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Functional analysis of schistosomes EF-hand domain-containing tegument proteins

Chinese Science Bulletin 2007年第15期52卷 2100-2107页

作者： YU FuDong1,2,3.KANG Bin1,3.LI YuanYuan3.4 & LI YiXue1,3.1 Bioinformatics Center,Key Laboratory of Systems Biology,shanghai Institutes for Biological Sciences,Chinese Academy of Sci-ences,shanghai 20003.,china 2 Graduate University of Chinese Academy of Sciences,shanghai 20003.,china 3.shanghai Center for Bioinformation Technology,shanghai 20023.,china 4 Key Laboratory of Systems Biology,shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,shanghai 20003.,china Bioinformatics Center Key Laboratory of Systems Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China Graduate University of Chinese Academy of Sciences Shanghai China shanghai Center for Bioinformation Technology Shanghai China Key Laboratory of Systems Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China

Schistosomes cause schistosomiasis disease which severely threatens human health. Little is known about the functions of EF-hand domain containing schistosomes tegument proteins other than as an-tigens. More possible functions of these tegument proteins were investigated with in silico analyses including protein-protein functional interaction,site-specific variation and glycosylation modification. The analysis results suggested that schistosomes could actively modulate host immune responses for its own favor through functional interactions with host proteins with immunomodulatory function,and passively regulate host immune responses through sequence variation under positive selection and glycosylating the recognition sites of host immune attack. In addition,the analysis of the C-terminal domain of these tegument proteins indicated that they could assist schistosomes in escaping host immune attacks through inhibiting chemotaxis and non-complement fixing antibody (IgG4) responses. In summary,our results suggested that these tegument antigen proteins could assist schistosomes in escaping and modulating host immune responses for self-protection during the process of host-para-site interaction.

关键词：寄生虫血吸虫皮蛋白质健康

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SHEsis,a powerful software platform for analyses of linkage disequilibrium,haplotype construction,and genetic association at polymorphism loci

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Cell Research 2005年第2期15卷 97-98页

作者： Yong Yong SHI1,2, Lin HE2,3.*1Bio-X Life Science Research Center, shanghai Jiao Tong University, shanghai, china 2Institute for Nutritional Sciences, shanghai Institute of Biological Sciences, Chinese Academy of Sciences, shanghai,china 3.HGG, Bio-X Center, shanghai Jiao Tong University, shanghai, china Bio-X Life Science Research Center Shanghai Jiao Tong University Shanghai China Institute for Nutritional Sciences Shanghai Institute of Biological Sciences Chinese Academy of Sciences Shanghai China NHGG Bio-X Center Shanghai Jiao Tong University Shanghai China

In multiloci-based genetic association studies of complex diseases, a powerful and high efficient tool for analyses oflinkage disequilibrium (LD) between markers, haplotype distributions and many chi-square/p values with a large numberof samples has been sought for long. In order to achieve the goal of obtaining meaningful results directly from raw data,we developed a robust and user-friendly software platform with a series of tools for analysis in association study withhigh efficiency. The platform has been well evaluated by several sets of real data.

关键词： software linkage disequilibrium haplotype analysis genetic association study.

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Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients

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Acta Pharmacologica Sinica 2006年第8期27卷 966-970页

作者： Sheng-nan WU~(2,3.5,6) Rui GAO~(2,3.6) Qing-he XING~(2,3.6) Hua-fang LI~4 Yi-feng SHEN~4 Niu-fan GU~4 Guo-yin FENG~4 Lin HE~(2,3.7)2 Bio-X Life Science Research Center,shanghai Jiaotong University,shanghai 20003.,china 3.Institute of Nutritional Sciences,SIBS,Chinese Academy of Sciences,shanghai 20003.,china 4 shanghai Institute of Mental Health,shanghai 20003.,china 5 shanghai Institute of Hypertension,Ruijin Hospital,Medical School of shanghai Jiaotong University,shanghai 200025,china Bio-X Life Science Research Center Shanghai Jiaotong University Shanghai China Institute of Nutritional Sciences SIBS Chinese Academy of Sciences Shanghai China shanghai Institute of Hypertension Ruijin Hospital Medical School of Shanghai Jiaotong University Shanghai China shanghai Institute of Mental Health Shanghai China

