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Science China Earth sciences 2006年第Z1期49卷 102-113页

作者： SONG Chunlei, CAO Xiuyun, LI Jianqiu, LI Qingman, CHEN Guoyuan & ZHOU Yiyong Institute of Hydrobiology, chinese academy of sciences, Wuhan 43.072, China {3. school.of the chinese academy of sciences, Beijing 10003., China Institute of Hydrobiology Chinese Academy of Sciences Wuhan China graduate school.of the chinese {3. of sciences Beijing China

Phosphatase may accelerate the process of lake eutrophication through improving phosphorus bioavailability. This mechanism was studied in three chinese eutrophic shallow lakes (Lake Taihu, Lake Longyang and Lake Lianhua). Phosphatase activity was related to the concentration of soluble reactive phosphorus (SRP) and chlorophyll a. Stability of dissolved phosphatase in reverse micelles may be attributed to molecular size, conformation and active residues of the *** the site with Microcystis bloomed in Lake Taihu, dissolved phosphatase activity was higher and more stable in micelles, SRP concentrations were lower in interstitial water, the contents of different forms of phosphorus and the amounts of aerobic bacteria were lower while respiration efficiency was higher in sediments. Phosphobacteria, both inorganic and organic and other microorganisms were abundant in surface water but rare in sediments. Therefore, internal phosphorus may substantially flux into water column by enzymatic hydrolysis and anaerobic release, together with mobility of bacteria,thereby initiating the bloom. In short, biological mechanism may act in concert with physical and chemical factors to drive the internal phosphorus release and accelerate lake eutrophication.

关键词： dissolved phosphatase, reverse micelle, internal loading, phosphorus form of sediment, microbiology, eutrophication, Microcystis bloom.

Cloning and Characterization of a New Isoform of Mouse Interleukin-18

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Acta Biochimica et Biophysica Sinica 2005年第12期37卷 826-834页

作者： Yong-Jie YANG Zhao-Yuan WANG Song-Hua CHEN Xi-Rui GEInstitute of Biochemistry and Cell Biology,Shanghai Inatitute for Bological sciences,chinese academy of sciences graduate school.of the chinese academy of Science.Shanghai 20003..China Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences graduate school.of the chinese {3. of sciencesShanghai 20003. China

Interleukin-18 (IL-18) is a novel proinflammatory cytokine with potent interferon (IFN)-yinducing activity that plays an important biological role in the enhancement of the activity of natural killer cellsand cytotoxic T *** this study,we have identified a novel short form of IL-18 in mouse,***-18s might be an alternative splicing variant of IL-18 and its cDNA contains a 57 bp *** IL-18,IL-18s is also widely expressed in mouse tissues,It was suggested that IL-18s mighthave a caspase-1-dependent mechanism for maturation and secretion similar to that of IL-18:when transfectedin COS-7 cells,pro-IL-18s (22 kDa) could be detected,and the mature IL-18s (16 kDa) could also be detectedwhen combined with *** observed that recombinant mouse IL-18s did not show any IL-18-likefunction,and IL-18s could enhance the ability of IL-18 to increase IFN-γ production by approximately 40%in mouse *** effect was observed primarily at relative low concentrations of *** IL-18s might regulate the activity of IL-18 in the physiological conditions.

关键词： IL-18 isoform IL-18s IFN-γ caspase-1 factor Xa

Pretreatment with insulin enhances anticancer functions of 5-fluorou racil in human esophageal and colonic cancer cells

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Acta Pharmacologica Sinica 2007年第5期28卷 721-730页

作者： Ke ZOU~(1,2),Ji-hang JU~(1,2),Hong XIE~(1,3.~1 Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological sciences,chinese academy of sciences,Shanghai 20003.,China ~2 graduate school.of the chinese academy of sciences,Beijing,100049,China Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China graduate school.of the chinese {3. of sciences Beijing China

Aim:To investigate the effects of insulin on enhancing 5-fluorouracil (5-FU) anti-cancer functions and its mechanisms in the human esophageal cancer cell line(Eca 109) and human colonic cancer cell line (Ls-174-t).Methods:The effect ofinsulin/5-FU combination treatment on the growth of Eca 109 and Ls-174-t cellswas evaluated by 3.(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide(MTT) *** insulin treatment or insulin/5-FU treatment,cell cycle distri-bution of both cell lines was analyzed by flow *** blot assay wasused to assess the expression of caspase-3.and thymidylate synthase (TS).Apoptosis was detected by flow cytometry,DNA fragmentation assay,and termi-nal transferase dUTP nick end labeling assay (TUNEL).Moreover,the changes of5-FU uptake after insulin pretreatment were detected by HPLC assay and Westernblot ***:We found that insulin enhanced the inhibitory effect of 5-FU on cell proliferation when Eca 109 cells and Ls-174-t cells were pretreated withinsulin for the appropriate *** increased the cell number of the S phaseand the uptake of ***/5-FU treatment enhanced apoptosis of tumor cellsand upregulated the expression of cleaved caspase-3.compared with 5-FU ***,insulin/5-FU treatment induced the changes of free TS and the TSternary complex level compared with 5-FU treatment in Eca 109 and Ls-174-t ***:These data suggest that insulin enhances anticancer functions of 5-FU when it is treated before 5-FU for the appropriate time in human esophagealand colonic cancer cell lines.

