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A novel marine-derived anti-acute kidney injury agent targeting peroxiredoxin 1 and its nanodelivery strategy based on ADME optimization

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3232-3250页

作者： Ping Yu Tanwei Gu Yueyang Rao Weimin Liang xi Zhang Huanguo Jiang Jindi Lu Jianglian She Jianmin Guo Wei Yang Yonghong Liu Yingfeng Tu Lan Tang Xuefeng Zhou Guangdong Provincial Key Laboratory of New Drug Screening Guangdong-Hong Kong-Macao Joint Laboratory for New Drug ScreeningSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology Guangdong Key Laboratory of Marine Materia MedicaSouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China NMPA Key Laboratory for Research and Evaluation of Drug Metabolism School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Guangdong Lewwin Pharmaceutical Research Institute Co. Ltd.Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and ResearchGuangdong Engineering Research Center for Innovative Drug Evaluation and ResearchGuangzhou 510990China

Insufficient therapeutic strategies for acute kidney injury(AKI)necessitate precision therapy targeting its *** study reveals the new mechanism of the marine-derived anti-AKI agent,piericidin glycoside S14,targeting peroxiredoxin 1(PRDX1).By binding to Cys83 of PRDX1 and augmenting its peroxidase activity,S14 alleviates kidney injury efficiently in Prdx1-overexpression(Prdx1-OE)***,S14 also increases PRDX1 nuclear translocation and directly activates the Nrf2.HO-1/NQO1 pathway to inhibit ROS *** to the limited druggability of S14 with low bioavailability(2.6%)and poor renal distribution,a pH-sensitive kidney-targeting dodecanaminechitosan nanoparticle system is constructed to load S14 for precise treatment of AKI.L-Serine conjugation to chitosan imparts specificity to kidney injury molecule-1(Kim-1)-overexpressed *** developed S14-nanodrug exhibits higher therapeutic efficiency by improving the in vivo behavior of S14 *** encapsulation with micelles,the AUC_(0-t),half-life time,and renal distribution of S14 increase 2.5-,1.8-,and 3.1-fold,*** main factors contributing to the improved druggability of S14 nanodrugs include the lower metabolic elimination rate and UDPglycosyltransferase(UGT)-mediated *** summary,this study identifies a new therapeutic target for the marine-derived anti-AKI agent while enhancing its ADME properties and druggability through nanotechnology,thereby driving advancements in marine drug development for AKI.

关键词： Acute kidney injury Piericidin glycoside Peroxiredoxin 1 Nanodrug Kim-1 targeted ADME Marine drug Druggability

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离子辐照对材料磁性的调控及其应用

物理学报 2024年第13期73卷 28-43页

作者：郭玺左亚路崔宝山申铁龙盛彦斌席力兰州大学物理科学与技术学院兰州730000 中国科学院近代物理研究所兰州730000

离子辐照技术具有离子束能量密度高、实验条件可精确控制,且不受化学剂量比影响的特点,利用离子束辐照材料,可实现定向掺杂,或精确引入和调控现缺陷位和密度等优势,因此在多个领域,如材料改性、芯片制造、生物医学、能源及化工领域都得... 详细信息

离子辐照技术具有离子束能量密度高、实验条件可精确控制,且不受化学剂量比影响的特点,利用离子束辐照材料,可实现定向掺杂,或精确引入和调控现缺陷位和密度等优势,因此在多个领域,如材料改性、芯片制造、生物医学、能源及化工领域都得到了广泛应用.尤其在磁性材料改性领域,该技术能够通过细致控制离子束的能量、剂量和辐照方向,实现对磁性材料的定制化性能优化.为进一步提升磁性材料的性能并探索新的磁性器件,本文深入地探讨了离子辐照如何精确调制各种磁相互作用,并分析其对自旋霍尔效应和磁结构动力学的影响.首先着重介绍了离子辐照在调控垂直磁各向异性、交换偏置及RKKY相互作用等磁性特征方面的最新研究成果.这些调控手段对于理解和优化磁性材料的微观结构和性质至关重要.接着,本文详细地探讨了离子辐照在调控自旋轨道力矩器件中的重要作用.这些应用展示了离子辐照技术在设计高性能磁性存储和处理器件方面的潜力.最后,还讨论了辐照离子种类、能量、剂量、辐照面积等参数对磁斯格明子成核位置、密度、尺寸、稳定性以及磁斯格明子霍尔效应的调控作用,阐明了离子辐照改变磁斯格明子生成、湮灭、运动规律等方面的内在机理,为制备基于磁斯格明子运动的低功耗存储器件提供新的途径.此外,本文还就离子辐照技术在未来多功能磁性传感器及信息存储磁介质制备方面的可能应用进行了前瞻性分析.离子辐照技术为磁性材料的性能调控和应用扩展提供了新的可能性.随着研究的深入,这项技术有望在未来的材料科学、电子器件以及信息技术等多个领域发挥更大的作用.

