检索结果-南通市图书馆

Lymphocyte Subsets and Sister-chromatid Exchanges in the Students Exposed to Formaldehyde Vapor

在线全文

学校读者我要写书评

暂无评论

Biomedical and environmental sciences 1999年第2期12卷 88-94页

作者： YING CHEN-JIANG YE XIAO-LEI XIE HONG YAN WEN-SHENG ZHAO MEI-YING XIA TONG AND YIN SHU-YI.(department of environmental {2., Tongji Medical {3., Wuhan 43.03., China department of public {2., Wenzhou Medical College, Wenzhou 3.7400, China department of Anatomy,Tongji Medical {3., Wuhan 43.03., China) 同济医科大学环境健康系湖北武汉温州医学院公共卫生系浙江温州 317400 同济医科大学解剖学系湖北武汉

The present report evaluates the effects of formaldehyde (FA) exposure on peripheral lymphocytes by using heth genetic and immunological parameters. Twenty-three non-smoking students in the study had inhalation exposure to 0.508 ±0. 2.9 mg/m3.of FA for a Period of 8 weeks (3. × 3.times each week) during anatomy classes. As for composition of lymphocyte subsets after FA exposare,significant increase was found in the percentage of CD19(B cells), while sighficant decrease was observed in CD3.total T cells), CD4(T helper-inducer cells), and CD8(T cytotoxic-suppressior cells) with a P 0 .05) was reported between lymphocyte prolifendion rate and sisterchromatid exchange (SCE) at the exposure level and duration. It is suggested that the lymphocyte subsets may be most susceptible to the effects of FA, though a single immunological endpoint is rarely related with pathophysiological interpretation.

关键词： Res FA DNA Lymphocyte Subsets and Sister-chromatid Exchanges in the Students Exposed to Formaldehyde Vapor Heck

Effect of Zinc on Bone Metabolism in Fetal Mouse Limb Culture

在线全文

学校读者我要写书评

暂无评论

Biomedical and environmental sciences 2002年第4期15卷 323-329页

作者： LI YUN AND YU ZENG-LIdepartment of Nutrition and Food Hygiene, Huaxi school of public health, Sichuan {2., Chengdu 610041. China department of Nutrition and Food Hygiene Huaxi School of Public Health Sichuan University Chengdu 610041

Objective To determine the effects of zine-deficiency and zine-excess on hone metabolism. Methods We developed the culture model of fetal mouse limbs (16th day) cultivated in self-made rotator with continuing flow of mixed gas for six days in vitro. The cultured limbs were examined by the techniques of 45Ca tracer and X-roentgenography. Results The right limbs cultivated had longer bone length, higher bone density than the left limbs uncultivated from the same embryo; and histologically, the right limbs had active bone cell differentiation, proliferation, increased bone trabecula. clearly calcified cartilage matrix, and osteogenic tissue. Compared with the control group, the zinc-deficient group and zine-excess (Zn2. l2.) μmol/L) group contained less osteocalcin (BGP) and 45Ca content, and lower AKP activity; whereas zine-normal (Zn2. 45 μmol/L and Zn2. 70 μmol/L) groups contained more BGP and 45Ca contents, and higher AKP (alkaline phosphatase) activity. Conclusion Both zine-deficiency and zine-excess can alter bone growth and normal metabolism. The results indicate that the culture model of fetal mouse limbs (16th day) in vitro can be used as a research model of bone growth and development.

关键词： Zinc excess Zinc deficiency Bone metabolism Organic culture

Microwave digestion method in environmental analysis

在线全文

学校读者我要写书评

暂无评论

Journal of environmental sciences 1996年第4期8卷 407-413页

作者： Zhang Yue (Wadsworth Centre ,New York State department of health{2.,State {3. of New York at Albany.USA) Yu Yong, Hou Huiqi,Li Changlin(environmental Science institute,Fudan {3.,Shanghai 2.043., China) New York State department of health School of Public Health State University of New York Albany United States environmental Science Institute Fudan University Shanghai 200433 China

This paper introduced the history,equipment and mechanism of the microwave digestion method. This paper studied the optimization parameter of digestion conditions, such as acid and acid combination, digestion time and applied microwave power,particle size,and other *** analytical performance in environmental research and the modification of the microwave digestion method were also discussed.

关键词： microwave digestion environmental analysis optimization parameter.

The reconstruction of fossil planation surface in Chin

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2002年第5期47卷 434-440页

作者： FENG Jinliang & GUI Zhijiudepartment of Urban and environmental {2.,{3., beijing 100871, China Institute of Geography, Hebei Academy of {2., Shijiazhuang 050011, China department of Urban and environmental {2. Peking University Beijing China Institute of Geography Hebei Academy of Sciences Shijiazhuang China

On the basis of results of relative subjects, the fossil planation surface has been discussed by the authors from the point of geomorphologic view. The discussion contents included the characteristic information, research methods, paleotopography (gradient and altitude) and other problems about fossil planation surface. The recognition and reconstruction of fossil planation surface mainly rely on the following characteristic information: (i) the character of erosion unconformity surface; (ii) the paleo-weathering crust and residual deposits; (iii) the paleo-karst and filled deposit in the paleo-karst under the unconformity surface, and (iv) the character and environment of sediment above the unconformity surface. According to the above-mentioned characteristic information, the authors recognized and reconstructed two stages of fossil planation surface on Pa-leo-land of North China and Yangtze Paleo-land. These two fossil planation surfaces formed from Middle Ordovician to Lower Carboniferous and from

关键词： fossil planation surface characteristic information pa-leotopography reconstruction.

