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A further study on the role of lysosomal chymotrypsin B in apoptosis

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生物物理学报 2009年第S1期25卷 233-234页

作者： Xingyu Zhao, Kai Zhao, Taotao Wei, Fuyu Yang National Laboratory of Bio macromolecules, institute of Biophysics, chinese academy of sciences, 15 Datun Road, Chaoyang District, Beijing, 100101, china

We have reported that chymotrypsin B is not just a digestive enzyme secreted by the pancreas, but also cached in rat liver lysosomes and mediates extrinsic apoptotic pathway (1). Herein,

关键词： digestive pancreas cathepsin secreted extrinsic intestine cytosolic ovary hairpin stomach

From dissection of disease pathogenesis to elucidation of mechanisms of targeted therapies:leukemia research in the genomic era

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Acta Pharmacologica Sinica 2007年第9期28卷 1434-1449页

作者： Guang-blao ZHOU~(1,2),Guo LI~1,Sai-juan CHEN~1,Zhu CHEN~(1,3.~1 State Key Laboratory of Medical Genomics and Shanghai institute of Hematology,Rui Jin Hospital Affiliated to Shanghai Jiao TongUniversity School of Medicine,Shanghai 200025, china ~2 Guangzhou institute of Biomedicine and Health,{3. academy of sciences,Guangzhou 510663.china State Key Laboratory of Medical Genomics and Shanghai institute ofHematology Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200025China Guangzhou institute of Biomedicine and Health Chinese Academy of Scien

Leukemia is a group of heterozygous diseases of hematopoietic stem/progenitorcells that involves dynamic change in the *** of genetic abnor-malities critical to leukemia initiation provides insights into the elusiveleukemogenesis,identifies distinct subsets of leukemia and predicts prognosisindividually,and can also provide rational therapeutic targets for *** past three decades have seen tremendous advances in theanalysis of genotype-phenotype connection of leukemia,and in the identifica-tion of molecular biomarkers for leukemia ***,differentiationtherapy,targeted therapy and chemotherapy have turned several subtypes ofleukemia from highly fatal to highly *** use of all-trans retinoic acid andarsenic trioxide,which trigger degradation of PML-RARα,the causative fusionprotein generated by t (15;17) translocation in acute promyelocytic leukemia (APL),has led to a dramatic improvement of APL clinical outcome,lmatinib mesylate/Gleevec/STI571,which inhibits the tyrosine kinase activity of BCR-ABLoncoprotein,has now become the new gold standard for the treatmtent of chronicmyeloid *** use of chemotherapeutic agents together with a strin-gent application of prognostic factors for risk-directed therapy in clinical trialshas resulted in a steady improvement in the treatment outcome of acute lympho-blastic ***,the pace of progress extrapolates to a prediction ofleukemia control in the twenty-first century.

关键词： leukemia genomics cancer therapy

Solvability for Nonlinear Reaction Diffusion Equation with Boundary Perturbation

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Wuhan University Journal of Natural sciences 2009年第6期14卷 481-483页

作者： CHEN Lihua1, MO Jiaqi2,3.1. Department of Mathematics and Computer Science, Fujian Normal University, Fuqing 3.03.0, Fujian, china 2. Department of Mathematics, Anhui Normal University, Wuhu 241000, Anhui, china 3. Division of Computational Science, E-institutes of Shanghai Universities at Shanghai Jiao Tong University, Shanghai 200240, china Department of Mathematics and Computer Science Fujian Normal University Fuqing 350300 Fujian China Department of Mathematics Anhui Normal University Wuhu 241000 Anhui China Division of Computational Science E-Institutes of Shanghai Universities at Shanghai Jiao Tong University Shanghai 200240 China

In this paper, the nonlinear reaction diffusion equation with boundary perturbation is considered. Using discussions on solvability, the perturbed solution of original problem is obtained, and the uniform validity of ... 详细信息

