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Effects of Cu^(2+) on characteristic of SV currents

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science china Chemistry 2006年第6期49卷 560-564页

作者： ZHANG Liping1,2 & YANG Pin1 1. Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, institute of Molecular science, shanxi University, taiyuan 030006, china 2. institute of Environment science, taiyuan University of science and Technology, taiyuan 030024, china 1. Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Institute of Molecular Science Shanxi University Taiyuan 030006 China 2. institute of Environment science Taiyuan University of Science and Technology Taiyuan 030024 China

Applying the patch-clamp technique to vacuoles from Radish we studied the effects of Cu2+ on Slow Vacuolar (SV) current’s characteristic. Our results show that Cu2+ in bath solution at higher concentration inhibits SV currents and the percentage of inhibition increases with increasing concentration and changes with different voltage. When at lower concentration, Cu2+ significantly promotes the SV currents and the promotion ratio decrease with increasing voltage. At the same time, the time constants of activation become lesser after adding Cu2+. These results show that there may be some Cu2+ binding sites on SV channels and binding to which can change SV current’s characteristic.

关键词： the patch-clamp technique, vacuolar, Cu2+, SV channel.

Mathematical Model for the Drying Process of Granular Materials in a Fluidized Bed

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International Journal of Minerals,Metallurgy and Materials 2000年第4期14卷 296-300页

作者： Xiulan Huai, Li Wang, Zhiyun Qu ( Mechanical Engineering School, University of science and Technology Beijing, Beijing 100083, china Chemical Industry Research institute of shanxi, taiyuan 030031, china) Mechanical Engineering School University of Science and Technology Beijing Beijing 100083 China Chemical Industry Research institute of shanxi Taiyuan 030031 China

The experiment of granular materials, barley, drying in a fluidized bed was carried out to investigate the influence of the factors, inlet air temperature, air moisture, bed height and original moisture content of the dried materials on drying process. Based on the experimental data, a corresponding mathematical model is presented. As a conclusion, a higher inlet air temperature and a reasonable bed height should be used so as to increase the dring rate and to improve the product quality.

关键词： fluidization granular materials drying, experimental investigation mathematical model Information

Metal-amyloid-β peptide interactions: a preliminary investigation of molecular mechanisms for Alzheimer’s disease

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science china Chemistry 2007年第4期50卷 453-467页

作者： JIAO Yong & YANG Pin Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, institute of Molecular science, shanxi University, taiyuan 030006, china 1. Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Institute of Molecular Science Shanxi University Taiyuan 030006 China

Although humans have spent exactly 100 years combating Alzheimer’s disease (AD), the molecular mechanisms of AD remain unclear. Owing to the rapid growth of the oldest age groups of the popula-tion and the continuous increase of the incidence of AD, it has become one of the crucial problems to modern sciences. It would be impossible to prevent or reverse AD at the root without elucidating its molecular mechanisms. From the point of view of metal-amyloid-β peptide (Aβ) interactions, we review the molecular mechanisms of AD, mainly including Cu2+ and Zn2+ inducing the aggregation of Aβ, cata-lysing the production of active oxygen species from Aβ, as well as interacting with the ion-channel-like structures of Aβ. Moreover, the development of therapeutic drugs on the basis of metal-Aβ interactions is also briefly introduced. With the increasingly rapid progress of the molecular mechanisms of AD, we are now entering a new dawn that promises the delivery of revolutionary developments for the control of dementias.

关键词： Alzheimer’s disease (AD) amyloid-β peptide Cu2+ Zn2+ molecular mechanisms aggregation active oxygen species ion channel

中国政治经济学年度发展报告（2023）（下）

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政治经济学评论 2024年第3期 90+207-208页

作者： Center for Studies of Contemporary Political Economy,Research institute for 21st-Century Marxism,Nankai University·University of Chinese Academy of Social science Center for Teaching and Research on Capital,Renmin University of china National institute of Socialist Political Economy with Chinese Characteristics,Renmin University of china 南开大学·中国社会科学院大学21世纪马克思主义研究院当代政治经济学研究中心中国人民大学《资本论》教学与研究中心中国人民大学全国中国特色社会主义政治经济学研究中心

编者按2023年，高质量发展扎实推进，新质生产力加快形成，我国经济总体回升向好，圆满实现发展主要预期目标。为针对性地破解经济恢复发展中的难题，聚焦推进中国式现代化进程中的重点、难点问题，中国政治经济学界开展系统深入研究，...

