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Spatio-temporal pattern analysis of single-trial EEG signals recorded during visual object recognition

Science China(Information Sciences) 2011年第12期54卷 2519-2527页

作者： WANG ChangMing 1 , HU XiaoPing 3., YAO Li 1,2 , XIONG Shi 2 & ZHANG JiaCai 2 1 National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China 2 College of Information Science and technology, Beijing Normal University, Beijing 100875, China 3.biomedical imaging technology center, emory University/{3. institute of technology, atlanta 3.3.2, usa 1. National Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University Beijing 100875 China3. Biomedical Imaging Technology Center Emory University/Georgia Institute of Technology Atlanta 30322 USA2. College of Information Science and Technology Beijing Normal University Beijing 100875 China

Object discrimination is a fundamental cognitive function for human brains. In this study, we utilized an analysis approach for single-trial electroencephalography (EEG) to analyze the spatio-temporal activation patterns of visual objects processing in human brains, and attempted to apply it to discriminate different visual objects. The spatial patterns were respectively extracted from scalp EEG and the reconstructed cortical sources, while the experiment participants were perceiving 4 different categories of visual objects (faces, buildings, cats and cars). By classifying the patterns extracted from single-trial EEG, the presented visual objects could be discriminated by a computer, and the classification accuracies may provide a quantitative index to evaluate the spatial differences of the brain activations related to different visual objects. Our results demonstrated that the spatial patterns on both the scalp and the sources levels resulted in higher classification accuracies than chance rate. We also examined the classification results using temporally non-overlapping time intervals of different event-related potential (ERP) components. The temporal changes of classification accuracies may reflect the temporal distribution of the discriminative information in the EEG responses. The present pattern extraction and classification methods may compose a computational model for single-trial EEG data analysis in investigations of the spatio-temporal activation patterns for object recognition. These spatio-temporal patterns in EEG may be useful to identifying the discriminative spatial areas and time stages to improve the accuracies and efficiencies of object discrimination. In addition, investigating and utilizing humans'cognitive mechanisms of object recognition may improve computers' processing efficiency of visual information.

关键词： EEG spatio-temporal pattern object recognition single-trial analysis visual information processing

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Real-time observation of integrin bending/unbending conformational changes on living cells

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医用生物力学 2010年第S1期25卷 9-10页

作者： Wei Chen,Cheng Zhu(Coulter Department of biomedical Engineering georgia institute of {3.,atlanta,GA 3.3.2-03.3.usa)

Introduction Integrins are a large family of adhesion molecules broadly expressed on the surface of a wide variety of cells as heterodimers. Binding of integrins to ligands provides not only mechanical anchorage for t... 详细信息

关键词： Real-time observation of integrin bending/unbending conformational changes on living cells time

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New Approaches for Molecular imaging with MRI

New Approaches for Molecular Imaging with MRI

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中华医学会第十八次全国放射学学术会议

作者： Xiaoping Hu emory University and georgia institute of {3.,usa

MRI is playing a growing role in molecular imaging for mapping cellular and molecular signatures of diseases and normal *** this regard,magnetic iron oxide nanoparticles(MION) are most widely used because of their high sensitivity and suitability for in vivo *** our own work,we have taken two approaches in developing MION based molecular ***,we have developed new imaging sequences for improved and quantitative mapping of MION ***,we have

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Characterization and Crystal Structure of a New Holmium(III) Complex with the Macrocyclic Ligand Derived from 2,6-Diformyl-4-methylphenol and Diethylenetriamine

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Chinese Journal of Structural Chemistry 2007年第12期26卷 1429-1434页

作者：胡学雷邱立赵元弟Key Laboratory of biomedical Photonics of Ministry of Education - Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics and Molecular imaging Key Laboratory - Key Laboratory of Molecular Biophysics of the Ministry of Education Huazhong University of Science and technology 潘志权 Key Laboratory of biomedical Photonics of Ministry of Education - Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics and Molecular imaging Key Laboratory - Key Laboratory of Molecular Biophysics of the Ministry of Education Huazhong University of Science and Technology Hubei Key Laboratory of Novel Chemical Reactor and Green Chemical technology Wuhan Institute of Technology

The title compound （13.27-dimethyl-3.6,9,17,20,23.hexaazatricyclo-[23.***.1.1^11.15]- triaconta-l（29）,2,9,11,13.15（3.）,16,23.25,27-decaene-29,3.-diol-N^3.N^6,N^9,O^29,O^3.）-bis（nitrato-O,O＇）- holmium（m） nitrate hydrate has been prepared and characterized by elemental analysis, infrared spectra, and electrospray mass spectra. Its crystal and molecular structures were determined by X-ray diffraction methods. The crystal crystallizes in the monoclinic system, space group C2/c with a = 23.73.（12）, b = 14.23.（7）, c = 19.801（10） A, β = 91.3.（1）^o, Mr = 83..57, V = 6690（6） A^3. Z = 8, Dc = 1.651 g/cm^3. F（000） = 3.44, R = 0.0482 and wR = 0.0923. The holmium ion is located in one of the compartments of the macrocyclic ligand and presents a distorted tricapped trigonal prismatic coordination geometry. The macrocycle is coordinated with two oxygen and three nitrogen atoms. Two nitrates are chelated in the opposite positions of the macrocycle, and the third one is ionic.

关键词： crystal structure lanthanide macrocycle

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Modeling for cell crowding effects on the adhesion of flowing cells

Modeling for cell crowding effects on the adhesion of flowin...