关键词： apoptosis cell cycle 5-fluorouracil insulin

Magnesium lithospermate B ameliorates renal cortical microperfusion in rats

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Acta Pharmacologica Sinica 2006年第2期27卷 217-222页

作者： Chun-guang CHEN~(2,3. Yi-ping WANG~(2,4) ~2State Key Laboratory of Drug Research.Shanghai Institute of Materia Medica,Shanghai Institutes for Biological sciences graduate school.of the {3. academy of sciences,{3. academy of sciences,Shanghai 201203.China State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Shanghai China graduate school.of the chinese {3. of sciences Chinese Academy of Sciences Shanghai China

Aim:To investigate the effects of magnesium lithospermate B（MLB）isolatedfrom Salviae miltiorrhizae on renal microcirculation,and renal and systemic he-modynamics in Sprague-Dawley ***:MLB（10,3.,and 60 mg/kg）wasinjected intravenously and renal blood flow（RBF）,renal cortical microperfusion（RCM）,and systemic hemodynamic function parameters including heart rate（HR）,mean arterial pressure（MAP）,left ventricular systolic pressure（LVSP）,left ven-tricular end-diastolic pressure（LVEDP）,and maximal velocity of pressure increase(dp/dtmax)were measured for 45 min after ***:IntravenousMLB at doses of 10,3.,and 60 mg/kg increased RCM significantly,but had noobvious effects on RBF or systemic *** effect of MLB on RCMreached its peak 15 rain after injection and returned to baseline after 45 *** to60 mg/kg MLB increased RCM by 62.4%±20.2%（changes from baseline,P3.7%±9.7% vs baseline）and renal vascular resistance（-1.4%±9.1%vs baseline）did not obviously ***:These results indicate thatMLB ameliorates renal microcirculation in a dose-dependent manner,which maybe related to the renoprotective effects of MLB.

关键词： magnesium lithospermate B hemodynamics renal blood flow renal cortical microperfusion

Formal analysis and design of multi-party fair exchange protocols

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Science in China(Series F) 2006年第2期49卷 155-174页

作者： QING Sihan1,2,3.& LI Gaicheng1,3.1. Engineering Research Center for Information Security Technology, Institute of Software, chinese academy of sciences, Beijing 100080, China 2. Beijing Zhongke Ansheng Corporation of Information Technology, Beijing 100080, China 3. {3. school.of the chinese academy of sciences, Beijing 10003., China Engineering Research Center for Information Security Technology Institute of Software Chinese Academy of Sciences Beijing China Beijing Zhongke Ansheng Corporation of Information Technology Beijing China graduate school.of the chinese {3. of sciences Beijing China

Based on the origin of message items and channel combination between transacting parties, and events and relations among events, this paper presents a concise, precise, and hierarchical model for general fair exchange protocols, formally specifies various security requirements which are able to reflect inherent requirements for fair exchange protocols more rigorously, and partition these security requirements with fine granularity. This work helps analyze, debug, and design multi-party fair exchange protocols more effectively and elaborately,

关键词： fair exchange logical protocol formal model security requirement.

Interannual variability of Antarctic Oscillation and its influence on East Asian climate during boreal winter and spring

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Science China Earth sciences 2006年第5期49卷 554-560页

作者： FAN Ke1,2,3.& WANG Huijun2 1. Nansen-Zhu International Research Center, Institute of Atmospheric Physics, chinese academy of sciences, Beijing 100029, China 2. Department of Atmospheric Science, Yunnan University, Kunming 650091, China 3. {3. University of the chinese academy of sciences, Beijing 100049, China Nansen-Zhu International Research Center Institute of Atmospheric Physics Chinese Academy of Sciences Beijing China Department of Atmospheric Science Yunnan University Kunming China graduate University of the chinese academy of {3. Beijing China

The interannual variability of Antarctic Oscillation (AAO) and its influence on East Asian climate during both boreal winter and spring are addressed. The results show that the positive AAO anomaly decreases the cold activity over East Asia during both boreal winter and spring. AAO-related barotropic meridional teleconnection from Antarctic to Arctic is found through analysis of mean me- ridional circulations. This meridional teleconnection is remarkable over Eurasia during boreal winter and over the Pacific Ocean during boreal spring. The results also show that zonal mean zonal wind at high latitudes in Southern Hemisphere has well positive correlation with that of Eurasia during boreal winter and has negative correlation with Pacific North American teleconnection (PNA) during boreal spring, which again display the meridional teleconnection. Thus, local meridional teleconnection is a possible linkage for interaction of circulations at mid-high latitudes between both hemispheres.

关键词： Antarctic Oscillation, Eurasian west wind, meridional teleconnection, mean meridional circulation.

