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Predominant expression of β-chain variable region genes of T-cell receptor in TILs from human renal cell carcinoma

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Chinese Science Bulletin 1997年第8期42卷 693-697页

作者： LI Xueyi, WANG Ying, ZHENG Zhongcheng, ZHANG Dongqing, FUSaili, LING Jianyu and ZHOU Guangyan (CHOU Kuangyen)1. shanghai Institute of Immunology, shanghai Second Medical University, shanghai 200025, {3. 2. shanghai Institute of Biochemistry, Chinese Academy of Sciences, shanghai 20003., {3. 3. shanghai Ruijin Hospital, shanghai 200025, {3. shanghai Institute of Immunology Shanghai Second Medical University Shanghai China shanghai Institute of Biochemistry Chinese Academy of Sciences Shanghai China shanghai Ruijin Hospital Shanghai China

THE repertoire of T-cell antigen receptor(TcR)can be effectively analysed by an approachwith quantitative polymerase chain reaction(qPCR),which allows to characterize the ex-panding T-cell clones by the patterns of re... 详细信息

关键词： renal cell carcinoma tumor-infiltrating lymphocyte T-cell receptor Vβ gene quantitative polymerase chain reaction.

A MONOTONE COMPACT IMPLICIT SCHEME FOR NONLINEAR REACTION-DIFFUSION EQUATIONS

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Journal of Computational Mathematics 2008年第2期26卷 123-148页

作者： Yuanming Wang Department of Mathematics,East china Normal University,shanghai 200241,china Division of Computational Science,E-Institute of shanghai Universities,shanghai Normal Benyu Guo Department of Mathematics,shanghai Normal University,shanghai 20023.,china Division of Computational Science,E-Institute of shanghai Universities,shanghai,china Department of Mathematics East China Normal University ShangHai Department of Mathematics Shanghai Normal University ShangHai

A monotone compact implicit finite difference scheme with fourth-order accuracy in space and second-order in time is proposed for solving nonlinear reaction-diffusion equations. An accelerated monotone iterative method for the resulting discrete problem is presented. The sequence of iteration converges monotonically to the unique solution of the discrete problem, and the convergence rate is either quadratic or nearly quadratic, depending on the property of the nonlinear reaction. The numerical results illustrate the high accuracy of the proposed scheme and the rapid convergence rate *** iteration.

关键词： Nonlinear reaction-diffusion equation Monotone compact implicit scheme High accuracy Monotone iteration Rapid convergence rate.

cDNA Expression Array Analysis of Gene Expression in Human Hepatocarcinoma Hep3. Cells Induced By BNIPL-1

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Acta Biochimica et Biophysica Sinica 2005年第9期37卷 618-624页

作者： Li XIE~(1,2) Wen-Xin QIN~(2,3.) Jin-Jun LI~(2,3. Xiang-Huo HE~1 Hui-Qun SHU~2 Gen-Fu YAO~2 Da-Fang WAN~(2,3.) Jian-Ren GU~~(2,3. 1 shanghai Medical College,Fudan University,shanghai 20003.,china 2 National Laboratory for Oncogenes and Related Genes,shanghai Cancer Institute,shanghai 20003.,china 3.Cancer Institute,shanghai Jiaotong Universiry,shanghai 20003.,china shanghai Medical College Fudan UniversityShanghai 200032 China National Laboratory for Oncogenes and Related Genes Shanghai Cancer InstituteShanghai 200032 China Cancer Institute Shanghai Jiaotong UniversityShanghai 200032 China

Bcl-2/adenovirus E1B 19 kDa interacting protein 2 like-1 （BNIPL-1） is a novel human proteinidentified in our laboratory,which can interact with Bcl-2 and Cdc42GAP and induce apoptosis via theBNIP-2 and Cdc42GAP homology （BCH） *** the present study,we established the Hep3.-Tet-onstable cell line in which expression of BNIPL-1 can be induced by *** cell proliferationactivity assay showed that the overexpression of BNIPL-1 suppresses Hep3. cell growth in *** expression profiles of 588 known genes from BNIPL-1-transfected Hep3.-Tet-on and vectorcontrol cells were determined using the Atlas human cDNA expression *** genes were differentiallyexpressed between these two cell lines,among which seven genes were up-regulated and eight genes weredown-regulated by ***,the differential expression result was confirmed by *** these differentially expressed genes,p16INK4,IL-12,TRAIL and the lympbotoxin β geneinvolved in growth suppression or cell apoptosis were up-regulated,and PTEN involved in cell proliferationwas down-regulated by *** results suggest that BNIPL-1 might inhibit cell growth though cellcycle arrest and/or apoptotic cell death pathway（s）.