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2008年全国生物流变学与生物力学学术会议

作者： Ying Fang~1,Quhuan Li~2,Cheng Zhu~3.Jianhua Wu~1(1.School of Bioscience and Bioengineering,South China University of technology,Guangzhou 510006 2.School of Life Science,Sun Yat-Sen University, Guangzhou 510275 3.Coulter Department of biomedical Engineering,georgia {3. of technology, atlanta,GA 3.3.2)

The adhesion of flowing cells to the vascular surface in localized sites will occur in many physiological and pathological processes, such as inflammatory reaction,tumor metastasis,and thrombus *** transport dependent process depends not only on the specific interactions of adhesive molecules but also on the hemodynamics of blood flow.A larger accumulation of adhesion cells may decay the local transport rate of flowing cells,increase the collision events of flowing cells each other or between the tethered and the flowing cells,

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Residues important to the allosteric regulation on ligand binding affinity in β3.integrins

Residues important to the allosteric regulation on ligand bi...

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第九届全国生物力学学术会议

作者： Jizhong Lou~(1*),Wei Chen~2,Mei-Yin Chou~3.Cheng Zhu~(1,2,3.4)(1 Parker H.Petit institute for Bioengineering and Bioscience,2Woodruff School of Mechanical Engineering,and 3.School of Physics,4 Coulter Department of biomedical Engineering,,georgia institute of technology,GA,usa)

Integrins are heterodimers that mediate cell adhesion and transduce signals bidirectionally across the cell membrane. Integrins often exist in low affinity(or inactive) states for ligand binding on the cell curface,but change conformations to high affinity(or activated) states when induced by stimuli from inside or outside the *** and electron microscopic studies have obtained evidence that the low affinity states correspond to bent conformations where

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Mechanochemistry of catch bonds between integrins and ligands

Mechanochemistry of catch bonds between integrins and ligand...

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第九届全国生物力学学术会议

作者： Fang Kong~1,Wei Chen~1,Jizhong Lou,Cheng Zhu~(1.3.)(1,Woodruff School of Mechanical Engineering,2 institute for Bioengineering and Bioscience,and 3.Coulter Department of biomedical Engineering georgia institute of technology, atlanta,GA 3.3.2-03.3.heng)

Integrins are a large family of adhesion molecules broadly expressed on the surface of a wide variety of cells as *** of integrins to ligands provides anchorage and signals for the cell,making them prime candidates for mechanosensing *** elucidate how force regulates integrin/ligand dissociation,we used molecular mechanics experiments to measure lifetimes of single bonds of or L integrins interacting with their respective ligands,fi-

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E-Selectin-mediated cell adhesion measuring by an inverted flow Chamber

E-Selectin-mediated cell adhesion measuring by an inverted f...

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2008年全国生物流变学与生物力学学术会议

作者： Quhuan Li~1,Yi Fu~2,Ying Fang~2,Cheng Zhu~3.Jianhua Wu~2(1.School of Life Science,Sun Yat-Sen University, Guangzhou 510275 2.School of Bioscience and Bioengineering,South China University of technology,Guangzhou 510006 3.Coulter Department of biomedical Engineering,georgia {3. of technology,atlanta,GA 3.3.2)

The kinetic and mechanical constraints govern selectin-ligand interactions that mediate adhesion of circulating leukocytes with the vessel wall during an inflammatory *** studies have been carried out to elucidate this transport dependent process that depends not only on the specific interactions of adhesive molecules but also on the hemodynamics of blood *** far,there is little known about

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Design and implementation of an optical simulation environment for bioluminescent tomography studies

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Progress in Natural Science:Materials International 2007年第1期17卷 87-94页

作者： LI Hui, TIAN Jie, LUO Jie, LU Yujie, CONG Wenxiang and WANG Ge ( Department of Education technology, Capital Normal University, Beijing 10003., China Key Laboratory of Complex Systems and Intelligence Science, institute of Automation, Chinese Academy of Sciences, Beijing 100080, China Bioluminescent Tomography Laboratory, Department of Radiology & Department of biomedical Engineering, University of Iowa, Iowa City, Iowa 52242,{3.) [a]Departhent of Education technology Capital Normal University Beijing China [b]Key Laboratoiy of Omplex Systems and Intelligence Science Institute of Automation Chinese Academy of Sciences Beijing China [c]Bioluminescent Tomography Laboratoiy Department of Radiology & Department of Biomedical Engineering University of Iowa Iowa City tIowa USA

As a challenging task for bioluminescent tomography simulation, a virtual optical environment is needed to solve the forward problem accurately, that is, to achieve a high precision for bioluminescent signal synthesis on the external body surface of a small animal. The molecular optical simulation environment named MOSE is implemented using the C++ programming language and the OpenGL techniques, including a user-friendly interface with interactive tools facilitating users' operations. The accuracy of the virtual optical environment is verified by error analysis of mesh simplification and comparison between MOSE results and experimental data. This virtual optical environment is accurate, flexible and efficient to simulate the photon propagation in complicated tissues, which has a great potential to become a software platform for bioluminescent tomography studies and other molecular imaging applications.

关键词： molecular imaging biolumlnescent tomography photon propagation Monte Carlo method.

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Two-dimensional Manipulation of Microbubbles using Standing Leaky Surface Acoustic Wave

Two-dimensional Manipulation of Microbubbles using Standing ...

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2011年全国压电和声波理论及器件应用研讨会

作者： Long Meng Fei-Yan Cai Hai-Rong Zheng~* Paul C.Lauterbur Research center for biomedical imaging,{3. of biomedical and Health Engineering,Shenzhen {3.s of Advanced technology,Chinese Academy of Sciences,Shenzhen 518055

A microfluidic device was developed to precisely transport the microbubbles by introducing phase-shifts to a two-dimensional standing leaky surface acoustic wave(SLSAW).The device consists of a polydimethyl-siloxane (... 详细信息

关键词： Surface acoustic wave Relative phase shift Microbubbles Acoustic radiation force

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