关键词： perturbation nonlinear reaction diffusion equation solvability

Investigation on the Performance of Supported Molybdenum Carbide for the Partial Oxidation of Methane

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Journal of Natural Gas Chemistry 2003年第1期12卷 23-30页

作者： Quanli Zhu, Jian Yang, Jiaxin Wang, Shengfu Ji, Hanqing WangState Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou institute of Chemical Physics, chinese academy of sciences, Lanzhou 73.000, china State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics Chinese Academy of Sciences

The performance of supported and unsupported molybdenum carbide for thepartial oxidation of methane (POM) to syngas was investigated. An evaluation of the catalystsindicates that bulk molybdenum carbide has a higher methane conversion during the initial stage buta lower selectivity to CO and H_2/CO ratio in the products. The rapid deactivation of the catalystis also a significant problem. However, the supported molybdenum carbide catalyst shows a muchhigher methane conversion, increased selectivity and significantly improved catalytic stability. Thecharacterization by XRD and BET specific area measurements depict an improved dispersion ofmolybdenum carbide when using alumina as a carrier. The bulk or the supported molybdenum carbideexists in the β-MO_2C phase, while it is transformed into molybdenum dioxide postcatalysis which isan important cause of molybdenum carbide deactivation.

关键词： molybdenum carbide molybdenum oxide partial oxidation of methane syngas deactivation

Study of Noble Metal Elements in Lower Cambrian Black Rock Series of Guizhou-Hunan Provinces, china

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Journal of Earth Science 1999年第1期18卷 93-96页

作者： Li Shengrong Department of Geology and Mineral Resources, china University of Geosciences, Beijing 100083.Gao Zhenmin institute of Geochemistry,{3., Guiyang 550002

Systematic analyses of noble metal elements in the Lower Cambrian black rock series of South china are reported. Correlations of w (Os)/ w (Ir), w (Au)/ w (Ir), w (Ag)/ w (Au), w (Pt+Pd)/ w (Os+Ru+Rh+Ir), relations of noble metal and platinum group element (PGE) distribution patterns reveal that the noble metals are not directly from extraterrestrial materials. Studying the data of 9 aspects, the authors conclude that the noble metals were mainly from ultramafic mafic igneous rocks and their enrichment in black rocks is mainly controlled by hydrothermal fluid.

关键词： black shale Au Ag PGE Lower Cambrian Guizhou Hunan provinces china.

分子筛改性Co／SiO2催化剂对Fischer-Tropsch合成汽油类烃的影响

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石油化工 2008年第5期37卷 445-449页

作者：李宇萍王铁军吴创之吕永兴李海滨中国科学院可再生能源与天然气水合物重点实验室

在中孔SiO2中添加USY，HZSM-5，β分子筛组成双功能载体，并采用初湿浸渍法在载体上浸渍钴盐，制备了一系列分子筛改性的Co／SiO2催化剂，考察了分子筛的类型、HZSM-5分子筛的骨架硅铝比、HZSM-5分子筛在载体中的含量对Fischer-Tropsch... 详细信息

在中孔SiO2中添加USY，HZSM-5，β分子筛组成双功能载体，并采用初湿浸渍法在载体上浸渍钴盐，制备了一系列分子筛改性的Co／SiO2催化剂，考察了分子筛的类型、HZSM-5分子筛的骨架硅铝比、HZSM-5分子筛在载体中的含量对Fischer-Tropsch合成汽油类烃（C5-12）的影响。实验结果表明，载体中SiO2和分子筛共同作用，提高了催化剂的活性，并使产物分布向汽油类烃偏移，其中，以HZSM-5分子筛改性的Co／SiO2催化剂的催化性能最好。HZSM-5分子筛改性催化剂对催化性能的影响受其骨架硅铝比的影响。当骨架硅铝比n（SiO2）：n（Al2O3.=3.、HZSM-5分子筛在载体中的质量分数为20％时，CO转化率达到80％以上，汽油类烃的选择性高达55％，其中异构烷烃的选择性在10％以上。

