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Determination of S-propargyl-cysteine in rat plasma by mixed-mode reversed-phase and cation-exchange HPLC-MS/MS method and its application to pharmacokinetic studies

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Determination of S-propargyl-cysteine in rat plasma by mixed...

第十二次全国临床药理学学术会议

作者： Yuanting Zheng~1,Hongrui Liu~(2,a),Guo Ma~1,Ping Yang~3.Lin Zhang~1,Yi Gu~4.Qing Zhu~2, Tengfei Shao~1,Peng Zhang~1,Yizhun Zhu~(2,*),Weimin Cai~1 (1 Department of Clinical Pharmacy,School of Pharmacy,Fudan university,Shanghai,china 2 Department of Pharmacology,School of Pharmacy and Institute of Biomedical Sciences,Fudan university,Shanghai,china 3.4. and testing center,School of Pharmacy,Fudan university,Shanghai,china 4.Drug Metabolism and Pharmacokinetics, Hutchison Medipharma Ltd.,Shanghai,china)

A simple,fast and sensitive mixed-mode reversed-phase and cation-exchange HPLC-MS/MS method for the quantification of S-propargyl-cysteine(SPRC),a novel cardioprotective agent,has been developed and validated for preclinical *** separation of SPRC and its internal standard(IS) was performed using a commercial analytical column which contained both C18 bonded silica particles and sulfonic acid cation-exchange *** optimized mobile phase was composed of acetonitrile/ammonium acetate buffer(10mM,pH=4.:3./70(v/v).

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Changes in plasma membrane protein structure after photodynamic action in freshly isolated rat pancreatic acini. An FTIR study.

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Changes in plasma membrane protein structure after photodyna...

中国细胞生物学学会第八届会员代表大会暨学术大会

作者： Nan Wang, Yuan Liu, Meng Xia Xie, Zong Jie Cui Institute of Cell Biology, and Centre for Measurement and testing, beijing normal university, beijing 100875, {3.

Photodynamic action of a plasma membrane-specific photosensitizer suphonatedaluminium phthalocyanine (SALPC) has been found to regulate cellular signallingpathways. The present study aimed to investigate whether SALPC photodynamicaction modulates the structure of plasma membrane proteins, and as control, of modelproteins. To check the photodynamic effect, intrinsic fluorescence of model proteinsbovine serum albumin (BSA), phospholipase A(PLA), and calmodulin weremonitored continuously during photodynamic action (SALPC 1 μM, light 14.000 luxat> 580 nm). Significant decrease in fluorescence intensity was observed in BSA and

关键词： Fourier transform infrared (FTIR) spectroscopy Photodynamic action Pancreatic acini Plasma membrane protein Rat

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中介效应检验程序及其应用

心理学报 2004年第5期36卷 614-620页

作者：温忠麟张雷侯杰泰刘红云华南师范大学教育科学学院广州510631 香港中文大学教育学院香港北京师范大学心理学院北京100875

讨论了中介变量以及相关概念、中介效应的估计;比较了检验中介效应的主要方法;提出了一个检验程序,它包含了依次检验和Sobel检验.该程序检验的第一类和第二类错误率之和通常比单一检验方法小,既可以做部分中介检验,也可以做完全中介检验... 详细信息

讨论了中介变量以及相关概念、中介效应的估计;比较了检验中介效应的主要方法;提出了一个检验程序,它包含了依次检验和Sobel检验.该程序检验的第一类和第二类错误率之和通常比单一检验方法小,既可以做部分中介检验,也可以做完全中介检验.作为示范例子,引入中介变量研究学生行为对同伴关系的影响.

关键词：中介变量检验第一类错误率功效同伴关系

Characterization of codon usage bias in the new discovered DEV dUTPase gene

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Characterization of codon usage bias in the new discovered D...

