检索结果-南通市图书馆

Chinese Experts Consensus on Biologic Therapy for Psoriasis

在线全文

学校读者我要写书评

暂无评论

International Journal of Dermatology and Venereology 2020年第2期3卷 76-85页

作者： Chen Ai-Jun Gao Xing-Hua Gu Heng Gu Jun Hao Fei Jiang Xian Jin Hong-Zhong Kang Xiao-Jing Li Cheng-Xin Li Yu-Zhen Liu Xiao-Ming Shi Yu-Ling Sun Qing Wang Gang Yang Bin Zhang Jun-Ling Zhang Xi-Bao Zhang Xue-Jun Zhao Yi Zheng Min Chinese Society of Dermatology china Dermatologist Association Dermatology and Venereology Specialized Committee of Chinese Association of Integrative medicine department of Dermatology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China department of Dermatology The First Hospital of China Medical UniversityShenyangLiaoning 110001China hospital for Skin Diseases(Institute of Dermatology) Chinese Academy of Medical SciencesNanjingJiangsu 210042China department of Dermatology Changhai HospitalThe Second Military Medical UniversityShanghai 200002China department of Dermatology The Third Affiliated Hospital of Chongqing Medical UniversityChongqing 401120China department of Dermatology West China Hospital of Sichuan UniversityChengduSichuan 610041China department of Dermatology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China department of Dermatology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang 830001China department of Dermatology The First Medical CenterPLA General HospitalBeijing 100853China department of Dermatology The Second Hospital of Harbin Medical University HarbinHeilongjiang 150086China department of Dermatology The University of Hong Kong-Shenzhen HospitalShenzhen 518053China department of Dermatology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China department of Dermatology Qilu HospitalShandong UniversityJinanShandong 250012China department of Dermatology Xijing HospitalThe Fourth Military Medical UniversityXi’anShaanxi 710032China Dermatology hospital of Southern medical university GuangzhouGuangdong 510091China department of Dermatology Tianjin Academy of Traditional Chinese Medicine Affiliated HospitalTianjin 300120China Institute of Dermatology Guangzhou Medical UniversityGuangzhouGuangdong 510095China department of Dermatology Huashan HospitalFudan UniversityShanghai 200040China department of Dermatology and Venereology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China department of

Biologic drugs have been increasingly used in the treatment of psoriasis and are especially favorable for severe,recalcitrant,and special-type ***,appropriate,effective,and safe use of biologic drugs has drawn attention from *** this purpose,Chinese experts majoring in psoriasis analyzed domestic and international research data,summarized current clinical experiences,investigated features of Chinese patients with psoriasis,and finally formulated the present consensus,which provides detailed guidances to clinicians in terms of the principles and methods of the application of biologics,the efficacy and safety profile,patient screening and monitoring,main adverse events and corresponding solutions,and precautions for special patient populations.

关键词： psoriasis treatment biologics consensus

在线全文

学校读者我要写书评

暂无评论

经皮种植体表面纳米二氧化硅抗菌涂层的研究

实用口腔医学杂志 2017年第1期33卷 5-9页

作者：王嘉吴国锋孙冠阳赵铱民魏洪波军事口腔医学国家重点实验室口腔疾病国家临床医学研究中心陕西省口腔医学重点实验室第四军医大学口腔医院修复科西安710032 南京大学医学院附属口腔医院南京市口腔医院军事口腔医学国家重点实验室口腔疾病国家临床医学研究中心陕西省口腔生物工程技术研究中心第四军医大学口腔医院口腔种植科

目的:研究纯钛表面制备可降解载药二氧化硅纳米颗粒的抗菌性能。方法:通过非模版法制备可降解载庆大霉素的二氧化硅纳米颗粒,采用纳米粒径分析仪和扫描电镜对纳米粒进行特征分析;将载药纳米粒振荡交联至纯钛微弧氧化处理后形成的微米级... 详细信息