编者按2023年，高质量发展扎实推进，新质生产力加快形成，我国经济总体回升向好，圆满实现发展主要预期目标。为针对性地破解经济恢复发展中的难题，聚焦推进中国式现代化进程中的重点、难点问题，中国政治经济学界开展系统深入研究，取得系列代表性成果。为准确刻画学界研究进展和轨迹，推动中国经济学理论体系的构建和完善，本刊精选议题如期奉上《中国政治经济学年度发展报告（2023）》。自2010年起，本刊连续十四年发布《中国政治经济学年度发展报告》，“年度发展报告”专栏已成为本刊标志性特色栏目。2023年报告聚焦12个专题，分为（上）（下）两篇，其中专题1—6于报告（上）篇刊登，专题7—12由报告（下）篇刊登。2023年报告（下）选题如下：

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Optimal power allocation for cognitive relay networks: amplify-and-forward versus selection relay

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science china(Information sciences) 2011年第4期54卷 861-872页

作者： YUE WenJing 1,2,ZHENG BaoYu 1,2,MENG QingMin 1,YUE WenJie 3 & CUI JingWu 1 1 institute of Signal Processing and Transmission,Nanjing University of Posts and Telecommunications,Nanjing 210003,china 2 Department of Electronic Engineering,Shanghai Jiaotong University,Shanghai 200240,china 3.shanxi institute of educational science,taiyuan 03.009,china 1. institute of Signal Processing and Transmission Nanjing University of Posts and Telecommunications Nanjing 210003 China2. Department of Electronic Engineering Shanghai Jiaotong University Shanghai 200240 China3. Shanxi Institute of Educational Science Taiyuan 030009 China

We consider a cognitive relay network which is defined by a source,a destination,and cognitive relay nodes and primary user *** this network,a source is assisted by cognitive relay nodes which allow coexisting with primary user nodes by imposing severe constraints on the transmission power so that they operate below the noise floor of primary user *** this paper,we mainly study the power allocation strategies of this system to minimize the outage probability subject to total and individual power constraints for cognitive relay nodes and subject to interference constraints for primary user nodes.A relay transmission scheme,namely amplify-and-forward (AF),is *** first present an optimal power allocation (OPA) scheme to minimize the system outage probability,based on instantaneous channel state information among the source,destination and relay nodes and mean channel gains between primary user nodes and cognitive ***,we propose a selection AF scheme (S-AF) where the single best relay is chosen to assist in the transmission and study power allocation strategy for S-AF to minimize outage *** analytical power allocation strategies have been validated through numerical *** results indicate that the AF with OPA and S-AF with OPA have significantly better outage behavior and average throughput than AF and S-AF schemes *** also find that S-AF with OPA achieves a higher throughput,and hence lower outage probability than AF with OPA.

关键词： cognitive radio (CR) relay networks power allocation outage probability

Binding and endocytosis of monoterbium transferrin by K562 cells

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Chinese science Bulletin 2003年第2期48卷 127-130页

作者： ZHAO Chungui1, YANG Binsheng1,2, ZHANG Wei3, BAI Haijing2 & LIU Wen2 1. institute of Biological Technology, shanxi University, taiyuan 030006, china 2. institute of Molecular science, shanxi University, taiyuan 030006, china 3. Chinese institute of Radiation Protection, taiyuan 030006, china Correspondence should be addressed to Yang Binsheng (e-mail: yangbs@***) institute of Biological Technology Shanxi University Taiyuan China institute of Molecular science Shanxi University Taiyuan China Chinese institute of Radiation Protection Taiyuan China

Using isotopic labeling of human serumapotransferrin, the binding and the endocytosis of monoter-bium transferrin (TbC-apotransferrin, TbC-apotransferrin-FeN) by K562 cells, a human leukemic cell line, have beeninvestigated. There are about (8.58±2.41)×105 binding sites per cell surface at 0℃. The association constant for TbC-apotransferrin binding is 4.1×107 mol-1·L, for TbC-apotransferrin-FeN 2.7×107 mol-1·L at 0℃. At pH 7.4, upon warming cells to 37℃, endocytosis starts. The rate constantsfor the endocytosis are about 0.97 min-1 and 0.31 min-1 and the endocytosis ratio reaches 56% and 80% for TbC-apotransferrin and TbC-apotransferrin-FeN, respectively.

