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湖南农业科学 2024年第5期 1-6页

作者：刘强林元山粟桂蓉周喜新湖南农业大学生物科学技术学院湖南长沙410128

以硝化纤维素为筛选培养基,对采样分离所得菌株和实验室保藏菌株进行平板筛选,获得长势优良的6株降解菌;经固态发酵复筛,获得硝化纤维素降解菌TL06;经ITS序列分析及构建进化树分析,TL06被鉴定为西蒙斯木霉,且命名为西蒙斯木霉TL06。分... 详细信息

以硝化纤维素为筛选培养基,对采样分离所得菌株和实验室保藏菌株进行平板筛选,获得长势优良的6株降解菌;经固态发酵复筛,获得硝化纤维素降解菌TL06;经ITS序列分析及构建进化树分析,TL06被鉴定为西蒙斯木霉,且命名为西蒙斯木霉TL06。分别探究培养基成分、培养条件对西蒙斯木霉TL06产生纤维素酶和酯酶活力的影响,结果表明:培养基中添加有机氮源会显著降低纤维素酶和酯酶活力,而添加无机氮源硫酸铵会显著提高纤维素酶活力;添加碳源会显著降低纤维素酶活力,但对酯酶活力影响不明显。为优化发酵条件设置正交试验,发现在硫酸铵浓度1.5%、硝化纤维素与麸皮的质量比5∶5、发酵时间5 d、料水比10∶12、培养温度3.℃、自然pH值条件下,纤维素酶活力达到1.3. IU/g,比优化前提高了189.3.%。初步探明,西蒙斯木霉TL06降解硝化纤维素的机制是分泌纤维素酶和酯酶,水解β-1,4糖苷键和硝酸酯键,其中糖苷键的水解优先启动。

关键词：硝化纤维素生物降解纤维素酶酯酶西蒙斯木霉

Synergistically Directed Assembly of Aromatic Stacks Based Metal-Organic Frameworks by Donor-Acceptor and Coordination Interactions

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Chinese Journal of Chemistry 2019年第9期37卷 871-877,I0002页

作者： xi Wang Ying Zhang Ze Chang Hui Huang xiao-Ting Liu Jialiang Xu xian-He Bu School of Materials Science and Engineering National Institute for Advanced MaterialsTianjin Key Laboratory of Metal and Molecule-Based Material ChemistryNankai UniversityTianjin 300350China state Key laboratory of Elemento-Organic Chemistry College of ChemistryNankai UniversityTianjin 300071China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China School of Chemical Engineering and Technology Hebei University of TechnologyTianjin 300130

A synergistically directed assembly approach to distinctive metal-organic frameworks utilizing both donor-acceptor (D-A) interaction from aromatic systems and coordination interactions is *** on such an approach,the coronene-tpt (tpt =2,4,6-tri(4-pyridyl)-1,3.5-triazine) stacks based coronene-MOF-1-4 have been successfully *** structural discrepancies with coroneneabsent control products,1'-4',illustrate clearly the significance of coronene-tpt based D-A interactions in these *** these coronene-MOFs contain varied coronene-tpt stacks as organic secondary building blocks (SBUs),which are closely interrelated with the coordination based framework ***,porous coronene-MOF-1 and-2 exhibit high physicochemical stability and significant light hydrocarbons storage and separation performances.

关键词： Aromatic Stacks Based Metal-Organic Frameworks Donor-Acceptor Coordination Interactions

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民航运输业的网络经济性与政府管制变迁

西南交通大学学报（社会科学版） 2004年第2期5卷 46-49页

作者：秦占欣西北大学经济管理学院陕西西安710069

　民航运输业在网络经济效应的作用下,与市场容量扩张、需求增长等形成一种正反馈机制,从而引致该产业由垄断性到竞争性的动态演变,并由此引发了政府管制的变迁。基于这一理论,中国民航运输业进行了管制改革。

关键词：民航运输业中国政府职能网络经济效应资源配置市场经济

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Java技术的基于Web的网络管理应用

计算机工程与应用 2001年第16期37卷 79-81页

作者：杨帆李平均西安交通大学计算机系统结构与网络研究所西安710049

文章论述了网络管理的新趋势──基于Web的网络管理（Web－Based Management）的主要特点，实现WBM的主要方法及与WBM相关的实现技术，并探讨了用Java技术实现WBM的网络管理模式。

关键词：网络管理 Web Java 计算机网络

Synthesis of the fluid machinery network in a circulating water system

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Fine-Grained Multivariate Time Series Anomaly Detection in IoT

中国化学工程学报（英文版） 2019年第3期

作者： Wei Gao xiao Feng*School of Chemical Engineering and Technology xi′an Jiaotong university xi′an 710049 china

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Computers, Materials & Continua 2023年第6期75卷 5027-5047页

作者： Shiming He Meng Guo Bo Yang Osama Alfarraj Amr Tolba Pradip Kumar Sharma xi’ai Yan School of Computer&Communication Engineering Changsha University of Science&TechnologyChangsha410114China Computer Science Department Community CollegeKing Saud UniversityRiyadh11437Saudi Arabia Department of Computing Science University of AberdeenAberdeenAB243FXUK Hunan Provincial Key laboratory of network Investigational Technology Hunan Police AcademyChangsha410138China

