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Mining and Integrating Reliable Decision Rules for Imbalanced Cancer Gene Expression Data Sets

Tsinghua science and technology 2012年第6期17卷 666-673页

作者： Hualong Yu 1 , Jun Ni 2 , Yuanyuan Dan 3., Sen Xu 4 1. school of Computer science and engineering,{3., zhenjiang 212003, china 2. Department of Radiology, Carver College of Medicine, The university of Iowa, Iowa City, IA 52242, USA 3. school of biology and chemical engineering,{3., zhenjiang 212003, china 4. school of Information engineering, Yancheng Institute of {13., Yancheng 224051, china school of Computer science and engineering Jiangsu University of Science and Technology Zhenjiang 212003 China Department of Radiology Carver College of Medicine The University of Iowa Iowa City IA 52242 USA school of biology and chemical {3. Jiangsu University of Science and Technology Zhenjiang 212003 China school of Information engineering Yancheng Institute of Technology Yancheng 224051 China

There have been many skewed cancer gene expression datasets in the post-genomic era. Extraction of differential expression genes or construction of decision rules using these skewed datasets by traditional algorithms will seriously underestimate the performance of the minority class, leading to inaccurate diagnosis in clinical trails. This paper presents a skewed gene selection algorithm that introduces a weighted metric into the gene selection procedure. The extracted genes are paired as decision rules to distinguish both classes, with these decision rules then integrated into an ensemble learning framework by majority voting to recognize test examples; thus avoiding tedious data normalization and classifier construction. The mining and integrating of a few reliable decision rules gave higher or at least comparable classification performance than many traditional class imbalance learning algorithms on four benchmark imbalanced cancer gene expression datasets.

关键词： cancer gene expression data class imbalance paired differential expression genes decision ruleensemble learning majority voting

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Enhanced Hoek-Brown(H-B)criterion for rocks exposed to chemical corrosion

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International Journal of Mining science and technology 2024年第5期34卷 609-630页

作者： Hao Li Leo Pel zhenjiang You David Smeulders Department of Mechanical engineering Eindhoven University of TechnologyEindhoven 5600 MBthe Netherlands Department of Applied Physics Eindhoven University of TechnologyEindhoven 5600 MBthe Netherlands Center for Sustainable Energy and Resources School of EngineeringEdith Cowan UniversityJoondalupWA 6027Australia school of chemical engineering The University of QueenslandBrisbaneQLD 4072Australia Gas and Energy Transition Research Centre The University of QueenslandBrisbaneQLD 4072Australia

Underground constructions often encounter water environments,where water–rock interaction can increase porosity,thereby weakening engineering ***,the failure criterion for chemically corroded rocks becomes essential in the stability analysis and design of such *** study enhances the applicability of the Hoek-Brown(H-B)criterion for engineering structures operating in chemically corrosive conditions by introducing a kinetic porosity-dependent instantaneous mi(KPIM).A multiscale experimental investigation,including nuclear magnetic resonance(NMR),X-ray diffraction(XRD),scanning electron microscopy(SEM),pH and ion chromatography analysis,and triaxial compression tests,is employed to quantify pore structural changes and their linkage with the strength responses of limestone under coupled chemical-mechanical(C-M)*** employing ion chromatography and NMR analysis,along with incorporating the principles of free-face dissolution theory accounting for both congruent and incongruent dissolution,a kinetic chemical corrosion model is *** model aims to calculate the kinetic porosity alterations within rocks exposed to varying H+concentrations and ***,utilizing the generalized mixture rule(GMR),the kinetic porositydependent mi is *** of the KPIM-enhanced H-B criterion using compression test data from 5 types of rocks demonstrated a high level of consistency between the criterion and the experimental results,with a coefficient of determination greater than 0.96,a mean absolute percentage error less than 4.84%,and a root-mean-square deviation less than 5.95 ***,the physical significance of the porosity-dependent instantaneous mi is clarified:it serves as an indicator of a rock’s capacity to leverage the confining pressure effect.

关键词： Hoek-Brown(H-B)criterion Instantaneous mi Kinetic porosity-dependency chemical corrosion Compressive strength

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Synthesis and Properties Research of Quercetin-Copper Complexes Modified by Nano Fe3.4

Synthesis and Properties Research of Quercetin-Copper Comple...

