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Electric-stimulus rate encoding algorithm of Mandarin tonal information in cochlear implant

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Progress in Natural Science:Materials International 2006年第12期16卷 1315-1321页

作者： GUAN Tian~1, GONG Qin~1 and YE Datian~2**(1. department of Biomedical engineering, tsinghua university, {3. 100084, china 2. Research center of Biomedical engineering, Graduate School at Shenzhen, tsinghua university, Shenzhen 518055, china) [a]department of Biomedical engineering Tsinghua University Beijing China [b]Research center of Biomedical engineering Graduate School at Shenzhen Tsinghua University Shenzhen China

The modern multi-channel cochlear implants usually extract and encode the temporal envelope cues. This kind of algorithms can hardly satisfy the users who speak tonal languages, such as Mandarin. Many studies have tried to enhance the recognition ability of Mandarin through encoding tonal information and made suggestions to frequency-modulate the fixed pulse-rate carrier with the extracted tonal information based on the rate-pitch theory in electric hearing. However, how to encode and deliver the tonal information such as F_0by changing electric-stimulus rate has not got further study in clinical electric-stimulus mode. The present paper focuses on this matter by piecewise calculating the appreciable electric-stimulus rates. Then an electric-stimulus encoding algorithm of Mandarin tone is brought forward and testified through acoustic simulations. Such conclusion can be drawn that this algorithm of electric-stimulus rate could convey tonal information well and help to enhance the Mandarin speech recognition ability.

关键词： cochlear implant tone fundamental frequency electric-stimulus rate.

Numerical simulation analysis of Guixi copper flash smelting furnace

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Rare Metals 2002年第4期21卷 260-265页

作者： LIXinfeng MEIChi 等 NationalCIMSengineeringResearchcenter TsinghuaUniversityBeijing100084China departmentofHeatengineering CentralSouthUniversityChangsha410083China

A numerical simulation analysis for reactions of chalcopyrite and pyriteparticles coupled with momentum, heat and mass transfer between the particle and gas in a flashsmelting furnace is presented. In the simulation, the equations governing the gas flow are solvednumerically by Eular method. The particle phase is introduced into the gas flow by theparti-cle-source-in-cell technique (PSIC). Predictions including the fluid flow field, temperaturefield, concentration field of gas phase and the tracks of particles have been obtained by thenumerical simulation. The visualized results show that the reaction of sulfide particles is almostcompleted in the upper zone of the shaft within 1.5 m far from the central jet distributor (CJD)type concentrate burner. The simulation results are in good agreement with data obtained from aseries of experiments and tests in the plant and the error is less than 2%.

关键词： numerical simulation flash smelting furnace copper

The dynamical properties of Rydberg hydrogen atom near a metal surface

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Science china(physics,Mechanics & Astronomy) 2005年第6期48卷 667-675页

作者： GE Meihua1, ZHANG Yanhui1, WANG Dehua2, DU Mengli3.& LIN Shenglu1 1. College of physics and Electronics, Shandong Normal university, Jinan 250014, china 2. {3. of Mathematics and physics, Shandong Institute of Architecture and engineering, Jinan 250014, china 3. Institute of Theoretical physics, Chinese Academy of Sciences, beijing 100080, china 1. College of physics and Electronics Shandong Normal University 250014 Jinan China 2. department of Mathematics and physics Shandong Institute of Architecture and Engineering 250014 Jinan China 3. Institute of Theoretical physics Chinese Academy of Sciences 100080 Beijing China

The dynamical properties of Rydberg hydrogen atom near a metal surface are presented by using the methods of phase space analysis and closed orbit theory. Transforming the coordinates of the Hamiltonian, we find that the phase space of the system is divided into vibrational and rotational region. Both the Poincaré surface of section and the closed orbit theory verify the same conclusion clearly. In this paper we choose the atomic principal quantum number as n = 20. The dynamical character of the exited hydrogen atom depends sensitively on the atom-surface distance d. When d is sufficiently large, the atom-surface potential can be expressed by the traditional van der Waals force and the system is integrable. When d becomes smaller, there exists a critical value dc. For d > dc, the system is near-integrable and the motion is regular. While chaotic motion appears for d < dc, and the system tends to be non-integrable. The trajectories become unstable and the electron might be captured onto the metal surface.

关键词： Rydberg hydrogen atom, van der Waals interaction, Poincaré surface of section, closed orbit theory, chaos.

Molecular dynamics simulation of kink in 〈100〉 edge dislocation in body centred cubic iron

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Chinese Science Bulletin 2007年第16期52卷 2291-2296页

作者： CHEN LiQun1,2,WANG ChongYu2,3.4 & YU Tao2 1 College of Sciences,Central South university of Forestry & Technology,Changsha 410004,china 2 Central Iron and Steel Research Institute,beijing 100081,china 3.department of physics,tsinghua university,beijing 100084,china 4 International center for Materials physics,Chinese Academy of Sciences,Shenyang 110016,china College of Sciences Central South University of Forestry and Technology Changsha 410004 China

Using the molecular dynamics method,we have constructed two kink models corresponding to the 〈100〉{010} and 〈100〉{011} edge dislocations (EDs) in body centred cubic (bcc) Fe. It is found that the geometric structure of a kink depends on the type of edge dislocation and the structural energies of the atoms sites in the dislocation core region. The formation energies,migration energies and widths of the kinks in different types of EDs are calculated. The results show that formation and migration of the kink in the 〈100〉{010} edge dislocation are difficult. The 〈100〉{011} edge dislocation moves primarily through kink nucleation,rather than kink migration.

