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Enhanced Hoek-Brown(H-B)criterion for rocks exposed to chemical corrosion

International Journal of Mining Science and Technology 2024年第5期34卷 609-630页

作者： Hao Li Leo Pel zhenjiang You David Smeulders Department of Mechanical engineering Eindhoven University of TechnologyEindhoven 5600 MBthe Netherlands Department of Applied Physics Eindhoven University of TechnologyEindhoven 5600 MBthe Netherlands Center for Sustainable Energy and Resources School of EngineeringEdith Cowan UniversityJoondalupWA 6027Australia school of chemical engineering The University of QueenslandBrisbaneQLD 4072Australia Gas and Energy Transition Research Centre The University of QueenslandBrisbaneQLD 4072Australia

Underground constructions often encounter water environments,where water–rock interaction can increase porosity,thereby weakening engineering ***,the failure criterion for chemically corroded rocks becomes essential in the stability analysis and design of such *** study enhances the applicability of the Hoek-Brown(H-B)criterion for engineering structures operating in chemically corrosive conditions by introducing a kinetic porosity-dependent instantaneous mi(KPIM).A multiscale experimental investigation,including nuclear magnetic resonance(NMR),X-ray diffraction(XRD),scanning electron microscopy(SEM),pH and ion chromatography analysis,and triaxial compression tests,is employed to quantify pore structural changes and their linkage with the strength responses of limestone under coupled chemical-mechanical(C-M)*** employing ion chromatography and NMR analysis,along with incorporating the principles of free-face dissolution theory accounting for both congruent and incongruent dissolution,a kinetic chemical corrosion model is *** model aims to calculate the kinetic porosity alterations within rocks exposed to varying H+concentrations and ***,utilizing the generalized mixture rule(GMR),the kinetic porositydependent mi is *** of the KPIM-enhanced H-B criterion using compression test data from 5 types of rocks demonstrated a high level of consistency between the criterion and the experimental results,with a coefficient of determination greater than 0.96,a mean absolute percentage error less than 4.84%,and a root-mean-square deviation less than 5.95 ***,the physical significance of the porosity-dependent instantaneous mi is clarified:it serves as an indicator of a rock’s capacity to leverage the confining pressure effect.

关键词： Hoek-Brown(H-B)criterion Instantaneous mi Kinetic porosity-dependency chemical corrosion Compressive strength

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Mining and Integrating Reliable Decision Rules for Imbalanced Cancer Gene Expression Data Sets

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Tsinghua Science and Technology 2012年第6期17卷 666-673页

作者： Hualong Yu 1 , Jun Ni 2 , Yuanyuan Dan 3., Sen Xu 4 1. school of Computer Science and engineering, Jiangsu University of Science and Technology, zhenjiang 2.2.03. china 2. Department of Radiology, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA {3., Jiangsu University of Science and Technology, zhenjiang 2.2.03. china 4. school of Information engineering, Yancheng Institute of Technology, Yancheng 224051, china school of Computer Science and engineering Jiangsu University of Science and Technology Zhenjiang 212003 China|c|

There have been many skewed cancer gene expression datasets in the post-genomic era. Extraction of differential expression genes or construction of decision rules using these skewed datasets by traditional algorithms will seriously underestimate the performance of the minority class, leading to inaccurate diagnosis in clinical trails. This paper presents a skewed gene selection algorithm that introduces a weighted metric into the gene selection procedure. The extracted genes are paired as decision rules to distinguish both classes, with these decision rules then integrated into an ensemble learning framework by majority voting to recognize test examples; thus avoiding tedious data normalization and classifier construction. The mining and integrating of a few reliable decision rules gave higher or at least comparable classification performance than many traditional class imbalance learning algorithms on four benchmark imbalanced cancer gene expression datasets.

关键词： cancer gene expression data class imbalance paired differential expression genes decision ruleensemble learning majority voting

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Targeting cancer cells through Mn(Ⅱ)-dpa grafted silica nanoparticles

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Science china Chemistry 2010年第8期53卷 1728-1731页

作者： CHEN QiuYun1,WANG LingYun1,ZHANG LiRong2,GUO WenJie3.& GAO Jing3.1school of Chemistry and chemical engineering,Jiangsu University,{3. 212013.china 2Department of Radiology,the Affiliated Hospital of Jiangsu University,{3. 212001,china 3.0} of Pharmacy,Jiangsu University,{3. 212013.china school of Chemistry and chemical engineering Jiangsu University Zhenjiang China Department of Radiology the Affiliated Hospital of Jiangsu University Zhenjiang China school of Pharmacy Jiangsu University Zhenjiang China

The unique properties of paramagnetic nanoscale metal-organic frameworks provide them with high potential as key probes and vectors in the next generation of biomedical *** increase the nanoparticle targeting at the tumor site,the grafting of Mn(Ⅱ)-dpa (dpa =di(picolyl)amines) on oxide nanoparticles (SiO2) is *** new Mn(Ⅱ)-dpa-grafted silica nanoparticles can enhance the MR imaging area in cancer tissues and perturb the Ca2+-loaded mitochondria *** results indicate the cancer cells may be targeted through possible intracellular Ca2+ signaling mitochondria accumulating in vivo.

