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Possible Role of Histone H1 in the Regulation of Furin-dependent Proprotein Processing

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Acta Biochimica et Biophysica Sinica 2007年第3期39卷 173-180页

作者： Jinbo HAN~1 Jianxin GU~2 Chengwu CHI~(1,3*) 1 institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,Graduate School of the Chinese Academy of Sciences,shanghai 200031,china 2 Gene research Center,Medical Center of Fudan university,shanghai 200032,china 3.institute of protein research,tongji university,shanghai 200092,china institute of Biochemistry and Cell Biology Chinese Academy of Sciences Graduate School of the Chinese Academy of Sciences Shanghai China.

Histone H1 and its C-terminal lysine rich fragments were recently found to be potent inhibitorsof furin,a mammalian proprotein ***,its role in the regulation of furin-dependent proproteinprocessing remains *** we report that histone H1 efficiently blocks furin-dependent pro-yonWillebrand factor（pro-vWF）processing in a dose-dependent *** and immunof-luorescence studies confirmed that histone H1 could interact with furin,and the interaction mainly took placeon the cell *** noted that histone H1 was released from cells undergoing necrosis and apoptosisinduced by *** findings suggested that histone H1 might be involved in extracellular and/or intracellu-lar furin regulation.

关键词： furin histone H1 pro-vWF proprotein processing

Flexural and Impact Resistance of FRC/Bamboo Laminate

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Journal of Materials Science & Technology 2002年第4期18卷 369-371页

作者： Wu YAOState Key Laboratory of Concrete Materials research, tongji university, shanghai 200092, china Lab. of Concrete Mat. Res. Tongji Univ. Shanghai 200092 China

The flexural and impact resistance of a newly developed FRC/bamboo laminate have been investigated. The laminate considered in this study was combined with reformed bamboo plate and extruded fiber reinforced cementitious (FRC) sheet. Innovated from the raw bamboo, reformed bamboo showed high tensile strength and high strength to weight ratio. It can not only remarkably strengthen the FRC sheet but also reduce the total weight of the laminate. Flexural and impact load, broken energy, deflection and duration were measured. Test results showed that the flexural strength value for the laminate can be improved to greater than 90 MPa, while the impact resistance is increased more than 10 times for the laminate when compared with the FRC sheet only.

关键词： Flexural strength Impact FRC/bamboo composite

Conus Peptides-A Rich Pharmaceutical Treasure

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Acta Biochimica et Biophysica Sinica 2004年第11期36卷 713-723页

作者： Cheng-Zhong WANG and Cheng-Wu CHIinstitute of Biochemistry and Cell Biology, shanghai institute of Biological Sciences, the Chinese Academy of Sciences, shanghai 200031, china institute of Neuroscience, the Chinese Academy of Sciences, shanghai 200031, china institute of protein research, tongji university, shanghai 200092, china institute of Biochemistry and Cell Biology Shanghai Institute of Biological Sciences the Chinese Academy of SciencesShanghai 200031 China institute of Neuroscience the Chinese Academy of SciencesShanghai 200031 China institute of protein research Tongji UniversityShanghai 200092 China

Marine predatory cone snails (genus Conus) with over 500 species represent what is arguably the largest single genus of marine animals alive today. All Conus are venomous and utilize a complex mixture of Conus peptide... 详细信息

关键词： Conus peptide conotoxin neuropathic disorder pharmaceutical potency

Dependence of binaural loudness summation on interaural level difference and frequency for pure tones

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Science china(Physics,Mechanics & Astronomy) 2010年第5期53卷 834-841页

作者： ZHANG Jie & MAO DongXing institute of Acoustics,tongji university,shanghai 200092,china institute of Acoustics Tongji University Shanghai China

Most of the existing loudness models are based on the diotic listening hypothesis,though human beings always hear in dichotic listening *** this situation,the arithmetic mean of loudness at both ears is usually taken as the approximate value of overall perceived loudness,unaffected by the interaural level difference(ILD).The present work investigated the overall perceived loudness for pure tones in dichotic listening conditions through a subjective *** experimental procedures and systematic errors were investigated to prove the accuracy of the subjective *** results showed that fluctuation was insignificant in the low frequency range,while apparent fluctuation of overall loudness could be observed at a high *** overall loudness deviated from the arithmetic mean value as the ILD became larger.A revised model for overall loudness in dichotic listening conditions was *** proposed model and experiment are consistent.

关键词： dichotic listening subjective experiment interaural level difference overall perceived loudness loudness model

Explicit Analytical Solutions for the Shearingand Radial Stresses in Curved Beams

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Communications in Nonlinear Science and Numerical Simulation 1999年第2期4卷 151-156页

作者： Aiming YU+ Xiangrong LI+++ (tongji university, shanghai 200092, china)++ (shanghai university, shanghai 200072, china) tongji university Shanghai 200092 China shanghai university Shanghai 200072 China

The shearing stresses in curved beams can be solved explicitly from anintegral equation, which is obtained by differentiation & integral manipulations. Twonovel formulae for shearing & radial stresses are also presented in the paper. The resultsof an example reveal that the shearing & radial stresses arrive at their maximum valuesslightly below the centroid of the section.

