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Post-Surgical Recurrence of Hepatocellular Carcinoma

The Chinese-German Journal of Clinical Oncology 2002年第1期1卷 30-31页

作者： CHENG Hongyan department of Radiology, Eastern Hepatobiliary Surgery hospital, second military medical university, shanghai 200438, china department of Radiology Eastem Hepatobiliary Surgery Hospital Second Military Medical University Shanghai China

Objective To analyze post-surgical recurrence of hepatocellular carcinoma (HHC) according to pathologic findings, primary tumor and angiographic features of the recurrent tumor.Methods In this series, 100 cases of recurrent HCC were analyzed in following aspects: ( 1) size, tumor nodular numbers, gross and histologic findings of the primary tumor; (2) post-surgical recurrent time; (3) size, tumor nodular numbers, blood supply, staining property, and accumulation of lipiodol oil in the recurrent tumor. Following angiography, arterial chemoembolization was performed. Results In the primary tumor, single nodules were seen in 80 cases, multiple nodules in 16 cases and multiple fused nodules in 4 cases. All tumors were classified as: trabecular type, 65 cases; compact type, 12; sclerotic type, 2 cases; mixed type, 15 cases and cholangiocarcinoma type, 6 cases. 38 cases had incomplete or no capsule. Satellite tumor nodules were grossly identified during operation in 33 cases, but were proven microscopically in 66 cases. Tumor thrombi of portal vein was noted in 18 cases during oeration, but 85 cases in histopathological sections. The recurrent tumors were diagnosed post surgically within 6 months in 67 cases, 6-12 months in 15 cases and after 12 months in 18 cases respectively. On angiography, 67 % recurrent tumors was rich in blood supply and with abundant accumulation of lipiodol after embolization.Conclusion The post-surgical recurrence rate of the HCC patients with massive size, incomplete or no capsule, satellite tumor nodules and portal vein tumor thrombus was high. The patients shoud receive angiography in 1 ?2 months after surgery in order to detect early recurrence and, if confirmed, the patients may be treated by transcatheter arterial chemoembolization

关键词： hepatocellular carcinoma recurrence

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子宫内膜异位症患者腹腔液对正常自然杀伤细胞活性的抑制及与白介素-6、前列腺素的关系

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上海医学 2002年第4期25卷 233-235页

作者：李文金志军杨帆第二军医大学长征医院妇产科上海200003

目的　探讨子宫内膜异位症 (EM)患者的腹腔液 (PF)对自然杀伤 (NK)细胞的作用 ,以及与腹腔液中白细胞介素 6 (IL 6 )、前列腺素 (PGs)的关系。方法　采用乳酸脱氢酶 (LDH)释放法测定与EM患者PF共同孵育后正常人血NK细胞活性的变化。放... 详细信息

目的　探讨子宫内膜异位症 (EM)患者的腹腔液 (PF)对自然杀伤 (NK)细胞的作用 ,以及与腹腔液中白细胞介素 6 (IL 6 )、前列腺素 (PGs)的关系。方法　采用乳酸脱氢酶 (LDH)释放法测定与EM患者PF共同孵育后正常人血NK细胞活性的变化。放免法测定腹腔液中PGs和IL 6的含量。结果　在作用 2h时 ,非EM患者和EM患者的PF对正常人外周血NK细胞活性的抑制率分别为 (37.1± 18.9) %和 (6 5 .2± 2 1.8) %,两者相比 ,差异具有显著性 (P 3,P 3± 0 .39) μg/L ,差异具有显著性 (P 36 ) μg/L与对照组相似 ,差异无显著性 (P >0 .0 5 )。PF中IL 6的含量与其对NK细胞活性的抑制率之间差异无显著性 (r=0 .2 38,P >0 .0 5 )。EM患者PF中PGE2 和PGF2a含量均明显升高 ,其中Ⅰ Ⅱ期患者PF对NK抑制率与PGE2 含量呈正相关 (r=0 .5 13,P <0 .0 5 ) ;与PGF2α呈正相关 (r =0 .42 5 ,P <0 .0 5 )。结论　EM患者的PF对NK细胞活性具有明显的抑制作用 ,Ⅰ

