检索结果-南通市图书馆

A land surface model incorporated with soil freeze/thaw and its application in GAME/Tibet

在线全文

学校读者我要写书评

暂无评论

Science china Earth sciences 2006年第12期49卷 1311-1322页

作者： HU Heping1, YE Baisheng2, ZHOU Yuhua3.& TIAN Fuqiang1 1. department of Hydraulic Engineering, Tsinghua university, beijing 100084, {3. 2. Cold and Arid Regions environmental and Engineering Research Institute, Chinese Academy of sciences, Lanzhou 73.000, {3. 3. department of Civil Engineering, Massachusetts Institute of Technology, USA department of Hydraulic Engineering Tsinghua University Beijing China Cold and Arid Regions environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou China department of Civil Engineering Massachusetts Institute of Technology USA

Land surface process is of great importance in global climate change, moisture and heat exchange in the interface of the earth and atmosphere, human impacts on the environment and eco- system, etc. Soil freeze/thaw plays an important role in cold land surface processes. In this work the diurnal freeze/thaw effects on energy partition in the context of GAME/Tibet are studied. A sophisti- cated land surface model is developed, the particular aspect of which is its physical consideration of soil freeze/thaw and vapor flux. The simultaneous water and heat transfer soil sub-model not only reflects the water flow from unfrozen zone to frozen fringe in freezing/thawing soil, but also demon- strates the change of moisture and temperature field induced by vapor flux from high temperature zone to low temperature zone, which makes the model applicable for various circumstances. The modified Picard numerical method is employed to help with the water balance and convergence of the numerical scheme. Finally, the model is applied to analyze the diurnal energy and water cycle char- acteristics over the Tibetan Plateau using the Game/Tibet datasets observed in May and July of 1998. Heat and energy transfer simulation shows that: (i) There exists a negative feedback mechanism between soil freeze/thaw and soil temperature/ground heat flux; (ii) during freezing period all three heat fluxes do not vary apparently, in spite of the fact that the negative soil temperature is higher than that not considering soil freeze; (iii) during thawing period, ground heat flux increases, and sensible heat flux decreases, but latent heat flux does not change much; and (iv) during freezing period, soil temperature decreases, though ground heat flux increases.

关键词： land surface model,soil freeze/thaw,GAME/Tibet,simultaneous liquid,vapor and heat transfer.

Effect of 7-hydroxystaurosporine on glioblastoma cell invasion and migration

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2005年第4期26卷 492-499页

作者： Qing-hui MENG~2 Li-xin ZHOU~3.Jia-lin LUO~4 Jian-ping CAO~4 Jian TONG~4 Sai-jun FAN~(2,4,5) 2 department of Oncology, Lombardi Comprehensive Caneer Center,Georgetown university,Washington DC 20057,USA 3.Institute of Medicine and Biotechnology,Chinese Academy of Medical sciences,{3. 100050,china 4 school of Radiation Medicine and public health,Soochow university,Suzhou 215007,china department of Oncology Lombardi Comprehensive Cancer Center Georgetown University Washington DC USA Institute of Medicine and Biotechnology Chinese Academy of Medical Sciences Beijing China school of Radiation Medicine and public health Soochow University Suzhou China

Aim:To investigate the effect of 7-hydroxystaurosporine（UCN-01）,a selectiveprotein kinase C（PKC）inhibitor,on cell growth,migration,and invasion in inva-sive human glioblastoma U-87MG ***:PKC activity was determinedbased on the PKC-catalyzed transfer of the3.p-phosphate group from[g-3.p]ATPinto a PKC-specific peptide *** viability was measured by MTT *** invasion and migration were evaluated by a Boyden chamber assay andscratch wound assay,*** expression was analyzed using West-ern blot *** formation of 3.dimensional cellular aggregates was examinedby a cell-cell aggregation ***:UCN-01 treatment resulted in concen-tration-and time-dependent inhibition of U-87MG cell growth at higher doses（>100 nmol/L）,and reduced cell invasion and migration capability at less cytotoxicdoses（3.acetate（PMA）and ethanol（EtOH）,2 PKC *** expression ofthe tumor suppressor genes BRCA1 and PTEN increased the anti-invasion poten-tial of *** to UCN-01 caused a dose-dependent increase in celladhesion molecule *** effect of UCN-01 on the formation of cell-cellaggregation was significantly reduced by the addition of an ***:UCN-01 inhibits the invasion and migration of humanglioma ***,UCN-01 can have potential clinical applications for thetreatment of human glioma metastasis.

