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Enzymatic cyclization of linear peptide to plant cyclopeptide heterophyllin B

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Science china Chemistry 2006年第1期49卷 63-66页

作者： JIA Aiqun1, LI Xiang2. TAN Ninghua1, LIU Xiaozhu3. SHEN Yuemao1 & ZHOU Jun1 1. State Key Laboratory of Phytochemistry and Plant Resources in West china, Kunming Institute of Botany, {2. Univer-sity of chinese Academy of {3., chinese Academy of {3., Kunming 6502.4, china 2. chinese Peptide Co., Ltd, Hangzhou 3.0018, china 3. Southwest Forestry College, Kunming 6502.4, china 1. State Key Laboratory of Phytochemistry and Plant Resources in West china Kunming Institute of Botany Graduate University of Chinese Academy of Sciences Chinese Academy of Sciences Kunming 650204 China 2. chinese Peptide Co. Ltd Hangzhou 310018 China 3. Southwest Forestry College 650204 Kunming China

The crude enzyme (PH-1) isolated from Pseudostellaria heterophylla by ourgroup has catalyzed enzymatic cyclization of linear peptideNH_2.Gly^1-Gly^2.Leu-Pro-Pro-Pro-lle-Phe-COOH (4) into cyclopeptide heterophyllin B (HB) from plantfor the first time. To ensure this reaction, some analytical methods including TLC, HPLC, MS, NMR,and ^(13.C labeling were used to prove that the reaction of substrate 4 sharing residue ofNH-Phe-Gly-CO was successful.

关键词： Pseudostellaria heterophylla, cyclopeptides, HB, enzymatic cyclization, isotope labeled.

Debating about the climate warming

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Progress in Natural Science:Materials International 2006年第1期16卷 1-6页

作者： WANG Shaowu1, LUO Yong2. ZHAO Zongci2. DONG Wenje2.and YANG Bao3.(1.Department of Atmospheric sciences, {2. of Physics, Peking University, Beijing 100871, china 2. Laboratory for Climate Studies, china Meteorological Administration, Beijing 100081, china 3. Institute of Cold and Arid Regions Environmental and Engineering, chinese Academy of sciences, Lanzhou 73.000, china) [a] Department of Atmospheric sciences School of Physics Peking University Beijing China [b] Laboratory for Climate Studies China Meterological Administration Beijing China [c] Institute of Cold and Arid Regions Environmental and Engineering Chinese Academy of Sciences Lanzhou China

Debating about the climate warming is reviewed. Discussions have focused on the validity of the temperature reconstruction for the last millennium made by Mann et al. Arguments against and for the reconstruction are introduced. Temperature reconstructions by other authors are examined, including the one carried out by Wang et al. in 1996. It is concluded that: (1) Ability of reproducing temperature variability of time scale less than 10 a is limited, so no sufficient evidence proves that the 1990s was the warmest decade, and 1998 was the warmest year over the last millennium. (2. All of the temperature reconstructions by different authors demonstrate the occurrence of the MWP (Medieval Warm Period) and LIA (Little Ice Age) in low frequency band of temperature variations, though the peak in the MWP and trough in LIA varies from one reconstruction to the others. Therefore, terms of MWP and LIA can be used in studies of climate change. (3. The warming from 1975 to 2.00 was significant, but we do not know if it was the strongest for the last millennium, which needs to be proved by more evidence.

关键词： climate warming MWP LIA the 2.th century.

Evaluation of the Interfacial Adhesion between Brittle Coating and Ductile Substrate by Cross-Sectional Indention

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材料热处理学报 2004年第5B期25卷 1187-1190页

作者： SUJian-yu ZHANGKun CHENGuang-nan InstituteofMechanics ChineseAcademyofSciencesBeijingChina／／GraduateSchooloftheChineseAcademyofSciencesBeijingChina InstituteofMechanics ChineseAcademyofSciencesBeijingChina

The cross-sectional indentation method is extended to evaluate the interfacial adhesion between brittle coating and ductile substrate. The experimental results on electroplated chromium coating/steel substrate show that the interfacial separation occurs due to the edge chipping of brittle coating. The corresponding models are established to elucidate interfacial separation processes. This work further highlights the advantages and potential of this novel indentation method.

关键词：分界面附着刻痕可锻衬底应力涂层铬钢

Susceptibility Assessment of Landslides Caused by the Wenchuan Earthquake Using a Logistic Regression Model

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Journal of Mountain Science 2010年第3期7卷 234-245页

作者： SU Fenghuan Key Laboratory of Mountain Hazards and Land Surface Processes Chinese Academy of Sciences Chengdu China Institute of Mountain Hazards and Environment Chinese Academy of Sciences Chengdu China graduate University of the chinese Academy of {2. Beijing China

