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智能全科医生中国专家共识

中国全科医学 2025年第2期28卷 135-142页

作者：清华大学万科公共卫生与健康学院北京大学公共卫生学院中国医师协会全科医师分会梁万年刘民路孝琴刘珏不详清华大学万科公共卫生与健康学院中国医师协会全科医师分会北京大学公共卫生学院首都医科大学全科医学与继续教育学院

人工智能大语言模型等新技术的飞速发展给医学临床实践带来了新的变革。国内外已开始了智能全科医生系统的研究及实践探索,但尚未形成共识。在此背景下,清华大学万科公共卫生与健康学院、北京大学公共卫生学院联合中国医师协会全科医师... 详细信息

人工智能大语言模型等新技术的飞速发展给医学临床实践带来了新的变革。国内外已开始了智能全科医生系统的研究及实践探索,但尚未形成共识。在此背景下,清华大学万科公共卫生与健康学院、北京大学公共卫生学院联合中国医师协会全科医师分会及来自国内多家单位的全科医学、公共卫生、人工智能、循证医学等多学科领域的专家学者,在广泛检索国内外文献的基础上,经过多轮专家研讨,最终形成《智能全科医生中国专家共识》,从智能全科医生的定义、特点、应用、挑战与建议等方面形成17条专家共识,为促进智能科技赋能全科医生临床实践、提升基层卫生智慧化服务水平提供科学参考。

关键词：人工智能大语言模型全科医生专家共识

Status of study on biological and toxicological effects of nanoscale materials

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Science China Chemistry 2005年第5期48卷 385-394页

作者： WANG Bing1, FENG Weiyue1, ZHAO Yuliang1, XING Gengmei1, CHAI Zhifang1, WANG Haifang2 & JIA Guang3.1. Laboratory for Bio-Environmental health Sciences of Nanoscale Materials (Nanosafety Lab), Institute of High Energy Physics, Chi-nese Academy of Sciences, Beijing 100049, China 2. College of Chemistry and Molecular Engineering, Peking university, Beijing 100871, China 3. Department of Occupational and Environmental health Sciences, {3. of public health, Peking university, Beijing 100083. China 1. Laboratory for Bio-Environmental health Sciences of Nanoscale Materials (Nanosafety Lab) Institute of High Energy Physics Chinese Academy of Sciences 100049 Beijing China 2. College of Chemistry and Molecular Engineering Peking University 100871 Beijing China 3. Department of Occupational and Environmental health Sciences School of Public Health Peking University 100083 Beijing China

Because the physical and chemical properties of nanosized materials mostly differ from the existing microsized materials, their potential impacts on human health and the envi-ronment will be topics under the serious discussions in press and in a number of international scientific journals. We analyze and summarize the existing data of the experimental study on the biological activities and adverse effects of nanoscale materials/particles including single wall carbon nanotubes, multi wall carbon nanotubes, titanium oxide and iron powders. Though some biological behaviors of nanoscale materials observed cannot be understood on the basis of the current knowledge, as the existing data are mostly preliminary, it is too early to make some ex-clusive conclusions on biological activities (or the toxicity) of any of nanoscale materials. The experimental techniques, the current topics, and the future research directions for this new re-search field are also discussed.

关键词： nanomaterials, single wall carbon nanotubes, multi wall carbon nanotubes, titanium oxide and iron, biological activity and toxicological effect.

Lys751Gln polymorphism in ERCC2 gene is associated with lung cancer susceptibility in the Chinese population

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Progress in Natural Science:Materials International 2007年第7期17卷 872-876页

作者： Liang Geyu Pu Yuepu Yin Lihong (school of public health,Southeast {3.,Nanjing 210009,China) school of public health Southeast University Nanjing 210009 China

The excision repair cross-complementing group 2(ERCC2)gene encodes a DNA repair protein,which is absolutely necessary in nucleotide excision repair.A polymorphism in codon 751 that induces a Lys→Gln substitution has been suggested to reduce the DNA repair ***,we conducted a matched case-control study to investigate the role of ERCC2 Lys751Gln polymor- phism in the development of lung cancer in the Chinese *** genotype of ERCC2 gene was analyzed by di-allele-specific-amplifi- cation with artificially modified primers(diASA-AMP)in 200 original lung cancer cases and 200 *** results showed that carriers of Lys/Gln and Gln/Gln genotypes had a 3.3.-fold higher risk of lung cancer compared with carriers of Lys/Lys ***, the mutant genotypa of 751Gln allele was found to be associated with an increased risk in both lung squamous cell carcinoma and lung ade- ***,no significant interaction between 751Gln variants and smoking was observed after stratifying according to the smoking status in this *** results suggest that the Lys751Gln polymorphism in ERCC2 gene is a potential biomarker for suscepti- bility of lung cancer in the Chinese population.

