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体育学刊 2004年第1期11卷 127-128页

作者：杨庆玲刘伟吉林大学体育教研中心吉林长春130023 吉林体育学院教务处吉林长春130022

分析了《竞技教育学》中关于育人夺标的理念 ,竞技与教育相结合的学科 ,科学与人文整合的理论 ,运动的竞赛、选材、教学、训练、恢复和评价结合的方式 ,探讨构建未来业余化、人性化和社会化的“新竞技” ,以此寻觅竞技中迷失的主体。

关键词：竞技教育竞技异化人文教育

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互动式教学是成人培训的重要方式

山东行政学院山东省经济管理干部学院学报 2004年第5期 93-94页

作者：陈红山东行政学院济南250014

培训要想获得好的效果 ,培训形式的选择至关重要。培训的形式很多 ,在选择具体方式的时候不必因循守旧 ,固执地套用已有的既定模式。互动式教学正是改变传统的教学方式。

关键词：成人学习互动式教学培训方式

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论50年代学习苏联体育经验

体育科学 1992年第3期13卷 9-12,92页

作者：毕世明国家体委北京100763

在本世纪50年代,我国的社会政治形势和体育的历史背景,决定了体育界着重学习苏联的体育经验。学习的主要内容是国家管理体育的体制、对运动员进行系统的有计划的训练、建立职工体育协会、建立运动竞赛制度等。这对我国的体育发展起了重... 详细信息

在本世纪50年代,我国的社会政治形势和体育的历史背景,决定了体育界着重学习苏联的体育经验。学习的主要内容是国家管理体育的体制、对运动员进行系统的有计划的训练、建立职工体育协会、建立运动竞赛制度等。这对我国的体育发展起了重要作用。缺点是在有的问题上结合自己的实际情况不够,同时学习其它国家的经验不够。在今天建设有中国特色的社会主义体育事业中,仍需广泛地学习各国对我国有用的经验。

关键词：学习别人从实际出发发展自已

Application of Rough Sets and Artificial Neural Network in Core Enterprise Performance Prediction

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Application of Rough Sets and Artificial Neural Network in C...

第二十七届中国控制会议

作者： Hu Jian 1,Shi Chengdong 1,2 1.School of Electric and Electronic Engineering,Shandong University of Technology,Zibo 255049,P.R.china 2.School of Business administration,Xi ’ an University of Technology,Xi ’ an 710048,P.R.china

A predication model of core enterprise performance was proposed based on rough sets and artificial neural network from Knowledge Discovery and Data Mining perspective at ***,the calculation and analysis process of the model were given and *** performance decision-making table and discernable matrix were designed,and the artificial neural network and Back Propagation algorithm（BP network） were put ***,the model was applied into a practical prediction example *** the Balanced Scorecard Index System was reduced and the reduction index was input to the artificial neural network for intelligent training,the predicted sample was input to the trained network,the prediction value of the core enterprise performance was *** prediction result is consistent with the actual result.

关键词： Rough sets Artificial neural network Discernable matrix Core enterprise Performance prediction model

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加强实训体系和实习基地的建设

实验技术与管理 2010年第3期 212-215页

作者：张丽琍中华女子学院管理学院

建设工商管理学科校内外相结合的一体化实训体系,以及探讨工商管理学科实训模式的有效性是目前高校工商管理学科培养应用与创新人才的重要课题。在构建工商管理学科实训体系过程中,重点放在培养学生的职业能力和专业技能,将实训体系和... 详细信息

建设工商管理学科校内外相结合的一体化实训体系,以及探讨工商管理学科实训模式的有效性是目前高校工商管理学科培养应用与创新人才的重要课题。在构建工商管理学科实训体系过程中,重点放在培养学生的职业能力和专业技能,将实训体系和理论体系有机结合、相互渗透。整合校内外实习、实训基地,与企业联手,合作双赢,加强投入,积极打造重点实习基地。借鉴国外实训经验,实现以职业为导向的人才培养模式的突破。

关键词：工商管理实训体系实习基地

Effects of bilateral lesions of the habenula on heroin self-administration in rats

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Effects of bilateral lesions of the habenula on heroin self-...

