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Engeering Zn（Ⅱ）-Binding Site into The βαβ Small Protein

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Engeering Zn（Ⅱ）-Binding Site into The βαβ Small Protei...

第六届全国化学生物学学术会议

作者： Cheng Zhu,Changsheng Zhang,Huanhuan Liang,Luhua Lai~* beijing National laboratory for molecular Sciences,{3. key laboratory for structural chemistry of unstable and stable species,college of chemistry and molecular engineering,peking university, beijing 100871,China

＜正＞De novo design of proteins provides a stringent test of our understanding of protein structures and their molecular mechanisms of biological functions.A small protein withβαβstructure,which consists of two parallelβstrands connected by anαhelix,has been designed for the first time in our *** designed sequence can fold quickly into a stable monomeric structure,providing a good starting point to introduce functions.

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RHEOLOGICAL BEHAVIOR OF EPOXY RESIN WATERBORNE DISPERSIONS

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Chinese Journal of Polymer Science 2001年第5期19卷 471-476页

作者： Zhen-zhong Yang Yuan-ze Xu De-lu Zhao state key laboratory of Polymer Physics & {3., Center for {3. Science Institute of {3., Chinese Academy of Sciences, beijing 100080 China Chinese Acad Sci Inst Chem State Key Lab Polymer Phys & Chem Ctr Mol Sci Beijing 100080 Peoples R China

The waterborne dispersions of epoxy resin were prepared by the phase inversion emulsification technique. Rheological behavior and its relationship with the structural change of the systems were studied. It was shown that the concentrated dispersions were highly viscoelastic and pseudoplastic, which was attributed to the formation of a physical network among the waterborne particles via hydrogen bond. The dilute dispersions were Newtonian fluids. The discrete clusters composed of small waterborne particles were found in diluted dispersions. With increasing solid content, there existed a structural transition via percolation through a cluster-cluster aggregation mode to form the physical network, which was qualitatively evidenced by the TEM morphologies.

关键词： epoxy resin waterborne dispersion rheological behavior cluster-cluster aggregation percolation transition

Application of Genetic Algorithm to the QSAR Research of Pyrrolobenzothiazepinones and Pyrrolobenzoxazepinones-Novel and Specific Non-Nucleoside HIV-1 Reverse Transcription Inhibitors

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Chinese Chemical Letters 1998年第7期9卷 651-654页

作者： Ting Jun HOU Jun Mei WANG You Yong LI Xiao Jie XU(chemistry department, Beida-Jiuyuan molecular Design laboratory,{3.,beijing 100871) peking Univ Dept Chem Beida Jiuyuan Mol Design Lab Beijing 100871 Peoples R China

Genetic Algorithm (GA) was used to study the quantitative structural parameters and activity relationship of pyrrolobenzothizepinones and pyrrolobenzoxazepinones's inhibitory activities with non-nucleoside HIV-1 reverse transcriptase (RT). A group of linear polynomial models with good relationship have been built to get some useful information that other methods can not offer.

关键词： QSAR GA(genetic algorithm) HIV

Using Different Methods to Synthesize New Cinchophen Derivatives

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Using Different Methods to Synthesize New Cinchophen Derivat...

中国化学会第四届有机化学学术会议

作者： LIU, Ying ZHOU,Lu ZHOU, Guang-Yan LAI, Lu-Hua (state key laboratory for {3. {3. of unstable and stable species, Institute of Physical {3. & college of chemistry and molecular engineering, peking university, beijing 100871)

＜正＞2-Phenylcinchoninic acid （cinchophen） and its derivatives are so useful as drugs and so comparatively non-toxic, that a study of its synthesis is very important. Herein, we report different methods to prepare the cinchophen derivatives: （1） Pfitzinger which consists in the condensation of isatin with acetophenone in the presence of alkalies;（2） Doebner-Miller synthesis from benzaldehyde, pyruvic acid and aniline. 3. new derivatives of cin-

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Crystal Structure of Triethyl 6-benzoyl-3.-(4-fluorophenyl)-2,3.3.,4,5,6-hexahydro-5-methyl-1H-pyro〔1,2-a〕〔1,5〕benzodiazepine-1,2-3.tricarboxylate

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Chinese Journal of structural chemistry 1999年第4期 18-22页

作者： WANG HongZhong\ XU JiaXi\ MI BaoYu\ JIN Sheng* (college of chemistry and molecular {3., peking university, beijing 100871)

１ＩＮＴＲＯＤＵＣＴＩＯＮＳｉｎｃｅｂｉｏｌｏｇｉｃａｌａｎｄｐｈａｍａｃｏｌｏｇｉｃａｌａｃｔｉｖｉｔｉｅｓｈａｖｅｂｅｅｎｗｅｌｋｎｏｗｎｆｏｒｎｕｍｅｒｏｕｓｈｅｔｅｒｏｃｙｃｌｉｃａｒｏｍａｔｉｃｔｒｉｃｙ... 详细信息

１ＩＮＴＲＯＤＵＣＴＩＯＮＳｉｎｃｅｂｉｏｌｏｇｉｃａｌａｎｄｐｈａｍａｃｏｌｏｇｉｃａｌａｃｔｉｖｉｔｉｅｓｈａｖｅｂｅｅｎｗｅｌｋｎｏｗｎｆｏｒｎｕｍｅｒｏｕｓｈｅｔｅｒｏｃｙｃｌｉｃａｒｏｍａｔｉｃｔｒｉｃｙｃｌｅｓｉｎｒｅｃｅｎｔｙｅａｒｓ...