关键词： lung cancer ERCC2 SNPs diASA-AMP

Impact of Long-term Exposure to Air Particulate Matter on Life Expectancy and Survival Rate of Shanghai Residents

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Biomedical and Environmental Sciences 2002年第3期15卷 209-214页

作者： KAN HAI-DONG1 AND CHEN BING-HENG Department of Environmental health, school of public health, Fudan university, Shanghai 20003., China Department of Environmental health School of Public Health Fudan University 上海 200032

Objective To evaluate the impact of long-term air particulate matter exposure on the life expectancy and survival rate of Shanghai residents. Methods Epidemiology - based exposure-response function was used for the calculation of attributable deaths to air particulate matter in Shanghai, and the effect of long-term exposure to particulate matter on life expectancy and survival rate was estimated using the life table of Shanghai residents in 1999. Results It was shown that in 1999, the long-term air particulate matter exposure caused 1.3.-1.69 years reduction of life expectancy and a decrease of survival rate for each age group of Shanghai residents. Conclusion The effect of long-term exposure to air particulate matter on life expectancy is substantial in Shanghai.

关键词： Particulate matter Life expectancy Survival rate Shanghai

Remote sensing and geographic information systems in the spatial temporal dynamics modeling of infectious diseases

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Science China(Life Sciences) 2006年第6期49卷 573-582页

作者： GONG Peng 1,XU Bing 2 & LIANG Song 1、3.1. State Key Laboratory of Remote Sensing Science,Jointly Sponsored by the Institute of Remote Sensing Applications,Chi-nese Academy of Sciences and Beijing Normal university,Box 9718,Beijing 100101,China 2. Department of Geography,university of Utah,Salt Lake City,UT 84112,usa {3.,university of california,berkeley,ca 9472.,usa 1. State Key Laboratory of Remote Sensing Science Jointly Sponsored by the Institute of Remote Sensing Applications Chinese Academy of Sciences and Beijing Normal University Box 9718 Beijing 100101 China 2. Department of Geography University of Utah Salt Lake City UT 84112 USA 3. school of public health University of California Berkeley CA 94720 USA

Similar to species immigration or exotic species invasion,infectious disease transmis-sion is strengthened due to the globalization of human activities. Using schistosomiasis as an exam-ple,we propose a conceptual model simulating the spatio-temporal dynamics of infectious diseases. We base the model on the knowledge of the interrelationship among the source,media,and the hosts of the disease. With the endemics data of schistosomiasis in Xichang,China,we demonstrate that the conceptual model is feasible; we introduce how remote sensing and geographic information systems techniques can be used in support of spatio-temporal modeling; we compare the different effects caused to the entire population when selecting different groups of people for schistosomiasis control. Our work illustrates the importance of such a modeling tool in supporting spatial decisions. Our mod-eling method can be directly applied to such infectious diseases as the plague,lyme disease,and hemorrhagic fever with renal syndrome. The application of remote sensing and geographic informa-tion systems can shed light on the modeling of other infectious disease and invasive species studies.

关键词： spatio-temporal modeling, spatial connectivity, prevention and control of infectious diseases, biological invasion.

传染病多点触发智慧化监测预警系统关键技术专家共识

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中华医学杂志 2024年第32期104卷 2995-3009页

作者：中国医学科学院北京协和医学院群医学及公共卫生学院北京大学公共卫生学院中国疾病预防控制中心传染病管理处四川大学华西公共卫生学院中国科学院地理科学与资源研究所首都医科大学附属北京地坛医院中华医学会公共卫生分会中国医学科学院北京协和医学院群医学及公共卫生学院北京大学公共卫生学院中国疾病预防控制中心传染病管理处四川大学华西公共卫生学院中国科学院地理科学与资源研究所首都医科大学附属北京地坛医院中华医学会公共卫生分会

有效的传染病监测预警系统是公共卫生安全体系的重要组成部分, 对预防与控制传染病暴发流行至关重要, 提升监测预警能力是推动疾病预防控制事业高质量发展的当务之急。专家组结合公共卫生与预防医学、临床医学、管理学、数据科学、计算... 详细信息

有效的传染病监测预警系统是公共卫生安全体系的重要组成部分, 对预防与控制传染病暴发流行至关重要, 提升监测预警能力是推动疾病预防控制事业高质量发展的当务之急。专家组结合公共卫生与预防医学、临床医学、管理学、数据科学、计算机科学等多学科专家的研究成果与实践经验, 经过反复多轮专家研讨, 形成了传染病多点触发智慧化监测预警系统关键技术专家共识。本共识内容主要包括传染病多点触发智慧化监测预警系统的相关概念和定义, 关键技术框架, 多渠道监测预警数据来源、获取与治理, 预警方法分类, 多点触发智慧化监测预警关键流程及路径, 多点触发预警及综合研判, 预警信号响应以及预警效果评价等方面, 以期为传染病多点触发智慧化监测预警系统建设及应用提供技术参考。

关键词：传染病监测预警多点触发智慧化

Effect of Zinc on Bone Metabolism in Fetal Mouse Limb Culture

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Biomedical and Environmental Sciences 2002年第4期15卷 323-329页

作者： LI YUN AND YU ZENG-LIDepartment of Nutrition and Food Hygiene, Huaxi school of public health, Sichuan {3., Chengdu 610041. China Department of Nutrition and Food Hygiene Huaxi School of Public Health Sichuan University Chengdu 610041 China