Preliminary results of the study on wind erosion in the Qinghai-Tibetan Plateau using 13.Cs technique

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2000年第11期45卷 1019-1025页

作者： YAN Ping, DONG Guangrong, ZHANG Xinbao & ZHANG Yiyun1. Key Laboratory of environmental Change and Natural Disaster, the Ministry of Education of China, beijing Normal {2., beijing 100875, China 2. Institute of Desert Research, Chinese Academy of sciences, Lanzhou 73.000, China 3. Institute of Mountain Hazards and Environment, Chinese Academy of sciences, Chengdu 610041, China 4. department of Physics, Sichuan Union {2., Chengdu 610041, China Key Laboratory of environmental Change and Natural Disaster the Ministry of Education of China Beijing Normal University Beijing China Institute of Desert Research Chinese Academy of Sciences Lanzhou China Institute of Mountain Hazards and Environment Chinese Academy of Sciences Chengdu China department of Physics Sichuan Union University Chengdu China

The worldwide fallout of caesium-13. (13.Cs) associated with the nuclear weapon tests during the 1950s and 1960s has provided a valuable man-made tracer for studies of soil erosion and sediment delivery. But relatively few researchers have used it to estimate wind erosion. In this note, the 13.Cs technique is introduced into the studies of wind erosion and its modern processes inthe Qinghai-Tibetan Plateau. Two 13.Cs reference inventories of 982.11 and 2.3.6.04 Bq · m-2.wereestablished preminarily, distributed in the south and middle-north parts of the studied arearespectively. By analyzing the patterns of 13.Cs depth profiles from sampling sites, the aeolianprocesses of erosion and deposition in nearly 40 years have been revealed, i.e. the shrub coppicedunes (S1) and semi-fixed dunefields (S3. experienced the alternation of erosion and deposition,while the grasslands (S4, S6 and S7) and dry farmlands (S5) suffered erosion only. By using 13.Csmodel, the average wind erosion rates for shrub coppice

关键词： 13.Cs technique Qinghai-Tibetan Plateau wind erosion.

Xylene-induced Effects on Brain Neurotransmitters, Behavior and Fos Protein in Rats

在线全文

学校读者我要写书评

暂无评论

Biomedical and environmental sciences 1999年第2期12卷 116-124页

作者： WANG XIU-LUNG JIN XI-PENG FU HUA CHEN ZI-QING DA CUI-DI HUANG XIAN-FEN DING BAO-QING (Institute of occupational Medicine, Chinese Academy of Preventive Medicine,2. Nan Wei Road, beijing 100050, China Deprtment of occupational {3., school of public health, Shanghai Medical university, Shanghai 2.003., China National Key Laboratory of Neurobiolegy, Shanghai Medical university Institute of occupational Diseases, Yumen Oil Administration, Gansu Province, China) 中国预防医学科学院职业病医学所北京 100050 上海医科大学公共卫生学院上海 200032 上海医科大学公共卫生学院上海上海医科大学医学神经生物学国家重点实验室上海玉门石油管理局职业病所甘肃玉门

Male Sprague-Dawley rats administered xylene intrapetitoneally on alternate days at a dose of 12. or 2.0mg/kg for 3. days exhibited no marked changes in locomotor activity, learning and memory capacity. However in rats given xylene on alternate day at a dose of 500 mg/kg for 3. days, a significant decrease in locomotor activity, deficits in leaming ability and memory loss were detected. These xylene-induced behavioral ehanges were assoryiated with a decrease in fyendorphin and leuenkaphlin concentrations in the pons-medulla. On the contrary, xylene at a dose of 500mg/kg increased the β-endorphin level in caudate and c-fos expression in hippocampus. These data suggest that the xylene-induced behavioral alterations might be associated with the expression of Fos protein in the hippocampus.

关键词： Behavior and Fos Protein in Rats Xylene-induced Effects on Brain Neurotransmitters Fos

Effects of the CNTF-collagen gel-controlled delivery system on rat neural stem/progenitor cells behavior

在线全文

学校读者我要写书评

暂无评论

Science China(Life sciences) 2010年第4期53卷 504-510页

作者： YANG ZhaoYang1, QIAO Hui2.& LI XiaoGuang1,3.1school of Biological Science and Medical Engineering, Beihang {2., beijing 100191, China 2.3. Heath school, Ningxia Medical {2., Yinchuan 750004, China 3.2. Institute for Neuroscience, Capital Medical {2., beijing 100069, China school of Biological Science and Medical Engineering Beihang University Beijing China public Heath school Ningxia Medical University Yinchuan China beijing Institute for Neuroscience Capital Medical University Beijing China