关键词：子宫内膜异位症自然杀伤细胞前列腺素白细胞介素-6 腹腔液

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The effects of the false vocal fold gaps on intralaryngeal pressure distributions and their effects on phonation

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Science china(Life Sciences) 2008年第11期51卷 1045-1051页

作者： LI Sheng1,2, WAN MingXi1 & WANG SuPin1 1 Key laboratory of Biomedical Information Engineering of Ministry of Education, department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong university, Xi’an 710049, china 2 department of Biomedical Engineering, Fourth military medical university, Xi’an 710032, china Key laboratory of Biomedical Information Engineering of Ministry of Education Department of Biomedical Engineering School of Life Science and Technology Xi’an Jiaotong University Xi’an China department of Biomedical Engineering Fourth Military Medical University Xi’an China

Human phonation does not merely depend on the vibration of the vocal folds. Research by clinical and computer simulations has demonstrated that the false vocal fold (FVF) is an important laryngeal con-striction that plays a vital role during human voice production. This study explored the effects of the FVF gaps using both the three-dimensional Plexiglas model and the numerical computation methods. Twelve FVF gaps (ranging from 0.02 to 2.06 cm) were used in this study at three glottal angles (uniform and convergent/divergent 40°), two minimal glottal diameters (Dg) (0.04 cm and 0.06 cm) separately, and the constant subglottal pressure (8 cm H2O). The results suggested that (1) the intralaryngeal pressure was the lowest and the flow was the highest (least flow resistance) when the FVF gap was 1.5-2 times greater than Dg; (2) the divergent glottal angle gave lower pressure and greater flow than the conver-gent and uniform glottal angle as there were no FVF conditions; (3) the presence of the FVF decreased the effects of the glottal angle to a certain extent; and more importantly, (4) the presence of the FVF also moved the separation points downstream, straightened the glottal jet for a longer distance, decreased the overall laryngeal resistance, and reduced the energy dissipation, suggesting the significance of FVF in efficient voice production. These results may be incorporated in the phonatory models (physical or computational) for better understanding of vocal mechanics. The results might also be helpful in exploring the surgical and rehabilitative intervention of related voice problems.

关键词： false vocal fold laryngeal physical model aerodynamics modeling phonation

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In vivo therapeutic effect of in situ injection of recombinant adenovirus expressing mIFN-y gene on glioblastoma

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中国实验血液学杂志 1997年第3期5卷 307-308页

作者： ZhijianYue, Bo Hong, Hong Lei, Xuclno Cao department of Neurosurgery, Changhai hospital, The second military medical university, Shangliai 200433.department of Immunology, The second military medical university, shanghai 200433

Patients with malignant glioma have a poorprognosis despite the combined use of surgery,irradiation, chemotherapy, and a variety ofimmunotherapies. These patient are known to showdecreased circulatory immune function ... 详细信息

关键词： expressing adenovirus suppression glioma chemotherapy Interferon irradiation despite necrotic subcutaneous

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An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy

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Cell Research 2003年第6期13卷 481-489页

作者： ZI LAI ZHANG, WEI Guo ZOU, CHUN XIA LUO, BING HUA LI, JIN HUI WANG, LAN YING SUN, QI JUN QIAN, XIN YUAN LIUlaboratory of Biotechnology, Institute of Biochemistry and Cell Biology, shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, shanghai 200031, china. E-mail: xyliu@*** Eastern Heptobiliary hospital, second military medical university, shanghai 200438, china laboratory of Biotechnology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China Eastern Heptobiliary hospital Second Military Medical University Shanghai China

ONYX-015 is an attractive therapeutic adenovirus for cancer because it can selectively replicate in tumor cells and kill them. To date, clinical trials of this adenovirus have demonstrated marked safety but not potent enough when it was used alone. In this paper, we put forward a novel concept of Gene-ViroTherapy strategy and in this way, we constructed an armed therapeutic oncolytic adenovirus system, ZD55-gene, which is not only deleted of ElB 55-kD gene similar to ONYX-015, but also armed with foreign antitumor gene. ZD55-gene exhibited similar cytopathic effects and replication kinetics to that of ONYX-015 in vitro. Importantly, the carried gene is expressed and the expression level can increase with the replication of virus. Consequently, a significant antitumoral efficacy was observed when ZD55-CD/5-FU was used as an example in nude mice with subcutaneous human SW620 colon cancer. Our data demonstrated that ZD55-gene, which utilizing the Gene-ViroTherapy strategy, is more efficacious than each ind

关键词： ZD55-gene oncolytic adenovirus ElB 55-kD gene cancer Gene-ViroTherapy.