关键词： crystal structure pyrro1 2a1 5benzodiazepine 1

Silver Enhancement-Aptamer-Gold Nanoparticles Aggregation Based Assay for Simple and Sensitive Detection of Adenosine

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Silver Enhancement-Aptamer-Gold Nanoparticles Aggregation Ba...

第一届全国生物物理化学会议暨生物物理化学发展战略研讨会

作者： Zhaofang Liu,Jing Ge,and Xin Sheng Zhao~* beijing National laboratory for molecular Sciences,{3. key laboratory for structural chemistry of unstable and stable species,and Department of Chemical Biology,college of chemistry and molecular engineering,peking university,beijing 100871,China

＜正＞Aptamers are oligonucleic acid or peptide molecules that bind to wide range specific targets from metal ions,small molecules,to large proteins,even *** gold nanoparticles （AuNPs） and silver enhancement were introduced to detect the target molecules[1]. Previous work in our group has prepared aptamer-Gold nanoparticles（Apt-AuNPs） by

关键词： Aptamer Gold nanoparticles Adenosine detection Silver enhancement

Micro-mechanical analysis of dynamic processes of nanomanipulation

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Science China(Physics,Mechanics & Astronomy) 2004年第z1期47卷 88-92页

作者： HU Jie, ZHANG Yujun, LI Peng, WANG Hui, HUANG Lan & HU Yuanzhongstate key laboratory of Tribology, Tsinghua {3., {3. 100084, China Department of Physics, Tsinghua {3., {3. 100084, China college of chemistry and molecular engineering, peking university, beijing 100871, China 1. state key laboratory of Tribology Tsinghua University 100084 Beijing China 2. Department of Physics Tsinghua University 100084 Beijing China 3. college of chemistry and molecular engineering Peking University 100871 Beijing China

In this study, atomic force microscope (AFM) tips are used as tools to cut and manipulate carbon nanotubes on various surfaces. The lateral forces acting on AFM tips during manipulation are also recorded and analyzed from the perspective of micro-mechanics. It is found that differences in surface conditions can lead to obvious increase in micro-friction between nanotube and substrate. And also due to rehybridization, carbon nanotubes present excellent resilience when undergoing different degrees of strain. Finally, carbon nanotubes can complexly deform from elastic stage to plastic stage before complete rupture.

关键词： nanomanipulation, carbon nanotubes, AFM tips, micro-mechanics.

SMALL ANGLE LIGHT SCATTERING MEASUREMENT OF THE ISOTROPIC TO NEMATIC TRANSITION OF A SIDE CHAIN NEMATIC POLYMETHACRYLATE

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Chinese Journal of Polymer Science 2002年第5期20卷 431-437页

作者： Zhong-ming Hu Ren-yuan Qian Shou-xi Chen Xiao-fang Chen Qi-feng Zhou Centre for molecular Science, Institute of chemistry Chinese Academy of Sciences, beijing 100080, China Department of Polymer Science & {3. college of chemistry & molecular {3. peking university beijing 100871, China Chinese Acad Sci Inst Chem Ctr Mol Sci Beijing 100080 Peoples R China peking Univ Coll Chem & Mol Engn Dept Polymer Sci & Engn Beijing 100871 Peoples R China

The kinetics of I-->N transition of a side chain nematic polymethacrylate has been studied by small angle depolarized light scattering intensity measurements using a charge coupled device linear image sensor. The polymer shows the transition temperatures K52N79I in degreesC, The H-v scattering intensity T(q,t) during the transition I (at 80.2degreesC)-->N (at 75.8degreesC) shows that T(q) is independent of q for all t, and during the initial stage (in 6 s) T(t) increases exponentially with t. In the later stage of the transition T(t) approaches a saturation value in 2 min. This experimental result indicates that the I-->N transition of a liquid crystalline polymer is a spinodal type of phase transition mediated by orientation fluctuation.

关键词： side chain nematic polymer isotropic-nematic transition small angle depolarized light scattering

Single-molecule Spectroscopy of Protein Folding with Tuning the Loop Closure

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Single-molecule Spectroscopy of Protein Folding with Tuning ...

第一届全国生物物理化学会议暨生物物理化学发展战略研讨会

作者： Ze Yong Zhi,Peng Cheng Liu,and Xin Sheng Zhao~* beijing National laboratory for molecular Sciences,{3. key laboratory for structural chemistry of unstable and stable species,and Department of Chemical Biology,college of chemistry and molecular engineering,peking university,beijing 100871,China

＜正＞The kinetics of loop closure sets the"speed limit"for protein *** molecule fluorescence resonance energy transfer（smFRET） is a powerful method to study the specific chain *** have used the combination of smFRE... 详细信息

关键词： FRET protein folding polymer