关键词：分子动力学边缘位移铁纽结结构

Approaches to improving critical current density of YBCO superconducting thick films deposited by electrophoresis

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Science china(physics,Mechanics & Astronomy) 2004年第2期47卷 165-172页

作者： ZHU Yabin1,2, ZHOU Yueliang2, LIU Zhen2, WANG Shufang2, CHEN Zhenghao2, L?Huibin2, YANG Guozhen2, XIAO Ling3. REN Hongtao3. JIAO Yulei3.& ZHENG Minghui3.1. department of physics, College of Science, beijing Jiaotong {3., beijing 100044, china 2. Laboratory of Optical physics, Institute of physics and center for Condensed Matter physics, Chinese Academy of Sciences, beijing 100080, china 3. General Research Institute for Nonferrous Metals, beijing 100088, china Correspondence should be addressed to Zhu Yabin (email: ybzhu@***) 1. department of physics College of Science Beijing Jiaotong University 100044 Beijing China 2. Laboratory of Optical physics Institute of physics and center for Condensed Matter physics Chinese Academy of Sciences 100080 Beijing China 3. General Research Institute for Nonferrous Metals 100088 Beijing China

Fabrication of YBCO superconducting thick films by electrophoresis has been widely reported. However, the value of critical current density (J c) is far from what the practical application requires. The superconducting thick films are obtained using top-seeded melt growth method with different proportional Y2BaCuO5 (Y211) addition. High-pressure oxygen has been used in the annealing process to improve the uniformity of the oxygen content in the superconducting thick films. When 40mol% Y211 powder is added to the YBa2Cu3.7–5 (Y123. powder,J c for the superconducting thick film by approaches described above reaches 7.008×103.A/cm2 (77 K, 0 T), which is greater than the value ever reported.

关键词： YBCO thick films, electrophoretic deposition, melt-textured.

Speciation of the elements and compositions on the surfaces of dust storm particles:The evidence for the coupling of iron with sulfur in aerosol during the long-range transport

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Chinese Science Bulletin 2005年第8期50卷 738-744页

作者： ZHANG Xingying1,2, ZHUANG Guoshun1,2,3. CHEN Jianmin2 & XUE Huaxin2 1. center for Atmospheric Environment Study, department of Chemistry, beijing Normal {3., beijing 100875, china 2. center for Atmospheric Chemistry Study, department of Environ- mental Science and engineering, Fudan {3., Shanghai 20043., china 3. LAPC/NZC, Institute of Atmospheric physics, NZC/LAPC, Chinese Academy of Sciences, beijing 100029, china center for Atmospheric Environment Study Department of Chemistry Beijing Normal University Beijing 100875 China center for Atmospheric Chemistry Study Department of Environmental Science and Engineering Fudan University Shanghai 200433 China LAPC/NZC Institute of Atmospheric Physics NZC/LAPC Chinese Academy of Sciences Beijing 100029 China

The speciation of the elements on the surface of the particles collected during dust storm and non-dust storm in beijing and Inner Mongolia was studied by XPS. The ma- jor species of iron on the surface were oxides, sulfate, silicate, FeOOH and minor part sorbed on SiO2/Al2O3. Sulfate is the dominant species of sulfur on the surface. SiO2 and Al2O3.are the main components of Si and Al on the surface respectively. One of the most important findings was that the Fe(II) (FeS and FeSO4) produced could account for up to 44.3. and 45.6% of the total Fe on the surface in the aerosol sample collected at that night and next day of the “peak” time of the dust storm occurring on March 20, 2002, while Fe2(SO4)3. one of the Fe(III) species on the surface decreased from 67.1% to 49.5% and 48.0% respectively. Both S and Fe en- riched on the surface of aerosol particles. Fe(II) accounted for 1.3.?5.3. of total Fe in bulk aerosol samples during dust storm. These results provided strong evidence to sup- port the hypothesis of the coupling between iron and sulfur in aerosols during the long-range transport, which would have important impact on the global biogeochemical cycle.