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胰岛素抵抗大鼠血糖正常阶段β细胞超微结构改变

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上海医学 2003年第5期26卷 335-337,T002页

作者：刘颖赵瑛刘志民第二军医大学长征医院内分泌科上海200003 第二军医大学长征医院神经内科上海200003

目的　观察胰岛素抵抗 (IR)大鼠血糖正常阶段的 β细胞超微结构改变。方法　高糖饲料喂养SD大鼠 12周 ,复制IR模型。普通饲料喂养的SD大鼠为正常对照。透射电镜观察胰岛β细胞超微结构。结果　与正常大鼠相比 ,IR大鼠收缩压 (SBP)、... 详细信息

目的　观察胰岛素抵抗 (IR)大鼠血糖正常阶段的 β细胞超微结构改变。方法　高糖饲料喂养SD大鼠 12周 ,复制IR模型。普通饲料喂养的SD大鼠为正常对照。透射电镜观察胰岛β细胞超微结构。结果　与正常大鼠相比 ,IR大鼠收缩压 (SBP)、血清三酰甘油 (TG)、低密度脂蛋白胆固醇 (LDL c)、游离脂肪酸 (FFA)、胰岛素 (Ins)水平均明显升高 (P值均 <0 .0 1) ,胰岛素敏感指数 (ISI)、血清HDL c降低 (P值均 <0 .0 1)。空腹血糖 (FBG)、餐后 2h血糖 (PBG2h)在正常范围。电镜观察IR大鼠 β细胞可见凋亡的早期改变 ,细胞浆内脂质沉积以及细胞核和细胞器的病理改变。结论　高糖膳食诱发的IR大鼠在血糖正常阶段已存在

关键词：胰岛素抵抗大鼠血糖正常阶段 β细胞超微结构 2型糖尿病发病机制

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Timosaponin B-Ⅱ protects against ischemic brain injury in a rat model of transient focal ischemia

Timosaponin B-Ⅱ protects against ischemic brain injury in a...

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第三届中俄国际药理学研讨会

作者： Tie-Jun LI~a Yan QIU~a Yao-Cheng RUI~a Wan-Sheng CHEN~b a department of Pharmacology,School of Pharmacy,second military medical university,325 GuoHe Road,shanghai 200433,china b department of Pharmacy,changzheng hospital shanghai 200003,china

＜正＞AIM Present experiments were performed to study the possible effect of timosaponin B-Ⅱ,one of the major active components of a traditional Chinese herbal drug,the rhizome of Anemarrhenae asphodeloides Bge （Lil...

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Transgenic tetraploid Isatis indigotica expressing cryIA (c) Bt gene and Pinellia ternata agglutinin showed enhanced resistance to moths and aphids

Transgenic tetraploid Isatis indigotica expressing cryIA (c)...

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中国植物学会七十五周年年会

作者： Ying Xiao~(1,2) Kai Wang~1 Ruxian Ding~1 Hanming Zhang~1 Lei Zhang~1 Wansheng Chen~2 (1.department of pharmacognosy,School of Pharmacy,second military medical university,shanghai 200433,china 2.department of Pharmacy,changzheng hospital,second military medical university,shanghai 200003,china)

Isatis indigotica Fort.,belonging to the family Cruciferae,is a biennial herbaceous plant species distributed widely in *** root of *** (Radix Isatidis),named "Ban-Lan-Gen"as a traditional Chinese medicine,is used for...