目的:研究纯钛表面制备可降解载药二氧化硅纳米颗粒的抗菌性能。方法:通过非模版法制备可降解载庆大霉素的二氧化硅纳米颗粒,采用纳米粒径分析仪和扫描电镜对纳米粒进行特征分析;将载药纳米粒振荡交联至纯钛微弧氧化处理后形成的微米级形貌表面,用扫描电镜进行形态观测;将处理前后的样品与金黄色葡萄球菌共培养,体外抑菌圈法考察抗菌性能;对载药二氧化硅纳米颗粒的抗菌涂层进行体外药物释放实验。结果:载药纳米粒为直径(298.1±12.2)mm的圆球状;通过振荡交联后固定在纯钛微弧氧化层火山口样的结构内形成抗菌涂层;体外抑菌圈大小为(16.7±1.4)mm,而对照组未观测到抑菌圈;载药二氧化硅纳米颗粒的抗菌涂层可有效释放庆大霉素长达28 d。结论:基于可降解二氧化硅纳米粒制备的抗菌涂层可实现庆大霉素的缓控释放,并对金黄色葡萄菌的生长起到抑制作用,有望在今后应用于种植体经皮部位的设计。

关键词：纳米二氧化硅颗粒药物控释经皮种植体抗菌

IBP促进人涎腺腺样囊性癌细胞侵袭和上皮间质转化的研究

在线全文

学校读者我要写书评

暂无评论

临床口腔医学杂志 2018年第4期34卷 202-205页

作者：熊剑李鹏范舒申涛简从相胡川闽周继祥湖北科技学院五官医学院湖北咸宁437100 第三军医大学西南医院口腔科重庆400038 第三军医大学临床生物化学教研室重庆400038

目的:探讨干扰素调节因子-4结合蛋白(interferon regulatory factor-4 binding protein,IBP)对人涎腺腺样囊性癌(salivary adenoid cystic carcinoma,SACC)细胞侵袭能力和上皮间质转化的影响。方法:采用Transwell试验,将穿膜细胞进行染色计数并分析各组细胞侵袭能力的变化,明确IBP对细胞侵袭能力的影响;通过波形蛋白和角蛋白的免疫荧光染色,观察比较ACC2-C1/IBP和ACC2-C1细胞的染色强度。结果:ACC2-C1/IBP细胞侵袭率大于ACC2-C1细胞和ACC2细胞;在波形蛋白中的染色ACC2-C1/IBP细胞强于ACC2-C1细胞,在角蛋白中的染色ACC2-C1/IBP细胞弱于ACC2-C1细胞。结论:IBP有促进SACC细胞侵袭的作用;初步证实了IBP能够促进人涎腺腺样囊性癌细胞上皮间质转化的发生。

关键词：干扰素调节因子-4结合蛋白(IBP) 腺样囊性癌(SACC) 上皮间质转化(EMT)

维持性血液透析患者疾病相关应对方式与症状负担和生活质量的相关性研究

在线全文

学校读者我要写书评

暂无评论

解放军护理杂志 2018年第19期35卷 6-10页

作者：罗丹戴榕娟陈静黄碧红解放军第455医院护理部上海200025 第二军医大学长征医院血透室上海200003 复旦大学附属华山医院血透室上海200040

目的探讨维持性血液透析(maintenance hemodialysis,MHD)患者的应对方式与症状负担和生活质量现况之间的相关性。方法 2016年2月至2017年2月,便利抽样法选择在上海市3所三级甲等医院和3所二级甲等医院血液透析中心进行MHD治疗的384名患... 详细信息

目的探讨维持性血液透析(maintenance hemodialysis,MHD)患者的应对方式与症状负担和生活质量现况之间的相关性。方法 2016年2月至2017年2月,便利抽样法选择在上海市3所三级甲等医院和3所二级甲等医院血液透析中心进行MHD治疗的384名患者为研究对象,采用一般资料问卷、医学应对方式问卷(medical coping modes questionnaire,MCMQ)、血液透析患者症状负担调查量表(dialysis frequency severity and symptom burden index,DFSSBI)和简明健康测量量表(the medical outcomes study 36-item short form health survey,SF-36)对其进行调查。结果 MHD患者"面对"的应对方式与心理症状负担呈正相关;"回避"和"屈服"应对方式与心理症状负担呈负相关,与症状负担3个维度均呈正相关(P0.05);"回避"的应对方式与生理功能(physical function,PF)和情感职能(role-emotional,RE)呈正相关;"屈服"的应对方式与生活质量8个维度均呈负相关(均P<0.01)。结论 MHD患者应对方式与症状负担和生活质量均存在相关性,护理人员应根据患者的具体情况制订针对性的干预措施,以减轻患者症状负担、提高其生活质量。

