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Spatio-temporal pattern analysis of single-trial EEG signals recorded during visual object recognition

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Science China(Information Sciences) 2011年第12期54卷 2519-2527页

作者： WANG ChangMing 1 , HU XiaoPing 3., YAO Li 1,2., XIONG Shi 2.& ZHANG JiaCai 2.1 National Key Laboratory of Cognitive Neuroscience and Learning, beijing Normal University,{2., China 2.College of Information Science and Technology, beijing Normal University,{2., China 3.Biomedical Imaging Technology center, Emory University/Georgia Institute of Technology, Atlanta 3.3.2. USA National Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University Beijing China Biomedical Imaging Technology center Emory University/Georgia Institute of Technology Atlanta USA College of Information Science and Technology Beijing Normal University Beijing China

Object discrimination is a fundamental cognitive function for human brains. In this study, we utilized an analysis approach for single-trial electroencephalography (EEG) to analyze the spatio-temporal activation patterns of visual objects processing in human brains, and attempted to apply it to discriminate different visual objects. The spatial patterns were respectively extracted from scalp EEG and the reconstructed cortical sources, while the experiment participants were perceiving 4 different categories of visual objects (faces, buildings, cats and cars). By classifying the patterns extracted from single-trial EEG, the presented visual objects could be discriminated by a computer, and the classification accuracies may provide a quantitative index to evaluate the spatial differences of the brain activations related to different visual objects. Our results demonstrated that the spatial patterns on both the scalp and the sources levels resulted in higher classification accuracies than chance rate. We also examined the classification results using temporally non-overlapping time intervals of different event-related potential (ERP) components. The temporal changes of classification accuracies may reflect the temporal distribution of the discriminative information in the EEG responses. The present pattern extraction and classification methods may compose a computational model for single-trial EEG data analysis in investigations of the spatio-temporal activation patterns for object recognition. These spatio-temporal patterns in EEG may be useful to identifying the discriminative spatial areas and time stages to improve the accuracies and efficiencies of object discrimination. In addition, investigating and utilizing humans'cognitive mechanisms of object recognition may improve computers' processing efficiency of visual information.

关键词： EEG spatio-temporal pattern object recognition single-trial analysis visual information processing

Chinese expert consensus on refined diagnosis,treatment,and management of advanced primary liver cancer(2.2.0}edition)

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Design and screening of antisense oligodeoxynucleotides against PAI-1 mRNA in endothelial cells in vitro

肝脏研究（英文） 2024年第2期8卷 61-71页

作者： Xiufeng Liu Feng Xia Yue Chen Huichuan Sun Zhengqiang Yang Bo Chen Ming Zhao Xinyu Bi Tao Peng Aizier Ainiwaer Zhiwen Luo Fusheng Wang Yinying Lu National Clinical Research center for Infectious Diseases Society of Hepatology,beijing Medical Association Translational Medicine Branch,China Association of Gerontology and Geriatrics Department of Medical Oncology Bayi Hospital Affiliated to Nanjing Chinese Medical University NanjingJiangsuChina Department of Hepatobiliary Surgery Southwest HospitalArmy Medical University ChongqingChina Senior Department of Hepatology The Fifth Medical Center of PLA General HospitalBeijingChina Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghaiChina Department of Interventional Therapy National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Minimally Invasive Interventional Therapy Liver Cancer Study and Service GroupSun Yat-sen University Cancer CenterGuangzhouGuangdongChina Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxiChina Senior Department of Infectious Diseases The Fifth Medical Center of PLA General HospitalBeijingChina Comprehensive Liver Cancer center The Fifth Medical Center of PLA General HospitalBeijingChina

Hepatocellular carcinoma(HCC),commonly known as primary liver cancer,is a major cause of malignant tumors and cancer-related deaths in China,accounting for approximately 85％of all cancer cases in the *** guidelines have been used to diagnose and treat liver ***,these guidelines provide a broad definition for classifying advanced liver cancer,with an emphasis on a singular approach,without considering treatment options for individual ***,it is necessary to establish a comprehensive and practical expert consensus,specifically for China,to enhance the diagnosis and treatment of HCC using the Delphi *** classification criteria were refined for Chinese patients with HCC,and the corresponding optimal treatment regimen recommendations were *** recommendations took into account various factors,including tumor characteristics,vascular tumor thrombus grade,distant metastasis,liver function status,portal hypertension,and the hepatitis B virus replication status of patients with primary HCC,along with treatment *** findings and rec-ommendations provide detailed,scientific,and reasonable individualized diagnosis and treatment strategies for clinicians.