Aim:Extrapyramidal syndrome (EPS) is most commonly affected by typical antip-sychotic drugs that have a high affinity with the D2 ***,manyresearch groups have reported on the positive relationship between the geneticvariations in the DRD2 gene and the therapeutic response in schizophrenia pa-tients as a result of the role of variations in the receptor in modulating *** this study,we evaluate the role DRD2 plays in chlorpromazine-induced EPS in schizophrenic ***:We identified seven SNP(singlenucleotide polymorphism) (-141Cins>del,TaqIB,TaqID,Ser3.1Cys,rs6275,rs6277and TaqIA) in the DRD2 gene in 146 schizophrenic inpatients (59 with EPS and 87without EPS according to the Simpson-Angus Scale) treated with chlorpromazineafter 8 *** alleles of all loci were determined by PCR (polymerase chainreaction).Results:Polymorphisms TaqlD,Ser3.1Cys and rs6277 were not poly-morphic in the population recruited in the present *** statistical signifi-cance was found in the allele distribution of-141Cins>del,TaqIB,rs6275 andTaqIA or in the estimated haplotypes (constituted by TaqIB,rs6275 and TaqIA) inlinkage disequilibrium between the two ***:Our results did notlend strong support to the view that the genetic variation of the DRD2 gene playsa major role in the individually variable adverse effect induced by chlorpromazine,at least in Chinese patients with *** results confirmed a previousstudy on the relationship between DRD2 and EPS in Caucasians.

关键词： dopamine receptors basal ganglia disease polymorphism chlorpromazine schizophrenia

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Preparation and Magnetic Properties of Mn-Zn Ferrites by the Co-precipitation Method

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Journal of Wuhan University of Technology(Materials Science) 2009年第6期24卷 875-878页

作者：李雪张俊喜 School of Environmental and Chemical Engineering Shanghai University Electrochemical Research Group Shanghai University of Electric PowerKey Laboratory of State Power Corporation of China

Mn-Zn ferrites （Mn1-xZnxFe2O4） with different compositions were prepared by the coprecipitation method, and the influences of such synthesis conditions as pH value, composition and volume ratio （R） of the mixed solution and NH4HCO3.solution on their microstructures and magnetic properties were discussed. The samples were characterized by X-ray diffraction （XRD） and magnetization measurement instrument. Lattice parameters and average crystalline size of the synthesized materials were calculated from the corresponding XRD patterns with the related software Jade.5. For samples of different pH values, only one phase was found when pH values were 7.0, 8.0 and 9.0. The sample with pH value of 7.0 exhibited the highest saturation magnetic induction, the lowest coercive force, and crystallized best. For samples of different R values with pH value of 7.0, only one phase was observed in all samples, and the sample with R value of 2.3.exhibited the highest saturation magnetic induction and the lowest coercive force. The composition has mainly afected the magnetic properties, and the saturation magnetic induction increases with the increase of the content of Zn （x）, but decreases when x is beyond 0.6. The trend of coercive force is on the contrary. However, no magnetism is exhibited when the x value is up to 0.8.

关键词： co-precipitation method microstructure magnetic property Mn-Zn ferrite

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Phylogeographic analysis of human papillomavirus 58

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Science china(Life Sciences) 2009年第12期52卷 1164-1172页

作者： LI YanYun1, LI ZuoFeng2, HE YiFeng1, KANG Yu1, ZHANG XiaoYan1, CHENG MingJun1, ZHONG Yang2, 3. & XU CongJian1· 1 Obstetrics and Gynecology Hospital of Fudan University, shanghai 200011, china 2 shanghai Bioinformation Research Center, shanghai 20023., china 3.School of Life Sciences, Fudan University, shanghai 20043., china Obstetrics and Gynecology Hospital of Fudan University Shanghai China shanghai Bio-information Research Center Shanghai China School of Life Sciences Fudan University Shanghai China

Human papillomavirus 58 (HPV58) is one type of HPV with high risk of causing cervical cancer. Unusually high prevalence of HPV58 has been reported in Asia, Africa and some other areas. However, due to the scattered distribution of global data, in addition to the lack of data of some HPV58 high-incidence nations and regions, like china's Mainland, a comprehensive analysis of the global geographical distribution of HPV58 remains blank so far. In this study, HPV58 from the human cervical cancer tissue was detected in china's Mainland, and 14 new HPV58-E6/L1 gene sequences were obtained. Moreover, phylogeographic analysis has been conducted combining the HPV58 sequences that have been deposited in GenBank since 1985. The study result shows that the sequences detected from the shanghai, Jiangsu and Sichuan areas are homologous with those found in the past from Hong Kong and Xi'an, china, as well as Japan and other Southeast Asian areas. Furthermore, Western Africa is considered to be the "root" source of the HPV58 variant, while china's Mainland and Southeast Asia are "transit points" and the new sources of HPV58 after receiving the isolates from the "root" source; like HPV16 and HPV18, the HPV58 might also be one of the major HPV types associated with the development and spread of cervical cancer.