关键词：物种形成原理 XPS 大气悬浮物 Fe-S结合粒子集合

Modeling the intracellular dynamics for Vif-APO mediated HIV-1 virus infection

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Chinese Science Bulletin 2010年第22期55卷 2329-2340页

作者： WANG Yi1,2 & LAI LuHua1,3.1 center for Theoretical Biology, Peking university, beijing 100871,{3. 2 School of physics, Peking university, beijing 100871,{3. 3.BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular engineering, Peking university, beijing 100871,{3. center for Theoretical Biology Peking University Beijing 100871 China School of physics Peking University Beijing 100871 China BNLMS State Key Laboratory for Structural Chemistry of Unstable and Stable Species College of Chemistry and Molecular Engineering Peking University Beijing 100871 China

The viral infectivity factor (Vif) was found to be essential for controlling HIV-1 virus infectivity. It targets cellular antiviral proteins in APOBEC family (APO) to trigger its fast degradation and inhibits APO packaging into nascent virion. In the present study, we propose a mathematical model to quantitatively study the intracellular dynamics of these typical virus-host interactions. Four sets of published experimental data were compared with simulation results to justify the model. Systematic parameter sensitivity and perturbation analysis showed that parameters related to APO are crucial to the infectivity of newly synthesized HIV-1 virus. Interestingly, we discovered that the synthesis rate of the viral structure protein Gag and the required number per nascent virion are optimized to achieve high virion production with minimal level of packaged APO, and large portion of model parameters are beneficial to virus only within a relatively small range. Furthermore, minor variations in several parameters related to viral protein Tat, the activator of viral RNA synthesis, were found to induce switch-like behaviors on both incorporated Vif and APO. These findings may provide new insights for understanding the high mutation rate of HIV-1 virus and its latency, as well as help identify key targets for therapeutic design.

关键词：病毒感染载脂蛋白 HIV 细胞内动力学抗病毒蛋白建模介导

Discovery of a high confidence soft lag from an X-ray flare of Markarian 421

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Science china(physics,Mechanics & Astronomy) 2010年第S1期53卷 224-227页

作者： ZHANG YouHong1,HOU ZhengTian2,SHAO Li3.& ZHANG Peng1 1 department of physics and tsinghua {3. for astrophysics(THCA),tsinghua university,beijing 100084,china 2 Group of Mathematics and physics,Shangqiu Medical College,Shangqiu 476100,china 3.Max-Planck-Institut für extraterrestrische Physik,Postfach 13.2,Garching 85741,Germany 1. department of physics and tsinghua {3. for astrophysics (THCA) Tsinghua University Beijing 100084 China 2. Group of Mathematics and physics Shangqiu Medical College Shangqiu 476100 China 3. Max-Planck-Institut für extraterrestrische Physik Postfach 1312 Garching 85741 Germany

We present the X-ray variability properties of the X-ray and TeV bright blazar Mrk 421 with a-60 ks long XMM-Newton observation performed on November 9-10,*** source experienced a pronounced flare,of which the inter-band time lags were determined with a very high confidence *** soft(0.6-0.8 keV) X-ray variations lagged the hard(4-10 keV) ones by 1.09+0.11-0.12 ks,and the soft lag increases with increasing difference in the photon *** energy-dependent soft lags can be well fitted with the difference of the energy-dependent cooling timescales of the relativistic electron distribution responsible for the observed X-ray emission,which constrains the magnetic field strength and Doppler factor of the emitting region to be Bδ 1/3.1.78 Gauss.

关键词： BL Lacertae objects:individual:Mrk-421 galaxies:active radiation mechanisms:non-thermal X-rays:galaxies

Fluorescence dynamics of interactions between polyamide PyPyPyβDp and DNA

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Science china Chemistry 2006年第1期49卷 75-80页

作者： ZHANG Huijuan1,2, WANG Jin3. WU Yishi1, YUAN Gu3. AI Xicheng1, WANG Li4 & ZHANG Jianping1 1. State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, beijing 100080, china 2. School of Life Science and Technology, beijing Institute of Technology, beijing 100081, china 3. College of Chemistry and Molecular engineering, Peking university, beijing 100080, china 4. center for Condensed Matter physics, Institute of physics, Chinese Academy of Sciences, beijing 100080, china Correspondence should be addressed to Ai Xicheng and Zhang Jianping 1. State Key Laboratory for Structural Chemistry of Unstable and Stable Species Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China 2. School of Life Science and Technology Beijing Institute of Technology Beijing 100081 China 3. College of Chemistry and Molecular engineering Peking University Beijing 100080 China 4. center for Condensed Matter physics Institute of Physics Chinese Academy of Sciences Beijing 100080 China

The photophysical properties of the polyamide PyPyPyβDp (PPP) were investigated by means of steady-state absorption and fluorescence spectroscopies, as well as time-resolved fluo-rescence spectroscopy. It was found that the excited-state properties of PPP are very sensitive to solvents. In TKMC buffer PPP exhibited weak fluorescence with a decay time constant of 16 ps, while with the decrease of the solvent polarity PPP showed the blue-shifted peak position, increased inten-sity and lengthened life-time for its fluorescence behavior. In the presence of calf thymus DNA, it was observed that the fluorescence intensity was enhanced and the fluorescence lifetime increased from 16 to 3. ps for PPP, which verified that PPP bound into the minor groove of DNA duplex.

关键词： polyamide (PPP), calf thymus DNA (ctDNA), time-resolved fluorescence spectroscopy, recognition dynamics.