关键词： Hepatocellular carcinoma (HCC) Targeted therapy Immunotherapy Refined diagnosis and treatment Expert consensus

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Acta Pharmacologica Sinica 2006年第8期27卷 1018-1023页

作者： Qi-sheng JIANG Sheng-qi WANG~2.beijing Institute of radiation Medicine,beijing 100850,China beijing Institute of radiation Medicine Beijing China

Aim:To design and screen antisense oligodeoxynucleotides(ASODNs),whichinhibit type-1 plasminogen activator inhibitor(PAI-1)expression in human umbili-cal vein endothelial cells(HUVEC)in ***:Twenty seven ASODNsagainst different sites of PAI-1 mRNA were designed and transfected to HUVECby lipofectin in *** effects of ASODNs on PAI-1 antigen,PAI-1 activityand PAI-1 mRNA expression were detected by ELISA,amidolytical assay and RT-PCR,***:Transforming growth factor β1(TGF-β1)-treatedHUVEC increased the expression of PAI-1 compared with the normal *** among twenty seven designed ASODNs were effective in inhibiting the in-crease in PAI-1 antigen and PAI-1 activity in a dose-dependent manner after *** particular,ASODN 14(AO14)exhibited the best inhibitory *** control sequences of AO14,including sense,scramble,and mismatchsequences,did not significantly inhibit PAI-1 *** was revealed that theinhibitory efficacy of AO14 was in a sequence-specific ***-PCR showedthat ASODN 1,7,8,14,and 15 decreased PAI-1 mRNA expression induced byTGF-β1and AO14 showed the best inhibitory ***:ASODN 1,7,8,14,and 15,among twenty seven designed ASODNs against PAI-1 mRNA,signifi-cantly decreased PAI-1 antigen and PAI-1 activity induced by TGF-β1x in a dose-dependent manner in HUVEC in ***14 showed the best inhibitory effect onPAl-1 expression in a sequence-specific *** results of RT-PCR indicatedthat inhibitory effects of ASODNs on PAI-1 biosynthesis occurred at the *** among five effective target sites of ASODNs located at the translationinitiation Site or within the translation area of PAI-1 mRNA,suggesting that thesesites may be promising sites for the design of effective ASODNs.

关键词： plasminogen activator inhibitor 1 antisense oligodeoxynucleotide endothelial cells

Key technology of mine underground mobile positioning based on LiDAR and coded sequence pattern

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中国有色金属学会会刊：英文版 2011年第S3期21卷 570-576页

作者： WANG Zhi1, 2. WU Li-xin1, 2. LI Hui-ying3.1. College of Resources and Civil Engineering, Northeastern University, Shenyang 110004, China 2. Academy of Disaster Reduction and Emergency Management, Ministry of Civil Affairs and Ministry of Education, beijing Normal University,{2., China 3. College of Computer Science and Technology, Jilin University, Changchun 13.012. China College of Resources and Civil Engineering Northeastern University Shenyang 110004 China Academy of Disaster Reduction and Emergency Management Ministry of Civil Affairs and Ministry of Education Beijing Normal University Beijing 100875 China College of Computer Science and Technology Jilin University Changchun 130012 China

Technologies of underground mobile positioning were proposed based on LiDAR data and coded sequence pattern landmarks for mine shafts and tunnels environment to meet the needs of fast and accurate positioning and navigation of equipments in the mine underground without satellite navigation signals. A coded sequence pattern was employed for automatic matching of 3. scans. The methods of SIFT feature, Otsu segmentation and fast hough transformation were described for the identification, positioning and interpretation of the coded sequence patterns, respectively. The POSIT model was presented for speeding up computation of the translation and rotation parameters of LiDAR point data, so as to achieve automatic 3. mapping of mine shafts and tunnels. The moving positioning experiment was applied to evaluating the accuracy of proposed pose estimation method from LiDAR scans and coded sequence pattern landmarks acquired in an indoor environment. The performance was evaluated using ground truth data of the indoor setting so as to measure derivations with six degrees of freedom.

关键词： LiDAR coded sequence pattern mobile positioning SLAM algorithm POSIT algorithm

Effective solutions to a global 3. visual system in networking environments

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Science China Earth Sciences 2005年第11期48卷 2032-2039页

作者： ZHANG Liqiang1,2. ZHANG Yan3. YANG Chongjun2. LIU Suhong1, REN Yingchao2. RUI Xiaoping2.& LIU Donglin2.1. State Key Laboratory of Remote Sensing Sciences, School of Geography and Remote Sensing, beijing Normal University,{2., China 2. State Key Laboratory of Remote Sensing Sciences, Institute of Remote Sensing Applications, Chinese Academy of Sciences, beijing 101001, China 3. Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, beijing 101001, China State Key Laboratory of Remote Sensing Sciences School of Geography and Remote Sensing Beijing Normal University Beijing China Chinese Academy of Sciences State Key Laboratory of Remote Sensing SciencesInstitute of Remote Sensing Applications China Institute of Geographical Sciences and Natural Resources Research Chinese Academy of Sciences China

The development of Web-based global 3. visual system has made progresses. However, there exist few mature and effective ways for managing, transmitting and visualizing massive spatial data. Based on the related work, the paper illustrates the ellipsoidal quadtree technique for rapid access multi-scale and multiple level geographical data, integrates the streaming with level-of-detail rendering method for transmitting the data on the network, and im-plements large-scale terrain surface simplification using M-band wavelet transforms and mul-tiresolution triangulations. We fulfil a web-based global terrain visual system using COM com-ponents on the basis of the above techniques. The system has a good prospect in the military simulation and city plans.