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加速功能材料自主创新，促进西部战略性新兴产业发展——2011中国功能材料科技与产业高层论坛

作者： Jianguo SHENG,Cancan ZHANG College of biology and chemical engineering,{3. university of science and technology,zhenjiang,{3.,china,212003

The quercetin and copper complex was prepared by quercetin and copper chloride reacted with each other under certain conditions,then it was joined in the Fe3.4 nanometer ethanol in 3. ℃and reacted 24h,the paramagnetic quercetin-Cu metal complexes can be *** last the antioxidant activity of quercetin-copper complexes modified by nano Fe3.4 was determinated by the scavenging of the stable radical *** complex of quercetin and copper modified by nano Fe3.4 was studied by UV,IR spectrophotometry and *** was formed quercetin-copper complex in A and C ring of quercetin,the quercetin hydroxyl and nano Fe3.4 was combined with chitosan,the complex of quercetin and copper modified by nano Fe3.4 is measured by magnetometer,the complex have magnetic *** was formed cladding by nano Fe3.4 and quercetin-Cu metal *** loading capability of drugs was 3.%,sealde rate was 67%.It could be served as a kind of drug load microspheres.

关键词： quercetin nanoparticles antioxidant

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Molecular mechanism of dehydrin in response to environmental stress in plant

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Progress in Natural science:Materials International 2007年第3期17卷 237-246页

作者： ZHANG Yuxiu , WANG Zi and XU Jin (Department of Bioengineering, school of chemical and Environmental engineering, china university of Mining and technology (Beijing), Beijing 100083. china Department of biology, Graduate university of Chinese Academy of sciences, Beijing 100049, china) Department of Bioengineering School of Chemical and Environmental Engineering China University of Mining and Technology (Beijing) Beijing 100083 China Department of biology Graduate University Chinese Academy of Sciences Beijing 100049 China

Dehydrins, known as the D-11 subgroup of late embryogenesis abundant (LEA) protein, are an immunologically distinct family of proteins, which typically accumulate in desiccation-tolerant seed embryo or in vegetative tissues in response to various environmental stresses such as drought, salinity and freezing. The existence of conservative sequences designated as K, S, and Y segments is a structural feature of dehydrins, and the K segment found in all dehydrins represents a highly conserved 15 amino acid motif (EKKGIMDKIKEKLPG) and forms an amphiphilicα-helix. According to the arrangement of these domains and clustering analysis, dehydrins are subdivided into 5 subtypes: YnSK, Kn, KnS, SKn and YnK. Different types of dehydrins are induced by different environmental stress in plants. Study results showed that dehydrins might play important protective roles under abiotic stress via a number of different mechanisms, including improving or protecting enzyme activities by the cryoprotective activity in responding to freeze/thaw or dehydration; stabilizing vesicles or other endomembrane structures by function as the membrane stabilizer during freeze induced dehydration, and preventing the membrane system from the oxidative damage induced by reactive oxygen radicals as the radical scavenger. Here, the gene expression and molecular mechanisms of dehydrin in response to stress in plants are discussed.

关键词： dehydrin stress mechanism.

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Study of the Functional Materials about Piezoelectric Nanogenerator

Study of the Functional Materials about Piezoelectric Nanoge...

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加速功能材料自主创新，促进西部战略性新兴产业发展——2011中国功能材料科技与产业高层论坛

作者： Jianguo SHENG,Ping ZENG College of biology and chemical engineering,{3. university of science and technology,zhenjiang,china,212003

With the development of science and technology,the smaller sizes generator,the more attention by *** main purpose of this article is to manufacture piezoelectric nanogenerator under micro vibration and its working principle is introduced and its performance is *** results show that,using the present nanomaterials,piezoelectric materials can be *** its wind in copper laps,under the situation of micro pulse vibration its can turn into electrical energy,thus yield piezoelectric *** ambient vibration condition,piezoelectric materials produce larger rated current and ***,copper laps cutting magnetic line of force produce less rated current and *** the piezoelectric nanogenerators can be separately used to supply *** multiple piezoelectric nanogenerator in tandem may produce higher voltage,current and power,which possess commercial value.