Hedychium menghaiense (Zingiberaceae),a new species from Yunnan,China

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Journal of Systematics and Evolution 2010年第2期48卷 146-151页

作者： 1,2,3.iu HU 1Nian LIU 1(Zhongkai University of Agriculture and Engineering,Guangzhou 510225,China) 2(South China Botanical Garden,chinese academy of sciences,Guangzhou 510650,China) 3.{3. school.of chinese academy of sciences,Beijing 100049,China) (Zhongkai University of Agriculture and Engineering Guangzhou 510225 China) (South China Botanical Garden Chinese Academy of Sciences Guangzhou 510650 China) (graduate school.of chinese {3. of sciences Beijing 100049 China)

Hedychium menghaiense *** & ***,a new species of the Zingiberaceae from Yunnan Province,China,is described and *** new species is currently known only from its type locality,Nannuoshan Mountain,Menghai County,growing under evergreen broad-leaved forests at altitudes of 1400-1700 *** is similar to Hedychium forrestii Diels,but differs in its narrower and emarginate labellum folded inwards lengthwise,narrower staminodes,and scarlet *** recognition of the new species is supported by the results from analysis of sequence-related amplified polymorphism markers.

关键词： Hedychium Hedychium menghaiense X.Hu & N.Liu new species SRAP markers Zingiberaceae

Review on the study of entanglement in quantum computation speedup

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chinese Science Bulletin 2007年第16期52卷 2161-2166页

作者： DING ShengChao1,3.& JIN Zhi1,2,1 Institute of Computing Technology,chinese academy of sciences,Beijing 100080,China 2 academy of Mathematics and Systems Science,chinese academy of sciences,Beijing 100080,China 3.graduate University of chinese academy of sciences,Beijing 100080,China Institute of Computing Technology Chinese Academy of Sciences Beijing China graduate University of chinese academy of {3. Beijing China academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing China

The role the quantum entanglement plays in quantum computation speedup has been widely disputed. Some believe that quantum computation's speedup over classical computation is impossible if entan-glement is absent,while others claim that the presence of entanglement is not a necessary condition for some quantum algorithms. This paper discusses this problem systematically. Simulating quantum computation with classical resources is analyzed and entanglement in known algorithms is reviewed. It is concluded that the presence of entanglement is a necessary but not sufficient condition in the pure state or pseudo-pure state quantum computation speedup. The case with the mixed state remains open. Further work on quantum computation will benefit from the presented results.

关键词：量子论量子纠缠量子计算加速模拟

Searching for Potential Drug Targets in Two-component and Phosphorelay Signal-transduction Systems using Three-dimensional Cluster Analysis

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Acta Biochimica et Biophysica Sinica 2005年第5期37卷 293-302页

作者： Xiao-Hui CAI Qing ZHANG Shuo-Yong SHI Da-Fu DING Key Laboratory of Proteonmics,Institute of Biochemistry and Cell Biology,Stanghai Institutes for Biological sciences, chinese academy of sciences,graduate school.of the chinese academy of sciences, Shanghai 20003.,China Key Laboratory of Proteomics Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Graduate School of the Chinese Academy of SciencesShanghai 200031 China

Two-component and phosphorelay signal transduction systems are central components in thevirulence and antimicrobial resistance responses of a number of bacterial and fungal pathogens;in somecases,these systems are essential for bacterial growth and ***,we analyze in detail the conservedsurface residue clusters in the phosphotransferase domain of histidine kinases and the regulatory domain ofresponse regulators by using complex structure-based three-dimensional cluster *** also investigatethe protein-protein interactions that these residue clusters participate *** Spo0B-Spo0F complex structurewas used as the reference structure,and the multiple aligned sequences of phosphotransferases and responseregulators were paired *** results show that a contiguous conserved residue cluster isformed around the active site,which crosses the interface of histidine kinases and response *** residue clusters of phosphotransferase and the regulatory domains are directly involved in thefunctional implementation of two-component signal transduction systems and are good targets for thedevelopment of novel antimicrobial agents.

关键词： two-component system phosphorelay histidine kinase response regulator three-dimensional cluster analysis

Applications of URANS on predicting unsteady turbulent separated flows

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Acta Mechanica Sinica 2009年第3期25卷 319-324页

作者： Jinglei Xu Huiyang Ma Department of Physics, graduate University of the chinese academy of {3., 100049 Beijing, China Department of Physics Graduate University of the Chinese Academy of Sciences Beijing China

Accurate prediction of unsteady separated turbulent flows remains one of the toughest tasks and a practi cal challenge for turbulence modeling. In this paper, a 2D flow past a circular cylinder at Reynolds number 3.900 is numerically investigated by using the technique of unsteady RANS （URANS）. Some typical linear and nonlinear eddy viscosity turbulence models （LEVM and NLEVM） and a quadratic explicit algebraic stress model （EASM） are evaluated. Numerical results have shown that a high-performance cubic NLEVM, such as CLS, are superior to the others in simulating turbulent separated flows with unsteady vortex shedding.

关键词： URANS Nonlinear eddy viscosity turbulencemodel ,Separated flows Circular cylinder