关键词： Mn(Ⅱ)-dpa silica nanoparticles mitochondria calcium

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Design,synthesis and biological evaluation of fluorescent derivatives of ursolic acid in living cells

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Chinese chemical Letters 2024年第5期35卷 287-289页

作者： Wenyi Mei Lijuan Xie Xiaodong Zhang Cunjian Shi Fengzhi Wang Qiqi Fu zhenjiang Zhao Honglin Li Yufang Xu Zhuo Chen Shanghai Key Laboratory of New Drug Design State Key Laboratory of Bioreactor EngineeringSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China Innovation Center for AI and Drug Discovery East China Normal UniversityShanghai 200062China Lingang Laboratory Shanghai 200031China

Ursolic acid(UA)is a naturally occurring ursane triterpenoid,which exhibits a wide range of unique biological *** clarify its mechanism of action(MOA),a series of fluorescent derivatives of UA(5a-c)were designed and synthesized by conjugation with 7-nitrobenzo-2-oxa-1,3.diazole(NBD)*** them,5c exhibited similar anti-proliferative activity with UA against HCT116 cells(half maximal inhibitory concentration(IC_(50))=9.21±0.50μmol/L).Cell imaging experiment indicated that 5c was rapidly taken up in HCT116 cells in a dose and time-dependent ***,5c was found to localize in endoplasmic reticulum(ER),lysosomes,and mitochondria,but not in nucleus of HCT116 cells by confocal microscopy *** MOA proved that UA induced autophagy with a unique intracellular distribution mechanism involving ER and *** all,our work provides new clues for revealing the molecular mechanism of UA as an antitumor agent.

关键词： Pentacyclic triterpenoid Ursolic acid Fluorescent derivatives Autophagy Apoptosis

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Kinetic theory of self-condensing vinyl polymerization

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Science china Chemistry 2010年第12期53卷 2429-2439页

作者： ZHOU ZhiPing 1 & YAN DeYue 2 1 school of Materials Science and engineering,Jiangsu University,zhenjiang 212013.{3. 2 school of Chemistry and chemical engineering,Shanghai Jiao Tong University,Shanghai 200240,{3. 1. school of Materials Science and engineering Jiangsu University Zhenjiang 212013 China2. School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 China

This review introduces the kinetic theory of self-condensing vinyl polymerization (SCVP),including the SCVP of AB inimers,the SCVP with non-equal reactivity between A and B groups,the SCVP in the presence of a small amount of multifunctional initiators,also the SCVP of both inimers and *** analytical expressions of various molecular parameters for the resulting hyperbranched polymers,such as the molecular size distribution function,the average molecular weight,the polydispersity index and the degree of branching,are reviewed systematically.

关键词： kinetic theory self-condensing vinyl polymerization (SCVP) hyperbranched polymers

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Protective effect of clodronate-containing liposomes on intestinal mucosal injury in rats with severe acute pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2011年第5期10卷 544-551页

作者： Jian-Xin Zhang, Sheng-Chun Dang, Kai Yin and De-Li Jiang Department of General Surgery, Affiliated Hospital of Jiangsu University, zhenjiang 212001, china school of Chemistry and {3. engineering of Jiangsu University, zhenjiang 212013. china [a] Department of General Surgery Affiliated Hospital of Jiangsu University Zhenjiang 212001 China [b] school of Chemistry and chemical engineering of Jiangsu University Zhenjiang212013 China

