pain at the site of injection of matrine in a few patients. CONCLUSION: These results indicate that intramuscular matrine may be an economical, efficacious, safe drug for the treatment of chronic hepatitis B.

关键词： chronic hepatitis B/therapy matrine/therapeutical effect HBV DNA hepatitis B surface antigen hepatitis Be antigen seroconversion

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Prognosis of 980 patients with gastric cancer after surgical resection

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chinese Journal of Cancer 2010年第11期29卷 923-930页

作者： Wei Wang1,2, Yuan-Fang Li1,2, Xiao-Wei Sun1,2, Ying-Bo Chen1,2, Wei Li1,2, Da-Zhi Xu1,2, Xuan-Xiang Guan1,2, Chun-Yu Huang1,2, You-Qing Zhan1,2, Zhi-Wei Zhou1,2 1 State Key Laboratory of Oncology in South china, guangzhou, guangdong 510060, P. R. china 2 department of Gastric and Pancreatic Surgery, Sun Yat-sen university Cancer Center, guangzhou, guangdong 510060, P. R. china department of Gastric and Pancreatic Surgery Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Guangdong Guangzhou 510060

Background and Objective: Although surgery is the only possible means to cure gastric cancer, the prognosis is often discrepant. The American Joint Committee on Cancer/International Union against Cancer (AJCC/UICC) published the TNM classification of Malignant Tumors (seventh edition) for gastric cancer recently. This study aimed to use this new edition staging system to investigate the prognostic factors for gastric cancer. Methods: The clinicopathologic data of 980 patients with gastric cancer treated by surgical resection in our hospital between January 2000 and December 2006 were analyzed retrospectively. The overall survival rate was determined by using Kaplan-Meier method and log-rank test was used to determine significance. The prognosis was analyzed using univariate analysis and multivariate analysis with the Cox proportional hazards model. The 6th and 7th edition AJCC/UICC TNM staging systems were used to compare the survival outcomes for the cohort of patients. Results: The overall 1-, 3-, 5-year survival rates for the whole group were 82.5%, 58.7%, and 52.6%. The 5-year survival rates for patients with pTNM stage I, II, III, and IV disease classified by the 7th edition staging system were 93.2%, 72.4%, 39.1%, and 5.2%, respectively. In both univariate analysis and Cox multivariate analysis, age, tumor site, tumor size, histological type, resection type, radical resection, lymphatic/venous invasion, depth of invasion, nodal status, metastasis, retrieved lymph nodes, metastatic lymph node ratio, and adjuvant chemotherapy were prognostic factors with these patients. Conclusion: Compared with the 6th edition system, the new edition of TNM staging system for gastric cancer can accurately predict the survival after operation.

关键词：手术切除胃癌预后多因素分析单因素分析恶性肿瘤 TNM 淋巴结

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Steroid elimination within 24 hours after orthotopic liver transplantation:effectiveness and tolerability

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Hepatobiliary & Pancreatic Diseases International 2012年第2期11卷 137-142页

作者： Lin-Wei Wu,Zhi-Yong Guo,Qiang Tai,Wei-Qiang Ju,Dong-Ping Wang,An-Bin Hu,Xiao-Feng Zhu and Xiao-Shun He Organ Transplantation Center, First affiliated hospital, Sun Yat-Sen university, guangzhou 510080, china Organ Transplantation Center First Affiliated Hospital Sun Yat-Sen University Guangzhou 510080 China Guangzhou China

BACKGROUND:Steroids have been the mainstay of immunosuppressive regimen in liver ***,the use of steroids is associated with various post-transplant *** study evaluated the efficacy and safety of reduced immunosuppressive regimen with steroids(steroid elimination within 24 hours post-transplant) in a cohort of chinese liver transplant ***:Seventy-six patients in line with the selection criteria were enrolled in this prospective *** patients received anti-IL-2 receptor antibody induction and tacrolimusbased maintenance *** recipients were divided into two groups according to the duration of steroid use:40 transplant in a 3-month withdrawal group and the remaining 36 in a 24-hour elimination *** survival,postoperative infections,biopsy-proven acute rejection and steroidresistant acute rejection,non-healing wound,recurrence of hepatitis B virus(HBV) and hepatocellular carcinoma(HCC),de novo diabetes,hyperlipidemia and hypertension were assessed in the two ***:There was no significant difference in patient survival,incidence of acute rejection episodes and hyperlipidemia,and recurrence of HBV and HCC between the two ***,the incidence rates of post-transplant infection,non-healing wound,de novo diabetes and hypertension were significantly lower in the 24-hour elimination group than in the 3-month withdrawal group(all P values <0.05).CONCLUSION:Under anti-IL-2 receptor antibody induction and tacrolimus-based maintainance,steroid elimination within 24 hours post-transplant is associated with reduced steroidrelated complications without increasing the risk of rejection.