关键词：维持性血液透析应对方式症状负担生活质量

在线全文

学校读者我要写书评

暂无评论

某部新兵心理调查及心理卫生服务建议

解放军医院管理杂志 2017年第5期24卷 445-449页

作者：徐力刘子璇王璐颖第二军医大学海军医学系海医一队上海200433 解放军94676部队医院上海202150 第二军医大学基础部政治理论教研室上海200433

目的回顾性分析新兵心理测评结果,为新训单位制定相关规定提供参考。方法采用明尼苏达多项人格调查表(简称MMPI)对某新训单位1 437名新兵进行心理测试,并从多个角度回顾性分析调查结果。结果 (1)大学组与高中组效度量表中L、F分值有明... 详细信息

目的回顾性分析新兵心理测评结果,为新训单位制定相关规定提供参考。方法采用明尼苏达多项人格调查表(简称MMPI)对某新训单位1 437名新兵进行心理测试,并从多个角度回顾性分析调查结果。结果 (1)大学组与高中组效度量表中L、F分值有明显差异(P0.05);城市组与农村组(t_2,P_2)在效度量表中K分值,临床量表中Hs、D、Pd、Mf、Pa、Pt、Sc、Ma分值均有显著差异(P_23,P_3)在临床量表中D、Mf、Pa的分值均有显著差异(P_33)恋爱组和单身组效度量表中L、K分值有明显差异(P0.05),临床量表中Hs、Hy分值差异有统计学意义(P<0.05)。结论针对不同新兵人群应从不同方面给予心理健康关注,并且通过多种方式加强新兵心理卫生服务。

关键词： MMPI 心理健康新兵

在线全文

学校读者我要写书评

暂无评论

亟待制定中医的中药质量标准

上海中医药杂志 2001年第6期35卷 10-12页

作者：孙华君胡晋红朱全刚第二军医大学附属长海医院药学部上海200433

针对当前中药研究趋于西药化的倾向 ,通过对中医、西医药物理论异同的分析 ,对如何建立有中医学特色的中药质量标准及其研究规范作一探讨。认为药物质量标准是治疗思想的体现 ,有效成分亦非中药质量的唯一标准。主张中药质量标准及其研... 详细信息

针对当前中药研究趋于西药化的倾向 ,通过对中医、西医药物理论异同的分析 ,对如何建立有中医学特色的中药质量标准及其研究规范作一探讨。认为药物质量标准是治疗思想的体现 ,有效成分亦非中药质量的唯一标准。主张中药质量标准及其研究规范应在中医理论指导下进行 ,并在其理论体系内构筑 ,同时引进西药研究的客观性评价方法 ;一味强调直观、实证而否认主观、辨证 ,也是非科学的态度。