Objective To determine the effects of zine-deficiency and zine-excess on hone metabolism. Methods We developed the culture model of fetal mouse limbs (16th day) cultivated in self-made rotator with continuing flow of mixed gas for six days in vitro. The cultured limbs were examined by the techniques of 45ca tracer and X-roentgenography. Results The right limbs cultivated had longer bone length, higher bone density than the left limbs uncultivated from the same embryo; and histologically, the right limbs had active bone cell differentiation, proliferation, increased bone trabecula. clearly calcified cartilage matrix, and osteogenic tissue. Compared with the control group, the zinc-deficient group and zine-excess (Zn2+ l20) μmol/L) group contained less osteocalcin (BGP) and 45ca content, and lower AKP activity; whereas zine-normal (Zn2+ 45 μmol/L and Zn2+ 70 μmol/L) groups contained more BGP and 45ca contents, and higher AKP (alkaline phosphatase) activity. Conclusion Both zine-deficiency and zine-excess can alter bone growth and normal metabolism. The results indicate that the culture model of fetal mouse limbs (16th day) in vitro can be used as a research model of bone growth and development.

关键词： Zinc excess Zinc deficiency Bone metabolism Organic culture

Adenovirus-mediated expression of Tob1 sensitizes breast cancer cells to ionizing radiation

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Acta Pharmacologica Sinica 2007年第10期28卷 1628-1636页

作者： Yang JIAO~2,Chun-min GE~3.Qing-hui MENG~2,Jian-ping caO~2,Jian TONG~2,Sai-jun FAN~(2,3.4)~2 school of Radiology and public health,Soochow {3.,Suzhou 215123.China,~3.Department of Oncology,Lombardi Comprehensive cancerCenter,Georgetown {3.,Washington DC 20057,usa school of Radiology and public health Soochow University Suzhou 215123 China Department of Oncology Lombardi Comprehensive Cancer Center Georgetown University Washington 20057 DC USA

Aim:To investigate the effect of the Tob1 gene,a member of the TransducingMolecule of ErbB2/B-cell Translocation Ggene (TOB/BTG) family,by usingthe adenovirus-mediated expression of Tob 1 on radiosensitivity in a human breastcancer cell line ***:Cell survival was determined byclonogenic *** was evaluated by DNA fragmentation gel electro-phoresis and terminal deoxynucleotidyl transferase-mediated nick end *** expression was analyzed by Western blot assay and DNA repairwas measured by a host cell reactivation ***:We demonstrated thatpre-irradiation treatment with Ad5-Tob 1 significantly increased radiosensitivity,accompanying the increased induction of apoptosis and the repression of DNAdamage ***,Ad5-Tob 1-mediated radiosensitivity correlates withthe upregulation of the pro-apoptotic protein Bax and the downregulation ofseveral DNA double strand break repair proteins,including DNA-dependent pro-tein kinases,Ku70 and Ku80,and X-ray-sensitive complementation group ***:Tob1,as a new radiosensitizer,is a new target in the radiotherapyof breast cancer via increasing apoptosis and suppressing DNA repair.

关键词： Tobl breast cancer radiosensitivity radiation

Dose-dependent Cytotoxicity and Oxidative Stress Induced by "Naked" Fe_3._4 Nanoparticles in Human Hepatocyte

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Chemical Research in Chinese Universities 2012年第1期28卷 114-118页

作者： LIN Xin-li1, ZHAO Shu-hua1, ZHANG Long1, HU Gui-qin1, SUN Zhi-wei1,3.and YANG Wen-sheng2 1. school of public health, Jilin {3., Changchun 13.021, P. R. China 2. College of Chemistry, Jilin {3., Changchun 13.012, P. R. China 3. school of public health and Family Medicine, capital Medical {3., Beijing 100069, P. R. China Jilin Univ Sch Publ Hlth Changchun 130021 Peoples R China Jilin Univ Coll Chem Changchun 130012 Peoples R China capital Med Univ Sch Publ Hlth & Family Med Beijing 100069 Peoples R China

The dose-dependent cytotoxicity effect on human hepatocyte（HL-7702 cells） induced by ＂naked＂ Fe3.4 nanoparticles was assessed through cell viabilities and lactate dehydrogenase（LDH） activities. Three important oxi dative indexes of the cells by glutathione peroxidase（GSH-Px）, superoxide dismutase（SOD） and malondialde hyde（MDA） were determined. The good correlation of the cell viabilities with their GSH-Px, SOD and MDA levels indicated that the cytotoxicity is related to activation of oxidative stress induced by Fe3.4 nanoparticles. The oxida tive stress also leads to corresponding DNA damage in a similar dose-dependent manner, followed by the changes of cell cycle and cell apoptosis. Such work provides important experimental data for the safety evaluation of superpa ramagnetic Fe3.4 nanoparticles.

关键词： Superparamagnetic Fe3.4 Cytotoxicity Oxidative stress DNA damage Cell cycle Cell apoptosis