关键词： 7-hydroxystaurosporine protein kinase C cell movement cadherins BRCA1 protein

成人高血压合并2型糖尿病和血脂异常基层防治中国专家共识(2024年版)

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国全科医学 2024年第28期27卷 3453-3475,3482页

作者：北京高血压防治协会中国老年学和老年医学学会北京市社区卫生协会北京社区健康促进会李杰王红姜岳不详首都医科大学附属北京友谊医院北京市东城区朝阳门社区卫生服务中心清华大学第一附属医院全科医学科

高血压、2型糖尿病、血脂异常被统称为“三高”,常同时存在于同一个体中,显著增加了患者的住院和死亡风险,以及相关疾病负担。因此,有必要对三者进行共同风险管理和规范治疗。基层医疗卫生机构是慢性病防治的“主战场”,现有临床证据对... 详细信息

高血压、2型糖尿病、血脂异常被统称为“三高”,常同时存在于同一个体中,显著增加了患者的住院和死亡风险,以及相关疾病负担。因此,有必要对三者进行共同风险管理和规范治疗。基层医疗卫生机构是慢性病防治的“主战场”,现有临床证据对“三高”人群的基层预防、治疗及管理具有重要启示,但目前国内外尚无适用于基层的“三高”共管规范、共识和指南。北京高血压防治协会等4家学/协会组织基层医务人员,并邀请心血管、内分泌、药学及公共卫生等诸多领域专家/学者共同参与,广泛征询基层医务人员临床实践需求,在整合与评价“三高”基层防治相关证据的基础上,经过多轮讨论、修订与投票表决,形成了包含21条推荐意见的“三高”基层防治专家共识。本共识的推荐意见旨在提高基层医务人员的“三高”防治意识和能力,为基层医疗卫生机构开展“三高”防治提供科学的策略支持,为实施具有基层特色的“三高”共管奠定坚实基础。

关键词：高血压糖尿病,2型血脂异常慢性病共病 “三高”防治初级卫生保健专家共识

CHARACTERISTICS OF CHANGE IN TEMPERATURE DURING THE PAST 50 YEARS IN JILIN PROVINCE OF china

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Chinese Geographical Science 2002年第4期12卷 329-332页

作者： ZHAO Xin -yi,WAN Jun,WU Xiu -qin(department of Urban and Environment al sciences,peking {3.,beijing 100871,P.R.china) department of Urban and environmental sciences Peking University Beijing P. R. China

Based on the monthly mean temperatu re,the changing processes and tendencies of temperature during1951-2000in Jilin Province,which i s in Northeast china,are analyzed.A nd the spatial characteristics of th e change are *** the past 50years the te mperature of Jilin Province was increasing just like the other areas in th e *** 1990,the increasing of temperature has been more obvious th an that in the previous *** the west to the east,the province has larger tem perature *** to Principal Component Analysis(PCA)of temperature field,Jilin Province is divided int o 3.egions and the degree of becoming warmer is different from region to re *** the period of 1951to 2000,the annual temperature in Jilin Province has been rising,so has the temperature in winter and *** average temperature in t he 1990s was 0.5-2.0℃higher than that in the *** the west to the east,the increasing of temperature becam e smaller.

关键词： temperature change spatial characteristics jilin province

Ecological planning of land use in the central area of Tianjin,china

在线全文

学校读者我要写书评

暂无评论

Journal of environmental sciences 1996年第4期8卷 426-433页

作者： Lu Yonglong (Research Center for Eco-environmental sciences,Chinese Academy of sciences,{3. 100085, china)Zong Yaoguang(department of Resources and Environment, {3. Normal university, {3. 100875, china) Res. Ctr. for Eco-Environmemal Sci. Chinese Academy of Sciences Beijing 100085 China department of Resources Beijing Normal University Beijing 100875 China

This paper is attempted to develop a set of suitable principles and methodologies for urban ecological planning of land use,to analyze the ecological suitability of different kinds of land use patterns of Tianjin City, to help local decision makers to work out concrete ecological strategies for promoting a sound development of the city and for improving the life quality of the citizens, and to provide the decision makers with a new approach for solving the environmental problems brought about by the improper mixture of industry and residence.