关键词： BNIPL-1 Tet-on Atlas human cDNA array apoptosis

THE LARGE TIME CONVERGENCE OF SPECTRAL METHOD FOR GENERALIZED KURAMOTO-SIVASHINSKY EQUATION (Ⅱ)

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Journal of Computational Mathematics 1998年第3期16卷 203-212页

作者： Xin-ming Xiang (shanghai Normal University, shanghai 20023., china) 上海师范大学上海

In this paper, we study fully discrete spectral method and long time behavior of solution of generalized Kuramoto-Sivashinsky equation with periodic initial condition. We prove that the large time error estimation for fully discrete solution of spectral method. We prove the existence of approximate attractors AN, ANk respectively and d(AN, A) → 0, d(ANk, A) → 0.

关键词： Kuramoto- Sivashinsky equation,large time convergence Approximate attractor Upper semicontinuity of attractors.

Localization of genes for lateral branch and female sex expression and construction of a molecular linkage map in cucumber (Cucumis sativus L.) with RAPD markers

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Progress in Natural Science:Materials International 2005年第2期15卷 48-53页

作者： LI Xiaozun1*, PAN Junsong1*, WANG Gang1, TIAN Libo3. SI Longting3. WU Aizhong2** and CAI Run1**(1. Agriculture and Biology School, shanghai Jiaotong University, shanghai 201101, china 2. shanghai Academy of Agricultural Science, shanghai 201106, china 3. Horticulture School, Shenyang Agricultural University, Shenyang 110161, china) Agriculture and Biology Sch. Shanghai Jiaotong Univ. Shanghai 201101 China Horticulture Sch. Shenyang Agricultural Univ. Shenyang 110161 China shanghai Acad. of Agric. Sci. Shanghai 201106 China

A cucumber (Cucumis sativus L.) molecular linkage map, including 79 random-amplified polymorphic DNAs (RAPD) and two genes , lb for lateral branch and f for female sex expression, is constructed from a cross between a line, S52, with weak lateral growing ability and staminate from Dabieshan Mountains area in china and another line, S06, with strong lateral growing ability and gynoecious from Europe. The map contains nine linkage groups and spans 1110.0 cM with an average distance of 13.7 cM between loci. The lb locus is located in a longer linkage group LG-2 and flanked by two markers, OP-Q5-1 and OP-M-2-2, at 9.3.cM and 15.9 cM, respectively. In the meantime, the RAPD loci, OP-Q5-2 and BC151, in a short linkage group were found to flank f at 13.7 cM and 13.4 cM, respectively. The construction of RAPD map has paved a way for further study of the genes for lateral branch, female sex expression and other agronomic traits in cucumber.

关键词： cucumber (Cucumis sativus L.) lateral branch gynoecy RAPD genetic mapping

Comparative Analysis of Two-component Signal Transduction System in Two Streptomycete Genomes

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Acta Biochimica et Biophysica Sinica 2007年第5期39卷 317-325页

Species of the genus Streptomyces are major bacteria responsible for producing most natural antibiotics. Streptomyces coelicolor A3.2) and Streptomyces avermitilis were sequenced in 2002 and 2003. respectively. Two-component signal transduction systems (TCSs), consisting of a histidine sensor kinase (SK) and a cognate response regulator (RR), form the most common mechanism of transmembrane signal transduction in prokaryotes. TCSs in S. coelicolor A3.2) have been analyzed in detail. Here, we identify and classify the SK and RR of S. avermitilis and compare the TCSs with those of S. coelicolor A3.2) by computational approaches. Phylogenetic analysis of the cognate SK-RR pairs of the two species indicated that the cognate SK-RR pairs fall into four classes according to the distribution of their orthologs in other organisms. In addition to the cognate SK-RR pairs, some potential partners of non-cognate SK-RR were found, including those of unpaired SK and orphan RR and the cross-talk between different components in either strain. Our study provides new clues for further exploration of the molecular regulation mechanism of streptomycetes with industrial importance.

关键词： Streptomyces two-component system cross-talk phylogenetic analysis

Virtual multi-dimensional internal bonds model and its application in simulation of rock mass

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Science china(Technological Sciences) 2008年第2期51卷 192-201页

作者： ZHANG ZhenNan1,2 & GE XiuRun3.4 1 Department of Civil Engineering,shanghai University,shanghai 200072,china 2 shanghai Institute of Applied Mathematics and Mechanics,shanghai University,shanghai 200072, china 3.Institute of Geotechnical Engineering,shanghai Jiao Tong University,shanghai 20003.,china 4 Institute of Rock and Soil Mechanics,Chinese Academy of Sciences,Wuhan 43.071,china Department of Civil Engineering Shanghai University Shanghai China shanghai Institute of Applied Mathematics and Mechanics Shanghai University Shanghai China Institute of Geotechnical Engineering Shanghai Jiao Tong University Shanghai China Institute of Rock and Soil Mechanics Chinese Academy of Sciences Wuhan China