关键词： liver transplantation immunosuppression steroid side effects

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穴位埋线疗法治疗慢性胃炎近10年研究进展

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上海针灸杂志 2004年第9期23卷 45-47页

作者：贺君庄礼兴广州中医药大学广东510405 广州中医药大学第一附属医院针灸科

本文从针灸穴位埋线疗法治疗慢性胃炎的临床疗效、动物实验及机理探讨等三个方面进行了综述 ,并就目前诊断、疗效标准及穴位埋线治疗本病等方面的不足。

关键词：穴位埋线疗法慢性胃炎针灸疗法胃黏膜

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The method of Bo-Shi abdominal acupuncture as a new alternative therapy to insomnia in women: A randomized controlled trial

The method of Bo-Shi abdominal acupuncture as a new alternat...

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首届腹针国际学术研讨会

作者： Xiao-yun Wang Hong-yan Yang Yan-mei Sun Xu-chun Huang Professor Zhi-yun Bo as the mentor The second affiliated hospital of traditional chinese medical university guangzhou

＜正＞Objectives To evaluate the efficacy and safety of short-term abdominal acupuncture as a new alternative therapy comparing with the estazolam of insomnia in chinese adult women. Design Randomized, controlled, single blind trial, with blinded evaluation and statistical analysis of Results. Setting This study was done in the second affiliated hospital of traditional chinese medical university of guangzhou in southern china, over a period of half a year. Participants 52 women outpatients presenting with insomnia aged range from 30 to 55. Interventions Patients were randomly separated into two groups, one receiving treatment of abdominal acupuncture plus placebo named acupuncture group （AG）（n = 36） and the other sham abdominal acupuncture plus estazolam named medicine group （MG）（n=16）. The women in AG received abdominal acupuncture once per day for first three days and subsequently once every three days for twice, at the same time, they also received placebo once a day for 11 days;women in MG sham abdominal acupuncture with same pattern and estazolam once a day. The durations of them both were 11 days. Main outcome measures The degrees of insomnia were measured with-Leeds Sleep Evaluation Questionnaire （LSEQ） before and after the trial respectively by the special researcher. The different values were regard as the index of efficacy evaluation. Furthermore, a series of examinations, including routine analysis of blood, urine, stool, the levels of blood glutamic pyruvic transaminase （GPT）, blood urea nitrogen （BUN）, electrocardiogram （ECG）, were done at the baseline and after this trial as the safety index. All data were analyzed with SPSS 10.0 version, and the method of independent T test was done when comparing measurement data while chi-square test or Fisher’ s Exact Test as numeration data. Results 52 outpatients completed the trial, after 11-day duration, the mean of different scores of women in AG was 25.5 ±11.30 while the MG 10. 0±20. 9, the T score was 3.48 an

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日立7170生化分析仪离子选择电极内标液的研制与应用

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检验医学 2009年第11期24卷 796-798页

作者：曹永坚徐宁罗强广东省中医院芳村分院检验科广东广州510370

目的探讨自配离子选择电极（ISE）内标液试剂能否应用于7170A生化分析仪的ISE模块测定。方法取自配ISE内标液,参照有关文件的内容,测定其理化参数,并评估精密度、准确度和线性范围,并与原装内标液同时检测45份患者样本,统计相关数据。... 详细信息

目的探讨自配离子选择电极（ISE）内标液试剂能否应用于7170A生化分析仪的ISE模块测定。方法取自配ISE内标液,参照有关文件的内容,测定其理化参数,并评估精密度、准确度和线性范围,并与原装内标液同时检测45份患者样本,统计相关数据。结果自配内标液与原装内标液的主要理化参数[pH值、电导率、渗透压、无机离子浓度（K＋、Na＋、Cl^-）]基本一致。2种内标液测定K＋、Na＋、Cl^-（高、低值质控品）的精密度及准确度均无差异（P均〉0.05）。线性方程为K＋（1-10 mmol/L）：Y=0.997 5X＋0.021,r=0.999;Na＋（80-180 mmol/L）：Y=0.999 7X＋0.15,r=0.999;Cl^-（60-160 mmol/L）：Y=1.015 4X-2.51,r=0.989。自配内标液用于测定常规样本的结果与原装内标液的检测结果基本一致（P〉0.05）。结论自配的ISE内标液可替代原装试剂用于7170A生化分析仪ISE模块测定。

关键词：生化分析仪离子选择电极内标液研制

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