关键词： piezoelectric functional materials nano generators power

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Baker's yeast mediated reduction of substituted acenaphthenequinones: Regio-and enantioselective preparation of mono-hydroxyacenaphthenones

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Chinese chemical Letters 2007年第6期18卷 681-684页

作者： Xing Yong Wang, Jing Nan Cui, Wei Min Ren, Feng Li, Chun Liang Lu, Xu Hong Qian State Key Laboratory of Fine chemicals, Dalian university of technology, Dalian 116012,{3. school of chemical engineering and technology,{3. university of Mining & technology, Xuzhou 221008,{3. Shanghai Key Laboratory of chemical {13., East{3. university of science and technology, Shanghai 20023.,{3. State Key Laboratory of Fine chemicals Dalian University of Technology Dalian 116012 China school of chemical engineering and {3. China University of Mining & Technology Xuzhou 221008 China Shanghai Key Laboratory of chemical biology East China University of Science and Technology Shanghai 200237 China

Baker's yeast mediated reduction of acenaphthenequinone within 4-10 h afforded mono-hydroxyacenaphthenone mainly with low enantioselectivity, the substrate and mono-hydroxyacenaphthenone product almost converted to dihydroxyacenaphthene after 48 h. By control of the reaction time and in the presence of DMF as co-solvent, the reduction of 6-substituted acenaphthenequinones under vigorous agitation afforded the corresponding 2-hydroxyacenaphthenones in 24-84% yields with 10-93. ee.

关键词： Baker's yeast Reduction Regio- and enantioselectivity Chiral hydroxyacenaphthenone

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Design,synthesis and biological evaluation of fluorescent derivatives of ursolic acid in living cells

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Chinese chemical Letters 2024年第5期35卷 287-289页

作者： Wenyi Mei Lijuan Xie Xiaodong Zhang Cunjian Shi Fengzhi Wang Qiqi Fu zhenjiang Zhao Honglin Li Yufang Xu Zhuo Chen Shanghai Key Laboratory of New Drug Design State Key Laboratory of Bioreactor EngineeringSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China Innovation Center for AI and Drug Discovery East China Normal UniversityShanghai 200062China Lingang Laboratory Shanghai 200031China

Ursolic acid(UA)is a naturally occurring ursane triterpenoid,which exhibits a wide range of unique biological *** clarify its mechanism of action(MOA),a series of fluorescent derivatives of UA(5a-c)were designed and synthesized by conjugation with 7-nitrobenzo-2-oxa-1,3.diazole(NBD)*** them,5c exhibited similar anti-proliferative activity with UA against HCT116 cells(half maximal inhibitory concentration(IC_(50))=9.21±0.50μmol/L).Cell imaging experiment indicated that 5c was rapidly taken up in HCT116 cells in a dose and time-dependent ***,5c was found to localize in endoplasmic reticulum(ER),lysosomes,and mitochondria,but not in nucleus of HCT116 cells by confocal microscopy *** MOA proved that UA induced autophagy with a unique intracellular distribution mechanism involving ER and *** all,our work provides new clues for revealing the molecular mechanism of UA as an antitumor agent.

关键词： Pentacyclic triterpenoid Ursolic acid Fluorescent derivatives Autophagy Apoptosis

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Mechanism and Kinetic Model of In-situ TiB_2/7055Al Nanocomposites Synthesized under High Intensity Ultrasonic Field

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Journal of Wuhan university of technology(Materials science) 2011年第5期26卷 920-925页

作者：陈登斌赵玉涛 school of Materials science and engineering Jiangsu University

In-situ TiB2/7055Al nanocomposites are fabricated by in situ melt chemical reaction from 7055Al-K2TiF6-KBF4 system under high intensity ultrasonic field,and the mechanism and kinetic model of in-situ melt chemical reaction are investigated.X-ray diffraction （XRD） and scanning electron microscope （SEM） analyses indicate that the sizes of in-situ TiB2 nanoparticles are in the range of 80-120 *** results of ice-water quenched samples show that the whole process contains four stages,and the overall in-situ reaction time is 10 *** in situ synthesis process is controlled mainly by chemical reaction in earlier stage （former 3.minutes）,and by the particulate diffusing in later *** mechanism of key reaction between Al3.i and AlB2 under high intensity ultrasonic in the 7055Al-K2TiF6-KBF4 system is the ***,the reactive kinetic models in 7055Al-K2TiF6-KBF4 system are established.

