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New insight into the role of miRNAs in leukemia

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Science china(Life Sciences) 2009年第3期52卷 224-231页

作者： ZHANG Hua & CHEN YueQin key laboratory of Genetic Engineering of the Ministry of Education,state key laboratory of Biocontrol,Sun Yan-Sen university,Guangzhou 510275,china key laboratory of Genetic Engineering of the Ministry of Education State Key Laboratory of Biocontrol Sun Yan-Sen University Guangzhou China

Recent studies have shown that microRNAs(miRNAs) play an important role in cell differentiation,growth,and death,including the functional study of miRNAs in *** date,miRNA expression profiles in many types of cancers have been identified and miRNA expression signatures associated with types and cytogenetics of leukemia have also been *** evidence has shown that miRNAs could function as either tumor suppressors or oncogenes in cancers such as leukemia,while other miRNAs might be benefitcial for diagnosis and prognosis,predicted to be newly developed *** this review,we summarize the recent progress about miRNAs in leukemia and present a miRNA-mediated network involved in differentiation,proliferation and apoptosis predicted to be the roles of miRNAs in the pathogenesis of leukemia.

关键词： miRNA leukemia regulation network clinical implication

Multi-symplectic method to analyze the mixed state of Ⅱ-superconductors

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Science china(Physics,Mechanics & Astronomy) 2008年第12期51卷 1835-1844页

作者： HU WeiPeng1↑ & DENG ZiChen1,2 1 School of Mechanics, Civil Engineering and Architecture, Northwestern Polytechnical university, xi’an 710072, china 2 state key laboratory of Structural Analysis of Industrial Equipment, Dalian university of Technology, Dalian 116023, china School of Mechanics Civil Engineering and Architecture Northwestern Polytechnical University Xi’an China state key laboratory of Structural Analysis of Industrial Equipment Dalian University of Technology Dalian China

The mixed state of two-band II-superconductor is analyzed by the multi-symplectic method. As to the Ginzburg-Landau equation depending on time that describes the mixed state of two-band II-superconductor, the multi-symplectic formulations with several conservation laws: a multi-symplectic conservation law, an energy con- servation law, as well as a momentum conservation law, are presented firstly; then an eighteen points scheme is constructed to simulate the multi-symplectic partial differential equations (PDEs) that are derived from the Ginzburg-Landau equation; finally, based on the simulation results, the volt-ampere characteristic curves are obtained, as well as the relationships between the temperature and resistivity of a suppositional two-band II-superconductor model under different magnetic intensi- ties. From the results of the numerical experiments, it is concluded that the notable property of the mixed state of the two-band II-superconductor is that: The trans- formation temperature decreases and the resistivity ρ increases rapidly with the increase of the magnetic intensity B. In addition, the simulation results show that the multi-symplectic method has two remarkable advantages: high accuracy and excellent long-time numerical behavior.

关键词： two-band Ginzburg-Landau equation mixed state multi-symplectic conservation law

The microtine distribution and its environmental significance since the Middle Pleistocene in Zhangping Caves of the Qinling Mountains

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Science china Earth Sciences 2008年第2期51卷 294-299页

作者： LI Yongxiang1 & XUE xiangXu1,2 1 state key laboratory of Continental Dynamics, Department of Geology, Northwest university, Institute of Cenozoic Geology and Environment, xi’an 710069, china 2 Institute of Earth Environment, state key laboratory of Loess and Quaternary Geology, Chinese Academy of Sciences, xi’an 710075, china state key laboratory of Continental Dynamics Department of Geology Northwest University Institute of Cenozoic Geology and Environment Xi’an China Institute of Earth Environment State Key Laboratory of Loess and Quaternary Geology Chinese Academy of Sciences Xi’an China

Three microtine species are recovered from the Zhangping Caves of the Qingling Mountains, namely Microtus oeconomus, Caryomys inez and Caryomys eva. They are climate-sensitive ones with different ecological habits, therefore their distribution well corresponds to environmental variations. Statistical comparison of the distribution of fossil microtines and their counterparts nowadays displays that the climate variation of the studied area and its contiguity since the middle Pleistocene are: warm and humid at 493 ka ago, cool and humid at 259 ka ago―cold and humid at 205 ka ago―cool and humid at 28 ka ago, and warm and dry at present.