第四届第九次全国学术研讨会暨饲料和动物源食品安全战略论坛

作者： ZHAO Lichan CHENG Anchun WANG Mingshu CAI Mingsheng YUAN Guiping (1.Research center of Avian Disease,College of Veterinary Medicine of Sichuan Agricultural university,Ya’an 625014.china 2.Key Laboratory of Animal Disease and Human Health of Sichuan Province,Ya’an 625014.china {4.analytical & testing center,Sichuan university,Chengdu,Sichuan 610064.china)

A 13.4.p gene of Duck Enteritis Virus (DEV) homologous to dUTPase,was first discovered by constructing the DEV genomic *** analyzed the codon usage of DEV dUTPase gene (GenBank accession number DQ4.614.) by using CAI (Codon Adaptation Index),CHIPS (Codon Heterozygosity in a Protein-coding Sequence) and CUSP (Create a codon usage table) program of EMBOSS (The European Molecular Biology Open Software Suite).The results showed that the DEV dUTPase gene had similar codon usage pattern with avian alpha- and ***-one codons were used in the polypeptide,with a strong bias towards the codons with A and T at the third codon *** of comparison analysis revealed that there are 19 codons showing distinct usage differences between DEV dUTPase and ***,16 between DEV dUTPase and yeast,15 between DEV dUTPase and *** analysis showed high significant differences in DEV dUTPase and yeast (r=0.53.,P<0.01).

关键词： DEV dUTPase codon usage bias EMBOSS

Distinguishing the authenticity of anti-freeze liquid and brake fluid by terahertz time-domain spectra technology

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Distinguishing the authenticity of anti-freeze liquid and br...

中国光学学会2010年光学大会

作者： ZHU Shou-ming 1,ZHAO Kun 1,2,4.TIAN Lu 1,ZHAO Song-qing 1,ZHAO Hui 1,BAO Ri-ma 1,MIAO Qing 1,ZHOU Qing-li 3.SHI Yu-lei 3.ZHAO Dong-mei 3.ZHANG Cun-lin 3.1.School of Science,{4. university of Petroleum,beijing 10224.,{4. 2.State Key Laboratory of Heavy Oil Processing,{4. university of Petroleum,beijing 10224.,{4. 3.beijing Key Laboratory for Terahertz Spectroscopy and Imaging,Key Laboratory of Terahertz Optoelectronics,Ministry of Education,Department of Physics,Capital {14. university,beijing 10004.,{4. 4.International {13. for Materials Physics,Chinese Academy of Sciences,Shenyang 110016,{4..

Terahertz time-domain spectra （THz-TDS） technology is a new kind of coherent far infrared spectroscopy measurement technique based on the femtosecond *** optical property and spectroscopy of methanol,anti-freeze liquid and brake fluid are studied based on the THz-TDS in the terahertz *** whether methanol exists in anti-freeze liquid or brake fluid by Using THz-TDS technology is crucial to its *** room temperature,the time-domain spectra and the absorption spectrum in the 0.2-2.5 THz region of these samples are obtained in the environment full of *** Results show that methanol,anti-freeze liquid and brake fluid have significant different absorption spectra in this wave *** absorption peaks of methanol are located at 0.72 THz and 0.3. THz and the main absorption peaks of anti-freeze liquid and brake fluid are located at 0.62 ***-TDS Technology can distinguish minor differences in structure and can be applied to physical testing and *** provides a new experimental method for the identification of the organic chemical products and the study of spectrum more wide.

关键词： terahertz methanol anti-freeze liquid brake fluid

A Practical Reconstruction Algorithm in 2D Industrial CT

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中国体视学与图像分析 2005年第3期 189-193页

作者： LI Hui 1,2, TIAN Jie 2, ZHANG ZhaoTian 3.(1. Department of Education Technology, Capital normal university, beijing, 10003., {3. 2. Medical Image Processing Group, Key Laboratory of Complex Systems and Intelligence Science, Institute of Automation, Chinese Academy of Sciences, P.O.Box 2728, beijing, 100080, {3. 3. Department of Information Science, National Natural Science Foundation of {3., beijing, 100085, {3.)

Computed tomography plays an important role in industrial non-destructive testing, medical applications, astronomy and many other fields to look inside the scanned object and to analysis its inner structures. A non-destructive testing software have been developed to efficiently detect inner flaws of space industrial components. As the core of our software, reconstruction algorithms including preprocess of raw data, re-arrange algorithm and filtered back-projection algorithms have been described in detail in this article. With real raw data from CASC of china, experimental results verified the applied reconstruction algorithm in our software. Furthermore, forward algorithms simulating generation of fan-beam raw data are also presented in this article.