关键词： ecological planning land use ecological suitability analysis.

Study of Mechanism on Muscle Injury Induced by Static Load

在线全文

学校读者我要写书评

暂无评论

Study of Mechanism on Muscle Injury Induced by Static Load

Above-and belowground biomass in relation to envi- ronmental factors in temperate grasslands, Inner Mongolia

The 6th Pan-Pacific Conference on occupational Ergonomics

作者： Wang Sheng, Limin Gao, Lihua He department of occupational and environmental {3. peking university {3. Science Center, beijing, china

In order to study the mechanisms of muscle injury induced by static load the intracellular Ca2 + concentrations, Ca2+-Mg2+-ATPase activity in mitochondria (MR) and sarcoplasmic reticulum(SR), content of malondialdehyde(MDA),activity of serum creatine kinase(CK) and alterations of energy supply were measured after static load. The results showed that muscular ATP content in treated groups decreased on the 4th day,6th day and 8th day respectively,and was significantly lower than that of controls on the 8th day(P<0.05) .The content of PCr and glycogen showed a tendency of decreasing,but PCr was significantly lower than that of control group on the 6th day and 8th day (P < 0.05, P < 0. 01) while glycogen was significantly lower on the 8th day. The activity of serum CK was significantly higher than that of control group during the whole experiment period(P<0. 01). Intracellular Ca2+ concentration increased significantly on the 4th day(P<0.05). The content of Ca2+ in both SR and MR decreased but that of SR was significantly lower on the 6th day and 8th day(P<0.01). The activity of Ca2+ -Mg2+ -ATPase in MR and SR decreased significantly on the 6th day and 8th day(P<0. 05). The MDA content in MR increased on the 4th day while that of SR increased from the 6th day respectively, both showed significant difference from the controls(P<0.01,P<0. 05). The results of those biochemical parameters demonstrated that in the process of static load the decrement of energy supply,alterations of intracellular Ca2+ *** enhancement of lipid hyperoxidation may play etiologic roles in muscle injury. However,relationships between those noxious factors remain to be further studied.

关键词： Static load Muscle injury Ca2+ ion Ca2+ -Mg2+ -ATPase MDA

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Science china(Life sciences) 2008年第3期51卷 263-270页

作者： MA WenHong1,2, YANG YuanHe1, HE JinSheng1, ZENG Hui1,2 & FANG JingYun1 1 department of Ecology, College of Urban and environmental sciences,{3., beijing 100871, china 2 school of Environment & Urban Study,{3. Shenzhen Graduate school, Shenzhen 518055, china department of Ecology College of Urban and Environmental Sciences Peking University Beijing China school of Environment & Urban Study Peking University Shenzhen Graduate School Shenzhen China

Above- and belowground biomasses of grasslands are important parameters for characterizing re- gional and global carbon cycles in grassland ecosystems. Compared with the relatively detailed in- formation for aboveground biomass (AGB), belowground biomass (BGB) is poorly reported at the re- gional scales. The present study, based on a total of 113.sampling sites in temperate grassland of the Inner Mongolia, investigated regional distribution patterns of AGB, BGB, vertical distribution of roots, and their relationships with environmental factors. AGB and BGB increased from the southwest to the northeast of the study region. The largest biomass occurred in meadow steppe, with mean AGB and BGB of 196.7 and 13.5.2 g/m2, respectively; while the lowest biomass occurred in desert steppe, with an AGB of 56.6 g/m2 and a BGB of 3.1.0 g/m2. In addition, about 47% of root biomass was distributed in the top 10 cm soil. Further statistical analysis indicated that precipitation was the primary determinant factor in shaping these distribution patterns. Vertical distribution of roots was significantly affected by precipitation, while the effects of soil texture and grassland types were weak.