关键词： K562细胞转铁蛋白铽离子结合内噬作用碘125标记

Effects of La^(3+) and Eu^(3+) on outward potassium channels in Vicia guard cells

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science china Chemistry 2009年第11期52卷 1821-1824页

作者： XUE ShaoWu & YANG Pin Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education,institute of Molecular science,shanxi University,taiyuan 030006,china 1. Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Institute of Molecular Science Shanxi University Taiyuan 030006 China

Effects of La3+ and Eu3+ on outward potassium channels(K+out) in Vicia guard cells have been studied by patch clamping *** La3+ inhibited K+out currents with a half-inhibition concentration(IC50) of 81 μmol·***,intracellular La3+ activated K+out currents at a free concentration of 1.13 × 10-14 mol·L-1,and inhibited K+out currents at a free concentration of 5.86 × 10-14 mol·*** Eu3+ also activated K+out currents at concentrations of 10 μmol·L-1 and 50 μmol·L-1,and inhibited K+out currents at concentrations of more than 1 mmol·*** effects of La3+ and Eu3+ on K+out currents may contribute to regulation of the plant water status,which may be one of the mechanisms of the biological effect of rare earth elements.

关键词： rare earth elements stomata guard cell outward potassium channel

Effects of lanthanum on calcium-activated K^+ currents and its kinetics in MC3T3 cells

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science china Chemistry 2010年第6期53卷 1281-1286页

作者： ZHANG LiPing1,2 & YANG Pin1 1Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education institute of Molecular science,shanxi University,taiyuan 030006,china 2College of Environment and Safety,taiyuan University of science and Technology,taiyuan 030024,china 1. Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education institute of Molecular science Shanxi University Taiyuan 030006 China2. College of Environment and Safety Taiyuan University of Science and Technology Taiyuan 030024 China

Using the whole cell patch-clamp technique,we studied the effects of La3+ on calcium-activated K+ currents and its kinetics of activation and inactivation in non-excitable MC3T3 *** results showed that the calcium-activated outward K+ currents were promoted with increasing concentration of Ca2+ in the pipette solution and a voltage- and Ca2+-dependent ***3+ in the bath solution inhibited the currents in a concentration-dependent manner and the inhibition EC50 was 8.23 ± 1.45 μmol/*** the concentration of 50 μmol/L,La3+ significantly changed the Vh of the activation curve and shifted the activation curve to more positive potentials,but shifted the inactivation curve to more negative *** had no effect on the slope factor k of the activation and inactivation *** currents inhibition could induce a series of physiological and molecular biological functions,presumably because of its ability to depolarize the plasma membrane and enhance cell excitability,resulting in increasing Ca2+ influx and cytoplast Ca2+ *** process may be one of the molecular mechanisms by which La3+ affects the cell growth and function of MC3T3 cells.

关键词： MC3T3 cell potassium ion channel La3+ patch-clamp technique

Study of transmembrane La^(3+) movement in rat ventricular myocytes by the patch-clamp technique

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Chinese science Bulletin 2002年第18期47卷 1518-1522页

作者： YANG Pin, DU Huizhi & XUE Shaowuinstitute of Molecular science, shanxi University, taiyuan 030006, china institute of Molecular science Shanxi University Taiyuan China

We have studied transmembrane La3+ movement in rat ventricular myocytes for the first time by using the whole-cell patch-clamp recording mode. La3+ (0.01-5.0 mmol/L) could not bring out inward currents through the L-type calcium channel in rat ventricular myocytes, while it could enter the cells by the same way carried by 1μmo1/L ionomycin. When the outward Na+ concentration gradient is formed, La3+ can enter the cells via Na-Ca exchange, and the exchange currents increase with the increase of external La3+ concentrations. But compared with Na-Ca exchange currents in the same concentration, the former is only 14%-38% of the latter. The patch-clamp experiment indicates that La3+ normally can not enter ventricular myocytes through L-type calcium channel, but it can enter the cells via Na-Ca exchange.

关键词： whole-cell patch-clamp recording ventricular myocyte L-type calcium channel Na-Ca exchange La3+ Ca2+.