The Wenchuan earthquake on May 12.2.08 caused numerous collapses,landslides,barrier lakes,and debris *** susceptibility mapping is important for evaluation of environmental capacity and also as a guide for post-earthquake *** this paper,a logistic regression model was developed within the framework of GIS to map landslide *** County,a heavily affected area,was selected for the *** of landslides was prepared by interpretation of multi-temporal and multi-resolution remote sensing images(ADS40 aerial imagery,SPOT5 imagery and TM imagery,etc.) and field *** Certainly Factor method was used to find the influencial factors,indicating that lithologic groups,distance from major faults,slope angle,profile curvature,and altitude are the dominant factors influencing *** weight of each factor was determined using a binomial logistic regression *** susceptibility mapping was based on spatial overlay analysis and divided into five *** faults have the most significant impact,and landslides will occur most likely in areas near the *** of the area has a high or very high susceptibility,located in the northeast,south and southwest,including 65.3. of all landslides coincident with the *** susceptibility map can reveal the likelihood of future failures,and it will be useful for planners during the rebuilding process and for future zoning issues.

关键词： Landslide susceptibility WenchuanEarthquake GIS logistic regression certainty factor

Geometry of Broad Line Regions of Active Galactic Nuclei

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chinese Journal of Astronomy and Astrophysics 2008年第1期8卷 50-62页

作者： Xiao-Rong Lü1 Key Laboratory for Particle Astrophysics, Institute of High Energy Physics, chinese Academy of sciences, Beijing 100049 2.{2. {3. of chinese Academy of sciences, Beijing 100049 Key Laboratory for Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 and graduate school of {2. Academy of {3. Beijing 100049

It has long remained an open question as to the geometry of the broad line region （BLR） in active galactic nuclei （AGNs）. The reverberation mapping technique which measures the response of the broad emission lines to the ionizing continuum, when combined with multiwavelength continuum fitted by sophisticated accretion disks, provides a way of probing the BLR geometry. We analyze a sample of 3. AGNs, which have been monitored by the reverberation mapping campaign. In view of energy budget, the reverberation-based BH masses are found to be in agreement with those obtained by accretion disk models in two thirds of the present sample while the reverberation mapping methods underestimate the BH masses in about one third of objects, as also suggested by CoUin et al. in a recent work. We point out that there are obviously two kinds of BLR geometry, which are strongly dependent on the Eddington ratio, and separated by the value LBol/LEdd - 0.1. These results prefer a scenario of the disk and wind configuration of the BLR and identify the Eddington ratio as the physical driver regulating the wind in the BLR.

关键词： accretion, accretion disks - galaxies active - galaxies Seyfert - quasars general

Artificial coordinating field and its application to motion planning of robots in uncertain dynamic environments

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Science china(Technological sciences) 2004年第5期47卷 577-594页

作者： JING Xingjian1, 2. WANG Yuechao1 & TAN Dalong1 1. Robotics Laboratory, Shenyang Institute of Automation, chinese Academy of sciences, Shenyang 110016,{2. 2. {3. school, chinese Academy of sciences, Beijing 10003.,{2. Correspondence should be addressed to Jing Xingjian 1. Robotics Laboratory Shenyang Institute of Automation Chinese Academy of Sciences 10016 Shenyang China 2. graduate school Chinese Academy of Sciences 10039 Beijing China

Artificial coordinating fields (ACF) are proposed to deal with the motion planning problems of mobile robots in uncertain dynamic environments. An ACF around an obstacle can generate two orthogonal force vectors to a robot: one is called the coordinating force vector which is purposively designed in this paper, and the other is the repulsive force vector which is the same as that in a conventional artificial potential field. The ACF is designed according to the updated motion purpose and the relative states of the robot with respect to its local environment, and it also satisfies the robot’s dynamic constraints. The direction of the coordinating force can be determiend on line according to an optimal evaluation function. The ACF can effectively remove the local minima, and reduce the oscillation of the planned trajectory between multiple obstacles. Only local knowledge of the environments is needed in the ACF-based motion planning. The properties of the ACF such as controllability, adaptability, safety and reachability are studied and discussed in detail in this paper. Theoretical analysis and simulations are given to illustrate our main results.

关键词： artificial coordinating fields, artificial potential fields, mobile robots, motion planning, uncertain dynamic environments.

Evidence-based expert consensus on clinical management of safety of Bruton’s tyrosine kinase inhibitors(2.2.)

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chinese Journal of Cancer Research 2024年第3期36卷 240-256页