关键词： temperate grasslands aboveground biomass (AGB) belowground biomass (BGB) spatial pattern vertical distribution precipitation

To enhance the reproduction of Phanerochaete chrysosporium by adding natural lixiviums in liquid medium

在线全文

学校读者我要写书评

暂无评论

Journal of environmental sciences 2003年第6期15卷 808-814页

作者： LIN Gang, WEN Xiang-hua, QIAN Yi (department of environmental Science and Engineering, Tsinghua university, {3. 100084, china. department of environmental Science and Engineering Tsinghua University 北京 100084

Great promotion to the reproduction of white rot fungus Phanerochaete chrysosporium by adding natural lixiviums such as from wood, maize core and potato in liquid medium was found in this research. Incubated in the liquid medium contained 10 mg/L glucose as carbon source with natural lixiviums for three days, the production of mycelium pellet reaches more than 80 g/L, which is 5 times more than that of without natural lixiviums. Incubated in the liquid medium contained 5 mg/L glucose as carbon source with natural lixiviums for three days, the production of mycelium pellet can reach 69.5 g/L, while the production in the medium without natural lixiviums is very low. When the liquid medium contained 1—20 g/L glucose as carbon source, the production of mycelium pellet in 3.d can only reach 12.5 g/L to 14.5 g/L. The fungus in the medium with potato lixiviums are easily contaminated by other microorganisms and in the medium with maize core lixiviums are easily bulking, while in the medium with wood lixiviums are neither easily contaminated nor bulking. Medium with wood lixiviums can produce more pellet than other medium, endure contamination and keep better sedimentation capacity. So that, wood lixivium is better additive to the culture of white rot fungi in liquid medium. Addition of the mixture of wood, maize core and potato lixiviums is of advantage to the production of mycelium pellet. The difference of the production in the medium with different amount of wood lixiviums showed little in the first 3.d, while it expanded after 3.d. Wood lixiviums stimulate the growth of P. chrysosporium instead of supply organics which fungi need.

关键词： white rot fungi medium additive

Effect of daidzin,genistin,and glycitin on osteogenic and adipogenic differentiation of bone marrow stromal cells and adipocytic transdifferentiation of osteoblasts

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2005年第9期26卷 1081-1086页

作者： Xiang-hui LI~1 Jin-chao ZHANG~(2,3. Sen-fang SUI~(1,4) Meng-su YANG~(3.4)1 State Key Laboratory of Biomembrane department of Biological sciences and Biotechnology,Tsinghua university,{3. 100084,china 2 department of Chemistry College of Chemistry and environmental Science,Hebei university,Baoding 071002,china 3.department of Biology and Chemistry,City university of Hong Kong,Hong Kong,china department of Biological sciences and Biotechnology State Key Laboratory of Biomembrane Tsinghua University Beijing China department of Chemistry College of Chemistry and Environmental Science Hebei University Baoding China department of Biology and Chemistry City University of Hong Kong Hong Kong China

Aim:To examine the effect of daidzin,genistin,and glycitin on the osteogenic andadipogenic differentiation of bone marrow stromal cells（MSC）and the adipogenictransdifferentiation of ***:MTT test,alkaline phosphatase（ALP）activity measurement,Oil Red O stain and measurement were ***:Daidzin,genistin,and glycitin 1×10-8,5×10-7,1×10-6,5×10-6,and 1×10-5mol/L all promoted the proliferation of primary mouse bone MSC and *** 5×10-7mol/L and genistin 1×10-6mol/L promoted the osteogenesis *** 1×10-8,5×10-7,1×10-6,5×10-6,and 1×10-5mol/L and glycitin 1×10-8,1×10-6,and 1×10-5mol/L inhibited the adipogenesis of ***,genistin,and glycitin 1×10-8,5×10-7,1×10-6,5×10-6,and 1×10-5mol/L all inhibited the adipocytictransdifferentiation of ***:Daidzin,genistin,and glycitinmay modulate differentiation of MSC to cause a lineage shift toward the osteo-blast and away from the adipocytes,and could inhibit adipocytic transdifferen-tiation of *** could also be helpful in preventing the developmentof osteonecrosis.

关键词： daidzin genistin glycitin bone marrow stro-real cells osteogenic differentiation adipogenic differentiation osteoblasts adipocytic transdifferentiation