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A　NEW　SYNTHESIS　OF　1,4.DISUBSTITUTED　AZO　UREAS

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Chinese chemical Letters 1996年第5期7卷 393-394页

作者： Jian Ping LI Jin Ye WANG Dong Lan MA Yu Lu WANG (Department of Chemistry, Henan Normal University, Xinxiang, 4.3002)(photobiology Group, photodynamics research center, The Institute of physical and chemical research, 19-1399 Koeji, Nagamachi, Aoba-ku, INST PHYS & CHEM RES PHOTOBIOL GRPPHOTODYNAM RES CTRAOBA KUSENDAIMIYAGI 980JAPAN

Abstract: Ten new 1, 4.disubstituted azo ureas were synthesized by the reaction of substituted semicarbazide compounds with a phenoxyl radical between two phases in good yield.

关键词： AZO UREAS SYNTHESIS OF DISUBSTITUTED NEW

Nanomedicine integrating the lipidic derivative of 5-fluorouracil,miriplatin and PD-L1 si RNA for enhancing tumor therapy

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Chinese chemical Letters 2024年第6期35卷 385-391页

作者： An Lu Yuhao Guo Yi Yan Lin Zhai Xiangyu Wang Weiran Cao Zijie Li Zhixia Zhao Yujie shi Yuanjun Zhu Xiaoyan Liu Huining He Zhiyu Wang Jian-Cheng Wang Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijing 100191China Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics School of PharmacyTianjin Medical UniversityTianjin 300070China Department of Immuno-oncology The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011China Department of Pharmacy Clinical Trial Research CenterChina-Japan Friendship HospitalBeijing 100029China Laboratory of innovative formulations and pharmaceutical excipients Ningbo Institute of Marine MedicinePeking UniversityNingbo 315832China

Immunosuppressive microenvironments present critical problems in clinical *** regulate the tumor immune microenvironment for enhancing antitumor effect,a combination of immune checkpoint inhibitors(ICIs)with chemotherapeutics has been applied *** this study,miriplatin(MiPt),the lipidic derivative of 5-fluorouracil(Fu-OA),as well as the programmed death ligand 1(PD-L1)target si RNA(siPD-L1)were integrated into Lip-Pt/Fu@siPD-L1 nanoparticles(NPs)for *** vitro results showed that Lip-Pt/Fu@siPD-L1 NPs could exhibit effective siRNA gene silencing and promote the phagocytosis of tumor cells by ***,in vivo results revealed that LipPt/Fu@siPD-L1 NPs showed significantly higher anti-tumor efficiency than that of the physical mixing of Mi Pt,5-fluorouracil,and Lip@siPD-L1 NPs(delivery of siPD-L1 by liposomes).The best anti-tumor efficiency of Lip-Pt/Fu@siPD-L1 NPs resulted from the synergistic immunotherapeutic effects of Mi Pt and siPD-L1 based on the inhibition of CD4. expression and the downregulation of PD-L1 in tumor cells,which elicited a robust anti-tumor immune response through the activation of macrophage phagocytosis and immune checkpoint *** Lip-Pt/Fu@siPD-L1 NPs provide a potential strategy for tumor chemo-immunotherapy.

关键词： Chemo-immunotherapy Immune checkpoint inhibition Gene silencing Miriplatin Macrophage phagocytosis Nanotechnology

Direct Generation of Tunable UV Picosecond Laser Pulses Using Spectrotemporal Selection

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Chinese Journal of Lasers 1997年第3期 7-15页

作者： Nguyen Dai Hung1) Yusaburo Segawa(Photodynamic research center, Institute of physical and chemical research(RIKEN),191399 Naganachi Koeji, Aoba, Sendai 980, japan 1) Institute of Material Sciences, National Centre for Sciences and Technol

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关键词： ultraviolet laser dye laser tunable picosecond laser

6种非标农药的改进QuEChERS结合GC-MS/MS技术检测方法的建立与应用

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现代食品科技 2024年第1期40卷 272-280页

作者：苏雅航车颖欣李永丽刘俊唐诗李海涛唐俊妮西南民族大学食品科学与技术学院四川成都610041 成都海关技术中心四川成都610041 食品安全检测四川省食品安全重点实验室四川成都610041 天津市理化分析中心有限公司天津300051

针对6种欧盟及日本进出口果蔬中重点检测,但在我国食品安全国家标准中暂无检测标准的农药物质进行研究,建立一种改进的QuEChERS(Quick,Easy,Cheap,Effective,Rugged and Safe)提取净化方法结合气相色谱-串联质谱技术(Gas Chromatography... 详细信息

针对6种欧盟及日本进出口果蔬中重点检测,但在我国食品安全国家标准中暂无检测标准的农药物质进行研究,建立一种改进的QuEChERS(Quick,Easy,Cheap,Effective,Rugged and Safe)提取净化方法结合气相色谱-串联质谱技术(Gas Chromatography-tandem Mass Spectrometry,GC-MS/MS)检测方法,能快速检测叶菜类蔬菜基质中邻苯基苯酚钠、二甲基敌草索等6种农药多残留。样品采用乙腈提取、无水MgSO4.NaCl盐析除水后,经N-丙基乙二胺(PSA)固相材料净化,使用GC-MS/MS在多反应监测模式(Multi Reaction Monitoring,MRM)下分析检测。结果表明:6种农药物质在0.002~0.5μg/mL范围内线性关系良好,相关系数R均大于0.998,方法检出限(RSN=3)为0.15~2.32μg/kg,平均回收率为84.50%~106.23%,相对标准偏差为0.96%~8.35%,此结果均符合欧盟农药残留分析质量控制程序要求与日本和欧盟对农残“一律标准”中农药限量要求。将建立的检测方法应用于其他蔬菜中高发农药物质的检测,检测效果良好。该方法重复性好、耗时短、易操作,为邻苯基苯酚钠、二甲基敌草索等多种农药残留的检测提供了新的检测技术和依据。