关键词： curved beam shearing stress radial stress integral equation

Smart Behavior of Carbon Fiber Reinforced Cement-based Composite

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Journal of Materials Science & Technology 2003年第3期19卷 239-242页

作者： Wu YAO, Bing CHEN Keru WUState Key Laboratory of Concrete Materials research, tongji university, shanghai 200092, china Lab. of Concrete Mat. Res. Tongji Univ. Shanghai 200092 China

The electrical characteristics of cement-based material can be remarkably improved by the addition of short carbon fibers. Carbon fiber reinforced cement composite (CFRC) is an intrinsically smart material that can sense not only the stress and strain, but also the temperature. In this paper, variations of electrical resistivity with external applied load, and relation of thermoelectric force and temperature were investigated. Test results indicated that the electrical signal is related to the increase in the material volume resistivity during crack generation or propagation and the decrease in the resistivity during crack closure. Moreover, it was found that the fiber addition increased the linearity and reversibility of the Seebeck effect in the cement-based materials. The change of electrical characteristics reflects large amount of information of inner damage and temperature differential of composite, which can be used for stress-strain or thermal self-monitoring by embedding it in the concrete structures.

关键词： Carbon fiber Cement-based composite Smart material Seebeck effect

STABILITY OF IMPULSIVE LINEAR HYBRID SYSTEMS WITH TIME DELAY

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Journal of Systems Science & Complexity 2010年第4期23卷 738-747页

作者： Yu ZHANG·Jitao SUN Department of Mathematics,tongji university,shanghai 200092,china. Department of Mathematics Tongji University Shanghai China

This paper investigates the stability of impulsive linear hybrid systems with time *** a number of delay-independent/delay-dependent stability criteria are obtained by using Lyapunovfunctions or Lyapunov *** examples ... 详细信息

关键词： Impulsive linear hybrid system Lyapunov function Lyapunov functional time delay.

Synthesis and Characteristics of an Aspartame Analogue,L-Asparaginyl L-3-Phenyllactic Acid Methyl Ester

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Acta Biochimica et Biophysica Sinica 2004年第6期36卷 385-389页

作者： Hu TAO1, Da-Fu CUI1, and You-Shang ZHANG1,2* 1institute of Biochemistry and Cell Biology, shanghai institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, shanghai 200031, china institute of protein research, tongji university, shanghai 200031, china institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Graduate School of the Chinese Academy of SciencesShanghai 200031 China institute of protein research Tongji UniversityShanghai 200031 China

An aspartame analogue, L-asparaginyl L-3-phenyllactic acid methyl ester was synthesized with aspartic acid replaced by asparagine and peptide bond replaced by ester bond. The aspartic acid of aspartame could be replaced by asparagine as reported in the literature. In this analogue, the hydrogen of amide group could still form a hydrogen bond with the oxygen of ester bond and the ester bond was isosteric with peptide bond. However, the product was not sweet, showing that the peptide bond could not be replaced by ester bond. The peptide C-N bond behaves as a double bond that is not free to rotate and the C, O, N and H atoms are in the same plane. The replacement of peptide bond by ester bond destroyed the unique conformation of peptide bond, resulting in the loss of sweet taste.

关键词： artificial sweetener aspartame derivative peptide bond

Structural Features and Molecular Evolution of Bowman-Birk Protease Inhibitors and Their Potential Application

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Acta Biochimica et Biophysica Sinica 2005年第5期37卷 283-292页

作者： Rui-Feng QI~(1.2) Zhan-Wu SONG~1 Cheng-Wu CHI~(2.3). 1 College of Life Science, Northwest Normal university, Lanzhou 730070, china: 2 institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, shanghai 200031, china 3.institute of protein research, tongji university, shanghai 200092, china College of Life Science Northwest Normal UniversityLanzhou 730070 China institute of Biochemistry and Cell Biology Chinese Academy of SciencesShanghai 200031 China institute of protein research Tongji UniversityShanghai 200092 China

The Bowman-Birk inhibitors(BBIs)are well-studied serine protease inhibitors that areabundant in dicotyledonous and monocotyledonous *** from dicots usually have a molecular weightof 8k and are double-headed with two reactive sites,whereas those from monocots can be divided into twoclasses,one approximately 8 kDa in size with one reactive site(another reactive site was lost)and the otherapproximately 16 kDa in size with two reactive *** reactive site is located at unique exposed surfacesformed by a disulfide-linked β-sheet loop that is highly conserved,rigid and mostly composed of *** structural features and molecular evolution of inhibitors are described,focusing on the conserveddisulfide *** sunflower trypsin inhibitor-1(SFTI-1),with 14 amino acid residues,is a recentlydiscovered bicyclic inhibitor,and is the most small and potent naturally occurring Bowman-Birk ***,BBIs have become a hot topic because of their potential *** are now used fordefense against pathogens and insects in transgenic plants,which has advantages over using toxic andpolluting *** could also be applied in the prevention of cancer,Dengue fever,and inflammatoryand allergic disorders,because of their inhibitory activity with respect to the serine proteases that play apivotal role in the development and pathogenesis of these *** canonical nine-residue loop of BBIs/STFI-1 provides an ideal template for drug design of specific inhibitors to target their respective proteases.

关键词： Bowman-Birk protease inhibitor sunflower trypsin inhibitor-1(SFTI-1) molecular evolution drug design