The injury of central nervous system (CNS) usually causes the cavity formation. Although transplantation of neural stem/precursor cells (NSPCs) into the lesioned area of CNS has been shown to be implicated in the functional restoration, the therapeutic result is limited by the poor survival of NSPCs as well as their insufficient proliferation and differentiation abilities. Type-1 collagen is considered as a candidate scaffold or drug delivery system to overcome the aforementioned obstacle. This study observed the effects of the CNTF (ciliary neurotrophic factor)-collagen gel-controlled delivery system and daily addition of soluble-form CNTF on the NSPC survival, migration, proliferation and differentiation. The results showed that, within 12.h of the initial co-culture, CNTF was released in a burst pattern, then the CNTF-collagen gel-controlled delivery system stably released CNTF for up to 12.d. The cell viability test, together with immunohistochemistry, RT-PCR and Western blotting, showed that the CNTF-collagen gel-controlled delivery system supported the NSPCs seeded on the surface of collagen gel survival and facilitated their migration and proliferation. The daily addition of soluble-form CNTF to the medium had similar effects to the CNTF-collagen gel-controlled delivery system, but large quantities of soluble-form CNTF were consumed during the entire process. Taken together, the CNTF-collagen gel-controlled delivery system not only provides a physical scaffold for the transplanted NSPCs to adhere and migrate, but also facilitates the NSPC survival, growth and proliferation, simultaneously reducing the consumption of the expensive growth factors. This system may be used to enhance the microenvironment in the lesioned area of CNS.

关键词： spinal cord neural stem/progenitor cells control release type-1 collagen CNTF

A new method for comprehensive division of mountainous area: taking Huaihua City as an example

在线全文

学校读者我要写书评

暂无评论

Journal of Geographical sciences 2001年第3期11卷 366-373页

作者： HU Bao-qing1, REN Dong-ming2. ZHANG Hong-en1, LIAO Chi-mei3.(1. Changsha Institute of Geotectonics, CAS, Changsha 410013. China 2. {2. of Resource and environmental sciences, {3. Normal university, {3. 100875, China 3. {2. of Ge Changsha Institute of Geotectonics CAS department of Resource and environmental {2. Beijing Normal University department of Geography Guangxi Normal College

This paper summarizes principles and measures of comprehensive division of mountainous areas, as well as clarifies meaning, structure, function and path established for the map and file information visibility system (MFIVS). And then, taking Huaihua City of Hunan Province as an example, and based on the MFIVS means, concrete attempts on regionalization are carried out. The result is relatively objective and accurate, which illuminates that the method is a comprehensive one with the characteristics of concision, applicability and effectiveness.

关键词： comprehensive division regional system of mountainous area map and file information visibility system (MFIVS) comprehensive evaluation of PRED system Huaihua City

Effect of daidzin,genistin,and glycitin on osteogenic and adipogenic differentiation of bone marrow stromal cells and adipocytic transdifferentiation of osteoblasts

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2005年第9期26卷 1081-1086页

作者： Xiang-hui LI~1 Jin-chao ZHANG~(2.3. Sen-fang SUI~(1,4) Meng-su YANG~(3.4)1 State Key Laboratory of Biomembrane {2. of Biological sciences and Biotechnology,Tsinghua university,{3. 100084,China 2.{2. of Chemistry College of Chemistry and environmental Science,Hebei university,Baoding 071002.China 3.{2. of Biology and Chemistry,City university of Hong Kong,Hong Kong,China department of Biological sciences and Biotechnology State Key Laboratory of Biomembrane Tsinghua University Beijing China department of Chemistry College of Chemistry and Environmental Science Hebei University Baoding China department of Biology and Chemistry City University of Hong Kong Hong Kong China

Aim:To examine the effect of daidzin,genistin,and glycitin on the osteogenic andadipogenic differentiation of bone marrow stromal cells（MSC）and the adipogenictransdifferentiation of ***:MTT test,alkaline phosphatase（ALP）activity measurement,Oil Red O stain and measurement were ***:Daidzin,genistin,and glycitin 1×10-8,5×10-7,1×10-6,5×10-6,and 1×10-5mol/L all promoted the proliferation of primary mouse bone MSC and *** 5×10-7mol/L and genistin 1×10-6mol/L promoted the osteogenesis *** 1×10-8,5×10-7,1×10-6,5×10-6,and 1×10-5mol/L and glycitin 1×10-8,1×10-6,and 1×10-5mol/L inhibited the adipogenesis of ***,genistin,and glycitin 1×10-8,5×10-7,1×10-6,5×10-6,and 1×10-5mol/L all inhibited the adipocytictransdifferentiation of ***:Daidzin,genistin,and glycitinmay modulate differentiation of MSC to cause a lineage shift toward the osteo-blast and away from the adipocytes,and could inhibit adipocytic transdifferen-tiation of *** could also be helpful in preventing the developmentof osteonecrosis.

关键词： daidzin genistin glycitin bone marrow stro-real cells osteogenic differentiation adipogenic differentiation osteoblasts adipocytic transdifferentiation