BACKGROUND: Severe acute pancreatitis (SAP) can result in intestinal mucosal injury. This study aimed to demonstrate the protective effect of clodronate-containing liposomes on intestinal mucosal injury in rats with SAP. METHODS: Liposomes containing clodronate or phosphate buffered saline (PBS) were prepared by the thin-film method SAP models were prepared by a uniform injection of sodium taurocholate (2 mL/kg body weight) into the subcapsular space of the pancreas. Sprague-Dawley rats were randomly divided into a control group (C group), a SAP plus PBS-containing liposomes group (P group) and a SAP plus clodronate-containing liposomes group (T group). At 2 and 6 hours after the establishment of SAP models, 2 mL blood samples were taken from the superior mesenteric vein to measure the contents of serum TNF-α and IL-12. Pathological changes in the intestine and pancreas were observed using hematoxylin and eosin staining, while apoptosis was detected using TUNEL staining. In addition, the macrophage markers cluster of differentiation 68 (CD68) in the intestinal tissue was assessed with immunohistochemistry. RESULTS: At the two time points, the levels of TNF-α and IL-12 in the P group were higher than those in the C group (P<0.05) Compared with the P group, the levels of TNF-α and IL-12 decreased in the T group (P<0.05). The pathological scores of the intestinal mucosa and pancreas in the T group were lower than those of the P group. In the T group, large numbers of TUNEL-positive cells were observed, but none or few in the C and P groups. The number of CD68-positive macrophages decreased in the T ***: Clodronate-containing liposomes have prote- ctive effects against intestinal mucosal injury in rats with SAP. The blockade of macrophages may provide a novel therapeutic strategy in SAP.

关键词： pancreatitis clodronate disodium macrophage intestinal mucosal injury

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Molecular mechanism of dehydrin in response to environmental stress in plant

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Progress in Natural Science:Materials International 2007年第3期17卷 237-246页

作者： ZHANG Yuxiu , WANG Zi and XU Jin (Department of Bioengineering, school of chemical and Environmental engineering, china University of Mining and Technology (Beijing), Beijing 100083. china Department of biology, Graduate University of Chinese Academy of Sciences, Beijing 100049, china) [a]Department of Bioengineering School of Chemical and Environmental Engineering China University of Mining and Technology (Beiing) Beijing China [b]Department of biology Graduate University of Chinese Academy of Sciences Beijing China

Dehydrins, known as the D-11 subgroup of late embryogenesis abundant (LEA) protein, are an immunologically distinct family of proteins, which typically accumulate in desiccation-tolerant seed embryo or in vegetative tissues in response to various environmental stresses such as drought, salinity and freezing. The existence of conservative sequences designated as K, S, and Y segments is a structural feature of dehydrins, and the K segment found in all dehydrins represents a highly conserved 15 amino acid motif (EKKGIMDKIKEKLPG) and forms an amphiphilicα-helix. According to the arrangement of these domains and clustering analysis, dehydrins are subdivided into 5 subtypes: YnSK, Kn, KnS, SKn and YnK. Different types of dehydrins are induced by different environmental stress in plants. Study results showed that dehydrins might play important protective roles under abiotic stress via a number of different mechanisms, including improving or protecting enzyme activities by the cryoprotective activity in responding to freeze/thaw or dehydration; stabilizing vesicles or other endomembrane structures by function as the membrane stabilizer during freeze induced dehydration, and preventing the membrane system from the oxidative damage induced by reactive oxygen radicals as the radical scavenger. Here, the gene expression and molecular mechanisms of dehydrin in response to stress in plants are discussed.

关键词： dehydrin stress mechanism.

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Expressed sequence tag analysis and cloning of trehalose-6-phosphate synthase gene from marine alga Laminaria japonica(Phaeophyta)

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Acta Oceanologica Sinica 2012年第6期31卷 139-148页

作者： XUAN Jinsong 1,4,FENG Yanbin 1,WENG Manli 1,ZHAO Ge 1,SHI Jinfeng 1,YAO Jianting 2,WANG Xiuliang 2,GUO Baotai 3.QIAO Lixian 3.DUAN Delin 2,WANG Bin 1 1 The State Key Laboratory of Plant Genomics,Institute of Genetics and Developmental biology,Chinese Academy of Sciences,Beijing 100101,china 2 The State Key Laboratory of Marine biology,Institute of Oceanology,Chinese Academy of Sciences,Qingdao 266071,china 3.College of Life Sciences,Qingdao Agricultural University,Qingdao 266109,china 4 Department of Biological Science and engineering,school of chemical and Biological engineering,University of Science and Technology Beijing,Beijing 100083.china 1. The State Key Laboratory of Plant Genomics Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China 4. Department of Biological Science and engineering School of Chemical and Biological Engineering University of Science and Technology Beijing Beijing 100083 China 2. The State Key Laboratory of Marine biology Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China 3. College of Life Sciences Qingdao Agricultural University Qingdao 266109 China