关键词：中药研究中药质量标准中医理论体系中西医药物理论

ER/PR^+和HER2^-型乳腺癌患者免疫组化指标的列线图预后模型

在线全文

学校读者我要写书评

暂无评论

中国肿瘤生物治疗杂志 2018年第9期25卷 934-939页

作者：吴莹洪晏谢轶群李曦洲刘洋上海市黄浦区中心医院乳腺外科上海200002 第二军医大学附属长海医院普外科上海200433 华东师范大学统计学院上海200241

目的:探讨改良雌激素受体(estrogen receptor,ER)/孕激素受体(progesterone receptor,PR)阳性(^+)及人类表皮生长因子受体2(human epidermal growth factor receptor 2,HER2)阴性(-)(ER/PR^+、HER2-)型乳腺癌患者的传统预后模型,满足目前的临床实际需求。方法:选取了2009年1月至2009年12月上海市黄浦区中心医院乳腺外科收治的335例ER/PR^+、HER2-型乳腺癌患者。将97个变量纳入模型,采用SCAD变量选择的方法,在充分考虑协变量是否存在对数线性关系、非对数线性关系(分段线性关系)临界值的合理确定、共线问题后,构建一个新的ER/PR^+、HER2-型乳腺癌患者传统免疫组化指标的Cox回归预后模型,并进一步建立其列线图模型;在此基础上建立了术后1、3和5年生存概率的列线图;并通过比较模型的区分度(discrimination)和校准度(calibration)来评价模型的预测能力。结果:通过乳腺癌预后建立Cox回归模型结果显示,患者的预后与组织级别、淋巴结转移、Ki67、PR和年龄等因素有关;其中组织级别和淋巴结转移对风险比的影响呈对数线性关系,Ki67、PR和年龄对风险比的影响呈非对数线性关系,其合理临界值分别为Ki67(60%)、PR(20%)和年龄(55岁)。该模型术后1、3和5年的ROC曲线下面积(AUC值)均高于0.85,说明该Cox回归模型具有较高的区分度。该模型Gr?nnesby-Borgan拟合优度检验统计量值为1.37、对应的P值为0.5,说明该Cox回归模型有较好的校准度。结论:通过改良ER/PR^+和HER2-型乳腺癌患者的传统预后模型,建立患者术后1、3和5年生存概率的列线图,能准确、直观、有效地预测患者的生存概率,对乳腺癌患者临床治疗有较好的指导意义。

关键词：乳腺癌雌激素受体孕激素受体人类表皮生长因子受体2 传统免疫组化指标列线图预后模型

Chinese medical Association consensus for standardized diagnosis and treatment of pancreatic neuroendocrine neoplasms

在线全文

学校读者我要写书评

暂无评论

Chinese medical Journal 2023年第20期136卷 2397-2411页

作者： Feng Jiao Jiujie Cui Deliang Fu Qi Li Zheng Wu Zan Teng Hongmei Zhang Jun Zhou Zhihong Zhang Xiaobing Chen Yuhong Zhou Yixiong Li Yiping Mou Renyi Qin Yongwei Sun Gang Jin Yuejuan Cheng Jian Wang Gang Ren Jiang Yue Guangxin Jin Xiuying Xiao Liwei Wang on behalf of Pancreatic Tumor Group,Society of Oncology,Chinese medical Association department of Oncology State Key Laboratory of Systems Medicine for CancerShanghai Cancer InstituteRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China department of Pancreatic Surgery Huashan HospitalFudan UniversityShanghai 200040China department of Oncology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200080China department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiao Tong UniversityXi’anShaanxi 710061China department of Oncology The First Hospital of China Medical UniversityShenyangLiaoning 110801China department of medical Oncology The First Affiliated Hospital of Air Force Medical UniversityXi’anShaanxi 710032China department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital and InstituteBeijing 100142China department of Pathology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China department of Oncology The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenan 450003China department of medical Oncology Zhongshan HospitalFudan UniversityShanghai 200032China department of General Surgery Xiangya HospitalCentral South UniversityChangshaHunan 410008China department of Gastrointestinal and Pancreatic Surgery Zhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhouZhejiang 310014China department of Biliary-Pancreatic Surgery Affiliated Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China department of Biliary-Pancreatic Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China department of Hepatobiliary Pancreatic Surgery Changhai HospitalNaval Medical UniversityShanghai 200433China department of medical Oncology Peking Union Medical College HospitalChinese Academy of Medical Sci

Pancreatic neuroendocrine neoplasms(pNENs)are rare and highly heterogeneous tumors originating from pluripotent stem cells with neuroendocrine differentiation in the pancreas,constituting approximately 3%of all pancreatic tumors.^([1])The global incidence of pNENs has been increasing recently,and most cases are sporadic and more common in women.^([1,2])pNENs are clinically divided into functioning and nonfunctioning tumors depending on whether the tumors are accompanied by a clinical syndrome related to specific hormone overproduction.