关键词： in-situ nanocomposites high intensity ultrasonic field reactive mechanism kinetic model

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Expressed sequence tag analysis and cloning of trehalose-6-phosphate synthase gene from marine alga Laminaria japonica(Phaeophyta)

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Acta Oceanologica Sinica 2012年第6期31卷 139-148页

作者： XUAN Jinsong 1,4,FENG Yanbin 1,WENG Manli 1,ZHAO Ge 1,SHI Jinfeng 1,YAO Jianting 2,WANG Xiuliang 2,GUO Baotai 3.QIAO Lixian 3.DUAN Delin 2,WANG Bin 1 1 The State Key Laboratory of Plant Genomics,Institute of Genetics and Developmental biology,Chinese Academy of sciences,Beijing 100101,china 2 The State Key Laboratory of Marine biology,Institute of Oceanology,Chinese Academy of sciences,Qingdao 266071,china 3.College of Life sciences,Qingdao Agricultural university,Qingdao 266109,china 4 Department of Biological science and engineering,school of chemical and Biological engineering,university of science and technology Beijing,Beijing 100083.china The State Key Laboratory of Plant Genomics Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing China Department of Biological science and engineering School of Chemical and Biological Engineering University of Science and Technology Beijing Beijing China The State Key Laboratory of Marine biology Institute of Oceanology Chinese Academy of Sciences Qingdao China College of Life sciences Qingdao Agricultural University Qingdao China

A high quality cDNA library was constructed from the brown alga Laminaria japonica,with the titer of 1.2×10 5 pfu/*** average insert size of the cDNA library is about 1.6 *** the cDNA library,591 cDNA clones were randomly selected and *** a result,574 EST(expressed sequence tag) sequences were *** of the 574 ESTs were submitted to the dbEST database section of GenBank with the accession numbers from CX942625 to *** cDNA library was screened with a α-3. p labeled 453.bp T P S gene probe,which is a partial sequence yielded from Porphyra *** positive cDNA clones were screened and the sequencing data showed that these four cDNA clones covered majority of *** TPS cDNA *** PCR amplification,sequencing and assembling,the entire ORF(open reading frame) sequence of the T P S gene was obtained,which was named *** encodes a protein containing 908 amino acids with a calculated molecular mass of 101 674 *** LjTPS gene was successfully expressed in *** and *** LjTPS gene has potential application both in plant breeding to stress tolerance and in deciphering the T P S gene function and mechanism to stress tolerance.

关键词： cDNA library comparative study expressed sequence tag(EST) analysis Laminaria japonica trehalose-6-phosphate synthase(TPS) T P S gene

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ADSORPTION BEHAVIOUR OF Mn(Ⅱ) AND Zn(Ⅱ) ON ATTAPULGITE WITH FAAS METHOD

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Chinese Journal of Reactive Polymers 2008年第Z1期 36-41页

作者： LI Bingbing1,3.LI Chunxiang2 LIU Aiqin2 XIAO Bo1,3.1. College of Environmental science and technology, Huazhong university of science and technology, Wuhan 43.074, china 2. school of Chemistry & chemical engineering, jiangsu university, zhenjiang 212013. china 3. Department of Biological engineering of Pingdingshan Institute of technology, Pingdingshan 467000, china

Active attapulbgite as adsorptive reagent, the adsorptive behavior of Mn(II) and Zn(II) was studied with Flame atomic absorption spectroscopy (FAAS) method. The mainly factors of influencing the adsorption and desorption of Mn(II) and Zn(II) were discussed. The interference of coexisting ions was investigated, and the actual sample determination from adzuki beans, mung beans and phosphating waste water was conducted with good result.

关键词： Attapulgit FAAS method Determination Mn(II) Zn(II) Foodstuff.

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