关键词：离子辐照磁相互作用能自旋轨道力矩磁斯格明子

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Generation of surface electrons in femtosecond laser-solid interactions

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Science china(Physics,mechanics & Astronomy) 2006年第3期49卷 335-340页

作者： XU Miaohua1, LI Yutong1, YUAN xiaohui1,2. ZHENG Zhiyuan1, LIANG Wenxi1, YU Quanzhi1, ZHANG Yi1, WANG Zhaohua1, WEI Zhiyi1 & ZHANG Jie1 1. Key Laboratory of Optical Physics, Institute of Physics,{2., Beijing 100080, china 2. State Key Laboratory of Transient optics Technology,{2., xi’an 710068, china Key Laboratory of Optical Physics Institute of Physics Chinese Academy of Sciences Beijing 100080 China State Key Laboratory of Transient optics Technology Chinese Academy of Sciences Xi’an 710068 China

The characteristics of hot electrons produced by p-polarized femtosecond laser-solid interactions are studied. The experimental results show that the outgoing electrons are mainly emitted in three directions: along the target surface, the normal direction and the laser backward direction. The electrons flowing along the target surface are due to the confinement of the electrostatic field and the surface magnetic field, while the electrons in the normal direction due to the resonant absorption.

关键词： hot electrons,surface magnetic field,femtosecond laser pulses

Distinguishing malignant from normal stomach tissues and its in vivo, in situ measurement in operating process using FTIR Fiber-Optic techniques

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Science china Chemistry 2005年第2期48卷 167-175页

作者： XU Yizhuang1, YANG Limin1, XU Zhi3, ZHAO Ying2. LING xiaofeng3, LI Qingbo1, WANG Jiansheng4, ZHANG Nengwei3, ZHANG Yuanfu1 & WU Jinguang1 1. The State Key Laboratory of Rare Earth Materials and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, china 2. Institute of Chemistry,{2., Beijing 100080, china 3. Department of Surgery, Third Hospital, Peking University, Beijing 100083, china 4. Department of Oncology Surgery, the First Hospital of xi’an Jiaotong University, xi’an 710061, china Correspondence should be addressed to Wu Jinguang (email: wujg@***) 1. The State Key Laboratory of Rare Earth Materials and Applications College of Chemistry and Molecular Engineering Peking University 100871 Beijing China 2. Department of Surgery Third Hospital Peking University 100083 Beijing China 3. Institute of Chemistry Chinese Academy of Sciences 100080 Beijing China 4. Department of Oncology Surgery the First Hospital of Xi’an Jiaotong University 710061 Xi’an China

Gastric tissue samples were studied using mid-IR fiber-optic attenuated total reflectance (ATR) spectroscopy. FTIR spectra of 90 tissue samples from 48 patients, including 32.normal and 58 malignant tissue samples, were chosen as examples. Malignancy was usually characterized by the absence of CH and C=O bands, a weak amide II band near 1545 cm-1, a shift of the amide I band to lower wave number, a decrease in the ～1450 cm-1 peak to less than the～1400 cm-1 peak. Subtraction spectra indicate that the amide I and amide II bands of normal and malignant tissues have larger differences in peak positions and relative intensities. The statistical analysis results confirm this conclusion. The results indicate that FTIR fiber optic techniques provide important information about cancerous tissue of the stomach, which can be used to differentiate the malignant tissue from the normal tissue. Based on the above results we successfully realize the detection of the tumor tissues of digestive tract in vivo and in situ. And the results of detection cancer near operating room and in vivo and in situ in the operating room are consistent with the conclusions for the samples stored in liquid N2. which is the basis for the clinical application.

关键词： FTIR, Fiber-optics, stomach tissues, cancer, diagnosis.

Stochastic parallel gradient descent based adaptive optics used for a high contrast imaging coronagraph

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Research in Astronomy and Astrophysics 2011年第8期11卷 997-1002页

作者： Bing Dong De-Qing Ren xi Zhang Physics ＆ Astronomy Department California State University Northridge CA 91330-8268 USA National Astronomical Observatories/Nanjing Institute of Astronomical optics ＆ Technology Chinese Academy of Sciences Nanjing 210042 China

An adaptive optics （AO） system based on a stochastic parallel gradient descent （SPGD） algorithm is proposed to reduce the speckle noises in the optical system of a stellar coronagraph in order to further improve the contrast. The principle of the SPGD algorithm is described briefly and a metric suitable for point source imaging optimization is given. The feasibility and good performance of the SPGD algorithm is demonstrated by an experimental system featured with a 140-actuator deformable mirror and a Hartrnann-Shark wavefront sensor. Then the SPGD based AO is applied to a liquid crystal array （LCA） based coronagraph to improve the contrast. The LCA can modulate the incoming light to generate a pupil apodization mask of any pattern. A circular stepped pattern is used in our preliminary experiment and the image contrast shows improvement from 10^-3 to 10^-4.5 at an angular distance of 2./D after being corrected by SPGD based AO.