关键词： neoplasms neuroendocrine diagnosis

Clinical practice guideline for transurethral plasmakinetic resection of prostate for benign prostatic hyperplasia(2021 Edition)

在线全文

学校读者我要写书评

暂无评论

military medical Research 2022年第5期9卷 515-533页

作者： Xian-Tao Zeng Ying-Hui Jin Tong-Zu Liu Fang-Ming Chen De-Gang Ding Meng Fu Xin-Quan Gu Bang-Min Han Xing Huang Zhi Hou Wan-Li Hu Xin-Li Kang Gong-Hui Li Jian-Xing Li Pei-Jun Li Chao-Zhao Liang Xiu-Heng Liu Zhi-Yu Liu Chun-Xiao Liu Jiu-Min Liu Guang-Heng Luo Yi Luo Wei-Jun Qin Jian-Hong Qiu Jian-Xin Qiu Xue-Jun Shang Ben-Kang Shi Fa Sun Guo-Xiang Tian Ye Tian Feng Wang Feng Wang Yin-Huai Wang Yu-Jie Wang Zhi-Ping Wang Zhong Wang Qiang Wei Min-Hui Xiao Wan-Hai Xu Fa-Xian Yi Chao-Yang Zhu Qian-Yuan Zhuang Li-Qun Zhou Xiao-Feng Zou Nian-Zeng Xing Da-Lin He Xing-Huan Wang 无 department of Urology Institute of UrologyZhongnan Hospital of Wuhan UniversityWuhan430071China Center for Evidence-Based and Translational medicine Zhongnan Hospital of Wuhan UniversityWuhan430071China department of Urology Tianjin Third Central Hospital Affiliated To Nankai UniversityTianjin300170China department of Urology Henan Provincial People’s HospitalZhengzhou University People’s HospitalZhengzhou450003China department of Urology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing102218China department of Urology China-Japan Union Hospital of Jilin UniversityChangchun130033China department of Urology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200080China department of Urology Qinghai University Affiliated HospitalXi’ning810012China department of Urology People’s Hospital of Hainan ProvinceHainan Affiliated Hospital of Hainan Medical University HaikouHaikou570311China department of Urology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou310016China department of Urology General Hospital of Ningxia Medical UniversityYinchuan750003China department of Urology The First Affiliated Hospital of Anhui Medical UniversityHefei230022China department of Urology Renmin Hospital of Wuhan UniversityWuhan430060China department of Urology The Second Hospital of Dalian Medical UniversityDalian116023LiaoningChina department of Urology Zhujiang Hospital of Southern Medical UniversityGuangzhou510282China department of Urology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou510080China department of Urology Surgery Guizhou Province People’s HospitalGuiyang550002China department of Urology Xijing Hospital of Air Force Military Medical UniversityXi’an710032China department of Urology The 980St Hospital of the PLA Joint Logistics Support Force(Bethune International Peace Hospital of PLA)Shijiazhuang050082China department of Urology

Benign prostatic hyperplasia (BPH) is highly prevalent among older men, impacting on their quality of life, sexual function, and genitourinary health, and has become an important global burden of disease. Transurethral plasmakinetic resection of prostate (TUPKP) is one of the foremost surgical procedures for the treatment of BPH. It has become well established in clinical practice with good efficacy and safety. In 2018, we issued the guideline “2018 Standard Edition”. However much new direct evidence has now emerged and this may change some of previous recommendations. The time is ripe to develop new evidence-based guidelines, so we formed a working group of clinical experts and methodologists. The steering group members posed 31 questions relevant to the management of TUPKP for BPH covering the following areas: questions relevant to the perioperative period (preoperative, intraoperative, and postoperative) of TUPKP in the treatment of BPH, postoperative complications and the level of surgeons’ surgical skill. We searched the literature for direct evidence on the management of TUPKP for BPH, and assessed its certainty generated recommendations using the grade criteria by the European Association of Urology. Recommendations were either strong or weak, or in the form of an ungraded consensus-based statement. Finally, we issued 36 statements. Among them, 23 carried strong recommendations, and 13 carried weak recommendations for the stated procedure. They covered questions relevant to the aforementioned three areas. The preoperative period for TUPKP in the treatment of BPH included indications and contraindications for TUPKP, precautions for preoperative preparation in patients with renal impairment and urinary tract infection due to urinary retention, and preoperative prophylactic use of antibiotics. Questions relevant to the intraoperative period incorporated surgical operation techniques and prevention and management of bladder explosion. The application to different

关键词： Transurethral plasmakinetic resection of prostate Benign prostatic hyperplasia Recommendation Treatment Guideline