A high quality cDNA library was constructed from the brown alga Laminaria japonica,with the titer of 1.2×10 5 pfu/*** average insert size of the cDNA library is about 1.6 *** the cDNA library,591 cDNA clones were randomly selected and *** a result,574 EST(expressed sequence tag) sequences were *** of the 574 ESTs were submitted to the dbEST database section of GenBank with the accession numbers from CX942625 to *** cDNA library was screened with a α-3. p labeled 453.bp T P S gene probe,which is a partial sequence yielded from Porphyra *** positive cDNA clones were screened and the sequencing data showed that these four cDNA clones covered majority of *** TPS cDNA *** PCR amplification,sequencing and assembling,the entire ORF(open reading frame) sequence of the T P S gene was obtained,which was named *** encodes a protein containing 908 amino acids with a calculated molecular mass of 101 674 *** LjTPS gene was successfully expressed in *** and *** LjTPS gene has potential application both in plant breeding to stress tolerance and in deciphering the T P S gene function and mechanism to stress tolerance.

关键词： cDNA library comparative study expressed sequence tag(EST) analysis Laminaria japonica trehalose-6-phosphate synthase(TPS) T P S gene

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Evaluation of non-covalent interaction between Seryl-Histidine dipeptide and cyclophilin A using NMR and molecular modeling

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Science china Chemistry 2010年第9期53卷 1987-1993页

作者： LIU Yan1,SHI YanHong2,LIU XiaoXia1,LIN MingKun1,LIN DongHai1,2 & ZHAO YuFen1,3.1Key Laboratory for chemical biology of Fujian Province,Department of chemical biology,Department of Chemistry,College of Chemistry and chemical engineering,Xiamen University,Xiamen 3.1005,china 2Shanghai Institute of Materia Medica,Shanghai Institutes of Biological Sciences,Chinese Academy of Sciences,Shanghai 201203.china 3.ey Laboratory for Bioorganic Phosphorus Chemistry and chemical biology,Ministry of Education,Department of Chemistry,school of Life Sciences and engineering,Tsinghua University,Beijing 100084,china 1. Key Laboratory for chemical biology of Fujian Province Department of Chemical Biology Department of Chemistry College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China2. Shanghai Institute of Materia Medica Shanghai Institutes of Biological Sciences Chinese Academy of Sciences Shanghai 201203 China3. Key Laboratory for Bioorganic Phosphorus Chemistry and Chemical Biology Ministry of Education Department of Chemistry School of Life Sciences and Engineering Tsinghua University Beijing 100084 China

Seryl-Histidine dipeptide(Ser-His) has been previously reported to be capable of cleaving DNAs and carboxyl esters,as well as *** protein cleavage mechanism has not been addressed *** an initial step of protein cleavage activity,the non-covalent binding affinity of Ser-His for proteins is a crucial *** this work,we took cyclophilin A(CyPA) as a substrate protein,and evaluated the non-covalent interaction between CyPA and Ser-His using a combination of NMR spectroscopy and molecular modeling *** independent Ser-His binding sites on CyPA were detected using 15N-1H heteronuclear single-quantum coherence(HSQC) *** binding site binds one Ser-His *** constants,Kd1 and Kd2,were estimated to be 2.07 and 6.66 mmol/L,respectively,indicative of the weak non-covalent interaction between Ser-His and *** on molecular modeling results,we suggest that both the α-amino and the side chain hydroxyl group of Ser-His are crucial for the non-covalent interaction between Ser-His and *** work sheds light on the molecular mechanism of Ser-His and its analogues cleaving proteins.

关键词： Ser-His cyclophilin A HSQC non-covalent interaction binding sites

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ADSORPTION BEHAVIOUR OF Mn(Ⅱ) AND Zn(Ⅱ) ON ATTAPULGITE WITH FAAS METHOD

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Chinese Journal of Reactive Polymers 2008年第Z1期 36-41页

作者： LI Bingbing1,3.LI Chunxiang2 LIU Aiqin2 XIAO Bo1,3.1. College of Environmental Science and Technology, Huazhong University of Science and Technology, Wuhan 43.074, china 2. school of Chemistry & chemical {3., Jiangsu University, zhenjiang 212013. china 3. Department of Biological {3. of Pingdingshan Institute of Technology, Pingdingshan 467000, china

Active attapulbgite as adsorptive reagent, the adsorptive behavior of Mn(II) and Zn(II) was studied with Flame atomic absorption spectroscopy (FAAS) method. The mainly factors of influencing the adsorption and desorption of Mn(II) and Zn(II) were discussed. The interference of coexisting ions was investigated, and the actual sample determination from adzuki beans, mung beans and phosphating waste water was conducted with good result.

关键词： Attapulgit FAAS method Determination Mn(II) Zn(II) Foodstuff.

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