湖北省优秀仰泳运动员赵菁的比赛成绩与技术的多维分析

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Yu-Hong WANG~3.Fu-Qiang ZHANG~(1,2),Shuai-En TANG~(12.,Miao-Jun LAI~(12.,Wen-Hua ZHOU~(12.,Wei HAO~3.1 Ningbo Addiction Research and Treatment Center 2 Laboratory of Behavioral Neuroscience,Medical School Ningbo University 3.Mental Health Institute,Second Xiangya Hospital,Central South University

＜正＞Rationale The mesolimbic dopamine system has been proved to be the key neural substrates underlying the rewarding effects of drugs of ***,a major relay station conveying information between the limbic forebrain and midbrain,mediates the negative feedback from forebrain dopamine-rich and limbic structures onto midbrain dopaminesecreting *** studied provided evidence that the habenula appears to be vulnerable to damage following chronic administration of most of the abused *** role of the habenula in mediating the acute rewarding effects of abused drugs is *** The present experiments examined the effects of bilateral electric lesion of the habenula on the acquisition and maintenance ofⅣheroin self-administration,in order to investigate the possible role of the habenula in heroin ***:Sprague Dawley rats received bilateral electric（1.0 mA,15 s） or sham lesions of the habenula prior to（acquisition） or after（maintenance）Ⅳheroin self-administration ***-administration training was conducted under a FR1 schedule in a daily 4 h *** active nose-poke resulted in a 0.05 mg/kgⅣheroin infusion,paired with a 5 s conditioned stimulus light,followed by a 3. s timeout period.A progressive schedule（PR-3.） was also used to evaluate the relative reward strength by measuring the "break point".Results Pre-training lesions of the habenula caused a higher baseline level of heroin infusions in both the FR1 and the PR-3. schedules compared with the sham ***-training lesions of the habenula had no effects on the re-establishment of heroin self-administration under the FR1 schedule and also no effects on the "break point" under the PR-3. *** These results indicate that the acquisition of heroin self-administration depend on the integrity of the *** the habenula is not critically involved in maintaining the heroin self-administration once the behavior has been *** findings sug

关键词： heroin habenula self-administration reward

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武汉体育学院学报 2009年第3期43卷 91-95页

作者：曾吉蔡仲林刘世极陶然石晓铭刘林芳张景张绍琼湖北大学体育学院湖北武汉430062 湖北省游泳跳水运动管理中心湖北武汉430033

采用文献资料、比较分析、数理统计等研究方法,对湖北省优秀仰泳运动员赵菁的比赛成绩与技术进行多维度分析比较,从中找出薄弱环节,为备战2009年全运会提供参考。

关键词：湖北省仰泳运动员赵菁比赛技术

Pharmacokinetic Study of Baicalein and Its Major Metabolites after iv administration in Dogs

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Chinese Herbal Medicines 2011年第3期3卷 196-201页

作者： TIAN Shuo1,DU Li-da2,WANG Shou-bao1,HE Guo-rong1,YANG Tao1,LI Xiao-xiu1,GUO Jing1,DU Guan-hua1 1.National centre for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,china 2.School of Pharmacy,china Pharmaceutical University,Nanjing 210009,china National centre for Pharmaceutical Screening Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China School of Pharmacy China Pharmaceutical UniversityNanjing 210009China

Objective To develop and validate a simple,rapid,sensitive,and reproducible HPLC method for simultaneous determination of baicalein and its metabolite baicalin in dog plasma and for the subsequent pharmacokinetic study after iv administration to *** An accurate and reproducible HPLC-UV method was developed and validated for simultaneous determination of baicalein and baicalin in dog plasma,using luteolin as internal *** analytes were separated by an Agilent Zorbax SB-C18 column(250 mm × 4.6 mm,5 μm) and the column temperature was maintained at 40 ℃.The mobile phase was a binary mixture of acetonitrile and water(27:73. ,containing 0.05% phosphoric acid in water,with a flow rate of 1.0 mL/*** UV detector was set at 276 *** Linear relationships were validated over the range of 0.05-25 μg/mL for baicalein and 0.05-20 μg/mL for *** intra-and inter-day precision values for all samples were within 8.0%,using relative standard *** method was successfully applied to the pharmacokinetic studies in dogs after iv administration of *** was converted to baicalin *** values were 21.13.μg/mL at 0.05 h for baicalein and 1.57 μg/mL at 0.5 h for baicalin,areas under the plasma concentration-time curve were 4.97 h·μg/mL for baicalein and 0.63.h·μg/mL for baicalin,and the elimination half-life is 0.50 h for baicalein and 0.75 h for baicalin,*** The method is able and sufficient to be used in drug metabolism and pharmacokinetic studies of baicalein.