关键词： environmental variation since Middle Pleistocene microtine fossils Zhangping Caves of the Qinling Mountains

The Properties of Native Silk Fibroin (SF) Solution/Gel from Bombyx mori Silkworms during the Full Fifth Instar Larval Stage

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Journal of Wuhan university of Technology(Materials Science) 2011年第2期26卷 263-269页

作者：王洪 key laboratory of Textile Science & Technology Ministry of EducationDonghua University

The properties of native silk fibroin （SF） solution in the gland of silkworms during the full fifth instar larval stage were examined in an attempt to elucidate the mechanism of natural silk spinning in the *** flow and gelation behavior,birefringence phenomenon,rheological properties,specific viscosity and conformation of SF solutions from the gland of silkworms were measured by polarized light microscope,HAKKE rheometer,Ubbelohde viscometer and Solid-state 13C NMR,*** comparing their properties with regenerated SF solutions from natural silk fibers,it is believed that there exists a progressive maturation process favorable to spin silk fibers with excellent properties from native SF solution and a weak bonded and highly oriented SF gel network with SF molecules partly extended in α-helix conformation is formed in the middle section of the gland of *** suggests that a biomimetic maturation process for making spinnable solution might be necessary for artificial silk fiber spinning in order to obtain improved fiber properties.

关键词： silk fibre spin viscosity sol/gel

“Blocking and rebalance”mechanism-guided design strategies of bimetallic doped 2D a-phosphorus carbide as efficient catalysts for N_(2) electroreduction

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Journal of Energy Chemistry 2024年第10期97卷 68-78,I0003页

作者： Cheng He Jianglong Ma Shen xi Wenxue Zhang state key laboratory for Mechanical Behavior of Materials School of Materials Science and EngineeringXi'an Jiaotong UniversityXian 710049ShanxiChina School of Materials Science and Engineering Chang'an UniversityXi'an 710064ShaanxiChina

Compared to single atom catalysts(SACs),the introduction of dual atom catalysts(DACs)has a significantly positive effect on improving the efficiency in the electrocatalytic nitrogen reduction reaction(NRR)which provides an environmental alternative to the Haber-Bosch ***,the research on the mechanism and strategy of designing bimetallic combinations for better performance is still in its early ***,based on"blocking and rebalance"mechanism,45 combinations of bimetallic pair dopedα-phosphorus carbide(TM_(A)TM_(B)@PC)are investigated as efficient NRR catalysts through density functional theory and machine learning *** a multi-step screening,the combinations of TiV,TiFe,MnMo,and FeW exhibit highly efficient catalytic performance with significantly lower limiting potentials(-0.17,-0.18,-0.14,and-0.30 V,respectively).Excitingly,the limiting potential for CrMo and CrW combinations is 0 V,which are considered to be extremely suitable for the NRR *** mechanism of"blocking and rebalance"is revealed by the exploration of charge transfer for phosphorus atoms in electron blocking ***,the descriptorφis proposed with machine learning,which provides design strategies and accurate prediction for finding efficient *** work not only offers promising catalysts TM_(A)TM_(B)@PC for NRR process but also provides design strategies by presenting the descriptorφ.

关键词： DACs Nitrogen reduction reaction 2D a-phosphorus carbide Inherent attributes Machine learning

A New Watermarking Protocol against Conspiracy

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Wuhan university Journal of Natural Sciences 2006年第6期11卷 1671-1674页

作者： ZHANG Jun KOU Weidong FAN Kai CAO Xuefei state key laboratory of integrated Service networks Xidian University Xi＇an 710071 Shaanxi China

A trusted third party introduced in watermarking protocols would decrease the security and affect the implementation of the protocols. In this paper, a new watermarking protocol with an un-trusted third party （UTTP） was proposed. Based on the idea of all-or-nothing disclosure of secret （ANDOS）, all of the buyer, the seller and the third party didn＇t know the exact watermark, which was embedded in a digital content for tracing piracy. The proposed protocol provided mechanisms to trace piracy and protect customer＇s right. In addition, the problem that a seller colluded with UTTP to frame the buyer, namely, the conspiracy problem, could be avoided.

关键词： watermarking protocol electronic commerce security digital copyright protection conspiracy problem

Atmospheric correction of HJ-1A/B CCD images over Chinese coastal waters using MODIS-Terra aerosol data

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Science china(Technological Sciences) 2010年第S1期53卷 191-195页

作者： TIAN LiQiao 1,LU JianZhong 1,CHEN xiaoLing 1,2,3,YU ZhiFeng 1,xiAO JingJing 1,QIU Feng 1 & ZHAO xi 1 1 state key laboratory of Information Engineering in Surveying,Mapping and Remote Sensing,Wuhan university,Wuhan 430079,china 2key laboratory of Poyang Lake Wetland and Watershed Research,Ministry of Education,Jiangxi Normal university,Nanchang 330022,china 3 The key laboratory of Poyang Lake Environment and Resource Utilization,Ministry of Education,Nanchang university,Nanchang 330031,china state key laboratory of Information Engineering in Surveying Mapping and Remote Sensing Wuhan University Wuhan China key laboratory of Poyang Lake Wetland and Watershed Research Ministry of Education Jiangxi Normal University Nanchang China The key laboratory of Poyang Lake Environment and Resource Utilization Ministry of Education Nanchang University Nanchang China