关键词： human papillomavirus 58 (HPV58) cervical cancer phylogeography molecular evolution

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Design,synthesis and antitumor evaluation of a new series of N-substi-tuted-thiourea derivatives

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Acta Pharmacologica Sinica 2006年第9期27卷 1259-1271页

作者： Jian LI~2 Jin-zhi TAN~2 Li-li CHEN~2 Jian ZHANG~2 Xu SHEN~(2,3.Chang-lin MEI~(4,6)Li-li FU~4 Li-ping LIN~5 Jian DING~5 Bing XIONG~2 Xi-shan XIONG~4 Hong LIU~(2,6)Xiao-min LUO~(2,6)Hua-liang JIANG~(2,3.2 Drug Discovery and Design Centre,State Key Laboratory of Drug Research,shanghai Institute of Materia Medica,shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,shanghai 201203.{3. 3.School of Pharmacy.East {3. University of Science and Technology,shanghai 20023.,{3. 4 Division of Nephrology,Department of Internal Medicine,Changzheng Hospital,Second Military Medical University,shanghai 200003.{3. 5 Division of Antitumor Pharmacology,shanghai Institute of Materia Medica,shanghai 201203.{3. Drug Discovery and Design Centre State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China School of Pharmacy East China University of Science and Technology Shanghai China Division of Nephrology Department of Internal Medicine Changzheng Hospital Second Military Medical University Shanghai China Division of Antitumor Pharmacology Shanghai Institute of Materia Medica Shanghai China

Aim:To design and synthesize a novel class of protein tyrosine kinase inhibitors,featuring the N-(2-oxo-1,2-dihydroquinolin-3.yl-methyl)-thiourea ***:First,compounds 1 and 2 were identified using the virtual screeningapproach in conjunction with binding assay based on surface plasmon ***,3.regions of compounds 1 and 2 were selected for chemical *** compounds were characterized potent inhibitory activities toward thehuman lung adenocarcinoma cell line SPAC ***:Forty new compounds(1-2,3.-g,4a-w,and 5a-l)were designed,synthesized and *** com-pounds(1,3.,41,4w,5a,and 5b)were found to show promising inhibitory activityagainst the SPAC1 tumor cell *** inhibitory activity of compound 5aincreases approximately 10 times more than that of the original compound ***:This study provides a promising new template with potential antitu-mot activity.

关键词： N-substituted-thiourea derivatives antitumor SPAC1 tyrosine kinase inhibitor virtual screening

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SIMULATION OF THE OIL SLICK MOVEMENT IN TIDAL WATER-WAYS

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Journal of Hydrodynamics 2010年第1期22卷 96-102页

作者： WUZhao-chun WANG Dao-zeng shanghai Institute of Applied Mathematics and Mechanics Shanghai University Shanghai 200072 China School of Construction and Safety Engineering Shanghai Institute of Technology Shanghai 200235 China

Based on particle approach and tidal flow model this article studies the behavior of the oil slick on the water surface in the Huangpu River, a tidal waterway in shanghai. In order to track the oil slick motion, a two-dimensional oil trajectory model is used. The dynamical properties of spilled oil characterized by advection, oil spreading and turbulent diffusion are considered in the model. The simulation results consistent with the flume experimental data show that the model is applicable. Both simulation and experiment illustrate that the tidal flow has a great influence on the oil slick motion. The calculated results can be used as a reference for the response to oil spill accidents in rivers.