关键词： Reconstruction algorithms industrial CT imaging data preprocess

Global view of Hopf bifurcations of a van der Pol oscillator with delayed state feedback

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Science china(Technological Sciences) 2010年第3期53卷 595-607页

作者： ZHANG Li1,WANG HuaiLei1 & HU HaiYan1,2 1 MOE Key Lab of Mechanics and Control of Aerospace Structures,Nanjing university of Aeronautics and Astronautics,Nanjing 210016,china 2 School of Aerospace Engineering,beijing Institute of Technology,beijing 100081,china 1. MOE Key Lab of Mechanics and Control of Aerospace Structures Nanjing University of Aeronautics and Astronautics Nanjing 210016 China2. School of Aerospace Engineering Beijing Institute of Technology Beijing 100081 China

This paper presents both analytical and numerical studies on the global view of Hopf bifurcations of a van der Pol oscillator with delayed state *** on a detailed analysis of the stability switches of the trivial equilibrium of the system,the stability charts are given in a parameter space consisting of the time delay and the feedback *** center manifold reduc-tion and the normal form method are used to study Hopf bifurcations with respect to the time *** gain an insight into the persistence of a Hopf bifurcation as the time delay varies farther away from its critical value,the method of multiple scales is used to obtain the global view of Hopf bifurcations with respect to the time *** the analytical results of Hopf bifurca-tions and global view of those bifurcations are validated via a collocation scheme implemented on *** most important discovery in this paper is the well-structured global view of Hopf bifurcations for the system of concern,showing the generality of the persistence of Hopf bifurcations.

关键词： Hopf bifurcation global view center manifold reduction method of multiple scales collocation scheme

中国南海海绵Spheciospongia sp.中的甾体化合物

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沈阳药科大学学报 2010年第3期27卷 191-194页

作者：刘东林文瀚邓志威吴立军沈阳药科大学中药学院辽宁沈阳110016 北京大学国家天然药物与仿生药物重点实验室北京100191 北京师范大学化学分析中心北京100073

目的研究中国南海海绵Spheciospongia sp.的化学成分。方法采用多种色谱方法分离纯化,依据理化性质、波谱数据和文献对照的方法鉴定结构。结果从中国南海海绵Spheciospongia sp.石油醚提取物中分离鉴定了6个甾体类化合物:胆甾醇(cholest... 详细信息

目的研究中国南海海绵Spheciospongia sp.的化学成分。方法采用多种色谱方法分离纯化,依据理化性质、波谱数据和文献对照的方法鉴定结构。结果从中国南海海绵Spheciospongia sp.石油醚提取物中分离鉴定了6个甾体类化合物:胆甾醇(cholesterol,1),胆甾-4.稀-3.酮(cho-lest-4.en-3.one,2),胆甾-3.6-二酮(cholest-3.6-dione,3.,3.-羟基-胆甾-5-稀-7-酮(3.-hydroxy-cholest-5-en-7-one,4.,6β-羟基-胆甾-4.稀-3.酮(6β-hydroxy-cholest-4.en-3.one,5),胆甾-3.,5α,6β-三醇(cholest-3.,5α,6β-triol,6)。结论化合物2-6为首次从该属海绵中分离得到。

关键词：海绵 Spheciospongia sp. 甾体结构鉴定

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荧光光度法快速测定片剂中氨酰心安的含量

分析测试学报 1994年第6期13卷 81-84页

作者：赵慧春闫娜花张永安北京师范大学化学系北京师范大学分析测试中心

研究了氨酰心安的荧光光度法，其最大激发波长和荧光波长分别为２２２．３ｎｍ和２９７．４ｎｍ。该法灵敏度高，操作简便。氨酰心安浓度在０～３．００μｇ／ｍＬ范围内与相对荧光强度呈线性关系，相关系数为０．９９９７，检测限为０... 详细信息

研究了氨酰心安的荧光光度法，其最大激发波长和荧光波长分别为２２２．３ｎｍ和２９７．４ｎｍ。该法灵敏度高，操作简便。氨酰心安浓度在０～３．００μｇ／ｍＬ范围内与相对荧光强度呈线性关系，相关系数为０．９９９７，检测限为０．０１６９μｇ／ｍＬ。该法用于测定片剂中氨酰心安含量，结果满意。

关键词：氨酰心安片剂荧光光度法