关键词： instrumentation: adaptive optics -- methods: laboratory -- techniques: image processing coronagraph

Comprehensive performance analysis of popular odd-symmetric phase masks used for wave-front coded imaging system

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Comprehensive performance analysis of popular odd-symmetric ...

2.10亚洲光电子会议光学设计和检验分会场

作者： Hui Zhao and Yingcai Li xi’an Institute of optics and {2. mechanics chinese academy of Science No.17 xinxi Road xi’an china 710119

Wave-front coding was proposed in 1995 and is a powerful system-level technique used to extend the depth of field（DOF） of incoherent imaging *** key to wave-front coding lies in the design of suitable phase masks which make the imaging system insensitive to defocus and defocus-related *** all phase masks used for wave-front coding,odd-symmetric types are dominant and can provide larger extended *** the acceptable degradation of MTF（Modulation Transfer Function） taken as a criterion,optimization procedure is used to obtain the optimum parameters for popular odd-symmetric phase masks and then a comprehensive analysis is carried out by considering four factors:DOF extension capability,sensitiveness to elementary aberrations,PSF（Point Spread Function） shifting effect and restorability of intermediate blurred *** the best of our knowledge,the comprehensive analysis on performance of popular odd-symmetric phase masks,as done in this manuscript,has not been made ***,the work reported here could be considered as a complementary part to the field of wave-front coding.

关键词： wave-front coding depth of field odd-symmetric phase masks incoherent imaging system

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紫外单光子成像系统的研究

物理学报 2008年第7期57卷 4238-4243页

作者：张兴华赵宝升缪震华朱香平刘永安邹玮中国科学院西安光学精密机械研究所瞬态光学与光子技术国家重点实验室

搭建了紫外单光子成像系统,详细介绍了该系统的组成、工作原理和分辨率性能测试.由汞灯发出的紫外光经过大气散射、多块减光片得到了紫外单光子流.单光子直接打在微通道板上,微通道板产生的倍增电子由楔条形阳极收集,电荷灵敏前置放大... 详细信息

搭建了紫外单光子成像系统,详细介绍了该系统的组成、工作原理和分辨率性能测试.由汞灯发出的紫外光经过大气散射、多块减光片得到了紫外单光子流.单光子直接打在微通道板上,微通道板产生的倍增电子由楔条形阳极收集,电荷灵敏前置放大器将阳极输出的电荷信号转变为电压信号,主放大器对前放信号进行滤波整形.利用高速数据采集卡连续采集主放大器的输出波形,通过软件对采集波形进行处理,采用图像处理技术得到了紫外单光子10min的计数图像,并对图像进行了畸变校正.此外,通过自己设计的分辨率板,测得该系统的分辨率可达150μm.该系统在极微弱光探测成像,生物发光,空间环境探测等方面具有广泛应用.

关键词：单光子计数成像阳极探测器楔条形阳极分辨率

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基于细菌视紫红质光子逻辑门的实验研究

物理学报 2003年第11期52卷 2803-2806页

作者：冯晓强侯洵杨文正杨青陈烽中国科学院西安光学精密机械研究所瞬态光学技术国家重点实验室

研究了基于细菌视紫红质 (简称BR或菌紫质 )变种材料D96N的 3种光逻辑操作 .在 6 33nm激发光照射下 ,菌紫质分子会被激发到M态 ,处于M态的菌紫质对 4 12.m的紫光呈较大吸收 ,会抑制同时入射的紫光 .选择合适的紫光强度 ,通过CCD观测被... 详细信息

研究了基于细菌视紫红质 (简称BR或菌紫质 )变种材料D96N的 3种光逻辑操作 .在 6 33nm激发光照射下 ,菌紫质分子会被激发到M态 ,处于M态的菌紫质对 4 12.m的紫光呈较大吸收 ,会抑制同时入射的紫光 .选择合适的紫光强度 ,通过CCD观测被抑制的 4 12.m检测光透射强度分布 ,模拟了“非”、“或非”、“与非”几种基本的光子逻辑操作 .

关键词：细菌视紫红质光子逻辑门互补抑制非线性光学透射强度分布光致变色光学器件

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星载ATP平台的建模与仿真

系统仿真学报 2009年第12期21卷 3813-3815页

作者：张涛梁雁冰许峰王晨冯希中国科学院西安光学精密机械研究所西安710119

采用了分析力学中的拉格朗日方程对星载ATP平台进行了动力学分析,推导出了较准确的运动方程,并说明了为什么U型转台比T型、L型转台具有更高的精度和结构稳定性。利用无刷直流电机的方程式,给出了星载ATP平台系统的非线性数学模型,并利用... 详细信息

采用了分析力学中的拉格朗日方程对星载ATP平台进行了动力学分析,推导出了较准确的运动方程,并说明了为什么U型转台比T型、L型转台具有更高的精度和结构稳定性。利用无刷直流电机的方程式,给出了星载ATP平台系统的非线性数学模型,并利用MATLAB进行了数学仿真,通过实验进行了验证,此模型可作为设计和调试星载ATP平台控制器的基础。

关键词：星载ATP平台模型仿真动力学分析