关键词： particle approach track of oil slick numerical simulation

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Support vector machine for SAR/QSAR of phenethyl-amines

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Acta Pharmacologica Sinica 2007年第7期28卷 1075-1086页

作者： Bing NIU~2,Wen-cong LU~(2,3.6),Shan-sheng YANG~2,Yu-dong CAI~(3.4,6),Guo-zheng LI~5 ~2 College of Material Science and Engineering,shanghai University,shanghai 200444,china ~3.Laboratory of Chemical Data Mining,Department of Chemistry,College of Sciences,shanghai University,shanghai 200444,china ~4 Department of Combinatorics and Geometry,CAS-MPG Partner Institute for Computational Biology,shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,shanghai20003.,china ~5 School of Computer Science and Engineering,shanghai University,shanghai 200072,china College of Material Science and Engineering Shanghai University Shanghai China Department of Chemistry Laboratory of Chemical Data Mining College of Sciences Shanghai University Shanghai China Department of Combinatorics and Geometry CAS-MPG Partner Institute for Computational Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China School of Computer Science and Engineering Shanghai Univeristy Shanghai China

Aim:To discriminate 3. phenethyl-amines between antagonists and agonists,and predict the activities of these ***:The support vectormachine (SVM) is employed to investigate the structure-activity relationship(SAR)/quantitative structure-activity relationship (QSAR) of phenethyl-aminesbased on molecular ***:By using the leave-one-out cross-vali-dation (LOOCV) test,1 optimal SAR and 2 optimal QSAR models for agonists andantagonists were *** accuracy of prediction for the classification ofphenethyl-amines by using the LOOCV test is 91.67%,and the accuracy of predic-tion for the classification of phenethyl-amines by using the independent test is100%;the results are better than those of the Fisher,the artificial neural network(ANN),and the K-nearest neighbor models for this real world *** RMSE(root mean square error)of antagonists' QSAR model is 0.5881,and the RMSE ofagonists' QSAR model is 0.4779,which are better than those of the multiple linearregression,partial least squares,and ANN models for this real world ***:The SVM can be used to investigate the SAR and QSAR of phenethyl-amines and could be a promising tool in the field of SAR/QSAR research.

关键词： support vector machine QSAR phenethylamines antagonists agonists

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Numerical Solution of Heat Tranfer Problemwith Flow and Solidification in Round BilletContinuous Casting of Steel

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Communications in Nonlinear Science and Numerical Simulation 1999年第3期4卷 236-239页

作者： Jiahong GUO(shanghai Institute of Applied Mathematics and Mechanics, shanghai University,shanghai 200072, {3.)Xin HONG(College of Material Science, shanghai University, shanghai 200072, {3.) shanghai Institute of Applied Mathematics and Mechanics Shanghai University Shanghai 200072 China College of Material Science Shanghai University Shanghai 200072 China

IntroductionThetechnologyofc***g,***,itisimportallttostudythep... 详细信息

IntroductionThetechnologyofc***g,***,itisimportallttostudythep...

关键词： heat transfer flow and solidification round billet continuous casting

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Induced electromagnetic stirring behavior in a resistance spot weld nugget

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Science china(Technological Sciences) 2010年第5期53卷 1271-1277页

作者： LI YongBing1,LIN ZhongQin1,2,LAI XinMin1,2,CHEN GuanLong1,2 & ZHANG Ke3.1 shanghai Key Laboratory of Digital Autobody Engineering,shanghai Jiao Tong University,shanghai 200240,{3. 2 State Key Laboratory of Mechanical System and Vibration,shanghai Jiao Tong University,shanghai 200240,{3. 3.Welding Engineering Institute,shanghai Jiao Tong University,shanghai 200240,{3. shanghai Key Laboratory of Digital Autobody Engineering Shanghai Jiao Tong University Shanghai China State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong University Shanghai China Welding Engineering Institute Shanghai Jiao Tong University Shanghai China

A multi-physics hybrid numerical model,which couples electric,magnetic,thermal and flow fields,was used to investigate electromagnetic stirring behavior in a resistance spot weld *** differences of two kinds of different excitation inputs,i.e.,a sinusoidal current and its root-mean-square(RMS) value,were studied to examine if they could produce equivalent electromagnetic stirring effects in the weld *** showed that the two types of current inputs could produce almost identical fluid flow and heat transfer patterns and consistent evolution of flow and thermal fields in the *** the end of the welding cycles,the maximum flow velocity and temperature between the two inputs differed by 11.6% and 0.3.,***,the RMS current can be assumed to produce an approximately equivalent electromagnetic stirring effect with the sinusoidal current,and can be used in the future research to greatly improve the solution efficiency of the electromagnetic stirring behavior in the resistance spot weld nugget.

关键词： induced magnetic field electromagnetic stirring resistance spot welding fluid flow heat transfer

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