关键词： QuEChERS 气相色谱-串联质谱法农药残留叶菜类蔬菜

Mass predictions of the relativistic continuum Hartree-Bogoliubov model with radial basis function approach

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Chinese Physics C 2019年第7期43卷 53-60页

作者： Min shi Zhong-Ming Niu Hao-Zhao Liang School of Mathematics and Physics Anhui Jianzhu UniversityHefei 230601China School of Physics and Materials Science Anhui UniversityHefei 230601China Institute of physical Science and Information Technology Anhui UniversityHefei 230601China RIKEN nishina center Wako 351-0198Japan Department of Physics Graduate School of ScienceThe University of TokyoTokyo 113-0033Japan

The radial basis function(RBF) approach is a powerful tool to improve nuclear mass predictions. By combining the RBF approach with the latest relativistic continuum Hartree-Bogoliubov(RCHB) model, the local systematic deviations between the RCHB mass predictions and the experimental data are eliminated, and the root-meansquare(rms) mass deviation is significantly reduced from 7.923 MeV to 0.386 MeV. However, systematic deviations between the RBF improved mass predictions and the experimental data remain for nuclei with four different odd-even parities, i.e.(even Z, even N),(even Z, odd N),(odd Z, even N), and(odd Z, odd N). They can be reduced by separately training RBF for the four groups of nuclei, and the resulting rms deviation decreases to 0.229 MeV. It is found that the RBF approach can describe the deformation effects neglected in the present RCHB mass calculations, and also improves the description of the shell effect and the pairing effect.

关键词： nuclear masses radial basis function approach relativistic continuum Hartree-Bogoliubov model

Calculation of Surface Excitation Parameters by a Monte Carlo Method

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Chinese Journal of chemical Physics 2017年第1期30卷 83-89,I0002页

作者： Zhe Zheng Bo Da shi-feng Mao Ze-jun Ding CAS Key Laboratory of Geospace Environment Department of Modern Physics University of Science and Technology of China Hefei 230026 China National Institute for Materials Science 1-2-1 Sengen Tsukuba Ibaraki 305-0047 Japan School of Nuclear Science and Technology University of Science and Technology of China Hefei 230026 China Hefei National Laboratory for physical Sciences at the Microscale and Department of Physics University of Science and Technology of China Hefei 230026 China

Electron inelastic mean free path （IMFP） is an important parameter for surface chemical quantification by surface electron spectroscopy techniques. It can be obtained from analysis of elastic peak electron spectroscopy （EPES） spectra measured on samples and a Monte Carlo simulation method. To obtain IMFP parameters with high accuracy, the surface excitation effect on the measured EPES spectra has to be quantified as a surface excitation parameter （SEP）, which can be calculated via a dielectric response theory. However, such calculated SEP does not include influence of elastic scattering of electrons inside samples during their incidence and emission processes, which should not be neglected simply in determining IMFP by an EPES method. In this work a Monte Carlo simulation method is employed to determine surface excitation parameter by taking account of the elastic scattering effect. The simulated SEPs for different primary energies are found to be in good agreement with the experiments particularly for larger incident or emission angles above 60° where the elastic scattering effect plays a more important role than those in smaller incident or emission angles. Based on these new SEPs, the IMFP measurement by EPES technique can provide more accurate data.

关键词： Eelastic peak electron spectroscopy Surface excitation parameter Monte Carlo simulation

Epitaxial growth of trilayer graphene moiré superlattice

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Chinese Physics B 2023年第7期32卷 510-514页

作者：袁亚龙褚衍邦胡成田金朋刘乐吴帆帆季怡汝赵交交黄智恒昝晓洲杜罗军 Kenji Watanabe Takashi Taniguchi 时东霞史志文杨威张广宇 Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences(CAS)Beijing 100190China School of physical Sciences University of Chinese Academy of SciencesBeijing 100190China Key Laboratory of Artificial Structures and Quantum Control(Ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation center of Advanced Microstructures Nanjing 210093China research center for Functional Materials National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan International center for Materials Nanoarchitectonics National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Songshan Lake Materials Laboratory Dongguan 523808China

The graphene-based moiré superlattice has been demonstrated as an exciting system for investigating strong correlation phenomenon. However, the fabrication of such moiré superlattice mainly relies on transfer technology. Here, we report the epitaxial growth of trilayer graphene(TLG) moiré superlattice on hexagonal boron nitride(h BN) by a remote plasma-enhanced chemical vapor deposition method. The as-grown TLG/h BN shows a uniform moiré pattern with a period of ~ 15 nm by atomic force microscopy(AFM) imaging, which agrees with the lattice mismatch between graphene and h BN. By fabricating the device with both top and bottom gates, we observed a gate-tunable bandgap at charge neutral point(CNP) and displacement field tunable satellite resistance peaks at half and full fillings. The resistance peak at half-filling indicates a strong electron–electron correlation in our grown TLG/h BN superlattice. In addition, we observed quantum Hall states at Landau level filling factors ν = 6, 10, 14...., indicating that our grown trilayer graphene has the ABC stacking order. Our work suggests that epitaxy provides an easy way to fabricate stable and reproducible two-dimensional strongly correlated electronic materials.

关键词： epitaxial growth ABC-TLG/hBN moirésuperlattice electron correlations