Sensors produce a large amount of multivariate time series data to record the states of Internet of Things(IoT)*** time series timestamp anomaly detection(TSAD)can identify timestamps of attacks and ***,it is necessary to determine which sensor or indicator is abnormal to facilitate a more detailed diagnosis,a process referred to as fine-grained anomaly detection(FGAD).Although further FGAD can be extended based on TSAD methods,existing works do not provide a quantitative evaluation,and the performance is ***,to tackle the FGAD problem,this paper first verifies that the TSAD methods achieve low performance when applied to the FGAD task directly because of the excessive fusion of features and the ignoring of the relationship’s dynamic changes between ***,this paper proposes a mul-tivariate time series fine-grained anomaly detection(MFGAD)*** avoid excessive fusion of features,MFGAD constructs two sub-models to independently identify the abnormal timestamp and abnormal indicator instead of a single model and then combines the two kinds of abnormal results to detect the fine-grained *** on this framework,an algorithm based on Graph Attention Neural network(GAT)and Attention Convolutional Long-Short Term Memory(A-ConvLSTM)is proposed,in which GAT learns temporal features of multiple indicators to detect abnormal timestamps and A-ConvLSTM captures the dynamic relationship between indicators to identify abnormal *** simulations on a real-world dataset demonstrate that the proposed algorithm can achieve a higher F1 score and hit rate than the extension of existing TSAD methods with the benefit of two independent sub-models for timestamp and indicator detection.

关键词： Multivariate time series graph attention neural network fine-grained anomaly detection

Chinmedomics: A Powerful Approach Integrating Metabolomics with Serum Pharmacochemistry to Evaluate the Efficacy of Traditional Chinese Medicine

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Engineering 2019年第1期5卷 60-68页

作者： Ai-Hua Zhang Hui Sun Guang-Li Yan Ying Han Qi-Qi Zhao xi-Jun Wang National Chinmedomics Research Center & Sino-America Chinmedomics Technology Collaboration Center & National TCM Key laboratory of Serum Pharmacochemistry & laboratory of Metabolomics Department of Pharmaceutical Analysis Heilongjiang University of Chinese Medicine Harbin 150040 China

Evaluation of the efficacy of traditional Chinese medicines (TCMs) is an important prerequisite for discovering effective substances, lead compounds, and quality markers (Q markers). At present, there is an urgent need to develop a biological language that can act as abridge for the scientific elaboration of the efficacy of TCMs, and to further highlight the significant value of TCM. Chinese medicinal syndromes and formulae are two essential parts of TCM that directly relate to its efficacy. Syndromes and formulae have been taken as the research objects. The serum pharmacochemistry of the TCM approach with metabolomics were integrated to establish an innovative chinmedomics strategy, which is able to explore syndrome biomarkers and evaluate TCM efficacy in order to discover effective substances from TCMs. A great deal of concrete work in chinmedomics has already performed to bridge the gap between Chinese and Western medicine, and to provide a powerful approach to enhance the scientific value of TCM theory and clinical practice. This article summarizes the application of chinmedomics in identifying the candidate biomarkers of a syndrome and revealing the efficacy of the related formula. We also highlight the discovery of lead compounds and Q markers from TCMs.

关键词： Chinmedomics Serum pharmacochemistry of TCM Efficacy Metabolomics Syndrome Biomarkers Quality markers

近代职业教育思潮的现实旨归、终极关怀与价值传承

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陕西师范大学学报（哲学社会科学版） 2011年第1期40卷 171-176页

作者：张雁南陕西师范大学教育学院陕西西安710062

19世纪末20世纪初传入中国的实用主义教育思想,催迫着近代教育观念、教育体制的革新与重构。近代职业教育关于"人计"与"事计"的现实旨归,关于"平民"与"乡村"的终极关怀,关于"实用"与"生利"的经验价值,为中国近代教育的创新与转型奠定了... 详细信息

19世纪末20世纪初传入中国的实用主义教育思想,催迫着近代教育观念、教育体制的革新与重构。近代职业教育关于"人计"与"事计"的现实旨归,关于"平民"与"乡村"的终极关怀,关于"实用"与"生利"的经验价值,为中国近代教育的创新与转型奠定了坚实基础。从当前国内教育发展的时代背景与社会现状来看,近代实用主义职业教育思想依然具有鲜活的现实意义,尤其是值近代职业教育运动一百周年之际,《国家中长期教育改革与发展规划纲要(2010—2020)》对职业教育的重视,更充分说明近代职业教育的宗旨、手段、价值、意义,都应该得到传承、再造与复兴。

关键词：近代职业教育教育改革教育思潮

Significant differences of function and expression of microRNAs between ground state and serum-cultured pluripotent stem cells

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Journal of Genetics and Genomics 2017年第4期44卷 179-189页

作者： Ying Yan xi Yang Ting-Ting Li Kai-Li Gu Jing Hao Qiang Zhang Yangming Wang Beijing Key laboratory of Cardiometabolic Molecular Medicine Institute of Molecular Medicine Peking University Beijing 100871 China Department of Biomedical 1nformatics School of Basic Medical Sciences Peking University Health Science Center Beijing 100871 China

Serum- and 2i-cultured embryonic stem cells （ESCs） show different epigenetic landscapes and tran- scriptomic profiles. The difference in the function and expression of microRNAs （miRNAs） between these two states remains unclear. Here, we showed that 2i- and serum-cultured ESCs exhibited distinctive miRNA expression profiles with 〉100 miRNAs differentially expressed, and the expression changes were largely due to transcriptional regulation. We further characterized the function of miRNAs differentially expressed under two conditions and found that ESCs exhibited higher degree of dependency on miRNAs for rapid proliferation; since Dgcr8-/- or Dicerl-I- but not wild-type ESCs showed slower growth rate and more accumulation in the G1 phase under 2i than serum condition. More interestingly, introduction of various self-renewal-silencing miRNAs in wild-type or Dgcr8/- ESCs failed to silence the self-renewal in 2i medium, but regained the ability to silence the self-renewal upon the addition of serum. Our findings reveal significant differences in the expression and function of miRNAs between serum- and 2i- cultured ESCs.

关键词： Embryonic stem cells microRNAs Ground pluripotency state Self-renewal