关键词： Fischer-Tropsch合成钴/二氧化硅催化剂分子筛汽油类烃

Lead isotopic characteristics of the Xikuangshan superlarge Sb deposit and their geological implications

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chinese Science Bulletin 1999年第S2期44卷 52-53页

作者： PENG Jiantang~1, HU Ruizhong~1 and ZOU Liqun~2 1. institute of Geochemistry, chinese academy of sciences, Guiyang 550002, china 2. Xikuangshan Mining Bureau, Lengshuijiang 417502, china institute of Geochemistry Chinese Academy of Sciences Guiyang 550002 China Xikuangshan Mining Bureau Lengshuijiang 417502 China

THE Xikuangshan Sb ore deposit located in the central part of Hunan Province, china, is the only superlarge Sb deposit so far reported in the world, and is titled as the antimony capital of the world. The strataexposed in the Xikuangshan orefield are only Devonian to Permian Series. Except for a lamprophyre dykeseen in the eastern part, no igneous rocks outcrop within or around the mining district. Orebodies occurdominantly in the Devonian Shetianqiao Formation （D3./sub>s） and subordinately in the Qiziqiao Formation（D2q）. The orebodies usually appear stratiform and stratoid in shape and are rather constant in boththickness and grade. The compositions of ores are simple. The metallic mineral is stibnite and the gangueminerals include quartz and calcite, with minor amounts of fluorite, barite and secondary gypsum. Theores are dominated by the quartz-stibnite type, the quartz-calcite-stibnite type and the

关键词： lead isotope Xikuangshan superlarge Sb deposit Hunan.

An early aged ophiolite in the Western Kunlun Mountain, northwestern Tibet plateau and its tectonic implications

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An early aged ophiolite in the Western Kunlun Mountain, nort...

MOLECULAR DYNAMICS SIMULATION OF STRUCTURAL CHANGES OF LIQUID Fe_3.l

2004年全国岩石学与地球动力学研讨会

作者： Xuchang XIAO Jun Wang Wenhua Ji Li Su 1. institute of Geology, chinese academy of Geological {3. (CAGS) 2. Regional Geological Surveying Party of Shanxi Provence 3. Xi''An institute of Geology and Mineral Resources

＜正＞ The early aged ophiolites have attracted the studying from many geologists in recent decades （Colombo C. G. et al, 2001, Scarrow J. H. et al., Timothy M. Kusky et al., 2001.....）, because the early aged ophiolites can provide the information about the ancient oceanic processes relevant to the evolution of the plate tectonics in the early period of the earth, and also concem such problems as whether there existed a "Protero-Tethys" and the break-up and convergence of the Rodinia Supercontinent in the NW Tibet plateau. This paper reveals a definite complete ophiolite, the "Kudi- ophiolite" of late-Proterozoic-early Paleozoic, in the Westem Kunlun Mtns, NW. Tibet plateau, and reports the recent isotopic ages of 510±4Ma. And 502±13.a （U-Pb ratio in zircon） for the middle and upper portions of the mafic cumulates of the Kudi-ophiolite, operated at the most powerful dating tool, the SHRIMP-Ⅱ. The geochemical and geochronological data integrating with the geological setting suggest that the Kudi-ophiolite might have formed in an Archipelago not in a vast oceanic basin, the so-called Protero-Tethys, and was tectonically emplaced during the early Paleozoic in the NW. Tibet plateau.

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中国有色金属学会会刊：英文版 1998年第4期8卷 66-70页

作者： Li Hui, Bian Xiufang and Li Yuchen College of Materials Science and Engineering Shandong University of Technology, Jinan 250061, P. R. china Liu Hongbo and Chen Kuiying institute of Metal Research, chinese academy of sciences, Shenyang 110015, P. R College of Materials Science and Engineering Shandong University of Technology Jinan 250061 China institute of Metal Research Chinese Academy of Sciences Shenyang 110015 China

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关键词： tight binding potential rapid solidification molecular dynamics