VMIB (virtual multi-dimensional internal bonds) is a multiscale mechanical model developed from the VIB (virtual internal bond) theory. In VIB theory,the solid mate-rial is considered to consist of random-distributed material particles in microscale. These particles are connected with normal bonds. The macro constitutive relation is derived from the cohesive law between particles. However,in VMIB,the micro particles are connected with both normal and shear bonds. The macro constitutive relation is derived in terms of bond stiffness coefficients. It has been theoretically certified that there exists a corresponding relationship between the two bond stiffness coefficients and the two macro material constants,i.e. the Young’s modulus and Poisson ratio. This corresponding relationship suggests that it should be necessary and sufficient to simultaneously account for the normal and shear interactions between particles. Due to the fact that the fracture criterion is directly incorporated into the constitutive relation,both VIB and VMIB present many advantages in simulating fractures of materials. In the damage model of rock mass,a damage tensor is usually defined to describe the distribution of cracks. The damage value in one direction determines the relative stiffness of rock mass in this direction. In VMIB solid,the relative distribution density of micro bonds in one direction determines the relative macro stiffness of the material in this direction. The effects of the damage value and the relative distribution density of bonds are consistent. To simulate the failure behavior of rock mass with VMIB,the presented paper sets up a quantitative relationship between the damage tensor and the rela-tive distribution density of bonds. Comparison of the theoretical and the experi-mental results shows that VMIB model can represent the effect of distributed cracks on rock mass with this relationship. The presented work provides a founda-tion for further simulating fracture behavior

关键词： VMIB (virtual multi-dimensional internal bonds) rock mass VIB (virtual internal bonds) multi-cracked body numerical simulation

天府农博园“瑞雪”多功能展示馆,成都,四川,中国

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世界建筑 2024年第4期 20-23页

作者： shanghai Archi-Union Architects 上海创盟国际建筑设计有限公司

中国天府农业博览园位于四川省成都市新津区西北部,是一个融合数字化农业博览与乡村振兴的综合园区。天府农博园瑞雪展示馆便是其中的关键建筑之一,坐落于主展馆西侧。“瑞雪”的设计从线性的场地边界条件出发,将苛刻的用地限制转化为... 详细信息

中国天府农业博览园位于四川省成都市新津区西北部,是一个融合数字化农业博览与乡村振兴的综合园区。天府农博园瑞雪展示馆便是其中的关键建筑之一,坐落于主展馆西侧。“瑞雪”的设计从线性的场地边界条件出发,将苛刻的用地限制转化为自由连续的整体线性流动空间;起伏错落,形态类似雪后的地面,也像是正在消融的积雪,描摹出雪落大地、冬雪消融的景象,与周边景观及人文精神悄然融合。

关键词：乡村振兴展示馆数字化农业流动空间博览园博园主展馆人文精神

Anticoagulation property and security of artificial heart valve material

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Science china(Technological Sciences) 2005年第2期48卷 145-162页

作者： WANG Xianghui1, , LIU Xianghuai1,22, 3. ZHANG Feng2, LI Changrong2, YU Liujiang2, ZHENG Zhihong2, WANG Xi2, JIANG Zhenbin4, CHEN Anqing4 & XU Jingfang3.1. Department of Physics, East china Normal University, shanghai 200062, china 2. Ion Beam Lab, shanghai Institute of Mini-system and information, Chinese Academy of Sciences,shanghai 200050, china 3. Department of Electronics, School of Information Science and Technology, East china Normal Univer- sity, shanghai 200062, china 4. shanghai Cardiovascular Institute, Zhongshan Hospital, shanghai 20003., china Department of Physics East China Normal University Shanghai China Ion Beam Lab Shanghai Institute of Mini-system and information Chinese Academy of Sciences Shanghai China Department of Electronics School of Information Science and Technology East China Normal University Shanghai China shanghai Cardiovascular Institute Zhongshan Hospital Shanghai China

Heart valve diseases threaten human health. One reliable way to save lives of such patients is to replace the pathologically changed heart valves by artificial ones. Over 2 million patients have received LTI-carbon heart valve’s implantation. However, the thrombosis after the implantation is one of the difficulties that need to be solved. In order to improve the blood compatibility and security of mechanical heart valves, ion beam technology was used to modify the surface properties of the materials. The investigation results have been summarized in this paper.

关键词： artificial heart valve, ion implantation, plasma immersed ion implantation, ion beam enhanced deposition.