This paper demonstrates an atmospheric correction method to process HJ-1A/B CCD images over Chinese coastal waters with the aid of MODIS-Terra aerosol *** on the assumption of zero water-leaving radiance at the two near-infrared (NIR)bands or the shortwave infrared(SWIR)bands,the atmospheric aerosol optical depth(AOD)is firstly retrieved from MODIS-Terra with a simple extension of the NIR-SWIR combined atmospheric correction approach embedded in SeaDAS (SeaWiFS data analysis system).Then the"turbid"and"non-turbid"waters are separated by the turbid water *** probability of AOD at 551 nm band is derived based on the NIR information over"non-turbid"waters and FLAASH model is selected to do the atmospheric correction of the HJ-1A/B CCD imagery using the AOD values of highest probabilities as ***,according to the histogram of the AOD distribution at 551 nm band,the studied turbid water area is divided into several blocks and HJ-1A/B CCD imagery is corrected with the corresponding AOD values displayed with the highest frequency in each *** method has been applied to several HJ-1A/B images over Chinese coastal waters and validated by synchronous in-situ *** results have shown that this method is effective in the atmospheric correction process of HJ-1A/B CCD images for ocean color remote sensing study and application in the coastal waters.

关键词： ocean color remote sensing atmospheric correction turbid coastal waters HJ-1A/B MODIS

Characterization of cerebrovascular changes in Alzheimer's disease mice by photoacoustic imaging

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Journal of Innovative Optical Health Sciences 2024年第6期17卷 29-40页

作者： xi Li Zhongyang Zhang Hua Shi Feifan Zhou key laboratory of Biomedical Engineering of Hainan Province School of Biomedical Engineering Hainan university Sanya 572025P.R.China

The cerebral vasculature plays a significant role in the development of Alzheimer's disease(AD),however,the specific association between them remains *** this paper,based on the benefits of photoacoustic imaging(PAI),including label-free,high-resolution,in vivo imaging of vessels,we investigated the structural changes of cerebral vascular in wild-type(WT)mice and AD mice at different ages,analyzed the characteristics of the vascular in different brain regions,and correlated vascular characteristics with cognitive *** results showed that vascular density and vascular branching index in the cortical and frontal regions of both WT and AD mice decreased with ***,vascular lacunarity increased with age,and the changes in vascular structure were more pronounced in AD *** trend of vascular dysfunction aligns with the worsening cognitive dysfunction as the disease ***,we utilized in vivo PAI to analyze the changes in vascular structure during the progression of AD,elucidating the spatial and temporal correlation with cognitive impairment,which will provide more intuitive data for the study of the correlation between cerebrovascular and the development of AD.

关键词： Photoacoustic imaging Alzheimer's disease cerebrovascular vascular network cognitive impairment.

Petrogenesis of Songshugou dunite body in the Qinling orogenic belt, Central china: Constraints from geochemistry and melt inclusions

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Science china Earth Sciences 2005年第8期48卷 1146-1157页

作者： SU Li1,2, SONG Shuguang3 & ZHOU Dingwu1 1. key laboratory of Continental Dynamics of the Ministry of Education, Department of Geology, Northwestern university, xi’an 710069, china 2. The Geological Lab Center, china university of Geosciences (Beijing), Beijing 100083, china 3. key laboratory of Orogenic Belts of the Ministry of Education, Department of Geology, Peking university, Beijing 100871, china key laboratory of Continental Dynamics of the Ministry of Education Department of Geology Northwestern University Xi’an China The Geological Lab Center China University of Geosciences (Beijing)Beijing China key laboratory of Orogenic Belts of the Ministry of Education Department of Geology Peking University Beijing China

The Songshugou dunite body, which occupies an area of about 20 km2, is the largest ultramafic massif in the eastern Qinling orogenic belt, Central china. The major compo-nent of this body is dunitic rocks including mylonitic dunite and coarse-grained dunite; they oc-cupy about 95 vol% of the total body. Petrography, mineral composition, major and trace ele-ments and primitive melt inclusions have been investigated in this paper; all revealed that this dunite body is the product of melt-rock interaction by porous percolation flow. In comparison with dunite sills or veins in harzburgite from the basal part of Oman ophiolite, this dunite body is characterized by lower contents of Al2O3, CaO and HREE but higher content of highly incom-patible elements and Zr and Hf. The LREE enriched patterns and primitive mantle normalized spidergrams of trace elements are also different from the Oman dunite. Combining with melt in-clusions observed in olivines, we conclude that this dunite body is the product of large- scale porous percolation flow of high-MgO melts within depleted mantle peridotites. The high-MgO magma, in essence, was most probably produced at the hot head of an upwelling mantle plume. The occurrence of the Songshugou dunite body is closely associated with the activity of mantle super-plume in Neo-Proterozoic era in the Yangtze Craton.

关键词： Songshugou dunite body, geochemistry, melt inclusion, mantle plume, Qinling orogenic belt.