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Correlation of glycosyltransferases mRNA expression in extrahepatic bile duct carcinoma with clinical pathological characteristics

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Hepatobiliary & Pancreatic Diseases International 2004年第2期3卷 292-295页

作者： Xiao-Ling Jin, Shu-Sen Zheng, Bing-Sheng Wang and Hui-Li Chen Nanjing, china department of General Surgery, Nanjing First Hospi- tal Affiliated to Nanjing medical university, Nanjing 210006, china department of Hepatobiliary Surgery, First Affiliated hospital, Zhe- jiang university School of medicine, Hangzhou 310003, china department of General Surgery, Zhongshan hospital, Fudan Universi- ty, shanghai 200032 , china and Key laboratory of Glycocon- jugate Research, Ministry of Health, department of Biochemistry, Fudan university School of medicine, shanghai 200032, china department of General Surgery Nanjing First Hospital Affiliated to Nanjing Medical University Nanjing 210006 China. xiaoling_jin@***

BACKGROUND: The incidence of extrahepatic bile duct carcinoma (EBDC) has been increasing, especially in aged people, but the glycobiology of the tumor is not elucida- ted. In this study we investigated the expressions of three glycosyltransferases in 35 patients with EBDC and 35 pa- tients with benign biliary duct disease (BBDD) as well as their clinicopathological significance. METHOD: The patients were divided into several sub- groups by tumor differentiation, TNM stage, and invasion by the standards recommended by UICC. Tumor samples were immediately frozen in liquid nitrogen after resection, followed by mRNA determination of enzymes in the tissue using a mRNA selective reverse trancriptase-polymerase chain reaction kit. The mRNA levels of different groups were semi-quantitatively compared. RESULTS: The mRNA levels of N-acetylglucosaminyltrans- ferase V (GnT-V) and a subtype of α2,3 sialyltransferases for N-glycans, ST3Gal- were elevated 7.75 and 5.39 times in EBDC as compared with BBDD, respectively, and they were correlated to several clinicopathological factors including tumor advancement, differentiation, metastasis, and invasiveness. The mRNA expression of another sialyl- transferase, ST6Gal- , was also 0.63-fold higher in EBDC than in BBDD, but not involved in the clinicopathological characteristics. CONCLUSION: The elevated expression of these three gly- cosyltransferases can be considered as an important molecu- lar event in the occurrence and progression of EBDC.

关键词： extrahepatic bile duct carcinoma sialyltransferase N-acetylglucosaminyltransferase reverse trancriptase-polymerase chain reaction

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Angiotensin-（1-7） stimulates the release of nitric oxide via phosphatidylinositol 3-kinase/Akt pathway in the nucleus tractus solitarii of rats

Angiotensin-（1-7） stimulates the release of nitric oxide v...

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中国生理学会心血管生理学术研讨会

作者： Weizhong Wang department of Physiology,second military medical university,shanghai 200433,china

＜正＞Rationale:Angiotensin-1-7[Ang-（l-7）]via acting receptor Mas in the central nervous system is involved in cardiovascular *** oxide（NO） is implicated as an important modulator in the nucleus tractus solitarii（NTS）,a key region involved in cardiovascular regulation. However,the signaling link involved in the interaction between Ang-（l-7） and NO release in the NTS remains ***:The aim of the present study was to determine the role of phosphatidylinositol 3-kinase（PI3K）-Akt signaling pathways in mediating the effect of Ang-（l-7） on NO generation in the NTS of *** and Results:Ang-（l-7） injected into the NTS significantly increased NO generation and NO synthase（NOS） activity,which were abolished by the selective receptor Mas antagonist D-Alanine-[Ang-（l-7）]（A-779） or the PI3K inhibitor *** blotting analysis demonstrated that Ang-（l-7） stimulated the phosphorylations of Akt and NOS in the NTS,which was prevented in the presence of A-779 or *** of Ang-（l-7） into the NTS significantly augmented the response of blood pressure,heart rate,and renal sympathetic nerve activity to blockade of NOS,which was abolished by pretreatment with A-779 or *** with Ang-（l-7） significantly enhanced the cardiovascular inhibition evoked by the NO precursor L-arginine（2 nmol） injected into the *** addition,chronic intracerebroventricular infusion of Ang-（l-7）（200 pmol/day, 3 days） also increased NO release in the NTS in a Mas-dependent ***:We suggest that Ang-（l-7） stimulates the release of nitric oxide in the NTS,which is dependent on the Mas-PI3K-Akt-NOS signaling pathway.

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