关键词： massive spatial data, streaming transmission, system architecture, M-band wavelet

Synthesis of superheavy nuclei with ^(2.0})U target

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Science China(Physics,Mechanics & Astronomy) 2009年第10期52卷 1482-1488页

作者： LIU ZuHua1,3.& BAO JingDong2.4 1 Key Laboratory of Beam Technology and Material Modification of Ministry of Education,beijing Normal University,beijing {2.,China 2.Department of Physics,beijing Normal University,beijing {2.,China 3.China Institute of Atomic Energy,beijing 102.13.China 4 center of Theoretical Nuclear Physics,National Laboratory of Heavy Ion Accelerator of Lanzhou,Lanzhou 73.000,China Key Laboratory of Beam Technology and Material Modification of Ministry of Education Beijing Normal University Beijing China China Institute of Atomic Energy Beijing China Department of Physics Beijing Normal University Beijing China center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Accelerator of Lanzhou Lanzhou China

The production of superheavy nuclei with Z=108-116 via hot fusion reactions of the neutron-rich projectiles with 2.0}U target is systematically *** results show that the production cross sections of superheavy nuclei do not decrease monotonously as the atomic number Z *** cross sections of the superheavy nuclei at Z = 112.and 115 are enhanced as compared with the whole Z-trend in synthesis of the superheavy nuclei,which clearly illustrates that the reactions with large negative Q-value and shell correction are more favorable to synthesize superheavy nuclei.

关键词： superheavy nuclei fusion reaction cross section 2.0}U target

The kink-soliton and antikink-soliton in quasi-one-dimensional nonlinear monoatomic lattice

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Science China(Physics,Mechanics & Astronomy) 2005年第2期48卷 150-157页

作者： XU Quan1 & TIAN Qiang2.1. Scientific and Technological Office, Daqing Teacher College, Daqing 163.12. China 2. Department of Physics , beijing Normal University,{2., China Scientific and Technological Office Daqing Teacher College Daqing China Department of Physics Beijing Normal University Beijing China

The quasi-one-dimensional nonlinear monoatomic lattice is analyzed. The kink-soliton and antikink-soliton are presented. When the interaction of the lattice is strong in the x-direction and weak in the y-direction, the two-dimensional (2.) lattice changes to a quasi-one-dimensional lattice. Taking nearest-neighbor interaction into account, the vibration equation can be transformed into the KPI, KPII and MKP equation. Considering the cubic nonlinear potential of the vibration in the lattice, the kink-soliton solution is presented. Considering the quartic nonlinear potential and the cubic interaction potential, the kink-soliton and antikink-soliton solutions are presented.

关键词： two-dimensional nonlinear lattice, quasi-one-dimensional nonlinear lattice, kink-soliton, antikink-soliton.

Compactness of the commutators of parabolic singular integrals

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Science China Mathematics 2010年第10期53卷 2633-2648页

作者： CHEN YanPing1 & DING Yong2.3.1Department of Mathematics and Mechanics,University of Science and Technology beijing,beijing 100083.China 2.chool of Mathematical Science,beijing Normal University,beijing 100875,China 3.aboratory of Mathematics and Complex Systems (BNU),Ministry of Education of China,beijing 100875,China Department of Mathematics and Mechanics University of Science and Technology Beijing Beijing China School of Mathematical Science Beijing Normal University Beijing China Laboratory of Mathematics and Complex Systems (BNU) Ministry of Education of China Beijing China

In this paper,the authors prove that the commutator [b,T] of the parabolic singular integrals is a compact operator on Lp(Rn)(1 < p < ∞) if and only if b ∈ VMO(Rn,ρ).The result is substantial improvement and extens... 详细信息

关键词： parabolic singular integrals commutators compactness BMO VMO

Boundedness of solutions and existence of invariant tori for generalized pendulum type equation

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Chinese Science Bulletin 1997年第20期42卷 1673-1675页

作者： HUANG Hai and YUAN Rong1. Institute of Mathematics, Chinese Academy of Sciences, beijing 100080, China 2. Department of Mathematics, beijing Normal University,{2., China Institute of Mathematics Chinese Academy of Sciences Beijing China Department of Mathematics Beijing Normal University Beijing China

MOTIVATED by various significant applications to non-Newtonian fluid theory, diffusion offlows in porous media, nonlinear elasticity, and theory of capillary surfaces, several authors(see refs.[1,2. and references cited therein ) have recently studied the existence of periodicsolutions and other properties for the following differential equation:

关键词： boundeduess of solutions invariant tori quasiperlodic solutions Moser’s small twist theorem.