作者： Zaiwei Song Dan Jiang Lingling Yu Yixuan Chen Daobin Zhou Yue Li Depei Wu Lingli Zhang Liyan Miao Jun Ma Jun Zhu Hongmei Jing Rongsheng Zhao the Steering Committee,the Consensus Panel and the Evidence Synthesis Group Evidence-based Pharmacy Professional Committee of chinese Pharmaceutical Association(CPA) Hospital Pharmacy Professional Committee of chinese Pharmaceutical Association(CPA) Division of Therapeutic Drug Monitoring of chinese Pharmacological Society(CPS) Expert Committee on Lymphoma of chinese Society of Clinical Oncology(CSCO) Expert Committee on Leukemia of chinese Society of Clinical Oncology(CSCO) Society of Integrative Cardio-Oncology of china Anti-Cancer Association(CACA) chinese Society of Hematology of chinese Medical Association(CMA) Hospital Pharmacy Professional Committee of Cross-Straits Medicine Exchange Association(SMEA) Department of Pharmacy Peking University Third HospitalBeijing 100191China Institute for Drug Evaluation Peking University Health Science CenterBeijing 100191China Therapeutic Drug Monitoring and Clinical Toxicology Center Peking UniversityBeijing 100191China Department of Pharmacy Administration and Clinical Pharmacy School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Hematology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Department of Cardiology the First Affiliated HospitalHarbin Medical UniversityHarbin 150001China Department of Hematology the First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Pharmacy Evidence-based Pharmacy CenterWest China Second HospitalSichuan UniversityChengdu 610041China Department of Pharmacy the First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Hematology and Oncology Harbin Institute of Hematology and OncologyHarbin 150010China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of LymphomaPeking University Cancer Hospital&InstituteBeijing 100142China Department of Hematology Peking University Third HospitalBeijing 100191China 不详

Bruton’s tyrosine kinase inhibitors(BTKis)have revolutionized the treatment of B-cell ***,safety issues related to the use of BTKis may hinder treatment continuity and further affect clinical efficacy.A comprehensive and systematic expert consensus from a pharmacological perspective is lacking for safety issues associated with BTKi treatment.A multidisciplinary consensus working group was established,comprising 3. members from the fields of hematology,cardiovascular disease,cardio-oncology,clinical pharmacy,and evidencebased *** evidence-based expert consensus was formulated using an evidence-based approach and the Delphi *** Joanna Briggs Institute Critical Appraisal(JBI)tool and Grading of Recommendations Assessment,Development,and Evaluation(GRADE)approach were used to rate the quality of evidence and grade the strength of recommendations,*** consensus provides practical recommendations for BTKis medication based on nine aspects within three domains,including the management of common adverse drug events such as bleeding,cardiovascular events,and hematological toxicity,as well as the management of drug-drug interactions and guidance for special *** multidisciplinary expert consensus could contribute to promoting a multi-dimensional,comprehensive and standardized management of BTKis.

关键词： Consensus BTK inhibitors safety adverse drug events drug-drug interactions

The solid lubricating material experiment device for Shenzhou-7 Spaceship

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Science china(Technological sciences) 2010年第9期53卷 2521-2527页

作者： WANG Ke1,2.REN WeiJia1,WANG ShiDa1 & WENG LiJun3.1 Academy of Opto-Electronics,chinese Academy of {2.,Beijing 100190,china 2.{3. University of chinese Academy of {2.,Beijing 100049,china 3.Lanzhou Institute of Chemical Physics,chinese Academy of {2.,Lanzhou 73.000,china 1. Academy of Opto-Electronics Chinese Academy of Sciences Beijing 100190 China2. Graduate University of Chinese Academy of Sciences Beijing 100049 China3. Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 China

A solid lubricating material exposure experiment in space is one of the missions during the seventh manned spaceflight of china,and the key is to develop a device which can be fixed reliably outside of the orbital module and can be fetched conveniently by an astronaut during space *** solid lubricating material experiment device needs to be locked reliably in a vibrating and impacting environment during the launch phase,and should meet the requirement that it can be unlocked and fetched reliably by the astronaut wearing an extravehicular spacesuit via simple operations in orbit in an environment of high and low *** for the device we developed,the environmental characteristic of the mission was analyzed,the mechanical analysis and thermal analysis were carried out,and then a mechanism with functions of mechanical locking,structural self-locking and manual unlocking was *** device was verified by a sequence of experiments and was fetched by the astronaut during the flight of the Shenzhou-7 Spaceship.

关键词： manned spaceflight exposure experiment mechanism unlock

Research on the method for retrieving soil moisture using thermal inertia model

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Science china Earth sciences 2006年第5期49卷 539-545页

作者： LIU Zhenhua1 & ZHAO Yingshi2.1. Information College, South china Agricultural University, Guangzhou 510642. china 2. {2. University of {3. Academy of sciences, Beijing 100049, china 1. Information College South China Agricultural University Guangzhou 510642 China 2. graduate University of chinese Academy of {2. Beijing 100049 China

In order to improve accuracy of soil moisture inversion using remote sensing, a new thermal inertia model is proposed in this paper. The improved model needs only surface maximum temperature as the temperature parameter input instead of input of the surface temperature difference, as well as the surface sensible and latent fluxes are introduced into boundary conditions of thermal conductivity equation. Furthermore, surface soil conductive heat transfer equation of two-layer model is used to solve the soil thermal inertia so that the remote sensing thermal inertia method can be ap- plied to regions with better-covered vegetation, but usually only for the bare areas or worse vegetation covered areas. The model has been tested at several locations in the area of west Inner Mongolia. Comparing the simulation of the new model with the measurements obtained by apparent thermal inertia and by field test, the result shows that the inertia thermal model can be used to estimate soil moisture in more reasonable accuracy.

关键词： thermal model, thermal conductivity equation, soil initial, sensible flux, latent flux, two-layer model.