关键词： baicalein baicalin HPLC pharmacokinetics plasma

Flavonoid quercetin protects the neurovascular unit in the Aβ25-3.-induced amnesia model:consideration for novel strategy for Alzheimer's disease

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Flavonoid quercetin protects the neurovascular unit in the A...

中国药理学会第十一次全国学术会议

作者： LIU Rui~(1,2),WU Cai-xia~(1,2),ZHANG Tian-tai~(1,2),ZHANG Li~(1,2), LAN Xi~(1,2),LI Lin~3.DU Guan-hua~(1,2) (1.National centre for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100050,china 2.Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100050,china 3.Xuanwu Hospital Capital Medical University,Beijing 100053.china)

OBJECTIVE In the absence of a cure for Alzheimer’s disease(AD),development of preventative and therapeutical medications for this disease is particularly *** flavonoid quercetin has demonstrated protective effects against Aβ-induced toxicity on both neurons and endothelial cells,but whether there is an effect on the neurovascular coupling or the related mechanism is *** the present study,we aimed to investigate the anti-amnesic effects of quercetin and explore the underlying mechanisms. METHODS Mice were given an intracerebroventricular injection of Aβ.Quercetin was dissolved in saline administrated orally for 8 *** Morris Water Maze(MWM) training began on the 3.day of quercetin treatment,and mice of each group were trained for five consecutive days;on the 9th day of quercetin treatment,a single probe trial was *** step-through positive avoidance test was performed on the 8 day and 9 day in parallel to the MWM *** regional cerebral blood flow(rCBF) was monitored before the Aα injection and on seven consecutive *** of each group were sacrificed and cerebral cortices were isolated on the 9 *** effects of quercetin on NVU integrity,microvascular function,cholinergic neuronal changes,and the modification of BNDF,p-ERK and p-CREB levels were *** Our results suggested that oral administrations of quercetin conferred robust anti-amnesic effects and neurovascular coupling protection in Aβ-induced amnesic *** these effects,treatment with quercetin at 10 mg·kg,20 mg·kg or 40 mg·kg had a significant group effect on step-through latency and error times during retention trials in the step-through positive avoidance ***,the escape latency of 20 mg·kg quercetin-administrated mice significantly declined from day 4,and the escape latencies in the quercetin 10 mg·kg and 40 mg·kg groups declined in Day *** the quercetin 20 mg·kg group,major components of neurovascular unit were maintained by the increased fluoresc

关键词： Alzheimer’s disease Amyloidβpeptide Blood-brain barrier Neurovascular unit Natural product

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涂层在炭炭复合材料氧化中的保护作用

沈阳化工学院学报 2001年第2期15卷 92-95页

作者：隋英华牟俊林山东烟台冶金新材料研究所山东烟台264006 海军航空工程学院新装备培训中心山东烟台264001

通过炭炭复合材料飞机刹车盘氧化保护问题的研究 ,指出在炭炭复合材料的氧化保护涂层研制时所应考虑的各种因素 .试验结果和实际应用表明 ,据此研制出的硼玻璃防氧化涂层技术是成功的 .运用这项技术可使炭炭复合材料基体在各种条件... 详细信息

通过炭炭复合材料飞机刹车盘氧化保护问题的研究 ,指出在炭炭复合材料的氧化保护涂层研制时所应考虑的各种因素 .试验结果和实际应用表明 ,据此研制出的硼玻璃防氧化涂层技术是成功的 .运用这项技术可使炭炭复合材料基体在各种条件下的氧化速率降低 1 5 0～ 2 0 0倍。

关键词：涂层炭-炭复合材料氧化保护基体相容性